OPIPRAMOL DIHYDROCHLORIDE (BioDeep_00000749563)
代谢物信息卡片
化学式: C23H31Cl2N3O (435.1844)
中文名称: 恶丙嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CCO.Cl.Cl
InChI: 2*1H
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Maria Carmen Iglesias-Osma, Maria José García-Barrado, David Hernandez-Gonzalez, Kévin Perrier, Pénélope Viana, Christian Carpéné. The anxiolytic drug opipramol inhibits insulin-induced lipogenesis in fat cells and insulin secretion in pancreatic islets.
Journal of physiology and biochemistry.
2023 Feb; ?(?):. doi:
10.1007/s13105-023-00950-8
. [PMID: 36821072] - D G Pochernikov, A I Strelnikov, D S Bazunov, K A Efimychev, U S Serdyutskaya. [The incidence and antibiotic resistance of common nosocomial uropathogens in the urine of urological patients in the Ivanovo region].
Urologiia (Moscow, Russia : 1999).
2018 Jul; ?(3):49-53. doi:
. [PMID: 30035418]
- Szymon Dziomba, Michał Biernacki, Ilona Olędzka, Elżbieta Skrzydlewska, Tomasz Bączek, Piotr Kowalski. Repetitive injection field-amplified sample stacking for cationic compounds determination.
Talanta.
2014 Jul; 125(?):1-6. doi:
10.1016/j.talanta.2014.02.045
. [PMID: 24840407] - J Trocewicz. Urine sample preparation of tricyclic antidepressants by means of a supported liquid membrane technique for high-performance liquid chromatographic analysis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Mar; 801(2):213-20. doi:
10.1016/j.jchromb.2003.11.013
. [PMID: 14751789] - Frieder Kees, Andreas Jehkul, Michael Bucher, Georg Mair, Josef Kiermaier, Horst Grobecker. Bioavailability of opipramol from a film-coated tablet, a sugar-coated tablet and an aqueous solution in healthy volunteers.
Arzneimittel-Forschung.
2003; 53(2):87-92. doi:
10.1055/s-0031-1297077
. [PMID: 12642963] - R J Boerner, H Sommer, W Berger, U Kuhn, U Schmidt, M Mannel. Kava-Kava extract LI 150 is as effective as Opipramol and Buspirone in Generalised Anxiety Disorder--an 8-week randomized, double-blind multi-centre clinical trial in 129 out-patients.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2003; 10 Suppl 4(?):38-49. doi:
10.1078/1433-187x-00309
. [PMID: 12807341] - F Kees, M Bucher, G Mair, H Grobecker. Determination of opipramol in human plasma by high-performance liquid chromatography with photometric detection using a cyanopropyl column.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 753(2):337-42. doi:
10.1016/s0378-4347(00)00584-3
. [PMID: 11334349] - M Lappenberg-Pelzer. Identification and determination of opipramol metabolites in plasma and urine.
Journal of analytical toxicology.
1998 May; 22(3):215-9. doi:
10.1093/jat/22.3.215
. [PMID: 9602938] - G Misztal, H Hopkała, T Sławik. Chromatographic analysis (TLC) of fluoxetine, doxepine, imipramine and opipramol in human plasma.
Acta poloniae pharmaceutica.
1997 Jul; 54(4):257-9. doi:
NULL
. [PMID: 9511452] - E Taaning, S A Killmann. A case of 'auto-immune thrombocytopenic purpura' serologically similar to post-transfusion purpura.
Vox sanguinis.
1992; 62(2):108-12. doi:
10.1111/j.1423-0410.1992.tb01180.x
. [PMID: 1519365] - T S Rao, J A Cler, S J Mick, V M Dilworth, P C Contreras, S Iyengar, P L Wood. Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo.
Neuropharmacology.
1990 Dec; 29(12):1191-7. doi:
10.1016/0028-3908(90)90044-r
. [PMID: 1963476] - T Bobkiewicz, A Chodera, I Okulicz-Kozaryn, E Nowakowska. Influence of tricyclic antidepressant drugs on experimental arterial hypertension.
Archivum immunologiae et therapiae experimentalis.
1975; 23(4):543-7. doi:
NULL
. [PMID: 1164154] - J J Foldes. [Opipramel in the treatment of extragenital complaints of the climacteric].
Harefuah.
1972 Feb; 82(4):165-6. doi:
NULL
. [PMID: 4559642] - R Bourdon, A M Nicaise. [On the demonstration and determination of several 5-H-dibenz (b,f) azepines in biological fluids].
Annales de biologie clinique.
1969 Jan; 27(1):93-103. doi:
NULL
. [PMID: 5787203] - J Angst, H Brandenberger, B Herrmann. [Suicide with opipramol (Insidon)].
Psychopharmacologia.
1967; 11(2):174-8. doi:
10.1007/bf00401254
. [PMID: 5588187] - R Leanderson, L Levi. A new approach to the experimental study of stuttering and stress.
Acta oto-laryngologica.
1966 Jun; ?(?):Suppl 224:311+. doi:
10.3109/00016486709123598
. [PMID: 4868232] - J Drabner, H Bauer, W Schwerd. [The detection of opipramol (insidon) and nortriptyline (nortrilen) in urine].
Archiv fur Toxikologie.
1966; 21(6):367-72. doi:
NULL
. [PMID: 5989895] - R Hernández-Peón, R Naranjo. Depressant action of insidon on limbic mechanisms regulating autonomic and endocrine functions.
Medicina et pharmacologia experimentalis. International journal of experimental medicine.
1966; 14(1):45-53. doi:
10.1159/000135765
. [PMID: 5952127] - R Kuhn. [Studies on possible relations of metabolite excretion to the disease course in depressive states under imipramine medication].
Psychopharmacologia.
1965 Sep; 8(3):201-22. doi:
10.1007/bf00405018
. [PMID: 5887304] - B HERRMANN. [STUDIES ON THE METABOLISM OF 4-(3-(5H-DIBENZO(B,F)AZEPIN-5-YL)-PROPYL)-1-(2-HYDROXYETHYL)-PIPERAZINE DI-HC1].
Arzneimittel-Forschung.
1964 Mar; 14(?):219-21. doi:
NULL
. [PMID: 14235993] - T INADA, E KATAMURA, Y TAKAHASHI. [INSIDON IN UROLOGICAL PSYCHOSOMATIC DISTURBANCES].
Hinyokika kiyo. Acta urologica Japonica.
1964 Feb; 10(?):110-5. doi:
NULL
. [PMID: 14126654]