Fluticasone furoate (BioDeep_00000752556)
代谢物信息卡片
Fluticasone furoate
化学式: C27H29F3O6S (538.163685)
中文名称: 糠酸氟替卡松
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)SCF)OC(=O)C5=CC=CO5)C)O)F)C)F
InChI: InChI=1S/C27H29F3O6S/c1-14-9-16-17-11-19(29)18-10-15(31)6-7-24(18,2)26(17,30)21(32)12-25(16,3)27(14,23(34)37-13-28)36-22(33)20-5-4-8-35-20/h4-8,10,14,16-17,19,21,32H,9,11-13H2,1-3H3/t14-,16+,17+,19+,21+,24+,25+,26+,27+/m1/s1
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BA - Glucocorticoids
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AD - Corticosteroids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:74899
- KEGGdrug: D06315
- PubChem: 9854489
- DrugBank: DB08906
- ChEMBL: CHEMBL1676
- CAS: 397864-44-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Peter Daley-Yates, Brian Keppler, Amanda Baines, George Bardsley, James Fingleton. Metabolomic changes related to airway inflammation, asthma pathogenesis and systemic activity following inhaled fluticasone furoate/vilanterol: a randomized controlled trial.
Respiratory research.
2022 Sep; 23(1):258. doi:
10.1186/s12931-022-02164-w. [PMID: 36127726] - Ying Zhong, Lujin Li, Rui Chen, Qingshan Zheng. Quantitative comparison of dose-effect and time-course of fluticasone furoate and fluticasone propionate in adult and adolescent patients with persistent asthma: A systematic review and meta-analysis.
Respirology (Carlton, Vic.).
2022 03; 27(3):194-201. doi:
10.1111/resp.14203. [PMID: 35043513] - Shuying Yang, Laurie A Lee, Neal Sule, Andrew Fowler, Guy Peachey. Population Pharmacokinetic Modeling of Fluticasone Furoate, Umeclidinium Bromide, and Vilanterol in Patients with Asthma, Using Data from a Phase IIIA Study (CAPTAIN).
Clinical pharmacokinetics.
2021 07; 60(7):887-896. doi:
10.1007/s40262-021-00988-1. [PMID: 33598874] - Mohammed Bouhajib, Zia Tayab. The Pharmacokinetics of Fluticasone Furoate Given Intranasally in Healthy Subjects Using an Ultra-Sensitive Analytical Assay.
Drug research.
2020 Jul; 70(7):310-316. doi:
10.1055/a-1170-3083. [PMID: 32485781] - Rashmi Mehta, Colm Farrell, Siobhán Hayes, Ruby Birk, Malek Okour, David A Lipson. Population Pharmacokinetic Analysis of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease.
Clinical pharmacokinetics.
2020 01; 59(1):67-79. doi:
10.1007/s40262-019-00794-w. [PMID: 31321713] - Durgawati Patel, Kuldeep Kumar Namdev, Kanika Verma, Ritika Gururani, Akansha Tiwari, Puspendra Kumar, Rikeshwer Prasad Dewangan, Saikh Mohammad Wabaidur, Swapnil Sharma, Jaya Dwivedi. HPLC-UV and spectrofluorimetric methods for simultaneous estimation of fluticasone furoate and vilanterol in rabbit plasma: A pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Nov; 1132(?):121842. doi:
10.1016/j.jchromb.2019.121842. [PMID: 31669821] - Claire Ambery, Graeme Young, Teresa Fuller, Alex Georgiou, David Ramsay, Adeep Puri, Peter Daley-Yates. Open-Label, Crossover Study to Determine the Pharmacokinetics of Fluticasone Furoate and Batefenterol When Administered Alone, in Combination, or Concurrently.
Clinical pharmacology in drug development.
2019 02; 8(2):188-197. doi:
10.1002/cpdd.603. [PMID: 30070770] - Bartolome R Celli, Julie A Anderson, Robert Brook, Peter Calverley, Nicholas J Cowans, Courtney Crim, Ian Dixon, Victor Kim, Fernando J Martinez, Andrea Morris, David E Newby, Julie Yates, Joergen Vestbo. Serum biomarkers and outcomes in patients with moderate COPD: a substudy of the randomised SUMMIT trial.
