Minocycline hydrochloride (BioDeep_00000753852)
代谢物信息卡片
Minocycline hydrochloride
化学式: C23H28ClN3O7 (493.16156880000005)
中文名称: 盐酸米诺环素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C.Cl
InChI: /m0./s1
描述信息
C784 - Protein Synthesis Inhibitor > C1595 - Tetracycline Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect[1][2][3][4][5][6][7].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:50697
- KEGGdrug: D00850
- PubChem: 54685925
- ChEMBL: CHEMBL1200881
- ChEMBL: CHEMBL4576719
- MeSH: Minocycline
- CAS: 13614-98-7
- medchemexpress: HY-17412
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hui He, Haili He, Li Mo, Zili You, Jinqiang Zhang. Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice.
Brain, behavior, and immunity.
2024 01; 115(?):280-294. doi:
10.1016/j.bbi.2023.10.031. [PMID: 37914097] - Nana Zheng, Yuanyuan Xie, Meng Zhou, Yuzhen Liu, Haoxiang Xu, Rong Zeng, Chunping Wan, Min Li. Utilizing the Photodynamic Properties of Curcumin to Disrupt Biofilms in Cutibacterium acnes: A Promising Approach for Treating Acne.
Photodiagnosis and photodynamic therapy.
2023 Dec; ?(?):103928. doi:
10.1016/j.pdpdt.2023.103928. [PMID: 38070633] - Wenwen Gao, Mingliang Zhu, Yanhui Yin, Xiang Zhang, Lu Wang. Efficacy and safety of minocycline quadruple therapy for Helicobacter pylori eradication: A meta-analysis of RCTs.
Helicobacter.
2023 Dec; 28(6):e13022. doi:
10.1111/hel.13022. [PMID: 37839018] - Suyeon Park, Jihyun Choi, Dongwoo Shin, Ki Tae Kwon, Si-Ho Kim, Yu Mi Wi, Kwan Soo Ko. Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy.
International journal of antimicrobial agents.
2023 Oct; ?(?):107017. doi:
10.1016/j.ijantimicag.2023.107017. [PMID: 37884228] - Long Li, Shanbo Ma, Jin Wang, Yuhan Chen, Feiyan Wang, Meiling Zheng, Kun Zhang, Shan Miao, Xiaopeng Shi. Inflammatory Factors Predicted the Resilient Phenotype in Social Defeat-induced Depression of Male Mouse.
Neuroscience.
2023 05; 519(?):38-46. doi:
10.1016/j.neuroscience.2023.02.022. [PMID: 36893981] - Yawen Sun, Yuzhen Pan, Zhe Zhang, Zhen Chen, Jiali Wang, Baodong Wang, Zihong Cheng, Wei Ma. Study on the role of AlOOH in fluorescence correction and depth purification of Cyclops water.
Chemosphere.
2023 May; 322(?):138190. doi:
10.1016/j.chemosphere.2023.138190. [PMID: 36812996] - Eun-Joo Shin, Bao Trong Nguyen, Naveen Sharma, Ngoc Kim Cuong Tran, Yen Nhi Doan Nguyen, Yeonggwang Hwang, Jung Hoon Park, Seung-Yeol Nah, Sung Kwon Ko, Jae Kyung Byun, Yi Lee, Dae-Joong Kim, Ji Hoon Jeong, Hyoung-Chun Kim. Ginsenoside Re mitigates memory impairments in aged GPx-1 KO mice by inhibiting the interplay between PAFR, NFκB, and microgliosis in the hippocampus.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Mar; 173(?):113627. doi:
10.1016/j.fct.2023.113627. [PMID: 36682417] - Zhiwei Zeng, Xiao Chang, Dawei Zhang, Haiyun Chen, Xiaoyan Zhong, Yikun Xie, Qian Yu, Chunyan Yan. Structural elucidation and anti-neuroinflammatory activity of Polygala tenuifolia polysaccharide.
International journal of biological macromolecules.
2022 Oct; 219(?):1284-1296. doi:
10.1016/j.ijbiomac.2022.08.161. [PMID: 36037912] - Tingting Guo, Xiaoli Sun, Jie Yang, Liying Yang, Mengying Li, Yuhang Wang, Hongmei Jiao, Guocai Li. Metformin reverse minocycline to inhibit minocycline-resistant Acinetobacter baumannii by destroy the outer membrane and enhance membrane potential in vitro.
BMC microbiology.
2022 09; 22(1):215. doi:
10.1186/s12866-022-02629-4. [PMID: 36089583] - Akira Akamatsu, Miwa Nagae, Naoya Takeda. The CYCLOPS Response Element in the NIN Promoter Is Important but Not Essential for Infection Thread Formation During Lotus japonicus-Rhizobia Symbiosis.
Molecular plant-microbe interactions : MPMI.
2022 Aug; 35(8):650-658. doi:
10.1094/mpmi-10-21-0252-r. [PMID: 35343248] - H S Shin, C C Zouboulis, M K Kim, D H Lee, J H Chung. Minocycline suppresses lipogenesis via inhibition of p300 histone acetyltransferase activity in human SZ95 sebocytes.
Journal of the European Academy of Dermatology and Venereology : JEADV.
