apilimod (BioDeep_00000752562)
代谢物信息卡片
apilimod
化学式: C23H26N6O2 (418.2117136)
中文名称: 盐酸阿吡莫德
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=CC=C1)C=NNC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4
InChI: InChI=1S/C23H26N6O2/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28)/b25-17+
描述信息
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
C274 - Antineoplastic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daric J Wible, Zalak Parikh, Eun Jeong Cho, Miao-Der Chen, Collene R Jeter, Somshuvra Mukhopadhyay, Kevin N Dalby, Shankar Varadarajan, Shawn B Bratton. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control.
Cell death & disease.
2024 01; 15(1):80. doi:
10.1038/s41419-024-06423-0. [PMID: 38253602] - David H Drewry, Frances M Potjewyd, Armin Bayati, Jeffery L Smith, Rebekah J Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M Min, Mohammad Anwar Hossain, Mark Heise, Peter S McPherson, Nathaniel J Moorman, Alison D Axtman. Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.
Journal of medicinal chemistry.
2022 10; 65(19):12860-12882. doi:
10.1021/acs.jmedchem.2c00697. [PMID: 36111834] - Alex J B Kreutzberger, Anwesha Sanyal, Ravi Ojha, Jesse D Pyle, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen. Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease.
Journal of virology.
2021 10; 95(21):e0097521. doi:
10.1128/jvi.00975-21. [PMID: 34406858] - Zhuangzhuang Zhao, Pan Qin, Yao-Wei Huang. Lysosomal ion channels involved in cellular entry and uncoating of enveloped viruses: Implications for therapeutic strategies against SARS-CoV-2.
Cell calcium.
2021 03; 94(?):102360. doi:
10.1016/j.ceca.2021.102360. [PMID: 33516131] - Suzannah J Rihn, Andres Merits, Siddharth Bakshi, Matthew L Turnbull, Arthur Wickenhagen, Akira J T Alexander, Carla Baillie, Benjamin Brennan, Fiona Brown, Kirstyn Brunker, Steven R Bryden, Kerry A Burness, Stephen Carmichael, Sarah J Cole, Vanessa M Cowton, Paul Davies, Chris Davis, Giuditta De Lorenzo, Claire L Donald, Mark Dorward, James I Dunlop, Matthew Elliott, Mazigh Fares, Ana da Silva Filipe, Joseph R Freitas, Wilhelm Furnon, Rommel J Gestuveo, Anna Geyer, Daniel Giesel, Daniel M Goldfarb, Nicola Goodman, Rory Gunson, C James Hastie, Vanessa Herder, Joseph Hughes, Clare Johnson, Natasha Johnson, Alain Kohl, Karen Kerr, Hannah Leech, Laura Sandra Lello, Kathy Li, Gauthier Lieber, Xiang Liu, Rajendra Lingala, Colin Loney, Daniel Mair, Marion J McElwee, Steven McFarlane, Jenna Nichols, Kyriaki Nomikou, Anne Orr, Richard J Orton, Massimo Palmarini, Yasmin A Parr, Rute Maria Pinto, Samantha Raggett, Elaine Reid, David L Robertson, Jamie Royle, Natalia Cameron-Ruiz, James G Shepherd, Katherine Smollett, Douglas G Stewart, Meredith Stewart, Elena Sugrue, Agnieszka M Szemiel, Aislynn Taggart, Emma C Thomson, Lily Tong, Leah S Torrie, Rachel Toth, Margus Varjak, Sainan Wang, Stuart G Wilkinson, Paul G Wyatt, Eva Zusinaite, Dario R Alessi, Arvind H Patel, Ali Zaid, Sam J Wilson, Suresh Mahalingam. A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.
PLoS biology.
2021 02; 19(2):e3001091. doi:
10.1371/journal.pbio.3001091. [PMID: 33630831] - Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N Zolov, Sai Srinivas Panapakkam Giridharan, Lois S Weisman, Laurent O Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal. Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling.
Theranostics.
2021; 11(13):6491-6506. doi:
10.7150/thno.55821. [PMID: 33995670] - Maksim V Baranov, Frans Bianchi, Geert van den Bogaart. The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19.
Cells.
