Halofantrine hydrochloride (BioDeep_00000754776)
代谢物信息卡片
Halofantrine hydrochloride
化学式: C26H31Cl3F3NO (535.1423202)
中文名称: 盐酸卤泛群
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl
InChI: 1H
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D02485
- PubChem: 37392
- ChEMBL: CHEMBL1200901
- CAS: 106927-11-1
- CAS: 66051-64-7
- CAS: 36167-63-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ben J Boyd, Malinda Salim, Andrew J Clulow, Gisela Ramirez, Anna C Pham, Adrian Hawley. The impact of digestion is essential to the understanding of milk as a drug delivery system for poorly water soluble drugs.
Journal of controlled release : official journal of the Controlled Release Society.
2018 12; 292(?):13-17. doi:
10.1016/j.jconrel.2018.10.027. [PMID: 30359667] - A T Larsen, R Holm, A Müllertz. Solution or suspension - Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2017 Aug; 117(?):308-314. doi:
10.1016/j.ejpb.2017.04.023. [PMID: 28465239] - Maria Høtoft Michaelsen, Kishor M Wasan, Olena Sivak, Anette Müllertz, Thomas Rades. The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).
The AAPS journal.
2016 Jan; 18(1):180-6. doi:
10.1208/s12248-015-9832-7. [PMID: 26486790] - Isha Taneja, Kanumuri Siva Rama Raju, Sheelendra Pratap Singh, Muhammad Wahajuddin. Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.
Scientific reports.
2015 Nov; 5(?):17264. doi:
10.1038/srep17264. [PMID: 26602250] - Muhammad Wahajuddin, Sheelendra P Singh, Isha Taneja, Kanumuri S R Raju, Jiaur R Gayen, Hefazat H Siddiqui, Shio K Singh. Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study.
Malaria journal.
2015 Apr; 14(?):172. doi:
10.1186/s12936-015-0684-5. [PMID: 25895956] - W Armand Guiguemde, Nicholas H Hunt, Jintao Guo, Annael Marciano, Richard K Haynes, Julie Clark, R Kiplin Guy, Jacob Golenser. Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4745-54. doi:
10.1128/aac.01553-13. [PMID: 24913162] - Natalie L Trevaskis, Suzanne M Caliph, Gary Nguyen, Patrick Tso, William N Charman, Christopher J H Porter. A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport.
Pharmaceutical research.
2013 Dec; 30(12):3254-70. doi:
10.1007/s11095-013-1000-0. [PMID: 23430484] - Suzanne M Caliph, Enyuan Cao, Jürgen B Bulitta, Luojuan Hu, Sifei Han, Christopher J H Porter, Natalie L Trevaskis. The impact of lymphatic transport on the systemic disposition of lipophilic drugs.
Journal of pharmaceutical sciences.
2013 Jul; 102(7):2395-408. doi:
10.1002/jps.23597. [PMID: 23696002] - Yan Yan Yeap, Natalie L Trevaskis, Christopher J H Porter. The potential for drug supersaturation during intestinal processing of lipid-based formulations may be enhanced for basic drugs.
Molecular pharmaceutics.
2013 Jul; 10(7):2601-15. doi:
10.1021/mp400035z. [PMID: 23697606] - Sayed Hassan Seif El-Din, Abdel-Nasser Abdel-Aal Sabra, Olfat Ali Hammam, Naglaa Mohamed El-Lakkany. Effect of ketoconazole, a cytochrome P450 inhibitor, on the efficacy of quinine and halofantrine against Schistosoma mansoni in mice.
The Korean journal of parasitology.
2013 Apr; 51(2):165-75. doi:
10.3347/kjp.2013.51.2.165. [PMID: 23710083] - Suzanne M Caliph, Natalie L Trevaskis, William N Charman, Christopher J H Porter. Intravenous dosing conditions may affect systemic clearance for highly lipophilic drugs: implications for lymphatic transport and absolute bioavailability studies.
Journal of pharmaceutical sciences.
2012 Sep; 101(9):3540-6. doi:
10.1002/jps.23211. [PMID: 22623170] - Jigar P Patel, Dalia A Hamdy, A O El-Kadi, Dion R Brocks. Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes.
Chirality.
