(Melle-4)cyclosporin (BioDeep_00000752383)

   


代谢物信息卡片


(Melle-4)cyclosporin

化学式: C62H111N11O12 (1201.8413246)
中文名称: (melle-4)环孢素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C/C[C@H]([C@@H](O)[C@@]1(N(C)C([C@]([H])(C(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@]([H])(CC(C)C)N(C)C([C@@H](C)NC([C@H](C)NC([C@@H](N(C([C@@]([H])(NC([C@@]([H])(N(C(CN(C([C@@H](NC1=O)CC)=O)C)=O)C)[C@H](CC)C)=O)C(C)C)=O)C)CC(C)C)=O)=O)=O)=O)=O)=O)[H])C
InChI: InChI=1S/C62H111N11O12/c1-25-28-29-40(15)52(75)51-56(79)65-43(27-3)58(81)67(18)33-47(74)71(22)50(39(14)26-2)55(78)66-48(37(10)11)61(84)68(19)44(30-34(4)5)54(77)63-41(16)53(76)64-42(17)57(80)69(20)45(31-35(6)7)59(82)70(21)46(32-36(8)9)60(83)72(23)49(38(12)13)62(85)73(51)24/h25,28,34-46,48-52,75H,26-27,29-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b28-25+/t39-,40+,41-,42+,43-,44-,45-,46-,48-,49-,50-,51-,52+/m0/s1

描述信息

D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D003524 - Cyclosporins
NIM811 ((Melle-4)cyclosporin; SDZ NIM811) is an orally bioavailable mitochondrial permeability transition and cyclophilin dual inhibitor, which exhibits potent in vitro activity against hepatitis C virus (HCV) [1][2].

同义名列表

3 个代谢物同义名

(Melle-4)cyclosporin; NIM811; SDZ NIM811



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Khairat Bahgat Youssef El Baradie, Mohammad B Khan, Bharati Mendhe, Jennifer Waller, Frederick O'Brien, Mark W Hamrick. The cyclophilin inhibitor NIM-811 increases muscle cell survival with hypoxia in vitro and improves gait performance following ischemia-reperfusion in vivo. Scientific reports. 2021 03; 11(1):6152. doi: 10.1038/s41598-021-85753-x. [PMID: 33731782]
  • Emese Tóth, József Maléth, Noémi Závogyán, Júlia Fanczal, Anna Grassalkovich, Réka Erdős, Petra Pallagi, Gergő Horváth, László Tretter, Emese Réka Bálint, Zoltán Rakonczay, Viktória Venglovecz, Péter Hegyi. Novel mitochondrial transition pore inhibitor N-methyl-4-isoleucine cyclosporin is a new therapeutic option in acute pancreatitis. The Journal of physiology. 2019 12; 597(24):5879-5898. doi: 10.1113/jp278517. [PMID: 31631343]
  • Jiangting Hu, Venkat K Ramshesh, Mitchell R McGill, Hartmut Jaeschke, John J Lemasters. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver. Toxicological sciences : an official journal of the Society of Toxicology. 2016 Mar; 150(1):204-15. doi: 10.1093/toxsci/kfv319. [PMID: 26721299]
  • Kazuhiro Niimi, Takahiro Yasui, Atsushi Okada, Yasuhiko Hirose, Yasue Kubota, Yukihiro Umemoto, Noriyasu Kawai, Keiichi Tozawa, Kenjiro Kohri. Novel effect of the inhibitor of mitochondrial cyclophilin D activation, N-methyl-4-isoleucine cyclosporin, on renal calcium crystallization. International journal of urology : official journal of the Japanese Urological Association. 2014 Jul; 21(7):707-13. doi: 10.1111/iju.12425. [PMID: 24661223]
  • David Garbaisz, Zsolt Turoczi, Peter Aranyi, Andras Fulop, Oliver Rosero, Edit Hermesz, Agnes Ferencz, Gabor Lotz, Laszlo Harsanyi, Attila Szijarto. Attenuation of skeletal muscle and renal injury to the lower limb following ischemia-reperfusion using mPTP inhibitor NIM-811. PloS one. 2014; 9(6):e101067. doi: 10.1371/journal.pone.0101067. [PMID: 24968303]
  • Ching-Hsueh Cheng, Han-Chen Lin, I-Rue Lai, Hong-Shiee Lai. Ischemic postconditioning attenuate reperfusion injury of small intestine: impact of mitochondrial permeability transition. Transplantation. 2013 Feb; 95(4):559-65. doi: 10.1097/tp.0b013e31827e6b02. [PMID: 23423267]
  • Han-Chen Lin, Tsai-Kun Lee, Chia-Chin Tsai, I-Rue Lai, Kuo-Shyan Lu. Ischemic postconditioning protects liver from ischemia-reperfusion injury by modulating mitochondrial permeability transition. Transplantation. 2012 Feb; 93(3):265-71. doi: 10.1097/tp.0b013e31823ef335. [PMID: 22198494]
  • Leah J Anderson, Kai Lin, Teresa Compton, Brigitte Wiedmann. Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion. Virology journal. 2011 Jun; 8(?):329. doi: 10.1186/1743-422x-8-329. [PMID: 21711559]
  • Hui Wang, Yuguo Zhang, Tailing Wang, Hong You, Jidong Jia. N-methyl-4-isoleucine cyclosporine attenuates CCl -induced liver fibrosis in rats by interacting with cyclophilin B and D. Journal of gastroenterology and hepatology. 2011 Mar; 26(3):558-67. doi: 10.1111/j.1440-1746.2010.06406.x. [PMID: 21332552]
  • Hasibur Rehman, Junjiang Sun, Yanjun Shi, Venkat K Ramshesh, Qinlong Liu, Robert T Currin, John J Lemasters, Zhi Zhong. NIM811 prevents mitochondrial dysfunction, attenuates liver injury, and stimulates liver regeneration after massive hepatectomy. Transplantation. 2011 Feb; 91(4):406-12. doi: 10.1097/tp.0b013e318204bdb2. [PMID: 21131897]
  • Martin Cour, Joseph Loufouat, Mélanie Paillard, Lionel Augeul, Joëlle Goudable, Michel Ovize, Laurent Argaud. Inhibition of mitochondrial permeability transition to prevent the post-cardiac arrest syndrome: a pre-clinical study. European heart journal. 2011 Jan; 32(2):226-35. doi: 10.1093/eurheartj/ehq112. [PMID: 20430770]
  • Tom P Theruvath, Zhi Zhong, Peter Pediaditakis, Venkat K Ramshesh, Robert T Currin, Andrey Tikunov, Ekhson Holmuhamedov, John J Lemasters. Minocycline and N-methyl-4-isoleucine cyclosporin (NIM811) mitigate storage/reperfusion injury after rat liver transplantation through suppression of the mitochondrial permeability transition. Hepatology (Baltimore, Md.). 2008 Jan; 47(1):236-46. doi: 10.1002/hep.21912. [PMID: 18023036]
  • L H Mbye, I N Singh, P G Sullivan, J E Springer, E D Hall. Attenuation of acute mitochondrial dysfunction after traumatic brain injury in mice by NIM811, a non-immunosuppressive cyclosporin A analog. Experimental neurology. 2008 Jan; 209(1):243-53. doi: 10.1016/j.expneurol.2007.09.025. [PMID: 18022160]