G-1 (BioDeep_00000752959)

   


代谢物信息卡片


1-(4-(6-Bromobenzo[1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)-ethanone

化学式: C21H18BrNO3 (411.0469978)
中文名称: G-1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1=CC2=C(C=C1)NC(C3C2C=CC3)C4=CC5=C(C=C4Br)OCO5
InChI: InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen

同义名列表

3 个代谢物同义名

1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone; G-1; 1-(4-(6-Bromobenzo[1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl)-ethanone



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xuming Sun, Hao Wang, Hunter Hodge, Kendra N Wright, Sarfaraz Ahmad, Carlos M Ferrario, Leanne Groban. Amplifying effect of chronic lisinopril therapy on diastolic function and the angiotensin-(1-7) Axis by the G1 agonist in ovariectomized spontaneously hypertensive rats. Translational research : the journal of laboratory and clinical medicine. 2021 09; 235(?):62-76. doi: 10.1016/j.trsl.2021.04.004. [PMID: 33915312]
  • Julia Tutzauer, Ernesto Gonzalez de Valdivia, Karl Swärd, Ioannis Alexandrakis Eilard, Stefan Broselid, Robin Kahn, Björn Olde, L M Fredrik Leeb-Lundberg. Ligand-Independent G Protein-Coupled Estrogen Receptor/G Protein-Coupled Receptor 30 Activity: Lack of Receptor-Dependent Effects of G-1 and 17β-Estradiol. Molecular pharmacology. 2021 09; 100(3):271-282. doi: 10.1124/molpharm.121.000259. [PMID: 34330822]
  • Shao-Kuan Chen, Yen-Chieh Wang, Tai-Yuan Lin, Hsin-Jou Wu, Chi-Jung Huang, Wei-Chi Ku. G-Protein-coupled Estrogen Receptor 1 Agonist G-1 Perturbs Sunitinib Resistance-related Phosphoproteomic Signatures in Renal Cell Carcinoma. Cancer genomics & proteomics. 2021 May; 18(3):207-220. doi: 10.21873/cgp.20253. [PMID: 33893075]
  • Eman Y Gohar, Rawan N Almutlaq, Elizabeth M Daugherty, Maryam K Butt, Chunhua Jin, Jennifer S Pollock, David M Pollock, Carmen De Miguel. Activation of G protein-coupled estrogen receptor 1 ameliorates proximal tubular injury and proteinuria in Dahl salt-sensitive female rats. American journal of physiology. Regulatory, integrative and comparative physiology. 2021 03; 320(3):R297-R306. doi: 10.1152/ajpregu.00267.2020. [PMID: 33407017]
  • Eman Y Gohar, Elizabeth M Daugherty, Jeffrey O Aceves, Randee Sedaka, Ijeoma E Obi, J Miller Allan, Reham H Soliman, Chunhua Jin, Carmen De Miguel, Sarah H Lindsey, Jennifer S Pollock, David M Pollock. Evidence for G-Protein-Coupled Estrogen Receptor as a Pronatriuretic Factor. Journal of the American Heart Association. 2020 05; 9(10):e015110. doi: 10.1161/jaha.119.015110. [PMID: 32390531]
  • Yun-Xiu Wang, Zhao-Wei Gu, Li-Ying Hao. The environmental hormone nonylphenol interferes with the therapeutic effects of G protein-coupled estrogen receptor specific agonist G-1 on murine allergic rhinitis. International immunopharmacology. 2020 Jan; 78(?):106058. doi: 10.1016/j.intimp.2019.106058. [PMID: 31835084]
  • Jing Wang, Rui Yu, Qiu-Qin Han, Hui-Jie Huang, Ya-Lin Wang, Hao-Yuan Li, Hui-Mei Wang, Xiao-Rong Chen, Shu-Lan Ma, Jin Yu. G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats. Behavioural brain research. 2019 02; 359(?):845-852. doi: 10.1016/j.bbr.2018.07.017. [PMID: 30041006]
