SB505124 (BioDeep_00000749238)

   


代谢物信息卡片


2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine

化学式: C20H21N3O2 (335.1633686)
中文名称: SB-505124
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NC(=CC=C1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=C(C=C3)OCO4
InChI: InChI=1S/C20H21N3O2/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15/h5-10H,11H2,1-4H3,(H,22,23)

描述信息

同义名列表

2 个代谢物同义名

2-(4-(Benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine; SB505124



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Noushin Miralaei, Ahmad Majd, Kamran Ghaedi, Maryam Peymani, Masoomeh Safaei. Integrated pan-cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance. Cancer medicine. 2021 09; 10(18):6428-6441. doi: 10.1002/cam4.4161. [PMID: 34337875]
  • Yaling Liu, Tulika Sharma, I-Ping Chen, Ernst Reichenberger, Yasuyoshi Ueki, Yumna Arif, Daniel Parisi, Peter Maye. Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling. Bone. 2018 06; 111(?):28-35. doi: 10.1016/j.bone.2018.03.009. [PMID: 29530719]
  • Katja Rateitschak, Lars Kaderali, Olaf Wolkenhauer, Robert Jaster. Autocrine TGF-β/ZEB/microRNA-200 signal transduction drives epithelial-mesenchymal transition: Kinetic models predict minimal drug dose to inhibit metastasis. Cellular signalling. 2016 Aug; 28(8):861-70. doi: 10.1016/j.cellsig.2016.03.002. [PMID: 27000495]
  • Jiayu Jiang, Yuandong Zhang, Quan Zhang, Yanping Li, Tao Gong, Zhirong Zhang, Rui Ding, Xun Sun. Development and validation of an LC-MS/MS method for the determination of SB-505124 in rat plasma: Application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2016 Jan; 117(?):205-9. doi: 10.1016/j.jpba.2015.09.002. [PMID: 26363490]
  • Cheng Hua Jin, Maddeboina Krishnaiah, Domalapally Sreenu, Vura B Subrahmanyam, Kota S Rao, Hwa Jeong Lee, So-Jung Park, Hyun-Ju Park, Kiho Lee, Yhun Yhong Sheen, Dae-Kee Kim. Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. Journal of medicinal chemistry. 2014 May; 57(10):4213-38. doi: 10.1021/jm500115w. [PMID: 24786585]
  • Alexandra Mikhailova, Tanja Ilmarinen, Hannu Uusitalo, Heli Skottman. Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells. Stem cell reports. 2014 Feb; 2(2):219-31. doi: 10.1016/j.stemcr.2013.12.014. [PMID: 24527395]
  • Valorie L Chiasson, Kathleen A Jones, Shelley E Kopriva, Ashutosh Mahajan, Kristina J Young, Brett M Mitchell. Endothelial cell transforming growth factor-β receptor activation causes tacrolimus-induced renal arteriolar hyalinosis. Kidney international. 2012 Oct; 82(8):857-66. doi: 10.1038/ki.2012.104. [PMID: 22495293]