2022 Aug; 36(8):1325-1333. doi:
10.1111/jdv.18079. [PMID: 35285066] - Xiaoyun Gong, Elaine Jensen, Simone Bucerius, Martin Parniske. A CCaMK/Cyclops response element in the promoter of Lotus japonicus calcium-binding protein 1 (CBP1) mediates transcriptional activation in root symbioses.
The New phytologist.
2022 08; 235(3):1196-1211. doi:
10.1111/nph.18112. [PMID: 35318667] - Luis Javier Galindo, David S Milner, Suely Lopes Gomes, Thomas A Richards. A light-sensing system in the common ancestor of the fungi.
Current biology : CB.
2022 07; 32(14):3146-3153.e3. doi:
10.1016/j.cub.2022.05.034. [PMID: 35675809] - Taylor Abbey, Alesia Vialichka, Michele Jurkovic, Mark Biagi, Eric Wenzler. Activity of Omadacycline Alone and in Combination against Carbapenem-Nonsusceptible Acinetobacter baumannii with Varying Minocycline Susceptibility.
Microbiology spectrum.
2022 06; 10(3):e0054222. doi:
10.1128/spectrum.00542-22. [PMID: 35647655] - Olamide B Adelusi, Anup Ramachandran, John J Lemasters, Hartmut Jaeschke. The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Toxicology and applied pharmacology.
2022 06; 445(?):116043. doi:
10.1016/j.taap.2022.116043. [PMID: 35513057] - Majid Motaghinejad, Manijeh Motevalian. Neuroprotective Properties of Minocycline Against Methylphenidate-Induced Neurodegeneration: Possible Role of CREB/BDNF and Akt/GSK3 Signaling Pathways in Rat Hippocampus.
Neurotoxicity research.
2022 Jun; 40(3):689-713. doi:
10.1007/s12640-021-00454-7. [PMID: 35446003] - Majid Shokoohi, Arash Khaki, Ayda Roudi Rasht Abadi, Linda MohammadZadeh Boukani, Sepideh Hassanpour Khodaie, Hossein Kalarestaghi, Amir Afshin Khaki, Maryam Moghimian, Hamid Reza Niazkar, Hamed Shoorei. Minocycline can reduce testicular apoptosis related to varicocele in male rats.
Andrologia.
2022 May; 54(4):e14375. doi:
10.1111/and.14375. [PMID: 35266181] - Ema Ozaki, Conor Delaney, Matthew Campbell, Sarah L Doyle. Minocycline suppresses disease-associated microglia (DAM) in a model of photoreceptor cell degeneration.
Experimental eye research.
2022 04; 217(?):108953. doi:
10.1016/j.exer.2022.108953. [PMID: 35090890] - Alireza Nasiri, Akbar Shafiee, Ali Hosseinsabet, Azita Hajhosein Talasaz, Arash Jalali, Mojtaba Salarifar. Effect of minocycline on the left ventricular function following ST-elevation myocardial infarction treated by primary percutaneous coronary intervention.
Trials.
2022 Feb; 23(1):112. doi:
10.1186/s13063-021-05921-2. [PMID: 35120566] - Kazuhiro Itoh, Ippei Sakamaki, Tomoya Hirota, Hiromichi Iwasaki. Evaluation of minocycline combined with favipiravir therapy in coronavirus disease 2019 patients: A case-series study.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Jan; 28(1):124-127. doi:
10.1016/j.jiac.2021.09.016. [PMID: 34627706] - Qi Lu, Jun Xiong, Yuan Yuan, Zhanwei Ruan, Yu Zhang, Bo Chai, Lei Li, Shufang Cai, Jian Xiao, Yanqing Wu, Peng Huang, Hongyu Zhang. Minocycline improves the functional recovery after traumatic brain injury via inhibition of aquaporin-4.
International journal of biological sciences.
2022; 18(1):441-458. doi:
10.7150/ijbs.64187. [PMID: 34975343] - Kenichi Yokota, Isao Kurihara, Toshifumi Nakamura, Seishi Nakatsuka, Kazutoshi Miyashita, Sakiko Kobayashi, Ayano Murai-Takeda, Masakatsu Sone, Hiroshi Itoh. Remission of Angiographically Confirmed Minocycline-induced Renal Polyarteritis Nodosa: A Case Report and Literature Review.
Internal medicine (Tokyo, Japan).
2022 Jan; 61(1):103-110. doi:
10.2169/internalmedicine.7340-21. [PMID: 34176836] - Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases.
Antimicrobial agents and chemotherapy.
2021 11; 65(12):e0106521. doi:
10.1128/aac.01065-21. [PMID: 34516251] - Hui-Chun Huang, Hsin-Ling Ho, Ching-Chih Chang, Chiao-Lin Chuang, Chon Kit Pun, Fa-Yauh Lee, Yi-Hsiang Huang, Ming-Chih Hou, Shao-Jung Hsu. Matrix metalloproteinase-9 inhibition or deletion attenuates portal hypertension in rodents.
Journal of cellular and molecular medicine.
2021 11; 25(21):10073-10087. doi:
10.1111/jcmm.16940. [PMID: 34647412] - Sara Akalay, Thomas Vanassche, Paul De Munter. Tigecycline-induced life-threatening coagulopathy in a patient with a Mycobacterium abscess: a case report and step-by-step diagnostic approach.