2012 Jul; 24(7):558-65. doi:
10.1002/chir.22054. [PMID: 22589120] - René Holm, Henrik Tønsberg, Erling B Jørgensen, Puyan Abedinpour, Shafiq Farsad, Anette Müllertz. Influence of bile on the absorption of halofantrine from lipid-based formulations.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2012 Jun; 81(2):281-7. doi:
10.1016/j.ejpb.2012.03.005. [PMID: 22465095] - N Thomas, R Holm, A Müllertz, T Rades. In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS).
Journal of controlled release : official journal of the Controlled Release Society.
2012 May; 160(1):25-32. doi:
10.1016/j.jconrel.2012.02.027. [PMID: 22405903] - Natalie L Trevaskis, William N Charman, Christopher J H Porter. Acute hypertriglyceridemia promotes intestinal lymphatic lipid and drug transport: a positive feedback mechanism in lipid and drug absorption.
Molecular pharmaceutics.
2011 Aug; 8(4):1132-9. doi:
10.1021/mp100462d. [PMID: 21604764] - Anthony A Attama, Collins N Igbonekwu. In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug: halofantrine.
Asian Pacific journal of tropical medicine.
2011 Apr; 4(4):253-8. doi:
10.1016/s1995-7645(11)60081-3. [PMID: 21771465] - René Holm, Erling Bonne Jørgensen, Michael Harborg, Rune Larsen, Per Holm, Anette Müllertz, Jette Jacobsen. A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2011 Mar; 42(4):416-22. doi:
10.1016/j.ejps.2011.01.007. [PMID: 21256961] - Insaf F Khalil, Ulla Abildrup, Lene H Alifrangis, Deogratius Maiga, Michael Alifrangis, Lotte Hoegberg, Lasse S Vestergaard, Ola Per-Eric Persson, Nyagonde Nyagonde, Martha M Lemnge, Thor G Theander, Ib C Bygbjerg. Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection.
Journal of pharmaceutical and biomedical analysis.
2011 Jan; 54(1):168-72. doi:
10.1016/j.jpba.2010.08.009. [PMID: 20832961] - Jigar P Patel, Dion R Brocks. Effect of experimental hyperlipidaemia on the electrocardiographic effects of repeated doses of halofantrine in rats.
British journal of pharmacology.
2010 Nov; 161(6):1427-40. doi:
10.1111/j.1476-5381.2010.00983.x. [PMID: 20698852] - Jigar P Patel, Hesham M Korashy, Ayman O S El-Kadi, Dion R Brocks. Effect of bile and lipids on the stereoselective metabolism of halofantrine by rat everted-intestinal sacs.
Chirality.
2010 Feb; 22(2):275-83. doi:
10.1002/chir.20740. [PMID: 19496124] - Steve O Ijarotimi, Joseph M Agbedahunsi, Cyprian O Onyeji, Clement O Adewunmi. Chemotherapeutic interaction between Khaya grandifoliola (WELW) CDC stem bark extract and two anti-malarial drugs in mice.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2010; 7(4):370-6. doi:
10.4314/ajtcam.v7i4.56705. [PMID: 21731168] - C P Babalola, Y T Kolade, A A Olaniyi, A Adedapo, G K E Scriba. Effect of fluconazole on the pharmacokinetics of halofantrine in healthy volunteers.
Journal of clinical pharmacy and therapeutics.
2009 Dec; 34(6):677-82. doi:
10.1111/j.1365-2710.2009.01064.x. [PMID: 20175801] - Karen L White, Gary Nguyen, William N Charman, Glenn A Edwards, W A Fried Faassen, Christopher J H Porter. Lymphatic transport of Methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU.
The Journal of pharmacology and experimental therapeutics.
2009 Nov; 331(2):700-9. doi:
10.1124/jpet.109.154542. [PMID: 19696095] - Jigar P Patel, Jackie G Fleischer, Kishor M Wasan, Dion R Brocks. The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (+/-)-halofantrine.
Journal of pharmaceutical sciences.
2009 Jul; 98(7):2516-28. doi:
10.1002/jps.21607. [PMID: 18972574] - Wahajuddin, Sheelendra Pratap Singh, Girish Kumar Jain. Determination of lumefantrine in rat plasma by liquid-liquid extraction using LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(11-12):1133-9. doi:
10.1016/j.jchromb.2009.02.058. [PMID: 19285925] - Marianne L Lind, Jette Jacobsen, René Holm, Anette Müllertz. Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2008 Oct; 35(3):211-8. doi:
10.1016/j.ejps.2008.07.003. [PMID: 18675904] - Oluwatosin A Adaramoye, Dorcas O Osaimoje, Adewale M Akinsanya, Chiaka M Nneji, Michael A Fafunso, Olusegun G Ademowo. Changes in antioxidant status and biochemical indices after acute administration of artemether, artemether-lumefantrine and halofantrine in rats.
