Premarin (BioDeep_00000749381)
代谢物信息卡片
Premarin
化学式: C18H19NaO5S (370.0850844)
中文名称: 共轭雌激素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(=CCC4=C3C=CC(=C4)OS(=O)(=O)[O-])C1CCC2=O.[Na+]
InChI: /q
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ye Feng, Yang Xie, Meishu Xu, Linhao Li, Kyle W Selcer, Patrick J Oberly, Samuel M Poloyac, Hongbing Wang, Chengjiang Li, Fengqin Dong, Chaohui Yu, Wen Xie. Hepatic steroid sulfatase critically determines estrogenic activities of conjugated equine estrogens in human cells in vitro and in mice.
The Journal of biological chemistry.
2019 08; 294(32):12112-12121. doi:
10.1074/jbc.ra119.009181. [PMID: 31217279] - Wen-juan Li, Liang-zhi Xu, Hong-wei Liu, Jing Zhang, Liu-lin Tang, Ling-ling Zhou, Jing Zhuang, Ying Liu, Xiao-fang Liu. [Effects of Kuntai Capsule and hormone replacement therapy on cognitive function and mental symptoms of early postmenopausal women: a randomized controlled trial].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2010 Apr; 8(4):321-7. doi:
10.3736/jcim20100404. [PMID: 20388471] - George E Christodoulakos, Irene V Lambrinoudaki, Emmanuel V Economou, Constantinos Papadias, Nikolaos Vitoratos, Constantinos P Panoulis, Evangelia E Kouskouni, Sofia A Vlachou, George C Creatsas. Circulating chemoattractants RANTES, negatively related to endogenous androgens, and MCP-1 are differentially suppressed by hormone therapy and raloxifene.
Atherosclerosis.
2007 Jul; 193(1):142-50. doi:
10.1016/j.atherosclerosis.2006.05.045. [PMID: 16842799] - Hiroya Okano, Muthuvel Jayachandran, Akiko Yoshikawa, Virginia M Miller. Differential effects of chronic treatment with estrogen receptor ligands on regulation of nitric oxide synthase in porcine aortic endothelial cells.
Journal of cardiovascular pharmacology.
2006 Apr; 47(4):621-8. doi:
10.1097/01.fjc.0000211749.24196.98. [PMID: 16680078] - Mert Gol, Pinar Akan, Erbil Dogan, Cigdem Karas, Ugur Saygili, Cemal Posaci. Effects of estrogen, raloxifene, and hormone replacement therapy on serum C-reactive protein and homocysteine levels.
Maturitas.
2006 Feb; 53(3):252-9. doi:
10.1016/j.maturitas.2005.05.006. [PMID: 15990257] - Urszula Stopińska-Głuszak, Jacek Waligóra, Tomasz Grzela, Michał Głuszak, Jarosław Jóźwiak, Dariusz Radomski, Piotr I Roszkowski, Jacek Malejczyk. Effect of estrogen/progesterone hormone replacement therapy on natural killer cell cytotoxicity and immunoregulatory cytokine release by peripheral blood mononuclear cells of postmenopausal women.
Journal of reproductive immunology.
2006 Feb; 69(1):65-75. doi:
10.1016/j.jri.2005.07.006. [PMID: 16236362] - Stefano Palomba, Francesco Orio, Tiziana Russo, Angela Falbo, Achille Tolino, Francesco Manguso, Vincenzo Nunziata, Pasquale Mastrantonio, Gaetano Lombardi, Fulvio Zullo. BsmI vitamin D receptor genotypes influence the efficacy of antiresorptive treatments in postmenopausal osteoporotic women. A 1-year multicenter, randomized and controlled trial.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2005 Aug; 16(8):943-52. doi:
10.1007/s00198-004-1800-5. [PMID: 15739035] - Sylvia Wassertheil-Smoller, Susan L Hendrix, Marian Limacher, Gerardo Heiss, Charles Kooperberg, Alison Baird, Theodore Kotchen, J David Curb, Henry Black, Jacques E Rossouw, Aaron Aragaki, Monika Safford, Evan Stein, Somchai Laowattana, W Jerry Mysiw. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial.
JAMA.
2003 May; 289(20):2673-84. doi:
10.1001/jama.289.20.2673. [PMID: 12771114] - J Koudy Williams, Jason Hall, Mary S Anthony, Thomas C Register, Steven E Reis, Thomas B Clarkson. A comparison of tibolone and hormone replacement therapy on coronary artery and myocardial function in ovariectomized atherosclerotic monkeys.
Menopause (New York, N.Y.).
2002 Jan; 9(1):41-51. doi:
10.1097/00042192-200201000-00007. [PMID: 11791085] - M Sanada, Y Higashi, K Nakagawa, S Sasaki, I Kodama, M Tsuda, N Nagai, K Ohama. Relationship between the angiotensin-converting enzyme genotype and the forearm vasodilator response to estrogen replacement therapy in postmenopausal women.
Journal of the American College of Cardiology.
2001 May; 37(6):1529-35. doi:
10.1016/s0735-1097(01)01191-3. [PMID: 11345361] - G Y Kam, K C Leung, R C Baxter, K K Ho. Estrogens exert route- and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex.
The Journal of clinical endocrinology and metabolism.
2000 May; 85(5):1918-22. doi:
10.1210/jcem.85.5.6527. [PMID: 10843175] - H K Genant, J Lucas, S Weiss, M Akin, R Emkey, H McNaney-Flint, R Downs, J Mortola, N Watts, H M Yang, N Banav, J J Brennan, J C Nolan. Low-dose esterified estrogen therapy: effects on bone, plasma estradiol concentrations, endometrium, and lipid levels. Estratab/Osteoporosis Study Group.
Archives of internal medicine.
1997 Dec; 157(22):2609-15. doi:
10.1001/archinte.157.22.2609. [PMID: 9531230] - N B Watts, M Notelovitz, M C Timmons, W A Addison, B Wiita, L J Downey. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause.
Obstetrics and gynecology.
1995 Apr; 85(4):529-37. doi:
10.1016/0029-7844(94)00448-m. [PMID: 7898828]