Acta clinica Belgica.
2021 Oct; 76(5):410-414. doi:
10.1080/17843286.2020.1747197. [PMID: 32255411] - Liang Cai, Lingti Kong, Chenchen Wu, Desheng Wu, Xiaofei Wu. Pharmacokinetics of tigecycline in both plasma and sputum in patients with severe pneumonia.
Journal of global antimicrobial resistance.
2021 09; 26(?):1-3. doi:
10.1016/j.jgar.2021.04.023. [PMID: 34020074] - Christopher T Lucido, Jana Johnson. Serum Sickness-Like Reaction in an Adolescent Taking Minocycline for Acne.
South Dakota medicine : the journal of the South Dakota State Medical Association.
2021 Jul; 74(7):310-313. doi:
NULL. [PMID: 34449992] - Yangang Zhou, Ping Xu, Huande Li, Feng Wang, Han Yan, Wu Liang, Daxiong Xiang, Bikui Zhang, Hoan Linh Banh. Population pharmacokinetics and exposure-response analysis of tigecycline in patients with hospital-acquired pneumonia.
British journal of clinical pharmacology.
2021 07; 87(7):2838-2846. doi:
10.1111/bcp.14692. [PMID: 33283892] - Emma K A Schmidt, Pamela J F Raposo, Abel Torres-Espin, Keith K Fenrich, Karim Fouad. Beyond the lesion site: minocycline augments inflammation and anxiety-like behavior following SCI in rats through action on the gut microbiota.
Journal of neuroinflammation.
2021 Jun; 18(1):144. doi:
10.1186/s12974-021-02123-0. [PMID: 34174901] - Haoqing Wu, Manli Qi, Huiping Wang, Quanzhong Liu, Yuanjun Liu. Efficacy of minocycline in the treatment of early syphilis.
International journal of STD & AIDS.
2021 06; 32(7):648-653. doi:
10.1177/0956462420984695. [PMID: 33496202] - Giovanni Diana, Rocky Strollo, Davide Diana, Mirko Strollo, Alfredo R Galassi, Filippo Crea. Cardiac safety and potential efficacy: two reasons for considering minocycline in place of azithromycin in COVID-19 management.
European heart journal. Cardiovascular pharmacotherapy.
2021 05; 7(3):e53-e54. doi:
10.1093/ehjcvp/pvaa049. [PMID: 32379302] - Luis Henrique Angenendt da Costa, Nilton Nascimento Santos-Junior, Carlos Henrique Rocha Catalão, Maria José Alves Rocha. Microglial Activation Modulates Neuroendocrine Secretion During Experimental Sepsis.
Molecular neurobiology.
2021 May; 58(5):2133-2144. doi:
10.1007/s12035-020-02241-5. [PMID: 33415683] - Jiancheng Xu, Jing Ji, Zhan Wang, Tao Xu. Effects of minocycline on motor function recovery and expression of glial fibrillary acidic protein and brain-derived neurotrophic factor after spinal cord injury in rats.
The Journal of pharmacy and pharmacology.
2021 Mar; 73(3):332-337. doi:
10.1093/jpp/rgaa041. [PMID: 33793886] - Chien-Ning Hsu, Julie Y H Chan, Kay L H Wu, Hong-Ren Yu, Wei-Chia Lee, Chih-Yao Hou, You-Lin Tain. Altered Gut Microbiota and Its Metabolites in Hypertension of Developmental Origins: Exploring Differences between Fructose and Antibiotics Exposure.
International journal of molecular sciences.
2021 Mar; 22(5):. doi:
10.3390/ijms22052674. [PMID: 33800916] - Zaijian Li, Wenqiang Liu, Jianqing Su, Xiuling Chu, Changfa Wang. Pharmacokinetics and ex vivo pharmacodynamics of Minocycline against Salmonella abortus equi in donkey plasma and tissue cage fluid.
Research in veterinary science.
2021 Mar; 135(?):293-296. doi:
10.1016/j.rvsc.2020.10.003. [PMID: 33066989] - Thomas P Lodise, Scott Van Wart, Zoe M Sund, Adam M Bressler, Akram Khan, Amy T Makley, Yasir Hamad, Robert A Salata, Fernanda P Silveira, Matthew D Sims, Badih A Kabchi, Mohamed A Saad, Carrie Brown, Randolph E Oler, Vance Fowler, Richard G Wunderink. Pharmacokinetic and Pharmacodynamic Profiling of Minocycline for Injection following a Single Infusion in Critically Ill Adults in a Phase IV Open-Label Multicenter Study (ACUMIN).
Antimicrobial agents and chemotherapy.
2021 02; 65(3):. doi:
10.1128/aac.01809-20. [PMID: 33168615] - Majid Motaghinejad, Roya Mashayekh, Manijeh Motevalian, Sepideh Safari. The possible role of CREB-BDNF signaling pathway in neuroprotective effects of minocycline against alcohol-induced neurodegeneration: molecular and behavioral evidences.
Fundamental & clinical pharmacology.
