Bambuterol Hydrochloride (BioDeep_00000753768)

   

Volatile Flavor Compounds


代谢物信息卡片


Bambuterol Hydrochloride

化学式: C18H30ClN3O5 (403.18738800000006)
中文名称: 班布特罗盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O.Cl
InChI: 1H

描述信息

D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
Bambuterol hydrochloride ((±)-Bambuterol hydrochloride; KWD-2183 hydrochloride) is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma; it also is a proagent of terbutaline.

同义名列表

4 个代谢物同义名

Bambuterol Hydrochloride; (±)-Bambuterol hydrochloride; KWD-2183 hydrochloride; Bambuterol hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

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Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Mohamed Magdy Khalil, Waleed M A El Rouby, Mohamed Ali Korany. Potentiometric sensor based on novel flowered-like Mg-Al layered double hydroxides/multiwalled carbon nanotubes nanocomposite for bambuterol hydrochloride determination. Materials science & engineering. C, Materials for biological applications. 2019 Jul; 100(?):186-195. doi: 10.1016/j.msec.2019.02.103. [PMID: 30948052]
  • Trond-Eirik Strand, Hasse Z Khiabani, Alina Boico, Daniel Radiloff, Yulin Zhao, Karyn L Hamilton, Uwe Christians, Jelena Klawitter, Robert J Noveck, Claude A Piantadosi, Christopher Bell, David Irwin, Thies Schroeder. The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans. Canadian journal of physiology and pharmacology. 2017 Sep; 95(9):1009-1018. doi: 10.1139/cjpp-2016-0635. [PMID: 28467859]
  • Ting Zhou, Jing Zeng, Ting Zhao, Qisheng Zhong, Yang Yang, Wen Tan. Enantioselective analysis of bambuterol in human plasma using microwave-assisted chiral derivatization coupled with ultra high performance liquid chromatography and tandem mass spectrometry. Journal of separation science. 2017 Jul; 40(13):2779-2790. doi: 10.1002/jssc.201700280. [PMID: 28493436]
  • Shiru Liang, Hongyuan Yan, Jiankun Cao, Yehong Han, Shigang Shen, Ligai Bai. Molecularly imprinted phloroglucinol-formaldehyde-melamine resin prepared in a deep eutectic solvent for selective recognition of clorprenaline and bambuterol in urine. Analytica chimica acta. 2017 Jan; 951(?):68-77. doi: 10.1016/j.aca.2016.11.009. [PMID: 27998487]
  • Ting Zhou, Dan Zeng, Ting Zhao, Yang Yang, Shan Liu, Jie Wu, Ling Xu, Wen Tan. In vivo metabolism study of (R)-bambuterol in humans using ultra high performance liquid chromatography with tandem mass spectrometry. Journal of separation science. 2016 Aug; 39(15):2896-906. doi: 10.1002/jssc.201600424. [PMID: 27273913]
  • Su Guan, Chun-Yun Hu, Meng-Ying He, Ying-Ying Yang, Yu-Xin Tang, Jie-di Chen, Li-Jie Huang, Wen Tan. Comparative pharmacokinetics and bile transformation of R-enantiomer and racemic bambuterol after single-dose intravenous, oral administration in rats and beagle dogs. European journal of drug metabolism and pharmacokinetics. 2015 Dec; 40(4):453-60. doi: 10.1007/s13318-014-0228-3. [PMID: 25281237]
  • Ting Zhou, Shan Liu, Ting Zhao, Jing Zeng, Mingzhi He, Beining Xu, Shanshan Qu, Ling Xu, Wen Tan. Chiral analysis of bambuterol, its intermediate and active drug in human plasma by liquid chromatography-tandem mass spectrometry: Application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 997(?):38-44. doi: 10.1016/j.jchromb.2015.05.024. [PMID: 26092775]
  • Yanrui Ye, Hang Xu, Lei Quan, Long Zhu, Jing Zeng, Ting Zhou, ChengJuan Zou, Qing Cheng, Shujie Bu, Wen Tan. The Lipid-lowering Effects of R-bambuterol in Healthy Chinese Volunteers: A Randomized Phase I Clinical Study. EBioMedicine. 2015 Apr; 2(4):356-64. doi: 10.1016/j.ebiom.2015.02.006. [PMID: 26137575]