BMJ open respiratory research.
2019; 6(1):e000431. doi:
10.1136/bmjresp-2019-000431. [PMID: 31258919] - Philip D Adamson, Julie A Anderson, Robert D Brook, Peter M A Calverley, Bartolome R Celli, Nicholas J Cowans, Courtney Crim, Ian J Dixon, Fernando J Martinez, David E Newby, Jørgen Vestbo, Julie C Yates, Nicholas L Mills. Cardiac Troponin I and Cardiovascular Risk in Patients With Chronic Obstructive Pulmonary Disease.
Journal of the American College of Cardiology.
2018 09; 72(10):1126-1137. doi:
10.1016/j.jacc.2018.06.051. [PMID: 30165984] - Rashmi Mehta, Alison Moore, Kylie Riddell, Shashidhar Joshi, Robert Chan. Pharmacokinetic Comparison of a Unit Dose Dry Powder Inhaler with a Multidose Dry Powder Inhaler for Delivery of Fluticasone Furoate.
Journal of aerosol medicine and pulmonary drug delivery.
2017 Oct; 30(5):332-338. doi:
10.1089/jamp.2016.1322. [PMID: 28463040] - Claire Ambery, Kylie Riddell, Peter Daley-Yates. Open-Label, Randomized, 6-Way Crossover, Single-Dose Study to Determine the Pharmacokinetics of Batefenterol (GSK961081) and Fluticasone Furoate When Administered Alone or in Combination.
Clinical pharmacology in drug development.
2016 Sep; 5(5):399-407. doi:
10.1002/cpdd.274. [PMID: 27170445] - Ann Allen, Robert D Murdoch, Philippe Bareille, Olivia Burns, Stephen Hughes, Ashutosh Gupta, Sam R Miller. Pharmacokinetics, Safety, and Tolerability of Once-Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed-Dose Combination.
Clinical pharmacology in drug development.
2016 May; 5(3):225-31. doi:
10.1002/cpdd.218. [PMID: 27163502] - Xia Chen, Xin Zheng, Ji Jiang, Pei Hu, Kai Wu, Lihong Zhuang, Lian Liu, Xin Du, Rodger Kempsford, Ann Allen. Pharmacodynamics and pharmacokinetics of fluticasone furoate/vilanterol in healthy Chinese subjects.
Pharmacotherapy.
2015 Jun; 35(6):586-99. doi:
10.1002/phar.1598. [PMID: 26059225] - Shuying Yang, Laurie Lee, Stephen Mallett, Jonathan Ayer, Allen Wolstenholme, Steven Pascoe. A randomized, crossover study to investigate the pharmacokinetics and safety of inhaled fluticasone furoate and umeclidinium, administered separately and in combination via dry powder inhaler in healthy adult volunteers.
Advances in therapy.
2015 Feb; 32(2):157-71. doi:
10.1007/s12325-015-0184-6. [PMID: 25700806] - Kimihiro Okubo, Arisa Okamasa, Gosuke Honma, Masaki Komatsubara. Safety and efficacy of fluticasone furoate nasal spray in Japanese children 2 to <15 years of age with perennial allergic rhinitis: a multicentre, open-label trial.
Allergology international : official journal of the Japanese Society of Allergology.
2015 Jan; 64(1):60-5. doi:
10.1016/j.alit.2014.07.002. [PMID: 25572559] - Rodger Kempsford, Ann Allen, Philippe Bareille, Melanie Hamilton, Anne Cheesbrough. The pharmacodynamics, pharmacokinetics, safety and tolerability of inhaled fluticasone furoate and vilanterol administered alone or simultaneously as fluticasone furoate/vilanterol.
Clinical pharmacology in drug development.