Basic & clinical pharmacology & toxicology.
2008 Apr; 102(4):412-8. doi:
10.1111/j.1742-7843.2008.00211.x. [PMID: 18282195] - Yetunde T Kolade, Chinedum P Babalola, Ajibola A Olaniyi, Gerhard K E Scriba. Effect of kolanut on the pharmacokinetics of the antimalarial drug halofantrine.
European journal of clinical pharmacology.
2008 Jan; 64(1):77-81. doi:
10.1007/s00228-007-0387-0. [PMID: 17952423] - Sharon I Omoruyi, Cyprian O Onyeji, Michael O Daniyan. Effects of prior administration of amodiaquine on the disposition of halofantrine in healthy volunteers.
Therapeutic drug monitoring.
2007 Apr; 29(2):203-6. doi:
10.1097/ftd.0b013e31803d39f7. [PMID: 17417075] - Negar Gharavi, Somayeh Sattari, Anooshirvan Shayeganpour, Ayman O S El-Kadi, Dion R Brocks. The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism.
Chirality.
2007 Jan; 19(1):22-33. doi:
10.1002/chir.20334. [PMID: 17089336] - Natalie L Trevaskis, Christopher J H Porter, William N Charman. An examination of the interplay between enterocyte-based metabolism and lymphatic drug transport in the rat.
Drug metabolism and disposition: the biological fate of chemicals.
2006 May; 34(5):729-33. doi:
10.1124/dmd.105.008102. [PMID: 16467133] - Yetunde T Kolade, Chinedum P Babalola, Gerhard K E Scriba. Analysis of the antimalarial drug halofantrine and its major metabolite N-desbutylhalofantrine in human plasma by high performance liquid chromatography.
Journal of pharmaceutical and biomedical analysis.
2006 Apr; 41(1):315-9. doi:
10.1016/j.jpba.2005.11.002. [PMID: 16337357] - Natalie L Trevaskis, Christopher J H Porter, William N Charman. The lymph lipid precursor pool is a key determinant of intestinal lymphatic drug transport.
The Journal of pharmacology and experimental therapeutics.
2006 Feb; 316(2):881-91. doi:
10.1124/jpet.105.094094. [PMID: 16249368] - Natalie L Trevaskis, Christopher J H Porter, William N Charman. Bile increases intestinal lymphatic drug transport in the fasted rat.
Pharmaceutical research.
2005 Nov; 22(11):1863-70. doi:
10.1007/s11095-005-6808-9. [PMID: 16132351] - Helena Ljusberg-Wahren, Flemming Seier Nielsen, Mattias Brogård, Emma Troedsson, Anette Müllertz. Enzymatic characterization of lipid-based drug delivery systems.
International journal of pharmaceutics.
2005 Jul; 298(2):328-32. doi:
10.1016/j.ijpharm.2005.02.038. [PMID: 15979260] - Peter U Bassi, Cyprian O Onyeji, Otas E Ukponmwan. Effects of tetracycline on the pharmacokinetics of halofantrine in healthy volunteers.
British journal of clinical pharmacology.
2004 Jul; 58(1):52-5. doi:
10.1111/j.1365-2125.2004.02087.x. [PMID: 15206992] - Geoffrey S Dow, Michael L Koenig, Lesley Wolf, Lucia Gerena, Miriam Lopez-Sanchez, Thomas H Hudson, Apurba K Bhattacharjee. The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.
Antimicrobial agents and chemotherapy.
2004 Jul; 48(7):2624-32. doi:
10.1128/aac.48.7.2624-2632.2004. [PMID: 15215119] - Christopher J H Porter, Ann Marie Kaukonen, Agnes Taillardat-Bertschinger, Ben J Boyd, Jacquelyn M O'Connor, Glenn A Edwards, William N Charman. Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: studies with halofantrine.
Journal of pharmaceutical sciences.
2004 May; 93(5):1110-21. doi:
10.1002/jps.20039. [PMID: 15067688] - Vanessa C F Mosqueira, Philippe M Loiseau, Christian Bories, Philippe Legrand, Jean-Philippe Devissaguet, Gillian Barratt. Efficacy and pharmacokinetics of intravenous nanocapsule formulations of halofantrine in Plasmodium berghei-infected mice.
