Tenidap (BioDeep_00000749355)
代谢物信息卡片
CP-66248
化学式: C14H9ClN2O3S (320.0022)
中文名称: 替尼达普
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CSC(=C1)C(=O)C2=C(N(C3=C2C=C(C=C3)Cl)C(=O)N)O
InChI: InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:35847
- KEGGdrug: D06072
- PubChem: 60712
- DrugBank: DB13481
- ChEMBL: CHEMBL1097558
- ChEMBL: CHEMBL1908355
- CAS: 120210-48-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Tajur Rahman, Ghias Uddin, Muhammad Iqbal Choudhary. Short Communication: Discovery and molecular docking simulation of 7-hydroxy-6-methoxy-2H-chromen-2-one as a LOX Inhibitor.
Pakistan journal of pharmaceutical sciences.
2019 Jan; 32(1):217-220. doi:
". [PMID: 30772812] - Emanuele Bernardinelli, Roberta Costa, Charity Nofziger, Markus Paulmichl, Silvia Dossena. Effect of Known Inhibitors of Ion Transport on Pendrin (SLC26A4) Activity in a Human Kidney Cell Line.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2016; 38(5):1984-98. doi:
10.1159/000445559. [PMID: 27161422] - Mark D Parker, Xue Qin, Rosalind C Williamson, Ashley M Toye, Walter F Boron. HCO(3)(-)-independent conductance with a mutant Na(+)/HCO(3)(-) cotransporter (SLC4A4) in a case of proximal renal tubular acidosis with hypokalaemic paralysis.
The Journal of physiology.
2012 Apr; 590(8):2009-34. doi:
10.1113/jphysiol.2011.224733. [PMID: 22331414] - T Hattori, K Nakano, T Kawakami, A Tamura, T Ara, P L Wang. Therapy for nifedipine-induced gingival overgrowth by Saireito in rats.
European journal of medical research.
2009 Nov; 14(11):497-501. doi:
10.1186/2047-783x-14-11-497. [PMID: 19948446] - Caroline R Sussman, Jinhua Zhao, Consuelo Plata, Jing Lu, Christopher Daly, Nathan Angle, Jennifer DiPiero, Iain A Drummond, Jennifer O Liang, Walter F Boron, Michael F Romero, Min-Hwang Chang. Cloning, localization, and functional expression of the electrogenic Na+ bicarbonate cotransporter (NBCe1) from zebrafish.
American journal of physiology. Cell physiology.
2009 Oct; 297(4):C865-75. doi:
10.1152/ajpcell.00679.2008. [PMID: 19625604] - Muhammad S Soyfoo, Nurdan Bulur, Myrna Virreira, Karim Louchami, Pascale Lybaert, Raphael Crutzen, Jason Perret, Christine Delporte, Eleni Roussa, Frank Thevenod, Len Best, Allen P Yates, Willy J Malaisse, Abdullah Sener, Renaud Beauwens. Expression of the electrogenic Na+-HCO3--cotransporters NBCe1-A and NBCe1-B in rat pancreatic islet cells.
Endocrine.
2009 Jun; 35(3):449-58. doi:
10.1007/s12020-009-9175-1. [PMID: 19381888] - Christelle Boileau, Johanne Martel-Pelletier, Judith Caron, Philippe Msika, Georges B Guillou, Caroline Baudouin, Jean-Pierre Pelletier. Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13.
Arthritis research & therapy.
2009; 11(2):R41. doi:
10.1186/ar2649. [PMID: 19291317] - Elena Adinolfi, Cinzia Pizzirani, Marco Idzko, Elisabeth Panther, Johannes Norgauer, Francesco Di Virgilio, Davide Ferrari. P2X(7) receptor: Death or life?.
Purinergic signalling.
2005 Sep; 1(3):219-27. doi:
10.1007/s11302-005-6322-x. [PMID: 18404507] - Georg Lamprecht, Susannah Baisch, Elena Schoenleber, Michael Gregor. Transport properties of the human intestinal anion exchanger DRA (down-regulated in adenoma) in transfected HEK293 cells.
Pflugers Archiv : European journal of physiology.
2005 Feb; 449(5):479-90. doi:
10.1007/s00424-004-1342-x. [PMID: 15480750] - O Ducoudret, A Diakov, S Müller-Berger, M F Romero, E Frömter. The renal Na-HCO3-cotransporter expressed in Xenopus laevis oocytes: inhibition by tenidap and benzamil and effect of temperature on transport rate and stoichiometry.
