2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-ol (BioDeep_00000749315)
代谢物信息卡片
化学式: C13H20ClNO (241.123334)
中文名称: 3-氯-alpha-[1-(叔丁基氨基)乙基]苯甲醇, 外消旋二氢安非他酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C1=CC(=CC=C1)Cl)O)NC(C)(C)C
InChI: InChI=1S/C13H20ClNO/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10/h5-9,12,15-16H,1-4H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jamie N Connarn, Ruijuan Luo, Jim Windak, Xinyuan Zhang, Andrew Babiskin, Marisa Kelly, Gloria Harrington, Vicki L Ellingrod, Masoud Kamali, Melvin McInnis, Duxin Sun. Identification of non-reported bupropion metabolites in human plasma.
Biopharmaceutics & drug disposition.
2016 Dec; 37(9):550-560. doi:
10.1002/bdd.2046. [PMID: 27723114] - Valentina M Fokina, Meixiang Xu, Erik Rytting, Sherif Z Abdel-Rahman, Holly West, Cheryl Oncken, Shannon M Clark, Mahmoud S Ahmed, Gary D V Hankins, Tatiana N Nanovskaya. Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy.
Drug metabolism and disposition: the biological fate of chemicals.
2016 11; 44(11):1832-1838. doi:
10.1124/dmd.116.071530. [PMID: 27528039] - Valentina M Fokina, Holly West, Cheryl Oncken, Shannon M Clark, Mahmoud S Ahmed, Gary D V Hankins, Tatiana N Nanovskaya. Bupropion therapy during pregnancy: the drug and its major metabolites in umbilical cord plasma and amniotic fluid.
American journal of obstetrics and gynecology.
2016 10; 215(4):497.e1-7. doi:
10.1016/j.ajog.2016.05.016. [PMID: 27180885] - Aaron M Teitelbaum, Alicia M Flaker, Evan D Kharasch. Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Aug; 1027(?):239-53. doi:
10.1016/j.jchromb.2016.05.036. [PMID: 27318149] - Andy Z X Zhu, Qian Zhou, Lisa Sanderson Cox, Jasjit S Ahluwalia, Neal L Benowitz, Rachel F Tyndale. Gene variants in CYP2C19 are associated with altered in vivo bupropion pharmacokinetics but not bupropion-assisted smoking cessation outcomes.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Nov; 42(11):1971-7. doi:
10.1124/dmd.114.060285. [PMID: 25187485] - Jiake He, Yang Yu, Bhagwat Prasad, Xijing Chen, Jashvant D Unadkat. Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction.
Biopharmaceutics & drug disposition.
2014 Jul; 35(5):253-63. doi:
10.1002/bdd.1890. [PMID: 24436229] - Xiaoming Wang, Daria I Vernikovskaya, Doaa R Abdelrahman, Gary D V Hankins, Mahmoud S Ahmed, Tatiana N Nanovskaya. Simultaneous quantitative determination of bupropion and its three major metabolites in human umbilical cord plasma and placental tissue using high-performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2012 Nov; 70(?):320-9. doi:
10.1016/j.jpba.2012.05.008. [PMID: 22682512] - Leah M Hesse, David J Greenblatt, Lisa L von Moltke, Michael H Court. Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers.
Journal of clinical pharmacology.
2006 May; 46(5):567-76. doi:
10.1177/0091270006286981. [PMID: 16638740] - Katarzyna K Loboz, Annette S Gross, John Ray, Andrew J McLachlan. HPLC assay for bupropion and its major metabolites in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Sep; 823(2):115-21. doi:
10.1016/j.jchromb.2005.06.009. [PMID: 16011913] - Simon P R Worrall, Michael K Almond, Soraya Dhillon. Pharmacokinetics of bupropion and its metabolites in haemodialysis patients who smoke. A single dose study.
Nephron. Clinical practice.
2004; 97(3):c83-9. doi:
10.1159/000078635. [PMID: 15292684]