diphenoxylate hydrochloride (BioDeep_00000754779)

   


代谢物信息卡片


diphenoxylate hydrochloride

化学式: C30H33ClN2O2 (488.22304280000003)
中文名称: 地芬诺酯盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOC(=O)C1(CCN(CC1)CCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4.Cl
InChI: 1H

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
C78276 - Agent Affecting Digestive System or Metabolism > C266 - Antidiarrheal Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D005765 - Gastrointestinal Agents > D000930 - Antidiarrheals

同义名列表

1 个代谢物同义名

diphenoxylate hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Xiu-Min Wang, Li-Xia Lv, Yue-Si Qin, Yu-Zhu Zhang, Ni Yang, Shu Wu, Xiu-Wen Xia, Hong Yang, Hong Xu, Ying Liu, Wei-Jun Ding. Ji-Chuan decoction ameliorates slow transit constipation via regulation of intestinal glial cell apoptosis. World journal of gastroenterology. 2022 Sep; 28(34):5007-5022. doi: 10.3748/wjg.v28.i34.5007. [PMID: 36160643]
  • Zhitong Deng, Zhuotao Fu, Wen Yan, Kechao Nie, Lingli Ding, Duanhua Ma, Haodong Huang, Tao Li, Jianxing Xie, Linchun Fu. The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate. Food research international (Ottawa, Ont.). 2021 05; 143(?):110273. doi: 10.1016/j.foodres.2021.110273. [PMID: 33992373]
  • S U Xu, Jinhai Zhai, K E Xu, Xingguo Zuo, Chenghua Wu, Tao Lin, L I Zeng. M1 macrophages-derived exosomes miR-34c-5p regulates interstitial cells of Cajal through targeting SCF. Journal of biosciences. 2021; 46(?):. doi: . [PMID: 34544909]
  • Qian Tan, Jing Hu, Yujing Zhou, Yunxiao Wan, Chuanlan Zhang, Xin Liu, Xingyao Long, Fang Tan, Xin Zhao. Inhibitory Effect of Lactococcus lactis subsp. lactis HFY14 on Diphenoxylate-Induced Constipation in Mice by Regulating the VIP-cAMP-PKA-AQP3 Signaling Pathway. Drug design, development and therapy. 2021; 15(?):1971-1980. doi: 10.2147/dddt.s309675. [PMID: 34007157]
  • Junhong Lan, Kangli Wang, Guangyong Chen, Guangtian Cao, Caimei Yang. Effects of inulin and isomalto-oligosaccharide on diphenoxylate-induced constipation, gastrointestinal motility-related hormones, short-chain fatty acids, and the intestinal flora in rats. Food & function. 2020 Oct; 11(10):9216-9225. doi: 10.1039/d0fo00865f. [PMID: 33030479]
  • Teng-Gen Hu, Peng Wen, Hui-Zhan Fu, Guang-Yue Lin, Sen-Tai Liao, Yu-Xiao Zou. Protective effect of mulberry (Morus atropurpurea) fruit against diphenoxylate-induced constipation in mice through the modulation of gut microbiota. Food & function. 2019 Mar; 10(3):1513-1528. doi: 10.1039/c9fo00132h. [PMID: 30785176]
  • Xichuan Zhai, Dehui Lin, Yan Zhao, Xingbin Yang. Bacterial Cellulose Relieves Diphenoxylate-Induced Constipation in Rats. Journal of agricultural and food chemistry. 2018 Apr; 66(16):4106-4117. doi: 10.1021/acs.jafc.8b00385. [PMID: 29627986]
  • Suvra Mandal, Anupam Nayak, Manoj Kar, Samir K Banerjee, Ashes Das, S N Upadhyay, R K Singh, Avijit Banerji, Julie Banerji. Antidiarrhoeal activity of carbazole alkaloids from Murraya koenigii Spreng (Rutaceae) seeds. Fitoterapia. 2010 Jan; 81(1):72-4. doi: 10.1016/j.fitote.2009.08.016. [PMID: 19695314]