2020 12; 10(1):. doi:
10.3390/cells10010030. [PMID: 33375410] - Laura Riva, Shuofeng Yuan, Xin Yin, Laura Martin-Sancho, Naoko Matsunaga, Lars Pache, Sebastian Burgstaller-Muehlbacher, Paul D De Jesus, Peter Teriete, Mitchell V Hull, Max W Chang, Jasper Fuk-Woo Chan, Jianli Cao, Vincent Kwok-Man Poon, Kristina M Herbert, Kuoyuan Cheng, Tu-Trinh H Nguyen, Andrey Rubanov, Yuan Pu, Courtney Nguyen, Angela Choi, Raveen Rathnasinghe, Michael Schotsaert, Lisa Miorin, Marion Dejosez, Thomas P Zwaka, Ko-Yung Sit, Luis Martinez-Sobrido, Wen-Chun Liu, Kris M White, Mackenzie E Chapman, Emma K Lendy, Richard J Glynne, Randy Albrecht, Eytan Ruppin, Andrew D Mesecar, Jeffrey R Johnson, Christopher Benner, Ren Sun, Peter G Schultz, Andrew I Su, Adolfo García-Sastre, Arnab K Chatterjee, Kwok-Yung Yuen, Sumit K Chanda. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature.
2020 10; 586(7827):113-119. doi:
10.1038/s41586-020-2577-1. [PMID: 32707573] - Yuan-Lin Kang, Yi-Ying Chou, Paul W Rothlauf, Zhuoming Liu, Timothy K Soh, David Cureton, James Brett Case, Rita E Chen, Michael S Diamond, Sean P J Whelan, Tom Kirchhausen. Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2.
Proceedings of the National Academy of Sciences of the United States of America.
2020 08; 117(34):20803-20813. doi:
10.1073/pnas.2007837117. [PMID: 32764148] - Roya M Dayam, Chun X Sun, Christopher H Choy, Gemma Mancuso, Michael Glogauer, Roberto J Botelho. The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
Journal of immunology (Baltimore, Md. : 1950).
2017 09; 199(6):2096-2105. doi:
10.4049/jimmunol.1601466. [PMID: 28779020] - Elizabeth A Nelson, Julie Dyall, Thomas Hoenen, Alyson B Barnes, Huanying Zhou, Janie Y Liang, Julia Michelotti, William H Dewey, Lisa Evans DeWald, Richard S Bennett, Patrick J Morris, Rajarshi Guha, Carleen Klumpp-Thomas, Crystal McKnight, Yu-Chi Chen, Xin Xu, Amy Wang, Emma Hughes, Scott Martin, Craig Thomas, Peter B Jahrling, Lisa E Hensley, Gene G Olinger, Judith M White. The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection.
PLoS neglected tropical diseases.
2017 04; 11(4):e0005540. doi:
10.1371/journal.pntd.0005540. [PMID: 28403145] - Sophia Gayle, Sean Landrette, Neil Beeharry, Chris Conrad, Marylens Hernandez, Paul Beckett, Shawn M Ferguson, Talya Mandelkern, Meiling Zheng, Tian Xu, Jonathan Rothberg, Henri Lichenstein. Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma.
Blood.
2017 03; 129(13):1768-1778. doi:
10.1182/blood-2016-09-736892. [PMID: 28104689] - Nina Pettersen Hessvik, Anders Øverbye, Andreas Brech, Maria Lyngaas Torgersen, Ida Seim Jakobsen, Kirsten Sandvig, Alicia Llorente. PIKfyve inhibition increases exosome release and induces secretory autophagy.
Cellular and molecular life sciences : CMLS.
2016 12; 73(24):4717-4737. doi:
10.1007/s00018-016-2309-8. [PMID: 27438886] - Xinming Cai, Yongyao Xu, You-Me Kim, Joseph Loureiro, Qian Huang. PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3.
Journal of immunology (Baltimore, Md. : 1950).
2014 Apr; 192(7):3383-9. doi:
10.4049/jimmunol.1302411. [PMID: 24600036] - Xinming Cai, Yongyao Xu, Atwood K Cheung, Ronald C Tomlinson, Abel Alcázar-Román, Leon Murphy, Andreas Billich, Bailin Zhang, Yan Feng, Martin Klumpp, Jean-Michel Rondeau, Aleem N Fazal, Christopher J Wilson, Vic Myer, Gerard Joberty, Tewis Bouwmeester, Mark A Labow, Peter M Finan, Jeffrey A Porter, Hidde L Ploegh, Daniel Baird, Pietro De Camilli, John A Tallarico, Qian Huang. PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.
Chemistry & biology.
2013 Jul; 20(7):912-21. doi:
10.1016/j.chembiol.2013.05.010. [PMID: 23890009] - Hiroshi Keino, Takayo Watanabe, Yasuhiko Sato, Mamoru Niikura, Yumiko Wada, Annabelle A Okada. Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis.
Arthritis research & therapy.
2008; 10(5):R122. doi:
10.1186/ar2530. [PMID: 18847496]