2015 01; 4(1):2-11. doi:
10.1002/cpdd.160. [PMID: 27127998] - Andreina Bruno, Stefania Gerbino, Maria Ferraro, Liboria Siena, Angela Bonura, Paolo Colombo, Stefania La Grutta, Salvatore Gallina, Antonella Ballacchino, Marco Giammanco, Mark Gjomarkaj, Elisabetta Pace. Fluticasone furoate maintains epithelial homeostasis via leptin/leptin receptor pathway in nasal cells.
Molecular and cellular biochemistry.
2014 Nov; 396(1-2):55-65. doi:
10.1007/s11010-014-2142-z. [PMID: 25070832] - Ashley Woodcock, Jan Lötvall, William W Busse, Eric D Bateman, Sally Stone, Anna Ellsworth, Loretta Jacques. Efficacy and safety of fluticasone furoate 100 μg and 200 μg once daily in the treatment of moderate-severe asthma in adults and adolescents: a 24-week randomised study.
BMC pulmonary medicine.
2014 Jul; 14(?):113. doi:
10.1186/1471-2466-14-113. [PMID: 25007865] - Amanda Oliver, Sandi VanBuren, Ann Allen, Melanie Hamilton, Lee Tombs, Amir Inamdar, Rodger Kempsford. Tolerability of fluticasone furoate/vilanterol combination therapy in children aged 5 to 11 years with persistent asthma.
Clinical therapeutics.
2014 Jun; 36(6):928-939.e1. doi:
10.1016/j.clinthera.2014.03.014. [PMID: 24793536] - Ann Allen, Joanne Bal, Anne Cheesbrough, Melanie Hamilton, Rodger Kempsford. Pharmacokinetics and pharmacodynamics of intravenous and inhaled fluticasone furoate in healthy Caucasian and East Asian subjects.
British journal of clinical pharmacology.
2014 May; 77(5):808-20. doi:
10.1111/bcp.12263. [PMID: 24152086] - Joaquim Mullol, Laura Pujols, Isam Alobid, Maria Pérez-Gonzalez, Mireya Fuentes, Francisco de Borja Callejas, Antonio Valero, Cesar Picado, Jordi Roca-Ferrer. Fluticasone furoate inhibits cytokine secretion from nasal epithelial cells and reduces eosinophil survival in an in vitro model of eosinophilic inflammation.
International archives of allergy and immunology.
2014; 163(3):225-33. doi:
10.1159/000358489. [PMID: 24603043] - Ann Allen. The relationship between fluticasone furoate systemic exposure and cortisol suppression.
Clinical pharmacokinetics.
2013 Oct; 52(10):885-96. doi:
10.1007/s40262-013-0078-1. [PMID: 23719680] - Ann Allen, Isabelle Schenkenberger, Roopa Trivedi, Jeremy Cole, Wesley Hicks, Nadeem Gul, Loretta Jacques. Inhaled fluticasone furoate/vilanterol does not affect hypothalamic-pituitary-adrenal axis function in adolescent and adult asthma: randomised, double-blind, placebo-controlled study.
The clinical respiratory journal.
2013 Oct; 7(4):397-406. doi:
10.1111/crj.12026. [PMID: 23578031] - Norie Nakahara, Akira Wakamatsu, Rodger Kempsford, Ann Allen, Masanori Yamada, Shigeru Nohda, Toshiyasu Hirama. The safety, pharmacokinetics and pharmacodynamics of a combination of fluticasone furoate and vilanterol in healthy Japanese subjects.
International journal of clinical pharmacology and therapeutics.
2013 Aug; 51(8):660-71. doi:
10.5414/cp201822. [PMID: 23735179] - Rodger Kempsford, Ann Allen, Joanne Bal, David Rubin, Lee Tombs. The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of inhaled fluticasone furoate and vilanterol trifenatate in healthy subjects.
British journal of clinical pharmacology.
2013 Jun; 75(6):1478-87. doi:
10.1111/bcp.12019. [PMID: 23116485] - Ann Allen, Angela Davis, Kelly Hardes, Lee Tombs, Rodger Kempsford. Influence of renal and hepatic impairment on the pharmacokinetic and pharmacodynamic properties and tolerability of fluticasone furoate and vilanterol in combination.