2021 Feb; 35(1):113-130. doi:
10.1111/fcp.12584. [PMID: 32579730] - Dongdong Zhang, Sheng Li, Liyan Hou, Lu Jing, Zhengzheng Ruan, Bingjie Peng, Xiaomeng Zhang, Jau-Shyong Hong, Jie Zhao, Qingshan Wang. Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model.
Journal of neuroinflammation.
2021 Jan; 18(1):4. doi:
10.1186/s12974-020-02065-z. [PMID: 33402167] - Andrea Gillis, Smriti Ohri. 17-year-old girl • abdominal pain • lower-leg itching • dark urine and yellow eyes • Dx?.
The Journal of family practice.
2020 12; 69(10):520-522. doi:
10.12788/jfp.0120. [PMID: 33348348] - Hai-Yan Zhao, Bao-Jun Su, Wang-Jing Zhou, Ya-Qi Wang, Hai-Bing Liao, Heng-Shan Wang, Dong Liang. Diterpenoids and triterpenoids from Triadica rotundifolia and their effects on microglial nitric oxide production.
Bioorganic chemistry.
2020 12; 105(?):104332. doi:
10.1016/j.bioorg.2020.104332. [PMID: 33038553] - Shashank Shekhar Gautam, C S Gautam, Vivek Kumar Garg, Harmanjit Singh. Combining hydroxychloroquine and minocycline: potential role in moderate to severe COVID-19 infection.
Expert review of clinical pharmacology.
2020 Nov; 13(11):1183-1190. doi:
10.1080/17512433.2020.1832889. [PMID: 33008280] - Lei Niu, Shi Shi Luo, Yang Xu, Zhen Wang, Dan Luo, Hui Yang, Wei Li, Jie He, Xiao Lin Zhong, Zheng Hai Liu, Jia Yu Zeng, Wen Yu Cao, Wei Wan. The critical role of the hippocampal NLRP3 inflammasome in social isolation-induced cognitive impairment in male mice.
Neurobiology of learning and memory.
2020 11; 175(?):107301. doi:
10.1016/j.nlm.2020.107301. [PMID: 32882398] - Edoardo Francini, Salvatora T Miano, Anna I Fiaschi, Guido Francini. Doxycycline or minocycline may be a viable treatment option against SARS-CoV-2.
Medical hypotheses.
2020 11; 144(?):110054. doi:
10.1016/j.mehy.2020.110054. [PMID: 32758890] - Rizaldy C Zapata, Sara Brin Rosenthal, Kathleen Fisch, Khoi Dao, Mohit Jain, Olivia Osborn. Metabolomic profiles associated with a mouse model of antipsychotic-induced food intake and weight gain.
Scientific reports.
2020 10; 10(1):18581. doi:
10.1038/s41598-020-75624-2. [PMID: 33122657] - Hubert Ziółkowski, Agnieszka Jasiecka-Mikołajczyk, Hanna Madej-Śmiechowska, Joanna Janiuk, Aleksandra Zygmuntowicz, Michał Dąbrowski. Comparative pharmacokinetics of chlortetracycline, tetracycline, minocycline, and tigecycline in broiler chickens.
Poultry science.
2020 Oct; 99(10):4750-4757. doi:
10.1016/j.psj.2020.06.038. [PMID: 32988509] - Harmanjit Singh, Ashish Kumar Kakkar, Prerna Chauhan. Repurposing minocycline for COVID-19 management: mechanisms, opportunities, and challenges.
Expert review of anti-infective therapy.
2020 10; 18(10):997-1003. doi:
10.1080/14787210.2020.1782190. [PMID: 32552044] - Begoña Lavin Plaza, Alkystis Phinikaridou, Marcelo E Andia, Myles Potter, Silvia Lorrio, Imran Rashid, Rene M Botnar. Sustained Focal Vascular Inflammation Accelerates Atherosclerosis in Remote Arteries.
Arteriosclerosis, thrombosis, and vascular biology.
2020 09; 40(9):2159-2170. doi:
10.1161/atvbaha.120.314387. [PMID: 32673527] - Xian Chen, Li Wang, Zhifang He, Haijiao Zhao, Yehua Cai, Shanglin Song, Qin Yu. Effects of xipayi mouth rinse combined with minocycline on localized aggressive periodontitis' therapeutic effect and the levels of CRP, TNF-α, IL-6 in serum.
Annals of palliative medicine.
2020 Sep; 9(5):3410-3417. doi:
10.21037/apm-20-1653. [PMID: 33065791] - Martin Kirchberg, Sigrun Eick, Mirko Buchholz, Fred Rosche, Andreas Kiesow, Sandra Sarembe, Karsten Mäder. Controlled release minocycline-lipid-complex extrudates for the therapy of periodontitis with enhanced flexibility.
International journal of pharmaceutics.
2020 Aug; 586(?):119578. doi:
10.1016/j.ijpharm.2020.119578. [PMID: 32615242] - Zhengzi Yi, Karen L Keung, Li Li, Min Hu, Bo Lu, Leigh Nicholson, Elvira Jimenez-Vera, Madhav C Menon, Chengguo Wei, Stephen Alexander, Barbara Murphy, Philip J O'Connell, Weijia Zhang. Key driver genes as potential therapeutic targets in renal allograft rejection.