Antimicrobial agents and chemotherapy.
2004 Apr; 48(4):1222-8. doi:
10.1128/aac.48.4.1222-1228.2004. [PMID: 15047523] - Michelle P McIntosh, William N Charman, Michael Campbell, Christopher J H Porter. Influence of physicochemical properties on the patterns of association of a series of aliphatic esters of halofantrine with plasma lipoproteins.
Journal of controlled release : official journal of the Controlled Release Society.
2004 Mar; 95(2):275-89. doi:
10.1016/j.jconrel.2003.12.003. [PMID: 14980776] - Ann Marie Kaukonen, Ben J Boyd, Christopher J H Porter, William N Charman. Drug solubilization behavior during in vitro digestion of simple triglyceride lipid solution formulations.
Pharmaceutical research.
2004 Feb; 21(2):245-53. doi:
10.1023/b:pham.0000016282.77887.1f. [PMID: 15032305] - Ann Marie Kaukonen, Ben J Boyd, William N Charman, Christopher J H Porter. Drug solubilization behavior during in vitro digestion of suspension formulations of poorly water-soluble drugs in triglyceride lipids.
Pharmaceutical research.
2004 Feb; 21(2):254-60. doi:
10.1023/b:pham.0000016283.87709.a9. [PMID: 15032306] - Michelle P McIntosh, Andrew J Batey, Susan J Coker, Christopher J H Porter, William N Charman. Evaluation of the impact of altered lipoprotein binding conditions on halofantrine induced QTc interval prolongation in an anaesthetized rabbit model.
The Journal of pharmacy and pharmacology.
2004 Jan; 56(1):69-77. doi:
10.1211/0022357022520. [PMID: 14980003] - Agnes Taillardat-Bertschinger, Christine S Perry, Alexandra Galland, Richard J Prankerd, William N Charman. Partitioning of halofantrine hydrochloride between water, micellar solutions, and soybean oil: Effects on its apparent ionization constant.
Journal of pharmaceutical sciences.
2003 Nov; 92(11):2217-28. doi:
10.1002/jps.10479. [PMID: 14603507] - René Holm, Christopher J H Porter, Glenn A Edwards, Anette Müllertz, Henning G Kristensen, William N Charman. Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2003 Sep; 20(1):91-7. doi:
10.1016/s0928-0987(03)00174-x. [PMID: 13678797] - Shui-Mei Khoo, David M Shackleford, Christopher J H Porter, Glenn A Edwards, William N Charman. Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs.
Pharmaceutical research.
2003 Sep; 20(9):1460-5. doi:
10.1023/a:1025718513246. [PMID: 14567642] - David M Shackleford, Christopher J H Porter, William N Charman. Does stereoselective lymphatic absorption contribute to the enantioselective pharmacokinetics of halofantrine In Vivo?.
Biopharmaceutics & drug disposition.
2003 May; 24(4):153-7. doi:
10.1002/bdd.351. [PMID: 12698498] - P Legrand, V Mosqueira, P Loiseau, C Bories, G Barratt. [Long circulating nanocapsules: interest in the treatment of severe malaria with halofantrine].
Annales pharmaceutiques francaises.
2003 May; 61(3):196-202. doi:
NULL. [PMID: 12714932] - Mei-Lin Go, Qiu-Tian Li. Interaction of the antimalarial agents halofantrine and lumefantrine with lipid bilayers.
Chemical & pharmaceutical bulletin.
2003 Mar; 51(3):241-6. doi:
10.1248/cpb.51.241. [PMID: 12612404] - Beny Charbit, Laurent Becquemont, Bénédicte Lepère, Gilles Peytavin, Christian Funck-Brentano. Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine.
Clinical pharmacology and therapeutics.
2002 Nov; 72(5):514-23. doi:
10.1067/mcp.2002.128148b. [PMID: 12426515] - F Bruneel, B Gachot, M Wolff, J P Bedos, B Regnier, M Danis, F Vachon. [Blackwater fever].
Presse medicale (Paris, France : 1983).
2002 Sep; 31(28):1329-34. doi:
NULL. [PMID: 12355996] - Mackenzi Mbai, Sridharan Rajamani, Craig T January. The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels.
Cardiovascular research.
2002 Sep; 55(4):799-805. doi:
10.1016/s0008-6363(02)00448-0. [PMID: 12176129] - Dion R Brocks, Kishor M Wasan. The influence of lipids on stereoselective pharmacokinetics of halofantrine: Important implications in food-effect studies involving drugs that bind to lipoproteins.
