Butadiene monoxide (BioDeep_00000752318)
代谢物信息卡片
Butadiene monoxide
化学式: C4H6O (70.0418626)
中文名称: 3,4-环氧-1-丁烯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C=CC1CO1
InChI: InChI=1S/C4H6O/c1-2-4-3-5-4/h2,4H,1,3H2
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Caitlin C Jokipii Krueger, S Lani Park, Guru Madugundu, Yesha Patel, Loic Le Marchand, Daniel O Stram, Natalia Tretyakova. Ethnic differences in excretion of butadiene-DNA adducts by current smokers.
Carcinogenesis.
2021 05; 42(5):694-704. doi:
10.1093/carcin/bgab020. [PMID: 33693566] - Srikanth Kotapati, Amanda Esades, Brock Matter, Chap Le, Natalia Tretyakova. High throughput HPLC-ESI(-)-MS/MS methodology for mercapturic acid metabolites of 1,3-butadiene: Biomarkers of exposure and bioactivation.
Chemico-biological interactions.
2015 Nov; 241(?):23-31. doi:
10.1016/j.cbi.2015.02.009. [PMID: 25727266] - Raffaela Fuccelli, Maria Vittoria Sepporta, Patrizia Rosignoli, Guido Morozzi, Maurizio Servili, Roberto Fabiani. Preventive activity of olive oil phenolic compounds on alkene epoxides induced oxidative DNA damage on human peripheral blood mononuclear cells.
Nutrition and cancer.
2014; 66(8):1322-30. doi:
10.1080/01635581.2014.956251. [PMID: 25299479] - Srikanth Kotapati, Brock A Matter, Amy L Grant, Natalia Y Tretyakova. Quantitative analysis of trihydroxybutyl mercapturic acid, a urinary metabolite of 1,3-butadiene, in humans.
Chemical research in toxicology.
2011 Sep; 24(9):1516-26. doi:
10.1021/tx2001306. [PMID: 21749114] - Vernon E Walker, Dale M Walker, Quanxin Meng, Jacob D McDonald, Bobby R Scott, Steven K Seilkop, David J Claffey, Patricia B Upton, Mark W Powley, James A Swenberg, Rogene F Henderson. Genotoxicity of 1,3-butadiene and its epoxy intermediates.
Research report (Health Effects Institute).
2009 Aug; ?(144):3-79. doi:
. [PMID: 20017413] - Ewan D Booth, Joanne D Kilgour, William P Watson. Dose responses for the formation of hemoglobin adducts and urinary metabolites in rats and mice exposed by inhalation to low concentrations of 1,3-[2,3-(14)C]-butadiene.
Chemico-biological interactions.
2004 Mar; 147(2):213-32. doi:
10.1016/j.cbi.2004.01.002. [PMID: 15013822] - Tiina Anttinen-Klemetti, Raija Vaaranrinta, Kimmo Peltonen. Dose-dependent excretion of unconjugated 3-butene-1,2-diol measured in urine with a gc/ms after 1,3-butadiene exposure.
Toxicology mechanisms and methods.
2002; 12(3):211-20. doi:
10.1080/15376520208951157. [PMID: 20021174] - A A Elfarra, R J Krause, R A Kemper. Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism.
Chemico-biological interactions.
2001 Jun; 135-136(?):239-48. doi:
10.1016/s0009-2797(01)00193-4. [PMID: 11397394] - P Begemann, R J Srám, H G Neumann. Hemoglobin adducts of epoxybutene in workers occupationally exposed to 1,3-butadiene.
Archives of toxicology.
2001 Jan; 74(11):680-7. doi:
10.1007/s002040000183. [PMID: 11218044] - K A Richardson, M M Peters, R H Megens, P A van Elburg, B T Golding, P J Boogaard, W P Watson, N J van Sittert. Identification of novel metabolites of butadiene monoepoxide in rats and mice.
Chemical research in toxicology.
1998 Dec; 11(12):1543-55. doi:
10.1021/tx970175v. [PMID: 9860500] - F Pacchierotti, I D Adler, D Anderson, M Brinkworth, N A Demopoulos, J Lähdetie, S Osterman-Golkar, K Peltonen, A Russo, A Tates, R Waters. Genetic effects of 1,3-butadiene and associated risk for heritable damage.
Mutation research.
1998 Jan; 397(1):93-115. doi:
10.1016/s0027-5107(97)00199-1. [PMID: 9463556] - R J Krause, J E Sharer, A A Elfarra. Epoxide hydrolase-dependent metabolism of butadiene monoxide to 3-butene-1,2-diol in mouse, rat, and human liver.
Drug metabolism and disposition: the biological fate of chemicals.
1997 Aug; 25(8):1013-5. doi:
NULL. [PMID: 9280411] - Tretyakova NYu, Y P Lin, P B Upton, R Sangaiah, J A Swenberg. Macromolecular adducts of butadiene.
Toxicology.
1996 Oct; 113(1-3):70-6. doi:
10.1016/0300-483x(96)03429-4. [PMID: 8901884] - A A Elfarra, J E Sharer, R J Duescher. Synthesis and characterization of N-acetyl-L-cysteine S-conjugates of butadiene monoxide and their detection and quantitation in urine of rats and mice given butadiene monoxide.
Chemical research in toxicology.
1995 Jan; 8(1):68-76. doi:
10.1021/tx00043a009. [PMID: 7703369] - R F Henderson, W E Bechtold, P J Sabourin, K R Maples, A R Dahl. Species differences in the metabolism of 1,3-butadiene in vivo.
IARC scientific publications.
1993; ?(127):57-64. doi:
NULL. [PMID: 8070887] - J E Sharer, R J Duescher, A A Elfarra. Species and tissue differences in the microsomal oxidation of 1,3-butadiene and the glutathione conjugation of butadiene monoxide in mice and rats. Possible role in 1,3-butadiene-induced toxicity.
Drug metabolism and disposition: the biological fate of chemicals.
1992 Sep; 20(5):658-64. doi:
. [PMID: 1358569] - S Osterman-Golkar, A Kautiainen, E Bergmark, K Håkansson, J Mäki-Paakkanen. Hemoglobin adducts and urinary mercapturic acids in rats as biological indicators of butadiene exposure.
Chemico-biological interactions.
1991; 80(3):291-302. doi:
10.1016/0009-2797(91)90089-p. [PMID: 1954657]