JCI insight.
2020 08; 5(15):. doi:
10.1172/jci.insight.136220. [PMID: 32634125] - Cheng-Fu Li, Kai-Qiang Li, Wei-Ning Liang, Zhi-Qiang Weng, Yong Zhong, Xue-Jun Shang. [Content of prostate small extracorporeal protein in the urine as an index in evaluating the therapeutic effect on chronic prostatitis].
Zhonghua nan ke xue = National journal of andrology.
2020 Aug; 26(8):726-730. doi:
NULL. [PMID: 33377735] - Feng Yang, Wen Zhu, Xiaofang Cai, Wen Zhang, Zhonghai Yu, Xiangting Li, Jingsi Zhang, Min Cai, Jun Xiang, Dingfang Cai. Minocycline alleviates NLRP3 inflammasome-dependent pyroptosis in monosodium glutamate-induced depressive rats.
Biochemical and biophysical research communications.
2020 06; 526(3):553-559. doi:
10.1016/j.bbrc.2020.02.149. [PMID: 32245616] - Dong-Bin Cai, Wei Zheng, Qing-E Zhang, Chee H Ng, Gabor S Ungvari, Xiong Huang, Yu-Tao Xiang. Minocycline for Depressive Symptoms: a Meta-Analysis of Randomized, Double-Blinded, Placebo-Controlled Trials.
The Psychiatric quarterly.
2020 06; 91(2):451-461. doi:
10.1007/s11126-019-09707-3. [PMID: 31965454] - Julia Paik. Topical Minocycline Foam 4\%: A Review in Acne Vulgaris.
American journal of clinical dermatology.
2020 Jun; 21(3):449-456. doi:
10.1007/s40257-020-00523-1. [PMID: 32468355] - Li-Xia Xie, Jian Zhou, Kimberly R Ledesma, Paul R Merlau, Vincent H Tam. The impact of serum protein binding on bacterial killing of minocycline.
Journal of global antimicrobial resistance.
2020 06; 21(?):252-254. doi:
10.1016/j.jgar.2019.11.011. [PMID: 31770603] - Majid Motaghinejad, Negin Farokhi, Manijeh Motevalian, Sepideh Safari. Molecular, histological and behavioral evidences for neuroprotective effects of minocycline against nicotine-induced neurodegeneration and cognition impairment: Possible role of CREB-BDNF signaling pathway.
Behavioural brain research.
2020 05; 386(?):112597. doi:
10.1016/j.bbr.2020.112597. [PMID: 32198107] - Shi Yu Chan, Liliana Capitão, Fay Probert, Corinna Klinge, Sebastian Hoeckner, Catherine J Harmer, Philip J Cowen, Daniel C Anthony, Philip W J Burnet. A single administration of the antibiotic, minocycline, reduces fear processing and improves implicit learning in healthy volunteers: analysis of the serum metabolome.
Translational psychiatry.
2020 05; 10(1):148. doi:
10.1038/s41398-020-0818-6. [PMID: 32404908] - Leman Sencar, Derviş Mansuri Yilmaz, Abdullah Tuli, Sait Polat. Effects of combined treatment of minocycline and methylprednisolone on the expression of tumor necrosis factor alpha and interleukine-6 in experimental spinal cord injury: a light and electron microscopic study.
Ultrastructural pathology.
2020 May; 44(3):283-299. doi:
10.1080/01913123.2020.1771493. [PMID: 32567988] - Er-Rong Du, Rong-Ping Fan, Li-Lou Rong, Zhen Xie, Chang-Shui Xu. Regulatory mechanisms and therapeutic potential of microglial inhibitors in neuropathic pain and morphine tolerance.
Journal of Zhejiang University. Science. B.
2020 Mar; 21(3):204-217. doi:
10.1631/jzus.b1900425. [PMID: 32133798] - Sathishkumar Chinnasamy, Gurudeeban Selvaraj, Chandrabose Selvaraj, Aman Chandra Kaushik, Satyavani Kaliamurthi, Abbas Khan, Sanjeev Kumar Singh, Dong-Qing Wei. Combining in silico and in vitro approaches to identification of potent inhibitor against phospholipase A2 (PLA2).
International journal of biological macromolecules.
2020 Feb; 144(?):53-66. doi:
10.1016/j.ijbiomac.2019.12.091. [PMID: 31838071] - Wei Shan Cassandra Chong, Gary A Dykes, Ranil Coorey. Chemical Composition and Anti-Nutritional Profiling of Wattle (Acacia cyclops, Acacia microbotrya and Acacia victoriae) Seed Originating from Western Australia.
Plant foods for human nutrition (Dordrecht, Netherlands).
2019 Dec; 74(4):518-524. doi:
10.1007/s11130-019-00772-4. [PMID: 31680210] - Jie Mou, Zongxiang Liu, Jie Liu, Jianwu Lu, Wentao Zhu, Dongsheng Pei. Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation.
Drug delivery.
2019 Dec; 26(1):179-187. doi:
10.1080/10717544.2019.1571121. [PMID: 30822158] - Yingjun Gao, Xing Zhang, Xiangyu Jin. Preparation and Properties of Minocycline-Loaded Carboxymethyl Chitosan Gel/Alginate Nonwovens Composite Wound Dressings.
