Zotarolimus (BioDeep_00000752571)
代谢物信息卡片
Zotarolimus
化学式: C52H79N5O12 (965.5724934)
中文名称: 佐他莫司
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)N5C=NN=N5)C)C)O)OC)C)C)C)OC
InChI: InChI=1S/C52H79N5O12/c1-31-16-12-11-13-17-32(2)43(65-8)28-39-21-19-37(7)52(64,69-39)49(61)50(62)56-23-15-14-18-41(56)51(63)68-44(34(4)26-38-20-22-40(45(27-38)66-9)57-30-53-54-55-57)29-42(58)33(3)25-36(6)47(60)48(67-10)46(59)35(5)24-31/h11-13,16-17,25,30-31,33-35,37-41,43-45,47-48,60,64H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,32-17+,36-25+/t31-,33-,34-,35-,37-,38+,39+,40+,41+,43+,44+,45-,47-,48+,52-/m1/s1
描述信息
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C61074 - Serine/Threonine Kinase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2201 - mTOR Inhibitor
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Eline H Ploumen, Rosaly A Buiten, Marlies M Kok, Carine J M Doggen, Ariel Roguin, Gillian A J Jessurun, Carl E Schotborgh, Peter W Danse, Edouard Benit, Adel Aminian, K Gert van Houwelingen, Martin G Stoel, Martijn Scholte, Marc Hartmann, Gerard C M Linssen, Paolo Zocca, Clemens von Birgelen. Treating diabetic all-comers with contemporary drug-eluting stents: Prespecified comparisons from the BIO-RESORT and the BIONYX randomized trials.
International journal of cardiology.
2021 02; 325(?):37-44. doi:
10.1016/j.ijcard.2020.10.051. [PMID: 33148427] - David E Kandzari, Ajay J Kirtane, Stephan Windecker, Azeem Latib, Elvin Kedhi, Roxana Mehran, Matthew J Price, Alexandre Abizaid, Daniel I Simon, Stephen G Worthley, Azfar Zaman, James W Choi, Ronald Caputo, Mihir Kanitkar, Brent McLaurin, Srinivasa Potluri, Timothy Smith, Douglas Spriggs, Thaddeus Tolleson, Tamim Nazif, Maria Parke, Lilian C Lee, Te-Hsin Lung, Gregg W Stone. One-Month Dual Antiplatelet Therapy Following Percutaneous Coronary Intervention With Zotarolimus-Eluting Stents in High-Bleeding-Risk Patients.
Circulation. Cardiovascular interventions.
2020 11; 13(11):e009565. doi:
10.1161/circinterventions.120.009565. [PMID: 33167705] - Setsu Nishino, Masashi Sakuma, Tomoaki Kanaya, Takahisa Nasuno, Michiaki Tokura, Shigeru Toyoda, Shichiro Abe, Daisuke Nakamura, Kentaro Tanaka, Guiherme F Attizzani, Hiram G Bezerra, Marco A Costa, Teruo Inoue. Neointimal tissue characterization after implantation of drug-eluting stents by optical coherence tomography: quantitative analysis of optical density.
The international journal of cardiovascular imaging.
2019 Nov; 35(11):1971-1978. doi:
10.1007/s10554-019-01651-4. [PMID: 31218524] - Elżbieta Paszek, Wojciech Zajdel, Piotr Musiałek, Andrzej Sokołowski, Bartłomiej Guzik, Anna Kabłak-Ziembicka, Łukasz Niewiara, Małgorzata Pankowska, Aleksandra Mielimonka, Krzysztof Żmudka. Percutaneous management of long and diffused coronary lesions using newer generation drug-eluting stents in routine clinical practice: long-term outcomes and complication predictors.
Polish archives of internal medicine.
2019 06; 129(6):392-398. doi:
10.20452/pamw.14864. [PMID: 31169263] - Shintaro Takamura, Nobuaki Suzuki, Ruri Ishibashi, Nozomu Yukimitsu, Kazuya Sasaki, Yukiko Terada, Hideyuki Kawashima, Hiroyuki Kyono, Ken Kozuma. Long-Term Clinical and Angiographic Outcomes After Implantation of New-Generation Drug-Eluting Stents for Patients on Maintenance Hemodialysis.
