Perhexiline maleate (BioDeep_00000754512)
代谢物信息卡片
Perhexiline maleate
化学式: C23H39NO4 (393.28789340000003)
中文名称: 马来酸哌克昔林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3.C(=CC(=O)O)C(=O)O
InChI: 2-1-
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
C93038 - Cation Channel Blocker
Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina[1][2][5].
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- KEGGdrug: D05442
- PubChem: 5284439
- ChEMBL: CHEMBL1334033
- CAS: 103516-76-3
- CAS: 103516-75-2
- CAS: 6724-53-4
- medchemexpress: HY-B1334A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alessandra Guidi, Greta Petrella, Valentina Fustaino, Fulvio Saccoccia, Sara Lentini, Roberto Gimmelli, Giulia Di Pietro, Alberto Bresciani, Daniel Oscar Cicero, Giovina Ruberti. Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy.
PLoS neglected tropical diseases.
2020 10; 14(10):e0008767. doi:
10.1371/journal.pntd.0008767. [PMID: 33044962] - Alessandra Guidi, Cristiana Lalli, Emerald Perlas, Giulia Bolasco, Martina Nibbio, Edith Monteagudo, Alberto Bresciani, Giovina Ruberti. Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems.
PLoS neglected tropical diseases.
2016 08; 10(8):e0004928. doi:
10.1371/journal.pntd.0004928. [PMID: 27518281] - Nicolas Delattin, Katrijn De Brucker, Katleen Vandamme, Els Meert, Arnaud Marchand, Patrick Chaltin, Bruno P A Cammue, Karin Thevissen. Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.
The Journal of antimicrobial chemotherapy.
2014 Apr; 69(4):1035-44. doi:
10.1093/jac/dkt449. [PMID: 24284780] - Hiroshi Kitoh, Masataka Achiwa, Hiroshi Kaneko, Kenichi Mishima, Masaki Matsushita, Izumi Kadono, John D Horowitz, Benedetta C Sallustio, Kinji Ohno, Naoki Ishiguro. Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial.
Orphanet journal of rare diseases.
2013 Oct; 8(?):163. doi:
10.1186/1750-1172-8-163. [PMID: 24131551] - Harel Gilutz, Michael P Frenneaux, John D Horowitz. A case series of concomitant treatment of perhexiline with amiodarone.
Therapeutic drug monitoring.
2012 Apr; 34(2):227-31. doi:
10.1097/ftd.0b013e318245e5a6. [PMID: 22322401] - Sally C Inglis, Megan K Herbert, Benjamin J L Davies, Janet K Coller, Heather M James, John D Horowitz, Raymond G Morris, Robert W Milne, Andrew A Somogyi, Benedetta C Sallustio. Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia.
Pharmacogenetics and genomics.
2007 May; 17(5):305-12. doi:
10.1097/fpc.0b013e32800ffba0. [PMID: 17429312] - S Stewart, D W Voss, D L Northey, J D Horowitz. Relationship between plasma perhexiline concentration and symptomatic status during short-term perhexiline therapy.
Therapeutic drug monitoring.
1996 Dec; 18(6):635-9. doi:
10.1097/00007691-199612000-00002. [PMID: 8946658] - P L Cole, A D Beamer, N McGowan, C O Cantillon, K Benfell, R A Kelly, L H Hartley, T W Smith, E M Antman. Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent.
Circulation.
1990 Apr; 81(4):1260-70. doi:
10.1161/01.cir.81.4.1260. [PMID: 2180591] - J D Horowitz, S T Sia, P S Macdonald, A J Goble, W J Louis. Perhexiline maleate treatment for severe angina pectoris--correlations with pharmacokinetics.
International journal of cardiology.
1986 Nov; 13(2):219-29. doi:
10.1016/0167-5273(86)90146-4. [PMID: 3793279] - A G Amoah, B J Gould, D V Parke, J D Lockhart. Further studies on the pharmacokinetics of perhexiline maleate in humans.
Xenobiotica; the fate of foreign compounds in biological systems.