Marine drugs.
2019 Oct; 17(10):. doi:
10.3390/md17100575. [PMID: 31614468] - Caroline A Arout, Andrew J Waters, R Ross MacLean, Peggy Compton, Mehmet Sofuoglu. Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients.
Psychopharmacology.
2019 Oct; 236(10):2857-2866. doi:
10.1007/s00213-018-5146-7. [PMID: 30564869] - Lulu Zhang, Hongbo Zheng, Rengrong Wu, Thomas R Kosten, Xiang-Yang Zhang, Jingping Zhao. The effect of minocycline on amelioration of cognitive deficits and pro-inflammatory cytokines levels in patients with schizophrenia.
Schizophrenia research.
2019 10; 212(?):92-98. doi:
10.1016/j.schres.2019.08.005. [PMID: 31416745] - Xin Shelley Wang, Qiuling Shi, Nishin A Bhadkamkar, Charles S Cleeland, Araceli Garcia-Gonzalez, Jonathan R Aguilar, Cobi Heijnen, Cathy Eng. Minocycline for Symptom Reduction During Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Phase II Randomized Clinical Trial.
Journal of pain and symptom management.
2019 10; 58(4):662-671. doi:
10.1016/j.jpainsymman.2019.06.018. [PMID: 31254639] - Yu-Ting Liao, Shih-Min Wang, Shun-Hua Chen. Anti-inflammatory and antiviral effects of minocycline in enterovirus 71 infections.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109271. doi:
10.1016/j.biopha.2019.109271. [PMID: 31377467] - Wei Zheng, Xiao-Min Zhu, Qing-E Zhang, Gen Cheng, Dong-Bin Cai, Jie He, Chee H Ng, Gabor S Ungvari, Xiao-Jiang Peng, Yu-Ping Ning, Yu-Tao Xiang. Adjunctive minocycline for major mental disorders: A systematic review.
Journal of psychopharmacology (Oxford, England).
2019 10; 33(10):1215-1226. doi:
10.1177/0269881119858286. [PMID: 31294649] - Anna K Schmidtner, David A Slattery, Joachim Gläsner, Andreas Hiergeist, Katharina Gryksa, Victoria A Malik, Julian Hellmann-Regen, Isabella Heuser, Thomas C Baghai, André Gessner, Rainer Rupprecht, Barbara Di Benedetto, Inga D Neumann. Minocycline alters behavior, microglia and the gut microbiome in a trait-anxiety-dependent manner.
Translational psychiatry.
2019 09; 9(1):223. doi:
10.1038/s41398-019-0556-9. [PMID: 31519869] - Iain Gibson, Arash Momeni, Mark Filiaggi. Minocycline-loaded calcium polyphosphate glass microspheres as a potential drug-delivery agent for the treatment of periodontitis.
Journal of applied biomaterials & functional materials.
2019 Jul; 17(3):2280800019863637. doi:
10.1177/2280800019863637. [PMID: 31452442] - Erlend Skaga, Ida Ø Skaga, Zanina Grieg, Cecilie J Sandberg, Iver A Langmoen, Einar O Vik-Mo. The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy.
Journal of cancer research and clinical oncology.
2019 Jun; 145(6):1495-1507. doi:
10.1007/s00432-019-02920-4. [PMID: 31028540] - Mark A J Bayliss, Katarina Rigdova, Mathew Kyriakides, Sally Grier, Andew M Lovering, Hannah Williams, David C Griffith, Alasdair MacGowan. Development, validation and application of a novel HPLC-MS/MS method for the measurement of minocycline in human plasma and urine.
Journal of pharmaceutical and biomedical analysis.
2019 May; 169(?):90-98. doi:
10.1016/j.jpba.2019.02.036. [PMID: 30844627] - Cai Zhang, Allan V Kalueff, Cai Song. Minocycline ameliorates anxiety-related self-grooming behaviors and alters hippocampal neuroinflammation, GABA and serum cholesterol levels in female Sprague-Dawley rats subjected to chronic unpredictable mild stress.
Behavioural brain research.
2019 05; 363(?):109-117. doi:
10.1016/j.bbr.2019.01.045. [PMID: 30703398] - Tymoteusz Żera, Artur Nowiński, Agnieszka Segiet, Paweł Smykiewicz. Microglia and brain angiotensin type 1 receptors are involved in desensitising baroreflex by intracerebroventricular hypertonic saline in male Sprague-Dawley rats.
Autonomic neuroscience : basic & clinical.
2019 03; 217(?):49-57. doi:
10.1016/j.autneu.2019.01.002. [PMID: 30704975] - Hong-Wei Wang, Monir Ahmad, Rami Jadayel, Fatimah Najjar, Diane Lagace, Frans H H Leenen. Inhibition of inflammation by minocycline improves heart failure and depression-like behaviour in rats after myocardial infarction.
PloS one.
2019; 14(6):e0217437. doi:
10.1371/journal.pone.0217437. [PMID: 31233508] - Erkut Baha Bulduk, Gokhan Kurt, Sureyya Barun, Onder Aydemir, Murat Kiziltas, Murat Oktem, Turan Turhan, Pergin Atilla, Sevda Muftuoglu. The Effects of Minocycline on the Hippocampus in Lithium- Pilocarpine Induced Status Epilepticus in Rat: Relations with Microglial/Astrocytic Activation and Serum S100B Level.