Pflugers Archiv : European journal of physiology.
2001 Aug; 442(5):709-17. doi:
10.1007/s004240100594. [PMID: 11512027] - S Müller-Berger, O Ducoudret, A Diakov, E Frömter. The renal Na-HCO3-cotransporter expressed in Xenopus laevis oocytes: change in stoichiometry in response to elevation of cytosolic Ca2+ concentration.
Pflugers Archiv : European journal of physiology.
2001 Aug; 442(5):718-28. doi:
10.1007/s004240100592. [PMID: 11512028] - C Ribbens, B Andre, J M Jaspar, O Kaye, M J Kaiser, D De Groote, M G Malaise. Matrix metalloproteinase-3 serum levels are correlated with disease activity and predict clinical response in rheumatoid arthritis.
The Journal of rheumatology.
2000 Apr; 27(4):888-93. doi:
NULL. [PMID: 10782811] - L Evans, L Aarons, P Coates. A pharmacokinetic model for tenidap in normal volunteers and rheumatoid arthritis patients.
Pharmaceutical research.
1999 Oct; 16(10):1608-15. doi:
10.1023/a:1018969024101. [PMID: 10554105] - J M Sanz, P Chiozzi, F Di Virgilio. Tenidap enhances P2Z/P2X7 receptor signalling in macrophages.
European journal of pharmacology.
1998 Aug; 355(2-3):235-44. doi:
10.1016/s0014-2999(98)00482-8. [PMID: 9760038] - N S Doherty, B H Littman, K Reilly, A C Swindell, J M Buss, N L Anderson. Analysis of changes in acute-phase plasma proteins in an acute inflammatory response and in rheumatoid arthritis using two-dimensional gel electrophoresis.
Electrophoresis.
1998 Feb; 19(2):355-63. doi:
10.1002/elps.1150190234. [PMID: 9548303] - M L Bliven, J D Eskra, I G Otterness. Limitation of activity in an acute model of arthritis: effect of drug treatment.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
1997 Dec; 46(12):491-5. doi:
10.1007/s000110050231. [PMID: 9459079] - B J Dezube, M M Lederman, B Chapman, D L Georges, A L Dogon, P Mudido, J Reis-Lishing, S L Cheng, S L Silberman, C S Crumpacker. The effect of tenidap on cytokines, acute-phase proteins, and virus load in human immunodeficiency virus (HIV)-infected patients: correlation between plasma HIV-1 RNA and proinflammatory cytokine levels.
The Journal of infectious diseases.
1997 Sep; 176(3):807-10. doi:
10.1086/517308. [PMID: 9291340] - H G Fouda, M J Avery, D Dalvie, F C Falkner, L S Melvin, R A Ronfeld. Disposition and metabolism of tenidap in the rat.
Drug metabolism and disposition: the biological fate of chemicals.
1997 Feb; 25(2):140-8. doi:
NULL. [PMID: 9029043] - M D Aleo, T Wang, G Giebisch, M J Sanders, A H Walsh, A Lopez-Anaya. Model development and analysis of tenidap-induced proteinuria in the rat.
The Journal of pharmacology and experimental therapeutics.
1996 Dec; 279(3):1318-26. doi:
NULL. [PMID: 8968356] - A Husebekk, T Stenstad. Experimental AA-amyloidosis in mice is inhibited by treatment with the anti-rheumatic drug tenidap.
Scandinavian journal of immunology.
1996 May; 43(5):551-5. doi:
10.1046/j.1365-3083.1996.d01-74.x. [PMID: 8633214] - H M Prupas, L D Loose, J S Spindler, A J Dietz, O B Gum, M H Weisman, G Gordon, R E Wolf, R A Turner, R L Collins, B F Germain, P Katz, S P Ballou, F Wolfe, J C Daniels, P A April, R F Willkens, K Pariser, B Hepburn, T M Zizic, N Ting, M Mehrban. Tenidap in patients with rheumatoid arthritis. A 4-week, placebo-controlled study.
Scandinavian journal of rheumatology.
1996; 25(6):345-51. doi:
10.3109/03009749609065645. [PMID: 8996468] - K D Rainsford, C Ying, F Smith. Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture: comparison with interleukin-1-synthesis inhibitors.
The Journal of pharmacy and pharmacology.
1996 Jan; 48(1):46-52. doi:
10.1111/j.2042-7158.1996.tb05875.x. [PMID: 8722494] - A Fujii, H Matsumoto, T Hashimoto, Y Akimoto. Tenidap, an anti-inflammatory agent, discharges intracellular Ca++ store and inhibits Ca++ influx in cultured human gingival fibroblasts.