  • Ting Zhou, Qing Cheng, Chengjuan Zou, Ting Zhao, Shan Liu, Marco Pistolozzi, Evina Tan, Ling Xu, Wen Tan. Simultaneous determination of bambuterol and its two major metabolites in human plasma by hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Sep; 967(?):225-34. doi: 10.1016/j.jchromb.2014.07.022. [PMID: 25128881]
  • Ting Zhou, Ting Zhao, Qing Cheng, Shan Liu, Ling Xu, Wen Tan. A sensitive LC-MS/MS method for simultaneous determination of R-bambuterol and its active metabolite R-terbutaline in human plasma and urine with application to a clinical pharmacokinetic study. Biomedical chromatography : BMC. 2014 Jul; 28(7):994-1002. doi: 10.1002/bmc.3107. [PMID: 24357101]
  • Wenxia Luo, Lin Zhu, Jifeng Deng, Aiming Liu, Bin Guo, Wen Tan, Renke Dai. Simultaneous analysis of bambuterol and its active metabolite terbutaline enantiomers in rat plasma by chiral liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2010 Jun; 52(2):227-31. doi: 10.1016/j.jpba.2009.12.020. [PMID: 20096531]
  • Eliane Boudinot, Véronique Bernard, Shelley Camp, Palmer Taylor, Jean Champagnat, Eric Krejci, Arthur S Foutz. Influence of differential expression of acetylcholinesterase in brain and muscle on respiration. Respiratory physiology & neurobiology. 2009 Jan; 165(1):40-8. doi: 10.1016/j.resp.2008.10.003. [PMID: 18977317]
  • Zrinka Kovarik, Vera Simeon-Rudolf. Interaction of human butyrylcholinesterase variants with bambuterol and terbutaline. Journal of enzyme inhibition and medicinal chemistry. 2004 Apr; 19(2):113-7. doi: 10.1080/14756360410001667300. [PMID: 15449725]
  • Ai-xin Shi, Ke-xin Li, Chun-hua Sun, Guo-ying Cao. [Study on bioequivalence of domestic bambuterol capsules and imported tablets by high performance capillary zone electrophoresis]. Yao xue xue bao = Acta pharmaceutica Sinica. 2003 Dec; 38(12):942-5. doi: NULL. [PMID: 15040091]
  • Johan Rosenburg. Clinical-pharmacokinetic aspects of prolonged effect duration as illustrated by beta2-agonists. European journal of clinical pharmacology. 2002 Jul; 58(4):S1-21. doi: 10.1007/s00228-002-0428-7. [PMID: 12214578]
  • X Y Chen, H Y Xu, D F Zhong, H Y Yang, Y F Zhang. [Determination of bambuterol in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to pharmacokinetic study]. Yao xue xue bao = Acta pharmaceutica Sinica. 2001 Oct; 36(10):762-5. doi: NULL. [PMID: 12579977]
  • X Y Chen, H Y Yang, D F Zhong, H Y Xu, Y F Zhang. [Rapid analysis of terbutaline by combined solid phase extraction/liquid chromatography tandem mass spectrometry]. Yao xue xue bao = Acta pharmaceutica Sinica. 2001 Sep; 36(9):686-9. doi: NULL. [PMID: 12580109]
  • C H Sun, L Liu, Q Yin. [Bioequivalence of bambuteral and its metabolites terbutaline after oral bambuteral tablet in healthy volunteers by HPLC/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2001 May; 36(5):368-72. doi: NULL. [PMID: 12584861]
  • J P Zarkovic, M Marenk, E Valovirta, A L Kuusela, G Sandahl, B Persson, H Olsson. One-year safety study with bambuterol once daily and terbutaline three times daily in 2-12-year-old children with asthma. The Bambuterol Multicentre Study Group. Pediatric pulmonology. 2000 Jun; 29(6):424-9. doi: 10.1002/(sici)1099-0496(200006)29:6<424::aid-ppul2>3.0.co;2-2. [PMID: 10821722]
  • D Ostergaard, S N Rasmussen, J Viby-Mogensen, N A Pedersen, R Boysen. The influence of drug-induced low plasma cholinesterase activity on the pharmacokinetics and pharmacodynamics of mivacurium. Anesthesiology. 2000 Jun; 92(6):1581-7. doi: 10.1097/00000542-200006000-00014. [PMID: 10839906]
