Tolperisone hydrochloride (BioDeep_00000753855)

   


代谢物信息卡片


Tolperisone hydrochloride

化学式: C16H24ClNO (281.15463239999997)
中文名称: 盐酸托哌酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)C(=O)C(C)CN2CCCCC2.Cl
InChI: 1H

描述信息

D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
D002491 - Central Nervous System Agents

同义名列表

1 个代谢物同义名

Tolperisone hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Marwa Ibrahim Helmy, Samah Sabry Saad, Maha Abdelmonem Hegazy, Ahmed Salah Fayed. Sensitive and selective LC-MS/MS for the determination of tolperisone and etodolac in human plasma and application to a pharmacokinetic study. Journal of separation science. 2022 May; 45(10):1646-1655. doi: 10.1002/jssc.202100991. [PMID: 35233941]
  • Mingheng Li, Yan Huang, Rongchun Chen, Ning Liu, Shibing Fang. Efficacy and safety of tolperisone versus baclofen among Chinese patients with spasticity associated with spinal cord injury: a non-randomized retrospective study. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2021; 54(11):e11293. doi: 10.1590/1414-431x2021e11293. [PMID: 34495247]
  • Judy Caron, Randall Kaye, Thomas Wessel, Amy Halseth, Gary Kay. An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine. Journal of clinical pharmacy and therapeutics. 2020 Aug; 45(4):774-782. doi: 10.1111/jcpt.13165. [PMID: 32390248]
  • Gulam Rabbani, Eun Ju Lee, Khurshid Ahmad, Mohammad Hassan Baig, Inho Choi. Binding of Tolperisone Hydrochloride with Human Serum Albumin: Effects on the Conformation, Thermodynamics, and Activity of HSA. Molecular pharmaceutics. 2018 04; 15(4):1445-1456. doi: 10.1021/acs.molpharmaceut.7b00976. [PMID: 29432019]
  • M Pawlowska, M Bogiel, J Duda, E Sieradzki. Influence of CYP2D6 and CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy volunteers. European journal of clinical pharmacology. 2015 Jun; 71(6):699-705. doi: 10.1007/s00228-015-1856-5. [PMID: 25953735]
  • Naoya Miura, Takeshi Saito, Takayuki Taira, Takeshi Yamagiwa, Sein Morita, Sadaki Inokuchi. Rapid simultaneous determination of eperisone, tolperisone, and tizanidine in human serum by using a MonoSpin® C18 extraction column and liquid chromatography/tandem mass spectrometry. Journal of AOAC International. 2014 Nov; 97(6):1546-51. doi: 10.5740/jaoacint.13-295. [PMID: 25632432]
  • R Nageswara Rao, S Satyanarayana Raju. Enantioselective separation and simultaneous determination of tolperisone and eperisone in rat plasma by LC-MS/MS. Chirality. 2013 Oct; 25(10):622-7. doi: 10.1002/chir.22187. [PMID: 23840024]
  • Chang-Ik Choi, Jung-In Park, Hye-In Lee, Yun-Jeong Lee, Choon-Gon Jang, Jung-Woo Bae, Seok-Yong Lee. Determination of tolperisone in human plasma by liquid chromatography/tandem mass spectrometry for clinical application. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Dec; 911(?):59-63. doi: 10.1016/j.jchromb.2012.10.027. [PMID: 23217307]
  • Frank Sporkert, Christophe Brunel, Marc P Augsburger, Patrice Mangin. Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases. Forensic science international. 2012 Feb; 215(1-3):101-4. doi: 10.1016/j.forsciint.2011.05.025. [PMID: 21683537]
  • J W Bae, M J Kim, Y S Park, C S Myung, C G Jang, S Y Lee. Considerable interindividual variation in the pharmacokinetics of tolperisone HCl. International journal of clinical pharmacology and therapeutics. 2007 Feb; 45(2):110-3. doi: 10.5414/cpp45110. [PMID: 17323790]
  • Jung-Woo Bae, Young-Seo Park, Uy-Dong Sohn, Chang-Sun Myung, Byung-Kwon Ryu, Choon-Gon Jang, Seok-Yong Lee. HPLC determination of tolperisone in human plasma. Archives of pharmacal research. 2006 Apr; 29(4):339-42. doi: 10.1007/bf02968581. [PMID: 16681042]
  • A Melka, R Tekle-Haimanot, F Lambien. Symptomatic treatment of neurolathyrism with tolperisone HCL (Mydocalm): a randomized double blind and placebo controlled drug trial. Ethiopian medical journal. 1997 Apr; 35(2):77-91. doi: ". [PMID: 9577009]
  • M Matsunaga, Y Uemura, Y Yonemoto, K Kanai, H Etoh, S Tanaka, Y Atsuta, Y Nishizawa, Y Yamanishi. Long-lasting muscle relaxant activity of eperisone hydrochloride after percutaneous administration in rats. Japanese journal of pharmacology. 1997 Mar; 73(3):215-20. doi: 10.1254/jjp.73.215. [PMID: 9127816]
  • T Yokoyama, K Fukuda, S Mori, M Ogawa, K Nagasawa. Determination of tolperisone enantiomers in plasma and their disposition in rats. Chemical & pharmaceutical bulletin. 1992 Jan; 40(1):272-4. doi: 10.1248/cpb.40.272. [PMID: 1576686]