International heart journal.
2019 May; 60(3):521-526. doi:
10.1536/ihj.18-359. [PMID: 31105145] - Ryota Kakizaki, Yoshiyasu Minami, Takehiro Hashikata, Teruyoshi Nemoto, Takuya Hashimoto, Kazuhiro Fujiyoshi, Kentaro Meguro, Takao Shimohama, Taiki Tojo, Junya Ako. Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation.
Coronary artery disease.
2018 12; 29(8):624-631. doi:
10.1097/mca.0000000000000654. [PMID: 29975201] - Matthew J Price, Richard A Shlofmitz, Douglas J Spriggs, Thomas A Haldis, Paul Myers, Alexandra Popma Almonacid, Akiko Maehara, Michelle Dauler, Yun Peng, Roxana Mehran. Safety and efficacy of the next generation Resolute Onyx zotarolimus-eluting stent: Primary outcome of the RESOLUTE ONYX core trial.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2018 08; 92(2):253-259. doi:
10.1002/ccd.27322. [PMID: 28940882] - Sho Torii, Gaku Nakazawa, Takeshi Ijichi, Ayako Yoshikawa, Yohei Ohno, Yuji Ikari. Comparison of the endothelial coverage in everolimus and zotarolimus-eluting stents in normal, atherosclerotic, and bifurcation rabbit iliac arteries.
Cardiovascular intervention and therapeutics.
2018 Jan; 33(1):55-61. doi:
10.1007/s12928-016-0437-6. [PMID: 27822890] - Ali Doğan, Emrah Özdemir, Serkan Kahraman, Tayfun Açıl, Yelda Saltan, Nuri Kurtoğlu. Impact of early (3 months) dual antiplatelet treatment interruption prior to renal transplantation in patients with second-generation DES on perioperative stent thrombosis and MACEs.
Anatolian journal of cardiology.
2017 Dec; 18(6):391-396. doi:
10.14744/anatoljcardiol.2017.7885. [PMID: 29256873] - Matthew J Price, Shigeru Saito, Richard A Shlofmitz, Douglas J Spriggs, Michael Attubato, Brent McLaurin, Alexandra Popma Almonacid, Sandeep Brar, Minglei Liu, Elizabeth Moe, Roxana Mehran. First Report of the Resolute Onyx 2.0-mm Zotarolimus-Eluting Stent for the Treatment of Coronary Lesions With Very Small Reference Vessel Diameter.
JACC. Cardiovascular interventions.
2017 07; 10(14):1381-1388. doi:
10.1016/j.jcin.2017.05.004. [PMID: 28728650] - Alexis Matteau, Robert W Yeh, Edoardo Camenzind, P Gabriel Steg, William Wijns, Joseph Mills, Anthony Gershlick, Mark de Belder, Gregory Ducrocq, Laura Mauri. Balancing Long-Term Risks of Ischemic and Bleeding Complications After Percutaneous Coronary Intervention With Drug-Eluting Stents.
The American journal of cardiology.
2015 Sep; 116(5):686-93. doi:
10.1016/j.amjcard.2015.05.036. [PMID: 26187674] - Khurshid Ahmed, Myung Ho Jeong, Rabin Chakraborty, Sumera Ahmed, Young Joon Hong, Doo Sun Sim, Keun Ho Park, Ju Han Kim, Youngkeun Ahn, Jung Chaee Kang, Myeong Chan Cho, Chong Jin Kim, Young Jo Kim. Comparison of zotarolimus- and everolimus-eluting stents in patients with ST-elevation myocardial infarction and chronic kidney disease undergoing primary percutaneous coronary intervention.
Journal of cardiology.
