Lapaquistat Acetate (BioDeep_00000752558)
代谢物信息卡片
化学式: C33H41ClN2O9 (644.2500446)
中文名称: 拉帕司他
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OCC(C)(C)CN1C2=C(C=C(C=C2)Cl)C(OC(C1=O)CC(=O)N3CCC(CC3)CC(=O)O)C4=C(C(=CC=C4)OC)OC
InChI: InChI=1S/C33H41ClN2O9/c1-20(37)44-19-33(2,3)18-36-25-10-9-22(34)16-24(25)30(23-7-6-8-26(42-4)31(23)43-5)45-27(32(36)41)17-28(38)35-13-11-21(12-14-35)15-29(39)40/h6-10,16,21,27,30H,11-15,17-19H2,1-5H3,(H,39,40)/t27-,30-/m1/s1
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alexios N Matralis, Angeliki P Kourounakis. Optimizing the Pharmacological Profile of New Bifunctional Antihyperlipidemic/Antioxidant Morpholine Derivatives.
ACS medicinal chemistry letters.
2019 Jan; 10(1):98-104. doi:
10.1021/acsmedchemlett.8b00469. [PMID: 30655954] - T Ebihara, T Takeuchi, Y Moriya, Y Tagawa, T Kondo, T Moriwaki, S Asahi. Characterization of Transporters in the Hepatic Uptake of TAK-475 M-I, a Squalene Synthase Inhibitor, in Rats and Humans.
Drug research.
2016 Jun; 66(6):316-23. doi:
10.1055/s-0035-1569441. [PMID: 27011383] - T Ebihara, K Teshima, T Kondo, Y Tagawa, T Moriwaki, S Asahi. Pharmacokinetics of TAK-475, a Squalene Synthase Inhibitor, in Rats and Dogs.
Drug research.
2016 Jun; 66(6):287-92. doi:
10.1055/s-0035-1569407. [PMID: 26839207] - Masanori Ichikawa, Masami Ohtsuka, Hitoshi Ohki, Masahiro Ota, Noriyasu Haginoya, Masao Itoh, Yoshihiro Shibata, Yutaka Ishigai, Koji Terayama, Akira Kanda, Kazuyuki Sugita, Hiroyuki Usui. Discovery of DF-461, a Potent Squalene Synthase Inhibitor.
ACS medicinal chemistry letters.
2013 Oct; 4(10):932-6. doi:
10.1021/ml400151c. [PMID: 24900587] - Evan A Stein, Harold Bays, Dennis O'Brien, Jim Pedicano, Edward Piper, Andrea Spezzi. Lapaquistat acetate: development of a squalene synthase inhibitor for the treatment of hypercholesterolemia.
Circulation.
2011 May; 123(18):1974-85. doi:
10.1161/circulationaha.110.975284. [PMID: 21518985] - M Shiomi, S Yamada, Y Amano, T Nishimoto, T Ito. Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions.
British journal of pharmacology.
2008 Jul; 154(5):949-57. doi:
10.1038/bjp.2008.143. [PMID: 18587443] - Raghda K Elsayed, Jeffery D Evans. Emerging lipid-lowering drugs: squalene synthase inhibitors.
Expert opinion on emerging drugs.
2008 Jun; 13(2):309-22. doi:
10.1517/14728214.13.2.309. [PMID: 18537523] - Tomoyuki Nishimoto, Eiichiro Ishikawa, Hisashi Anayama, Hitomi Hamajyo, Hirofumi Nagai, Masao Hirakata, Ryuichi Tozawa. Protective effects of a squalene synthase inhibitor, lapaquistat acetate (TAK-475), on statin-induced myotoxicity in guinea pigs.
Toxicology and applied pharmacology.
2007 Aug; 223(1):39-45. doi:
10.1016/j.taap.2007.05.005. [PMID: 17599378] - Tomoyuki Nishimoto, Ryuichi Tozawa, Yuichiro Amano, Takeo Wada, Yoshimi Imura, Yasuo Sugiyama. Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes.
Biochemical pharmacology.
2003 Dec; 66(11):2133-9. doi:
10.1016/j.bcp.2003.08.011. [PMID: 14609738] - Tomoyuki Nishimoto, Yuichiro Amano, Ryuichi Tozawa, Eiichiro Ishikawa, Yoshimi Imura, Hidefumi Yukimasa, Yasuo Sugiyama. Lipid-lowering properties of TAK-475, a squalene synthase inhibitor, in vivo and in vitro.
British journal of pharmacology.
2003 Jul; 139(5):911-8. doi:
10.1038/sj.bjp.0705332. [PMID: 12839864] - Yuichiro Amano, Tomoyuki Nishimoto, Ryu ichi Tozawa, Eiichiro Ishikawa, Yoshimi Imura, Yasuo Sugiyama. Lipid-lowering effects of TAK-475, a squalene synthase inhibitor, in animal models of familial hypercholesterolemia.
European journal of pharmacology.
2003 Apr; 466(1-2):155-61. doi:
10.1016/s0014-2999(03)01549-8. [PMID: 12679152] - Takashi Miki, Masakuni Kori, Hiroshi Mabuchi, Ryu-ichi Tozawa, Tomoyuki Nishimoto, Yasuo Sugiyama, Koichiro Teshima, Hidefumi Yukimasa. Synthesis of novel 4,1-benzoxazepine derivatives as squalene synthase inhibitors and their inhibition of cholesterol synthesis.
Journal of medicinal chemistry.
2002 Sep; 45(20):4571-80. doi:
10.1021/jm020234o. [PMID: 12238936]