The Journal of pharmacology and experimental therapeutics.
1995 Dec; 275(3):1447-52. doi:
NULL. [PMID: 8531115] - W D Blackburn, H M Prupas, J C Silverfield, J E Poiley, J R Caldwell, R L Collins, M J Miller, D H Sikes, H Kaplan, R Fleischmann. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone.
Arthritis and rheumatism.
1995 Oct; 38(10):1447-56. doi:
10.1002/art.1780381011. [PMID: 7575694] - M K Leung, R A Greenwald, N S Ramamurthy, S A Moak, R Koszulinski, D Dieudonne, L M Golub. Tenidap and flurbiprofen enhance uptake of matrix metalloproteinase inhibitor 4-dedimethylaminotetracycline in inflamed joints of adjuvant arthritic rats.
The Journal of rheumatology.
1995 Sep; 22(9):1726-31. doi:
NULL. [PMID: 8523353] - G Wylie, T Appelboom, W Bolten, F C Breedveld, J Feely, M R Leeming, X Le Loët, R Manthorpe, R Marcolongo, J Smolen. A comparative study of tenidap, a cytokine-modulating anti-rheumatic drug, and diclofenac in rheumatoid arthritis: a 24-week analysis of a 1-year clinical trial.
British journal of rheumatology.
1995 Jun; 34(6):554-63. doi:
10.1093/rheumatology/34.6.554. [PMID: 7543348] - B H Littman, D Bjarnason, G Bryant, J Engelbrecht, M Cohen, L Mertz, A Weaver, G G Hunder. Steroid sparing activity of tenidap in patients with polymyalgia rheumatica: a multicenter double blind randomized placebo controlled study.
The Journal of rheumatology.
1995 Jun; 22(6):1097-103. doi:
NULL. [PMID: 7674236] - I Matsushita, H Matsuno, K M Kadowaki, C Okada, H Tsuji. Immunomodulating effects of the new anti-rheumatic drug tenidap on collagen-induced arthritis.
International journal of immunopharmacology.
1995 Mar; 17(3):213-9. doi:
10.1016/0192-0561(95)00004-l. [PMID: 7558516] - P A McNiff, R E Laliberte, L Svensson, C J Pazoles, C A Gabel. Inhibition of cytokine activation processes in vitro by tenidap, a novel anti-inflammatory agent.
Cytokine.
1995 Feb; 7(2):196-208. doi:
10.1006/cyto.1995.1027. [PMID: 7780040] - K D Wilner, M J Gardner. Cimetidine does not alter the clearance or plasma binding of tenidap in healthy male volunteers.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):21S-24S. doi:
10.1111/j.1365-2125.1995.tb04497.x. [PMID: 7547088] - G Apseloff, K D Wilner, N Gerber. Effect of tenidap sodium on the pharmacodynamics and plasma protein binding of warfarin in healthy volunteers.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):29S-33S. doi:
10.1111/j.1365-2125.1995.tb04499.x. [PMID: 7547090] - P E Coates, R Mesure. An investigation into the effect of tenidap sodium on the pharmacokinetics of a combined oral contraceptive.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):47S-50S. doi:
10.1111/j.1365-2125.1995.tb04503.x. [PMID: 7547095] - J R Caldwell, D S Kirby, M J Gardner, R A Hansen. The effects of age and gender on the pharmacokinetics of tenidap sodium in patients with rheumatoid arthritis and osteoarthritis.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):3S-9S. doi:
10.1111/j.1365-2125.1995.tb04494.x. [PMID: 7547091] - P M Dewland, V C Grimwood, W G Rapeport, P E Coates. Effect of tenidap sodium on digoxin pharmacokinetics in healthy young men.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):43S-46S. doi:
10.1111/j.1365-2125.1995.tb04502.x. [PMID: 7547094] - G Apseloff, K D Wilner, D A von Deutsch, N Gerber. Tenidap sodium decreases renal clearance and increases steady-state concentrations of lithium in healthy volunteers.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):25S-28S. doi:
10.1111/j.1365-2125.1995.tb04498.x. [PMID: 7547089] - M J Gardner, K D Wilner, R A Hansen, H G Fouda, G F McMahon. Single and multiple dose pharmacokinetics of tenidap sodium in healthy subjects.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):11S-15S. doi:
10.1111/j.1365-2125.1995.tb04495.x. [PMID: 7547086] - P E Coates, R Mesure. Pharmacokinetics of tenidap sodium administered with food or antacid in healthy volunteers.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):17S-19S. doi:
10.1111/j.1365-2125.1995.tb04496.x. [PMID: 7547087] - B H Littman, C E Drury, R O Zimmerer, C B Stack, C G Law. Rheumatoid arthritis treated with tenidap and piroxicam. Clinical associations with cytokine modulation by tenidap.