Turkish neurosurgery.
2019; 29(1):95-105. doi:
10.5137/1019-5149.jtn.22744-18.1. [PMID: 30614506] - Alexander M Firsov, Elena A Kotova, Yuri N Antonenko. Minocycline prevents peroxidative permeabilization of cardiolipin-containing bilayer lipid membranes mediated by cytochrome c.
Biochemical and biophysical research communications.
2018 12; 507(1-4):510-513. doi:
10.1016/j.bbrc.2018.11.078. [PMID: 30454899] - Hamed Haghi-Aminjan, Maryam Baeeri, Mahban Rahimifard, Ahad Alizadeh, Mahshid Hodjat, Shokoufeh Hassani, Mohammad Hossein Asghari, Alireza Abdollahi, Tina Didari, Rohollah Hosseini, Mohammad Sharifzadeh, Mohammad Abdollahi. The role of minocycline in alleviating aluminum phosphide-induced cardiac hemodynamic and renal toxicity.
Environmental toxicology and pharmacology.
2018 Dec; 64(?):26-40. doi:
10.1016/j.etap.2018.09.008. [PMID: 30290328] - Bill Deakin, John Suckling, Thomas R E Barnes, Kelly Byrne, Imran B Chaudhry, Paola Dazzan, Richard J Drake, Annalisa Giordano, Nusrat Husain, Peter B Jones, Eileen Joyce, Emma Knox, Carl Krynicki, Stephen M Lawrie, Shôn Lewis, Danuta M Lisiecka-Ford, Naghmeh Nikkheslat, Carmine M Pariante, Richard Smallman, Andrew Watson, Steven C R Williams, Rachel Upthegrove, Graham Dunn. The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial.
The lancet. Psychiatry.
2018 11; 5(11):885-894. doi:
10.1016/s2215-0366(18)30345-6. [PMID: 30322824] - Kayo Tanita, Taku Fujimura, Yota Sato, Chunbing Lyu, Setsuya Aiba. Minocycline decreases Th2 chemokines from M2 macrophages: Possible mechanisms for the suppression of bullous pemphigoid by traditional bullous disease drugs.
Experimental dermatology.
2018 11; 27(11):1268-1272. doi:
10.1111/exd.13779. [PMID: 30192415] - Shu-Yue Zheng, Wen Shen, Yan-Mei Peng, Hui-Juan Cui, Hua Duan, Yu-Qin Qiu, Qiang Li, Jing-Yi Zhang, Chen-Yao Sun, Xu Zhang. Treatment of severe rash caused by crizotinib with both traditional Chinese medicine and Western medicine: Two case reports and literature review.
Medicine.
2018 Nov; 97(48):e13088. doi:
10.1097/md.0000000000013088. [PMID: 30508887] - Qiong Wu, Hua-Zhou Xu, Jiang-Xia Yang, Zhi-Li Li, Tian Fu, Hui-Lan DU, Cui-Miao Song. [Effect of GnRHa controlled ovarian hyperstimulation on mouse embryo implantation and its mechanism].
Sheng li xue bao : [Acta physiologica Sinica].
2018 Oct; 70(5):489-496. doi:
NULL. [PMID: 30377687] - Daniel A Martinez-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pardo. Epigallocatechin-3-Gallate Protects and Prevents Paraquat-Induced Oxidative Stress and Neurodegeneration in Knockdown dj-1-β Drosophila melanogaster.
Neurotoxicity research.
2018 Oct; 34(3):401-416. doi:
10.1007/s12640-018-9899-x. [PMID: 29667128] - Fang Liu, Bingkui Zhang, Liqin Xie, Ye Ruan, XiuFeng Xu, Yong Zeng, Louis Messina, Jingping Zhao, Xiaoduo Fan. Changes in plasma levels of nitric oxide metabolites and negative symptoms after 16-week minocycline treatment in patients with schizophrenia.
Schizophrenia research.
2018 09; 199(?):390-394. doi:
10.1016/j.schres.2018.03.003. [PMID: 29526457] - Haejeong Lee, Jin Yang Baek, So Yeon Kim, HyunJi Jo, KyeongJin Kang, Jae-Hoon Ko, Sun Young Cho, Doo Ryeon Chung, Kyong Ran Peck, Jae-Hoon Song, Kwan Soo Ko. Comparison of virulence between matt and mucoid colonies of Klebsiella pneumoniae coproducing NDM-1 and OXA-232 isolated from a single patient.
Journal of microbiology (Seoul, Korea).
2018 Sep; 56(9):665-672. doi:
10.1007/s12275-018-8130-3. [PMID: 30141159] - Lulu Zhang, Hongbo Zheng, Rengrong Wu, Furong Zhu, Thomas R Kosten, Xiang-Yang Zhang, Jingping Zhao. Minocycline adjunctive treatment to risperidone for negative symptoms in schizophrenia: Association with pro-inflammatory cytokine levels.
Progress in neuro-psychopharmacology & biological psychiatry.
