Pentoxyverine Citrate (BioDeep_00000753826)

   


代谢物信息卡片


Carbetapentane citrate

  化学式: C26H39NO10 (525.2574)
中文名称: 枸橼酸喷托维林
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: CCN(CC)CCOCCOC(=O)C1(CCCC1)C2=CC=CC=C2.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI: InChI=1S/C20H31NO3.C6H8O7/c1-3-21(4-2)14-15-23-16-17-24-19(22)20(12-8-9-13-20)18-10-6-5-7-11-18


描述信息

C78273 - Agent Affecting Respiratory System > C66917 - Antitussive Agent
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents
Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[1][2][3][4].

同义名列表

53 个代谢物同义名

Carbetapentane citrate; Pentoxyverine Citrate; UNII-4SH0MFJ5HJ; Carbetapentane (citrate); Pentoxyverine (citrate); 1-Phenyl-cyclopentanecarboxylic acid 2-[2-(Diethylamino)ethoxy]ethyl ester citrate; 1-phenyl-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester citrate;1-Phenylcyclopentane-1-carboxylic acid diethylami noethoxyethyl ester citrate;2-(Diethylaminoethoxy)ethyl 1-phenyl-1-cyclopentanecarboxylate citrate; 1-phenyl-cyclopentanecarboxylic acid 2-2-(diethylamino)ethoxyethyl ester citrate;1-Phenylcyclopentane-1-carboxylic acid diethylami n oethoxyethyl ester citrate;2-(Diethylaminoethoxy)ethyl 1-phenyl-1-cyclopentanecarboxylate citrate; 1-Phenylcyclopentanecarboxylic acid 2-(2-diethylaminoethoxy)ethyl ester citrate salt; 2-(2-(diethylamino)ethoxy)ethyl 1-phenylcyclopentanecarboxylate 2-hydroxypropane-1,2,3-tricarboxylate; 2-(2-(Diethylamino)ethoxy)ethyl 1-phenylcyclopentanecarboxylate citrate (1:1); 2-(2-(Diethylamino)ethoxy)ethyl 1-phenylcyclopentanecarboxylate monocitrate; 2-(2-(Diethylamino)ethoxy)ethyl 1-phenylcyclopentyl-1-carboxylate dihydrogen citrate; 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentane carboxylate citrate; 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentanecarboxylate citrate; 2-(2-diethylaminoethoxy)ethyl 1-phenylcyclopentyl-1-carboxylate; 2-(2(Diethylamino)ethoxy)ethyl 1-phenyl-cyclopentanecarboxylate citrate (1:1); 2-[2-(Diethylamino)ethoxy]ethyl 1-phenylcyclopentane-1-carboxylate citrate; 2-[2-(Diethylamino)ethoxy]ethyl 1-phenylcyclopentanecarboxylate monocitrate; 4SH0MFJ5HJ; AKJDEXBCRLOVTH-UHFFFAOYSA-N; Astomatop; Astomatop (TN); carbetapentane; carbetapentane 1,5-napthalenedisulfonate (2:1); carbetapentane 2,6-napthalenedisulfonate (2:1); CARBETAPENTANE CITRATE [MI]; Carbetapentane citrate [NF]; CARBETAPENTANE CITRATE [VANDF]; Carbetapentane citrate salt; carbetapentane tannate; Carbetapentone citrate; Cyclopentanecarboxylic acid, 1-phenyl-, 2-(2-(diethylamino)ethoxy)ethyl ester, citrate (1:1); Cyclopentanecarboxylic acid, 1-phenyl-, 2-[2-(diethylamino)ethoxy]ethyl ester, 2-hydroxy-1,2,3-propanetricarboxylate (1:1); Diethyl(2-(2-((1-phenylcyclopentyl)formyloxy)ethoxy)ethyl)ammoniumdihydrogen 2-hydroxypropane-1,2,3-tricarboxylate; Ethanol, 2-(2-(diethylamino)ethoxy)-, 1-phenylcyclopentanecarboxylate (ester) citrate; Loucarbate; Pentoxiverine citrate; pentoxyverine; Pentoxyverine citrate - Bio-X trade mark; Pentoxyverine citrate (JP17); Pentoxyverine citrate (JP18); PENTOXYVERINE CITRATE (MART.); PENTOXYVERINE CITRATE [JAN]; PENTOXYVERINE CITRATE [MART.]; PENTOXYVERINE CITRATE [WHO-DD]; Pentoxyverine citrate,(S); Pentoxyverine hydrogen citrate; PENTOXYVERINE HYDROGEN CITRATE (EP MONOGRAPH); PENTOXYVERINE HYDROGEN CITRATE [EP MONOGRAPH]; Toclase; Toclase citrate; Tox21_500313