  • J Rosenborg, P Larsson, L Nyberg. Pharmacokinetics of bambuterol during oral administration of plain tablets and solution to healthy adults. British journal of clinical pharmacology. 2000 Mar; 49(3):199-206. doi: 10.1046/j.1365-2125.2000.00143.x. [PMID: 10718774]
  • A L Kuusela, M Marenk, G Sandahl, J Sanderud, K Nikolajev, B Persson. Comparative study using oral solutions of bambuterol once daily or terbutaline three times daily in 2-5-year-old children with asthma. Bambuterol Multicentre Study Group. Pediatric pulmonology. 2000 Mar; 29(3):194-201. doi: 10.1002/(sici)1099-0496(200003)29:3<194::aid-ppul7>3.0.co;2-i. [PMID: 10686040]
  • H Ahlström, J Alvero, R Alvero, R Espos, L Fajutrao, J Herrera, B Kjellman, J Kubista, C Leviste, P Meyer, G Oldaeus, A Siricururat, P Vichyanond, G Wettrell, E Wong, L Laxmyr, L Nyberg, H Olsson, E Weibull, J Rosenborg. Pharmacokinetics of bambuterol during oral administration to asthmatic children. British journal of clinical pharmacology. 1999 Sep; 48(3):299-308. doi: 10.1046/j.1365-2125.1999.00028.x. [PMID: 10510139]
  • U Bang, L Nyberg, J Rosenborg, J Viby-Mogensen. Pharmacokinetics of bambuterol in subjects homozygous for the atypical gene for plasma cholinesterase. British journal of clinical pharmacology. 1998 May; 45(5):479-84. doi: 10.1046/j.1365-2125.1998.00697.x. [PMID: 9643621]
  • L Nyberg, J Rosenborg, E Weibull, S Jönsson, B M Kennedy, M Nilsson. Pharmacokinetics of bambuterol in healthy subjects. British journal of clinical pharmacology. 1998 May; 45(5):471-8. doi: 10.1046/j.1365-2125.1998.00695.x. [PMID: 9643620]
  • C H Florén, T Kjellström, C A Bauer. Bambuterol raises high-density lipoprotein levels in patients with hyperlipidaemia. Journal of internal medicine. 1997 Aug; 242(2):167-71. doi: 10.1046/j.1365-2796.1997.00180.x. [PMID: 9279294]
  • S Pálmarsdóttir, E Thordarson, L E Edholm, J A Jönsson, L Mathiasson. Miniaturized supported liquid membrane device for selective on-line enrichment of basic drugs in plasma combined with capillary zone electrophoresis. Analytical chemistry. 1997 May; 69(9):1732-7. doi: 10.1021/ac960668p. [PMID: 9145027]
  • S Pálmarsdóttir, L Mathiasson, J A Jönsson, L E Edholm. Determination of a basic drug, bambuterol, in human plasma by capillary electrophoresis using double stacking for large volume injection and supported liquid membranes for sample pretreatment. Journal of chromatography. B, Biomedical sciences and applications. 1997 Jan; 688(1):127-34. doi: 10.1016/s0378-4347(97)88064-4. [PMID: 9029322]
  • D S Sitar. Clinical pharmacokinetics of bambuterol. Clinical pharmacokinetics. 1996 Oct; 31(4):246-56. doi: 10.2165/00003088-199631040-00002. [PMID: 8896942]
  • S Pálmarsdóttir, L Mathiasson, J A Jönsson, L E Edholm. Micro-CLC as an interface between SLM extraction and CZE for enhancement of sensitivity and selectivity in bioanalysis of drugs. Journal of capillary electrophoresis. 1996 Sep; 3(5):255-60. doi: NULL. [PMID: 9384731]
  • G E D'Alonzo, M H Smolensky, S Feldman, Y Gnosspelius, K Karlsson. Bambuterol in the treatment of asthma. A placebo-controlled comparison of once-daily morning vs evening administration. Chest. 1995 Feb; 107(2):406-12. doi: 10.1378/chest.107.2.406. [PMID: 7842769]
  • N A Pedersen, F S Jensen. Clinical importance of plasma cholinesterase for the anaesthetist. Annals of the Academy of Medicine, Singapore. 1994 Nov; 23(6 Suppl):120-4. doi: NULL. [PMID: 7710221]