2018 07; 85(?):69-76. doi:
10.1016/j.pnpbp.2018.04.004. [PMID: 29678772] - Rong Zhang, Ning Dong, Yonglu Huang, Hongwei Zhou, Miaomiao Xie, Edward Wai-Chi Chan, Yanyan Hu, Jiachang Cai, Sheng Chen. Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract.
Emerging microbes & infections.
2018 Jul; 7(1):127. doi:
10.1038/s41426-018-0129-7. [PMID: 29985412] - Zahra Merati, Abbas Farshad, Amjad Farzinpour, Jalal Rostamzadeh, Mohsen Sharafi. Anti-apoptotic effects of minocycline on ram epididymal spermatozoa exposed to oxidative stress.
Theriogenology.
2018 Jul; 114(?):266-272. doi:
10.1016/j.theriogenology.2018.03.041. [PMID: 29660630] - Toyotaka Sato, Kazuki Harada, Masaru Usui, Yuzo Tsuyuki, Tsukasa Shiraishi, Yutaka Tamura, Shin-Ichi Yokota. Tigecycline Susceptibility of Klebsiella pneumoniae Complex and Escherichia coli Isolates from Companion Animals: The Prevalence of Tigecycline-Nonsusceptible K. pneumoniae Complex, Including Internationally Expanding Human Pathogenic Lineages.
Microbial drug resistance (Larchmont, N.Y.).
2018 Jul; 24(6):860-867. doi:
10.1089/mdr.2017.0184. [PMID: 29232167] - Hao-Yuan Lee, Shih-Yun Hsu, Jen-Fu Hsu, Chyi-Liang Chen, Yi-Hsin Wang, Cheng-Hsun Chiu. Risk factors and molecular epidemiology of Acinetobacter baumannii bacteremia in neonates.
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi.
2018 Jun; 51(3):367-376. doi:
10.1016/j.jmii.2017.07.013. [PMID: 28830746] - Aiden J Plant, Cressida Auckland. Should We Accept Colistin-Induced Nephrotoxicity To Ensure Attainment of a Therapeutic Steady State in Those with Good Renal Function?.
Antimicrobial agents and chemotherapy.
2018 06; 62(6):. doi:
10.1128/aac.00351-18. [PMID: 29802204] - J M Marto, L F Gouveia, L M D Gonçalves, H M Ribeiro, A J Almeida. Design of minocycline-containing starch nanocapsules for topical delivery.
Journal of microencapsulation.
2018 Jun; 35(4):344-356. doi:
10.1080/02652048.2018.1487472. [PMID: 29889598] - I Berkiks, H Benmhammed, A Mesfioui, A Ouichou, A El Hasnaoui, S Mouden, T Touil, Y Bahbiti, R Nakache, A El Hessni. Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress.
The International journal of neuroscience.
2018 Jun; 128(6):495-504. doi:
10.1080/00207454.2017.1398156. [PMID: 29077529] - Simone Vodret, Giulia Bortolussi, Alessandra Iaconcig, Elena Martinelli, Claudio Tiribelli, Andrés F Muro. Attenuation of neuro-inflammation improves survival and neurodegeneration in a mouse model of severe neonatal hyperbilirubinemia.
Brain, behavior, and immunity.
2018 05; 70(?):166-178. doi:
10.1016/j.bbi.2018.02.011. [PMID: 29458193] - Beth A Kimmitt, George E Moore, Jean Stiles. Comparison of the efficacy of various concentrations and combinations of serum, ethylenediaminetetraacetic acid, tetracycline, doxycycline, minocycline, and N-acetylcysteine for inhibition of collagenase activity in an in vitro corneal degradation model.
American journal of veterinary research.
2018 May; 79(5):555-561. doi:
10.2460/ajvr.79.5.555. [PMID: 29688786] - Kathryn M Harper, Darin J Knapp, Meredith A Park, George R Breese. Differential effects of single versus repeated minocycline administration-Lack of significant interaction with chronic alcohol history.
Pharmacology, biochemistry, and behavior.
2018 05; 168(?):33-42. doi:
10.1016/j.pbb.2018.03.007. [PMID: 29572015] - Ronald Domalaon, Yaroslav Sanchak, Linet Cherono Koskei, Yinfeng Lyu, George G Zhanel, Gilbert Arthur, Frank Schweizer. Short Proline-Rich Lipopeptide Potentiates Minocycline and Rifampin against Multidrug- and Extensively Drug-Resistant Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy.
2018 04; 62(4):. doi:
10.1128/aac.02374-17. [PMID: 29437631] - Jaclyn Mallard, Kenneth Williams. An SIV macaque model of SIV and HAND: the need for adjunctive therapies in HIV that target activated monocytes and macrophages.
Journal of neurovirology.
2018 04; 24(2):213-219. doi:
10.1007/s13365-018-0616-6. [PMID: 29435829] - Jorge A Irizarry-Caro, Carmelo Carmona-Rivera, Daniella M Schwartz, Sami S Khaznadar, Mariana J Kaplan, Peter C Grayson. Brief Report: Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation.
Arthritis & rheumatology (Hoboken, N.J.).
2018 03; 70(3):468-474. doi:
10.1002/art.40372. [PMID: 29121457]