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ahmed S Abo Dena, Alaa M Ali, Ibrahim M El-Sherbiny. Carbetapentane citrate. Profiles of drug substances, excipients, and related methodology. 2020; 45(?):41-53. doi: 10.1016/bs.podrm.2019.10.002. [PMID: 32164969]
  • Sabrein H Mohamed, Yousry M Issa, Shaimaa A Elfeky. Extraction-free spectrophotometric assay of the antitussive drug pentoxyverine citrate using sulfonephthalein dyes. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Nov; 222(?):117186. doi: 10.1016/j.saa.2019.117186. [PMID: 31176152]
  • Yi Kuang, Bin Li, Jingran Fan, Xue Qiao, Min Ye. Antitussive and expectorant activities of licorice and its major compounds. Bioorganic & medicinal chemistry. 2018 01; 26(1):278-284. doi: 10.1016/j.bmc.2017.11.046. [PMID: 29224994]
  • F Westphal, Th Junge, L Radünz, J Stegk, G Rochholz. Characterization of pentoxyverine metabolites in urine using GC/MS after intoxication with Silomat cough drops. Forensic science international. 2012 Feb; 215(1-3):124-35. doi: 10.1016/j.forsciint.2011.03.002. [PMID: 21450423]
  • Ming-qin Lin, Ying Cai, Wei Zhang, Xiu-qiong Wu, Jin-jun Rao, Shu-wen Liu. [Bioequivalence evaluation of orally disintegrating tablet of pentoxyverine citrate]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2010 Jul; 30(7):1621-3. doi: NULL. [PMID: 20650784]
  • Jinhua Wen, Hong Zhang, Chunhua Xia, Xiao Hu, Wenwei Xu, Xiaohua Cheng, Jun Gao, Yuqing Xiong. A sensitive liquid chromatography-electrospray ionization-mass spectrometry method for the simultaneous determination of pentoxyverine citrate and guaifenesin in human plasma---application to pharmacokinetic and bioequivalence studies. Biomedical chromatography : BMC. 2010 Apr; 24(4):351-7. doi: 10.1002/bmc.1298. [PMID: 19634120]
  • Ke-Hua Yu, Jin-Hua Wen, Fu-Gen Nie, Yu-Qing Xiong. [Quantification of pentoxyverine citrate in human plasma by LC-ESI/MS method and its application]. Yao xue xue bao = Acta pharmaceutica Sinica. 2009 Dec; 44(12):1402-5. doi: NULL. [PMID: 21351477]
  • Heike Deisemann, Nadine Ahrens, Irene Schlobohm, Christian Kirchhoff, Rainer Netzer, Clemens Möller. Effects of common antitussive drugs on the hERG potassium channel current. Journal of cardiovascular pharmacology. 2008 Dec; 52(6):494-9. doi: 10.1097/fjc.0b013e31818eec8d. [PMID: 19034038]
  • B J Stier, L Sieverding, H Moeller. [Pentoxyverine poisoning via maternal milk in a fully breast-fed newborn infant]. Deutsche medizinische Wochenschrift (1946). 1988 Jun; 113(22):898-900. doi: 10.1055/s-2008-1067740. [PMID: 3371222]