1986 Jan; 16(1):63-8. doi:
10.3109/00498258609043506. [PMID: 3946097] - J D Cooper, D C Turnell, J Pilcher, D Lockhart. Therapeutic monitoring of the anti-anginal drug perhexiline maleate.
Annals of clinical biochemistry.
1985 Nov; 22 ( Pt 6)(?):614-7. doi:
10.1177/000456328502200611. [PMID: 4073793] - J Pilcher, J D Cooper, D C Turnell, J Matenga, R Paul, J D Lockhart. Investigations of long-term treatment with perhexiline maleate using therapeutic monitoring and electromyography.
Therapeutic drug monitoring.
1985; 7(1):54-60. doi:
10.1097/00007691-198503000-00009. [PMID: 3992623] - R G Cooper, D A Evans, E J Whibley. Polymorphic hydroxylation of perhexiline maleate in man.
Journal of medical genetics.
1984 Feb; 21(1):27-33. doi:
10.1136/jmg.21.1.27. [PMID: 6694182] - A Ramu, Z Fuks, S Gatt, D Glaubiger. Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate.
Cancer research.
1984 Jan; 44(1):144-8. doi:
". [PMID: 6690032] - A Ramu, T C Shan, D Glaubiger. Enhancement of doxorubicin and vinblastine sensitivity in anthracycline-resistant P388 cells.
Cancer treatment reports.
1983 Oct; 67(10):895-9. doi:
. [PMID: 6354437] - J P Bendirdjian, G Viotte, M Bichara, B Foucher, J P Fillastre. Changes in the lysosomes and mitochondria isolated from the liver, kidney and heart of rats treated with perhexiline maleate.
Toxicological European research. Recherche europeenne en toxicologie.
1982 Nov; 4(6):297-300. doi:
NULL. [PMID: 7170723] - S Albouz, J M Boutry, G Dubois, R Bourdon, J J Hauw, N Baumann. Lipid and lysosomal enzymes in human fibroblasts cultured with perhexiline maleate.
Naunyn-Schmiedeberg's archives of pharmacology.
1981 Sep; 317(2):173-7. doi:
10.1007/bf00500076. [PMID: 7300921] - A Lageron, J Scotto, M Gautier. Effects of Pexid on liver cell cultures. Ultrastructural and histoenzymological studies.
European journal of clinical pharmacology.
1981; 19(6):417-21. doi:
10.1007/bf00548585. [PMID: 6265224] - P Bouche, M G Bousser, M A Peytour, H P Cathala. Perhexiline maleate and peripheral neuropathy.
Neurology.
1979 May; 29(5):739-43. doi:
10.1212/wnl.29.5.739. [PMID: 220563] - S Pollet, J J Hauw, J C Turpin, F Le Saux, R Escourolle, N Baumann. Analysis of the major lipid classes in human peripheral nerve biopsies. Age group differences and abnormalities of ganglioside level in perhexiline maleate therapy.
Journal of the neurological sciences.
1979 Apr; 41(2):199-206. doi:
10.1016/0022-510x(79)90039-x. [PMID: 220390] - E Singlas, M A Goujet, P Simon. Pharmacokinetics of perhexiline maleate in anginal patients with and without peripheral neuropathy.
European journal of clinical pharmacology.
1978 Nov; 14(3):195-201. doi:
10.1007/bf02089960. [PMID: 729614] - J J Hauw, B Singer, R Poupon, D Lecomte, P P de Saint-Maur, A Lageron, S Pollet. [Diffuse polymorphous inclusions in a patient treated with perhexiline maleate (author's transl)].
La Nouvelle presse medicale.
1978 Mar; 7(10):817-20. doi:
". [PMID: 205835] - S Pollet, J J Hauw, R Escourolle, N Baumann. Peripheral-nerve lipid abnormalities in patients on perhexiline maleate.
Lancet (London, England).
1977 Jun; 1(8024):1258. doi:
10.1016/s0140-6736(77)92464-3. [PMID: 68353]