  • Markus B Frenz, Paul Dunckley, Luigi Camporota, Derek P Jewell, Simon P L Travis. Comparison between prospective and retrospective evaluation of Crohn's disease activity index. The American journal of gastroenterology. 2005 May; 100(5):1117-20. doi: 10.1111/j.1572-0241.2005.30487.x. [PMID: 15842587]
  • T L Pierce, A G Murray, W Hope. Determination of methadone and its metabolites by high performance liquid chromatography following solid-phase extraction in rat plasma. Journal of chromatographic science. 1992 Nov; 30(11):443-7. doi: 10.1093/chromsci/30.11.443. [PMID: 1474132]
  • L S Jackson, J E Stafford. The evaluation and application of a radioimmunoassay for the measurement of diphenoxylic acid, the major metabolite of diphenoxylate hydrochloride (Lomotil), in human plasma. Journal of pharmacological methods. 1987 Nov; 18(3):189-97. doi: 10.1016/0160-5402(87)90069-6. [PMID: 3682841]
  • A W Frolkis. [New results in the diagnosis and therapy of functional disorders of the large intestine]. Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten. 1986; 46(2):122-9. doi: . [PMID: 3720635]
  • T J Crowley. Doctors' drug abuse reduced during contingency-contracting treatment. Alcohol and drug research. 1985 198; 6(4):299-307. doi: NULL. [PMID: 4091896]
  • W V Harford, G J Krejs, C A Santa Ana, J S Fordtran. Acute effect of diphenoxylate with atropine (Lomotil) in patients with chronic diarrhea and fecal incontinence. Gastroenterology. 1980 Mar; 78(3):440-3. doi: . [PMID: 7351282]
  • C J Niemegeers, J L McGuire, J J Heykants, P A Janssen. Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs. The Journal of pharmacology and experimental therapeutics. 1979 Sep; 210(3):327-33. doi: . [PMID: 480185]
  • H Pece. [Treatment of diarrhea with difenoxin hydrochloride in children (author's transl)]. Arzneimittel-Forschung. 1979; 29(5):849-51. doi: . [PMID: 582988]
  • N Thurnherr, P Spring. [Double-blind study on the influence of difenoxin hydrochloride on intestinal passage time in healthy volunteers (author's transl)]. Arzneimittel-Forschung. 1979; 29(3):559-62. doi: NULL. [PMID: 582746]
  • G N Mir, R L Alioto, J W Sperow, J R Eash, J B Krebs, J Yelnosky. In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide. Arzneimittel-Forschung. 1978; 28(8a):1448-54. doi: . [PMID: 582536]
  • B L Portnoy, H L DuPont, D Pruitt, J A Abdo, J T Rodriguez. Antidiarrheal agents in the treatment of acute diarrhea in children. JAMA. 1976 Aug; 236(7):844-6. doi: NULL. [PMID: 781336]
  • W Pelemans, F Vantrappen. A double blind crossover comparison of loperamide with diphenoxylate in the symptomatic treatment of chronic diarrhea. Gastroenterology. 1976 Jun; 70(6):1030-4. doi: . [PMID: 773736]
  • G C Ford, N J Haskins, R F Palmer, M J Tidd, P H Buckley. The measurement of diphenoxylic acid in plasma following administration of diphenoxylate. Biomedical mass spectrometry. 1976 Feb; 3(1):45-7. doi: 10.1002/bms.1200030109. [PMID: 1260116]
  • N H Lauersen, K H Wilson. Induction of midtrimester abortion by serial intravaginal administration of 15(S)-15-methyl-prostaglandin F2alpha (THAM) suppositories. Prostaglandins. 1975 Dec; 10(6):1037-45. doi: 10.1016/s0090-6980(75)80051-7. [PMID: 1208882]