Rostafuroxin (BioDeep_00000751701)
Volatile Flavor Compounds
代谢物信息卡片
Rostafuroxin
化学式: C23H34O4 (374.24569640000004)
中文名称: 罗他福辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(CC1CCC3C2CCC4(C3(CCC4(C5=COC=C5)O)O)C)O
InChI: InChI=1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Luca Villa, Roberta Buono, Mara Ferrandi, Isabella Molinari, Fabio Benigni, Arianna Bettiga, Giorgia Colciago, Masami Ikehata, Elisabetta Messaggio, Maria Pia Rastaldi, Francesco Montorsi, Andrea Salonia, Paolo Manunta. Ouabain Contributes to Kidney Damage in a Rat Model of Renal Ischemia-Reperfusion Injury.
International journal of molecular sciences.
2016 Oct; 17(10):. doi:
10.3390/ijms17101728. [PMID: 27754425] - Mara Ferrandi, Isabella Molinari, Maria Pia Rastaldi, Patrizia Ferrari, Giuseppe Bianchi, Paolo Manunta. Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.
The Journal of pharmacology and experimental therapeutics.
2014 Nov; 351(2):278-87. doi:
10.1124/jpet.114.217133. [PMID: 25187430] - Jan A Staessen, Lutgarde Thijs, Katarzyna Stolarz-Skrzypek, Antonella Bacchieri, John Barton, Ezio Degli Espositi, Peter W de Leeuw, Mirosław Dłużniewski, Nicola Glorioso, Andrzej Januszewicz, Paolo Manunta, Viktor Milyagin, Yuri Nikitin, Miroslav Souček, Chiara Lanzani, Lorena Citterio, Mario Timio, Andrzej Tykarski, Patrizia Ferrari, Giovanni Valentini, Kalina Kawecka-Jaszcz, Giuseppe Bianchi. Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.
Trials.
2011 Jan; 12(?):13. doi:
10.1186/1745-6215-12-13. [PMID: 21235787] - Patrizia Ferrari. Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
Biochimica et biophysica acta.
2010 Dec; 1802(12):1254-8. doi:
10.1016/j.bbadis.2010.01.009. [PMID: 20083196] - Mara Ferrandi, Isabella Molinari, Lucia Torielli, Gloria Padoani, Sergio Salardi, Maria Pia Rastaldi, Patrizia Ferrari, Giuseppe Bianchi. Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies.
Science translational medicine.
2010 Nov; 2(59):59ra86. doi:
10.1126/scitranslmed.3001815. [PMID: 21106940] - Chiara Lanzani, Lorena Citterio, Nicola Glorioso, Paolo Manunta, Grazia Tripodi, Erika Salvi, Simona Delli Carpini, Mara Ferrandi, Elisabetta Messaggio, Jan A Staessen, Daniele Cusi, Fabio Macciardi, Giuseppe Argiolas, Giovanni Valentini, Patrizia Ferrari, Giuseppe Bianchi. Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.
Science translational medicine.
2010 Nov; 2(59):59ra87. doi:
10.1126/scitranslmed.3001814. [PMID: 21106941] - Patrizia Ferrari, Mara Ferrandi, Giovanni Valentini, Paolo Manunta, Giuseppe Bianchi. Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.
Medical hypotheses.
2007; 68(6):1307-14. doi:
10.1016/j.mehy.2006.07.058. [PMID: 17097240] - T Iwamoto, S Kita. Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.
Kidney international.
2006 Jun; 69(12):2148-54. doi:
10.1038/sj.ki.5000421. [PMID: 16641927] - Patrizia Ferrari, Mara Ferrandi, Giovanni Valentini, Giuseppe Bianchi. Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology.
2006 Mar; 290(3):R529-35. doi:
10.1152/ajpregu.00518.2005. [PMID: 16467500] - Paolo Manunta, Mara Ferrandi, Elisabetta Messaggio, Patrizia Ferrari. A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin.
Cardiovascular & hematological agents in medicinal chemistry.
2006 Jan; 4(1):61-6. doi:
10.2174/187152506775268811. [PMID: 16529550] - Jan A Staessen, Giuseppe Bianchi. Adducin and hypertension.
Pharmacogenomics.
2005 Oct; 6(7):665-9. doi:
10.2217/14622416.6.7.665. [PMID: 16207143] - Jan A Staessen, Tatiana Kuznetsova, Rok Acceto, Antonella Bacchieri, Eva Brand, Michel Burnier, Hilde Celis, Lorena Citterio, Peter W de Leeuw, Jan Filipovský, Albert Fournier, Kalina Kawecka-Jaszcz, Paolo Manunta, Yuri Nikitin, Eoin T O'Brien, Josep Redón, Lutgarde Thijs, Patrizia Ferrari, Giovanni Valentini, Giuseppe Bianchi. OASIS-HT: design of a pharmacogenomic dose-finding study.
Pharmacogenomics.
2005 Oct; 6(7):755-75. doi:
10.2217/14622416.6.7.755. [PMID: 16207152] - Mara Ferrandi, Isabella Molinari, Paolo Barassi, Elena Minotti, Giuseppe Bianchi, Patrizia Ferrari. Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238.
The Journal of biological chemistry.
2004 Aug; 279(32):33306-14. doi:
10.1074/jbc.m402187200. [PMID: 15161929] - P Ferrari, M Ferrandi, L Torielli, P Barassi, G Tripodi, E Minotti, I Molinari, P Melloni, G Bianchi. Antihypertensive compounds that modulate the Na-K pump.
Annals of the New York Academy of Sciences.
2003 Apr; 986(?):694-701. doi:
10.1111/j.1749-6632.2003.tb07284.x. [PMID: 12763920] - Mara Ferrandi, Paolo Barassi, Elena Minotti, Liliana Duzzi, Isabella Molinari, Giuseppe Bianchi, Patrizia Ferrari. PST 2238: a new antihypertensive compound that modulates renal Na-K pump function without diuretic activity in Milan hypertensive rats.
Journal of cardiovascular pharmacology.
2002 Dec; 40(6):881-9. doi:
10.1097/00005344-200212000-00009. [PMID: 12451321] - P Ferrari, M Ferrandi, G Tripodi, L Torielli, G Padoani, E Minotti, P Melloni, G Bianchi. PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.
The Journal of pharmacology and experimental therapeutics.
1999 Mar; 288(3):1074-83. doi:
NULL. [PMID: 10027844] - A Goto, K Yamada, H Nagoshi, Y Dan, M Omata. Role of ouabain-like compound in the regulation of transmembrane sodium and potassium gradients in rats.
Hypertension (Dallas, Tex. : 1979).
1997 Sep; 30(3 Pt 2):753-8. doi:
10.1161/01.hyp.30.3.753. [PMID: 9323018]