Journal of pharmaceutical sciences.
2002 Aug; 91(8):1817-26. doi:
10.1002/jps.10182. [PMID: 12115809] - Dion R Brocks, Guru V Betageri. Enhanced oral absorption of halofantrine enantiomers after encapsulation in a proliposomal formulation.
The Journal of pharmacy and pharmacology.
2002 Aug; 54(8):1049-53. doi:
10.1211/002235702320266190. [PMID: 12195818] - J E Touze, P Heno, L Fourcade, J C Deharo, G Thomas, S Bohan, P Paule, P Riviere, E Kouassi, A Buguet. The effects of antimalarial drugs on ventricular repolarization.
The American journal of tropical medicine and hygiene.
2002 Jul; 67(1):54-60. doi:
10.4269/ajtmh.2002.67.54. [PMID: 12363064] - Margaretha Bindschedler, Gilbert Lefèvre, Peter Degen, Antoine Sioufi. Comparison of the cardiac effects of the antimalarials co-artemether and halofantrine in healthy participants.
The American journal of tropical medicine and hygiene.
2002 Mar; 66(3):293-8. doi:
10.4269/ajtmh.2002.66.293. [PMID: 12139223] - Shui-Mei Khoo, Richard J Prankerd, Glenn A Edwards, Christopher J H Porter, William N Charman. A physicochemical basis for the extensive intestinal lymphatic transport of a poorly lipid soluble antimalarial, halofantrine hydrochloride, after postprandial administration to dogs.
Journal of pharmaceutical sciences.
2002 Mar; 91(3):647-59. doi:
10.1002/jps.10045. [PMID: 11920750] - Dion R Brocks. Stereoselective halofantrine and desbutylhalofantrine disposition in the rat: cardiac and plasma concentrations and plasma protein binding.
Biopharmaceutics & drug disposition.
2002 Jan; 23(1):9-15. doi:
10.1002/bdd.286. [PMID: 11891669] - R Holm, A Müllertz, E Christensen, C E Høy, H G Kristensen. Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2001 Dec; 14(4):331-7. doi:
10.1016/s0928-0987(01)00186-5. [PMID: 11684408] - S M Khoo, G A Edwards, C J Porter, W N Charman. A conscious dog model for assessing the absorption, enterocyte-based metabolism, and intestinal lymphatic transport of halofantrine.
Journal of pharmaceutical sciences.
2001 Oct; 90(10):1599-607. doi:
10.1002/jps.1110. [PMID: 11745718] - R Holm, A Müllertz, G P Pedersen, H G Kristensen. Comparison of the lymphatic transport of halofantrine administered in disperse systems containing three different unsaturated fatty acids.
Pharmaceutical research.
2001 Sep; 18(9):1299-304. doi:
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Chemical & pharmaceutical bulletin.
2001 Jul; 49(7):871-6. doi:
10.1248/cpb.49.871. [PMID: 11456094] - E O Farombi, S Adoro, S Uhunmwangho. Antimalarial drugs exacerbate rat liver microsomal lipid peroxidation in the presence of oxidants.
Bioscience reports.
2001 Jun; 21(3):353-9. doi:
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British journal of clinical pharmacology.
2001 Mar; 51(3):231-7. doi:
10.1046/j.1365-2125.2001.00351.x. [PMID: 11298069] - D R Brocks. A high-performance liquid chromatographic assay for the determination of desbutylhalofantrine enantiomers in rat plasma.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2001 Jan; 4(1):24-31. doi:
NULL. [PMID: 11302787] - S M Khoo, C J Porter, W N Charman. The formulation of Halofantrine as either non-solubilizing PEG 6000 or solubilizing lipid based solid dispersions: physical stability and absolute bioavailability assessment.
International journal of pharmaceutics.
2000 Sep; 205(1-2):65-78. doi:
10.1016/s0378-5173(00)00485-3. [PMID: 11000543] - H Tie, B D Walker, C B Singleton, S M Valenzuela, J A Bursill, K R Wyse, S N Breit, T J Campbell. Inhibition of HERG potassium channels by the antimalarial agent halofantrine.
British journal of pharmacology.
2000 Aug; 130(8):1967-75. doi:
10.1038/sj.bjp.0703470. [PMID: 10952689] - S M Caliph, W N Charman, C J Porter. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats.
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