  • D S Sitar, F Y Aoki, C P Warren, A Knight, R F Grossman, M Alexander, S Soliman. A placebo-controlled dose-finding study with bambuterol in elderly patients with asthma. Chest. 1993 Mar; 103(3):771-6. doi: 10.1378/chest.103.3.771. [PMID: 8449067]
  • B Rosberg, C Schröder, L Nyberg, J Rosenborg, J E Wirén. Bambuterol and terbutaline in human cerebrospinal fluid and plasma. European journal of clinical pharmacology. 1993; 45(2):147-50. doi: 10.1007/bf00315496. [PMID: 8223836]
  • J B Wempe, E P Tammeling, G H Koëter, L Håkansson, P Venge, D S Postma. Blood eosinophil numbers and activity during 24 hours: effects of treatment with budesonide and bambuterol. The Journal of allergy and clinical immunology. 1992 Nov; 90(5):757-65. doi: 10.1016/0091-6749(92)90099-n. [PMID: 1430701]
  • D S Sitar, C P Warren, F Y Aoki. Pharmacokinetics and pharmacodynamics of bambuterol, a long-acting bronchodilator pro-drug of terbutaline, in young and elderly patients with asthma. Clinical pharmacology and therapeutics. 1992 Sep; 52(3):297-306. doi: 10.1038/clpt.1992.145. [PMID: 1526088]
  • C Lindberg, J Paulson, A Blomqvist. Evaluation of an automated thermospray liquid chromatography-mass spectrometry system for quantitative use in bioanalytical chemistry. Journal of chromatography. 1991 Aug; 554(1-2):215-26. doi: 10.1016/s0021-9673(01)88451-x. [PMID: 1795037]
  • A Tunek, E Hjertberg, J V Mogensen. Interactions of bambuterol with human serum cholinesterase of the genotypes EuEu (normal), EaEa (atypical) and EuEa. Biochemical pharmacology. 1991 Feb; 41(3):345-8. doi: 10.1016/0006-2952(91)90530-i. [PMID: 1994894]
  • U Bang, J Viby-Mogensen, J E Wirén, L T Skovgaard. The effect of bambuterol (carbamylated terbutaline) on plasma cholinesterase activity and suxamethonium-induced neuromuscular blockade in genotypically normal patients. Acta anaesthesiologica Scandinavica. 1990 Oct; 34(7):596-9. doi: 10.1111/j.1399-6576.1990.tb03152.x. [PMID: 2244449]
  • U Bang, J Viby-Mogensen, J E Wirén. The effect of bambuterol on plasma cholinesterase activity and suxamethonium-induced neuromuscular blockade in subjects heterozygous for abnormal plasma cholinesterase. Acta anaesthesiologica Scandinavica. 1990 Oct; 34(7):600-4. doi: 10.1111/j.1399-6576.1990.tb03153.x. [PMID: 2244450]
  • P Staun, C Lennmarken, L I Eriksson, J E Wirén. The influence of 10 mg and 20 mg of bambuterol on the duration of succinylcholine-induced neuromuscular blockade. Acta anaesthesiologica Scandinavica. 1990 Aug; 34(6):498-500. doi: 10.1111/j.1399-6576.1990.tb03131.x. [PMID: 2239124]
  • C Lindberg, S Jönsson, J Paulson, A Tunek. Determination of bambuterol, a prodrug of terbutaline, in plasma and urine by gas chromatography/mass spectrometry. Biomedical & environmental mass spectrometry. 1990 Apr; 19(4):218-24. doi: 10.1002/bms.1200190403. [PMID: 2340359]
  • I H Clemmensen, B K Pedersen, S Ravn, L C Laursen, B Weeke. Bambuterol: clinical effects of three doses of bambuterol once daily in asthmatic patients. Allergy. 1988 Nov; 43(8):573-6. doi: 10.1111/j.1398-9995.1988.tb00929.x. [PMID: 3061311]
  • A Tunek, E Levin, L A Svensson. Hydrolysis of 3H-bambuterol, a carbamate prodrug of terbutaline, in blood from humans and laboratory animals in vitro. Biochemical pharmacology. 1988 Oct; 37(20):3867-76. doi: 10.1016/0006-2952(88)90068-8. [PMID: 3190733]
  • N H Holstein-Rathlou, L C Laursen, F Madsen, U G Svendsen, Y Gnosspelius, B Weeke. Bambuterol: dose response study of a new terbutaline prodrug in asthma. European journal of clinical pharmacology. 1986; 30(1):7-11. doi: 10.1007/bf00614187. [PMID: 3519240]