2014 Oct; 64(4):273-8. doi:
10.1016/j.jjcc.2014.02.002. [PMID: 24631465] - Hanim Sen, Ming Kai Lam, Kenneth Tandjung, Mounir W Z Basalus, Frits H A F de Man, J Hans W Louwerenburg, Martin G Stoel, Gert K van Houwelingen, Marije M Löwik, Gerard C M Linssen, Salah A M Saïd, Mark B Nienhuis, Patrick M J Verhorst, Job van der Palen, Clemens von Birgelen. Clinical outcome following second-generation drug-eluting stent use for off-label versus on-label indications: insights from the two-year outcome of the TWENTE trial.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology.
2014 Oct; 10(6):664-71. doi:
10.4244/eijv10i6a117. [PMID: 25330500] - Kyung Woo Park, Joo Myung Lee, Si-Hyuck Kang, Hyo-Suk Ahn, Hyun-Jae Kang, Bon-Kwon Koo, Jay Young Rhew, Sun Ho Hwang, Sung Yoon Lee, Tae Soo Kang, Choong Hwan Kwak, Bum-Kee Hong, Cheol Woong Yu, In-Whan Seong, Taehoon Ahn, Han Cheol Lee, Sang Wook Lim, Hyo-Soo Kim. Everolimus-eluting Xience v/Promus versus zotarolimus-eluting resolute stents in patients with diabetes mellitus.
JACC. Cardiovascular interventions.
2014 May; 7(5):471-81. doi:
10.1016/j.jcin.2013.12.201. [PMID: 24852802] - Liu Haibo, Guo Xiaofang, Wang Chunming, Yuan Jie, Chen Guozhong, Zhang Limei, Cao Yong, Fang Yu, Bao Yingchun, Yu Wangjun, Ge Junbo. Prognostic value of plasma pentraxin-3 levels in patients with stable coronary artery disease after drug-eluting stent implantation.
Mediators of inflammation.
2014; 2014(?):963096. doi:
10.1155/2014/963096. [PMID: 25538378] - M Todd Reimer, Xia Wan, Jun Zhang. A case study of validation and sample analysis for the determination of zotarolimus in various tissues.
Bioanalysis.
2013 Apr; 5(7):811-7. doi:
10.4155/bio.13.29. [PMID: 23534425] - Yoshitaka Muraoka, Shinjo Sonoda, Kuninobu Kashiyama, Fumihiko Kamezaki, Yuki Tsuda, Masaru Araki, Masahito Tamura, Masaaki Takeuchi, Haruhiko Abe, Masahiro Okazaki, Yutaka Otsuji. Coronary arterial remodeling and out-stent plaque change after drug-eluting stent implantation--comparison between zotarolimus-eluting stents and paclitaxel-eluting stents.
Circulation journal : official journal of the Japanese Circulation Society.
2013; 77(2):363-71. doi:
10.1253/circj.cj-12-0575. [PMID: 23117679] - Daisuke Hachinohe, Myung Ho Jeong, Shigeru Saito, Min Chol Kim, Kyung Hoon Cho, Khurshid Ahmed, Seung Hwan Hwang, Min Goo Lee, Doo Sun Sim, Keun-Ho Park, Ju Han Kim, Young Joon Hong, Youngkeun Ahn, Jung Chaee Kang, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Taek Jong Hong, Donghoon Choi, Myeong Chan Cho, Chong Jin Kim, Ki Bae Seung, Wook Sung Chung, Yang Soo Jang, Seung Woon Rha, Jang Ho Bae, Seung Jung Park. Comparison of drug-eluting stents in acute myocardial infarction patients with chronic kidney disease.
The Korean journal of internal medicine.
2012 Dec; 27(4):397-406. doi:
10.3904/kjim.2012.27.4.397. [PMID: 23269880] - Martin T Rothman, Ajay K Jain. Outcomes in patients with renal impairment undergoing percutaneous coronary intervention and implantation of the Endeavor zotarolimus-eluting stent: 1- and 2-year data from the E-Five Registry.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2012 Nov; 80(6):885-92. doi:
10.1002/ccd.23484. [PMID: 22517785] - Nishant Kalra, David J Moliterno. Zotarolimus-eluting stents among patients with renal impairment undergoing percutaneous coronary intervention.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.