Clinical therapeutics.
2012 Dec; 34(12):2316-32. doi:
10.1016/j.clinthera.2012.11.001. [PMID: 23200625] - Joseph A Boscia, Krishna K Pudi, Michael T Zvarich, Lisa Sanford, Sarah K Siederer, Courtney Crim. Effect of once-daily fluticasone furoate/vilanterol on 24-hour pulmonary function in patients with chronic obstructive pulmonary disease: a randomized, three-way, incomplete block, crossover study.
Clinical therapeutics.
2012 Aug; 34(8):1655-66.e5. doi:
10.1016/j.clinthera.2012.06.005. [PMID: 22789766] - Hilary Medley, Socorro Orozco, Ann Allen. Efficacy and safety profile of fluticasone furoate administered once daily in the morning or evening: a randomized, double-blind, double-dummy, placebo-controlled trial in adult and adolescent patients with persistent bronchial asthma.
Clinical therapeutics.
2012 Aug; 34(8):1683-95. doi:
10.1016/j.clinthera.2012.06.024. [PMID: 22796247] - Ina Callebaut, Evelien Vandewalle, Valérie Hox, Sonja Bobic, Mark Jorissen, Ingeborg Stalmans, Annick De Vries, Glenis Scadding, Peter W Hellings. Nasal corticosteroid treatment reduces substance P levels in tear fluid in allergic rhinoconjunctivitis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2012 Aug; 109(2):141-6. doi:
10.1016/j.anai.2012.06.008. [PMID: 22840257] - Ashley Woodcock, Eugene R Bleecker, William W Busse, Jan Lötvall, Neil G Snowise, Lucy Frith, Loretta Jacques, Brett Haumann, Eric D Bateman. Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma.
Respiratory research.
2011 Dec; 12(?):160. doi:
10.1186/1465-9921-12-160. [PMID: 22188590] - Jorge F Maspero, Richard D Walters, Wei Wu, Edward E Philpot, Robert M Naclerio, Wytske J Fokkens. An integrated analysis of the efficacy of fluticasone furoate nasal spray on individual nasal and ocular symptoms of seasonal allergic rhinitis.
Allergy and asthma proceedings.
2010 Nov; 31(6):483-92. doi:
10.2500/aap.2010.31.3397. [PMID: 21708060] - Ita Tripathy, Arden Levy, Paul Ratner, Diane Clements, Wei Wu, Edward Philpot. HPA axis safety of fluticasone furoate nasal spray once daily in children with perennial allergic rhinitis.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2009 May; 20(3):287-94. doi:
10.1111/j.1399-3038.2008.00775.x. [PMID: 19175889] - Eli O Meltzer, Ita Tripathy, Jorge F Máspero, Wei Wu, Ed Philpot. Safety and tolerability of fluticasone furoate nasal spray once daily in paediatric patients aged 6-11 years with allergic rhinitis: subanalysis of three randomized, double-blind, placebo-controlled, multicentre studies.
Clinical drug investigation.
2009; 29(2):79-86. doi:
10.2165/0044011-200929020-00002. [PMID: 19133703] - Stephen C Hughes, Peter C Shardlow, Frank J Hollis, Rebecca J Scott, Dimple S Motivaras, Ann Allen, Victoria M Rousell. Metabolism and disposition of fluticasone furoate, an enhanced-affinity glucocorticoid, in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Nov; 36(11):2337-44. doi:
10.1124/dmd.108.022137. [PMID: 18694910] - Deepen Patel, Paul Ratner, Diane Clements, Wei Wu, Melissa Faris, Edward Philpot. Lack of effect on adult and adolescent hypothalamic-pituitary-adrenal axis function with use of fluticasone furoate nasal spray.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2008 May; 100(5):490-6. doi:
10.1016/s1081-1206(10)60476-0. [PMID: 18517083] - S M Harding. The human pharmacology of fluticasone propionate.
Respiratory medicine.
1990 Nov; 84 Suppl A(?):25-9. doi:
10.1016/s0954-6111(08)80004-2. [PMID: 2287792]