  • YongHong Zhang, Feng Wei, Jing Zhang, Lanxiang Hao, Jie Jiang, Liansheng Dang, Dan Mei, ShanShan Fan, Yajin Yu, Ling Jiang. Bisphenol A and estrogen induce proliferation of human thyroid tumor cells via an estrogen-receptor-dependent pathway. Archives of biochemistry and biophysics. 2017 11; 633(?):29-39. doi: 10.1016/j.abb.2017.09.002. [PMID: 28882636]
  • Lara E Terry, Mark VerMeer, Jennifer Giles, Quang-Kim Tran. Suppression of store-operated Ca2+ entry by activation of GPER: contribution to a clamping effect on endothelial Ca2+ signaling. The Biochemical journal. 2017 10; 474(21):3627-3642. doi: 10.1042/bcj20170630. [PMID: 28935720]
  • Ernesto Gonzalez de Valdivia, Stefan Broselid, Robin Kahn, Björn Olde, L M Fredrik Leeb-Lundberg. G protein-coupled estrogen receptor 1 (GPER1)/GPR30 increases ERK1/2 activity through PDZ motif-dependent and -independent mechanisms. The Journal of biological chemistry. 2017 06; 292(24):9932-9943. doi: 10.1074/jbc.m116.765875. [PMID: 28450397]
  • Liu Liu, Shreya Kashyap, Brennah Murphy, Dillion D Hutson, Rebecca A Budish, Emma H Trimmer, Margaret A Zimmerman, Aaron J Trask, Kristin S Miller, Mark C Chappell, Sarah H Lindsey. GPER activation ameliorates aortic remodeling induced by salt-sensitive hypertension. American journal of physiology. Heart and circulatory physiology. 2016 Apr; 310(8):H953-61. doi: 10.1152/ajpheart.00631.2015. [PMID: 26873963]
  • David Méndez-Luna, Martiniano Bello, José Correa-Basurto. Understanding the molecular basis of agonist/antagonist mechanism of GPER1/GPR30 through structural and energetic analyses. The Journal of steroid biochemistry and molecular biology. 2016 Apr; 158(?):104-116. doi: 10.1016/j.jsbmb.2016.01.001. [PMID: 26772481]
  • Zhuo Zhao, Hao Wang, Marina Lin, Leanne Groban. GPR30 decreases cardiac chymase/angiotensin II by inhibiting local mast cell number. Biochemical and biophysical research communications. 2015 Mar; 459(1):131-6. doi: 10.1016/j.bbrc.2015.02.082. [PMID: 25712524]
  • Akif Hakan Kurt, Kansu Buyukafsar. Vasoconstriction induced by G1, a G-protein-coupled oestrogen receptor1 (GPER-1) agonist, in the isolated perfused rat kidney. European journal of pharmacology. 2013 Feb; 702(1-3):71-8. doi: 10.1016/j.ejphar.2013.01.020. [PMID: 23376418]
  • Shoulei Kang, Ying Liu, Di Sun, Chunle Zhou, Aiying Liu, Chuanying Xu, Yanling Hao, Dongye Li, Changdong Yan, Hong Sun. Chronic activation of the G protein-coupled receptor 30 with agonist G-1 attenuates heart failure. PloS one. 2012; 7(10):e48185. doi: 10.1371/journal.pone.0048185. [PMID: 23110207]
  • Sarah H Lindsey, Liliya M Yamaleyeva, K Bridget Brosnihan, Patricia E Gallagher, Mark C Chappell. Estrogen receptor GPR30 reduces oxidative stress and proteinuria in the salt-sensitive female mRen2.Lewis rat. Hypertension (Dallas, Tex. : 1979). 2011 Oct; 58(4):665-71. doi: 10.1161/hypertensionaha.111.175174. [PMID: 21844484]
  • Siok L Dun, G Cristina Brailoiu, Xin Gao, Eugen Brailoiu, Jeffrey B Arterburn, Eric R Prossnitz, Tudor I Oprea, Nae J Dun. Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. Journal of neuroscience research. 2009 May; 87(7):1610-9. doi: 10.1002/jnr.21980. [PMID: 19125412]