2012 Nov; 80(6):893-4. doi:
10.1002/ccd.24686. [PMID: 23166098] - Jung-Sun Kim, Myeong-Ki Hong, Dong-Ho Shin, Byeong-Keuk Kim, Young-Guk Ko, Donghoon Choi, Yangsoo Jang. Quantitative and qualitative changes in DES-related neointimal tissue based on serial OCT.
JACC. Cardiovascular imaging.
2012 Nov; 5(11):1147-55. doi:
10.1016/j.jcmg.2012.01.024. [PMID: 23153915] - Young-Guk Ko, Dong-Min Kim, Jin Man Cho, So Yeon Choi, Jung Han Yoon, Jung-Sun Kim, Byeong-Keuk Kim, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong. Optical coherence tomography findings of very late stent thrombosis after drug-eluting stent implantation.
The international journal of cardiovascular imaging.
2012 Apr; 28(4):715-23. doi:
10.1007/s10554-011-9905-3. [PMID: 21656060] - Panagiotis Kallidonis, Panagiotis Kitrou, Dimitrios Karnabatidis, Iason Kyriazis, Christina Kalogeropoulou, Athanasios Tsamandas, Dimitrios J Apostolopoulos, Theofanis Vrettos, Despoina Liourdi, Stavros Spiliopoulos, Abdulrahman Al-Aown, Chrisoula D Scopa, Evangelos Liatsikos. Evaluation of zotarolimus-eluting metal stent in animal ureters.
Journal of endourology.
2011 Oct; 25(10):1661-7. doi:
10.1089/end.2011.0308. [PMID: 21905851] - Soon Jun Hong, Seung Cheol Choi, Chul Min Ahn, Jae Hyung Park, Jae Sang Kim, Do-Sun Lim. Telmisartan reduces neointima volume and pulse wave velocity 8 months after zotarolimus-eluting stent implantation in hypertensive type 2 diabetic patients.
Heart (British Cardiac Society).
2011 Sep; 97(17):1425-32. doi:
10.1136/hrt.2011.225193. [PMID: 21700754] - Konstantinos Toutouzas, Chrysoula Patsa, Andreas Synetos, Antonis Karanasos, John Karampelas, Eleftherios Tsiamis, Anastasios Spanos, Elli Stefanadi, Dimitris Tousoulis, Christodoulos Stefanadis. The impact of new generation drug-eluting stent implantation on patients with chronic kidney disease and a single lesion in the proximal segment of the left anterior descending artery.
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese.
2011 Mar; 52(2):103-10. doi:
NULL. [PMID: 21478119] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Leandro I Lasave, Alexandre A C Abizaid, Julio Paiva e Maia, José de Ribamar Costa, Fausto Feres, Luiz A Mattos, Andrea S Abizaid, Dimytri A Siqueira, Luiz F Tanajura, Rodolfo Staico, Pedro Beraldo de Andrade, Sérgio N Braga, Amanda G M R Sousa, J Eduardo Sousa. [Relationship between plasma C-reactive protein level and neointimal hyperplasia volume in patients with zotarolimus-eluting stents. Volumetric analysis by three-dimensional intracoronary ultrasound].
Revista espanola de cardiologia.
2007 Sep; 60(9):923-31. doi:
10.1157/13109645. [PMID: 17915148] - Jun Zhang, M Todd Reimer, Nicholas E Alexander, Qin C Ji, Tawakol A El-Shourbagy. Method development and validation for zotarolimus concentration determination in stented swine arteries by liquid chromatography/tandem mass spectrometry detection.
Rapid communications in mass spectrometry : RCM.
2006; 20(22):3427-34. doi:
10.1002/rcm.2742. [PMID: 17051612] - Chetan S Karyekar, Rajendra S Pradhan, Tony Freeney, Qin Ji, Timi Edeki, Wenzi Chiu, Walid M Awni, Charles Locke, Lewis B Schwartz, Richard G Granneman, Robert O'Dea. A phase I multiple-dose escalation study characterizing pharmacokinetics and safety of ABT-578 in healthy subjects.
Journal of clinical pharmacology.
2005 Aug; 45(8):910-8. doi:
10.1177/0091270005278807. [PMID: 16027401]