Arthritis and rheumatism.
1995 Jan; 38(1):29-37. doi:
10.1002/art.1780380105. [PMID: 7818568] - R A Blum, J J Schentag, M J Gardner, K D Wilner. The effect of tenidap sodium on the disposition and plasma protein binding of phenytoin in healthy male volunteers.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):35S-38S. doi:
10.1111/j.1365-2125.1995.tb04500.x. [PMID: 7547092] - K D Wilner, M J Gardner. Tenidap sodium does not alter the clearance or plasma protein binding of tolbutamide in healthy male volunteers.
British journal of clinical pharmacology.
1995; 39 Suppl 1(?):39S-42S. doi:
10.1111/j.1365-2125.1995.tb04501.x. [PMID: 7547093] - F Breedveld. Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis.
Scandinavian journal of rheumatology. Supplement.
1994; 100(?):31-44. doi:
10.3109/03009749409095199. [PMID: 7532319] - U Kyan-Aung, T H Lee, D O Haskard. The inhibitory effect of tenidap on leukocyte-endothelial cell adhesion.
The Journal of rheumatology.
1993 Jun; 20(6):1014-9. doi:
NULL. [PMID: 8350307] - L D Loose, J D Sipe, D S Kirby, A R Kraska, E S Weiner, W R Shanahan, M R Leeming, P Farrow, C B Stack, N Ting. Reduction of acute-phase proteins with tenidap sodium, a cytokine-modulating anti-rheumatic drug.
British journal of rheumatology.
1993 Jun; 32 Suppl 3(?):19-25. doi:
10.1093/rheumatology/32.suppl_3.19. [PMID: 7685226] - P L Cleveland, P J Millard, H J Showell, C M Fewtrell. Tenidap: a novel inhibitor of calcium influx in a mast cell line.
Cell calcium.
1993 Jan; 14(1):1-16. doi:
10.1016/0143-4160(93)90013-v. [PMID: 8382561] - D L Olivera, J T Laydon, L Hillegass, A M Badger, J C Lee. Effects of pyridinyl imidazole compounds on murine TNF-alpha production.
Agents and actions.
1993; 39 Spec No(?):C55-7. doi:
10.1007/bf01972719. [PMID: 8273586] - M J Avery, D Y Mitchell, F C Falkner, H G Fouda. Simultaneous determination of tenidap and its stable isotope analog in serum by high-performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry.
Biological mass spectrometry.
1992 Jul; 21(7):353-7. doi:
10.1002/bms.1200210706. [PMID: 1420376] - V Garg, R Blum, K D Wilner, W J Jusko. Effect of the anti-inflammatory agent tenidap on the pharmacokinetics and pharmacodynamics of prednisolone.
Journal of clinical pharmacology.
1992 Mar; 32(3):222-30. doi:
10.1002/j.1552-4604.1992.tb03830.x. [PMID: 1564126] - J D Sipe, L M Bartle, L D Loose. Modification of proinflammatory cytokine production by the antirheumatic agents tenidap and naproxen. A possible correlate with clinical acute phase response.
Journal of immunology (Baltimore, Md. : 1950).
1992 Jan; 148(2):480-4. doi:
NULL. [PMID: 1729367] - K E Proudman, R M McMillan. Are tolfenamic acid and tenidap dual inhibitors of 5-lipoxygenase and cyclo-oxygenase?.
Agents and actions.
1991 Sep; 34(1-2):121-4. doi:
10.1007/bf01993255. [PMID: 1793015] - I G Otterness, P P Pazoles, P F Moore, M B Pepys. C-reactive protein as an index of disease activity. Comparison of tenidap, cyclophosphamide and dexamethasone in rat adjuvant arthritis.
The Journal of rheumatology.
1991 Apr; 18(4):505-11. doi:
NULL. [PMID: 2066940] - E Moilanen, J Alanko, M Z Asmawi, H Vapaatalo. CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro.
Eicosanoids.
1988; 1(1):35-9. doi:
NULL. [PMID: 2856170]
