(+)-JQ-1 (BioDeep_00000749234)
代谢物信息卡片
化学式: C23H25ClN4O2S (456.1387)
中文名称: (+)-JQ1(DMSO溶液)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)OC(C)(C)C)C4=CC=C(C=C4)Cl)C
InChI: InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:137113
- ChEBI: CHEBI:95080
- PubChem: 46907787
- ChEMBL: CHEMBL1957266
- CAS: 1268524-70-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li. Combination Nano-Delivery Systems Remodel the Immunosuppressive Tumor Microenvironment for Metastatic Triple-Negative Breast Cancer Therapy.
Molecular pharmaceutics.
2024 May; 21(5):2148-2162. doi:
10.1021/acs.molpharmaceut.3c00242
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2022 Feb; 171(?):39-49. doi:
10.1016/j.ejpb.2021.10.017
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Journal of nanobiotechnology.
2021 Dec; 19(1):433. doi:
10.1186/s12951-021-01197-5
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Cancer medicine.
2021 09; 10(18):6428-6441. doi:
10.1002/cam4.4161
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Nature communications.
2021 07; 12(1):4628. doi:
10.1038/s41467-021-24822-1
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Biochemical and biophysical research communications.
2021 06; 558(?):216-223. doi:
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Carcinogenesis.
2021 02; 42(2):180-189. doi:
10.1093/carcin/bgaa131
. [PMID: 33284950] - Hiroshi Handa, Kazuki Honma, Tsukasa Oda, Nobuhiko Kobayashi, Yuko Kuroda, Kei Kimura-Masuda, Saki Watanabe, Rei Ishihara, Yuki Murakami, Yuta Masuda, Ken-Ichi Tahara, Hisashi Takei, Tetsuhiro Kasamatsu, Takayuki Saitoh, Hirokazu Murakami. Long Noncoding RNA PVT1 Is Regulated by Bromodomain Protein BRD4 in Multiple Myeloma and Is Associated with Disease Progression.
International journal of molecular sciences.
2020 Sep; 21(19):. doi:
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. [PMID: 32992461] - Kazuki Mochizuki, Masami Yamada, Takuya Inoue, Natsuyo Hariya, Takeo Kubota, Toshinao Goda. Bromodomain-containing protein 4 regulates a cascade of lipid-accumulation-related genes at the transcriptional level in the 3T3-L1 white adipocyte-like cell line.
European journal of pharmacology.
2020 Sep; 883(?):173351. doi:
10.1016/j.ejphar.2020.173351
. [PMID: 32650006] - Jessica Perrin, Thilo Werner, Nils Kurzawa, Anna Rutkowska, Dorothee D Childs, Mathias Kalxdorf, Daniel Poeckel, Eugenia Stonehouse, Katrin Strohmer, Bianca Heller, Douglas W Thomson, Jana Krause, Isabelle Becher, H Christian Eberl, Johanna Vappiani, Daniel C Sevin, Christina E Rau, Holger Franken, Wolfgang Huber, Maria Faelth-Savitski, Mikhail M Savitski, Marcus Bantscheff, Giovanna Bergamini. Identifying drug targets in tissues and whole blood with thermal-shift profiling.
Nature biotechnology.
2020 03; 38(3):303-308. doi:
10.1038/s41587-019-0388-4
. [PMID: 31959954] - Claudia Tonini, Mayra Colardo, Barbara Colella, Sabrina Di Bartolomeo, Francesco Berardinelli, Giuseppina Caretti, Valentina Pallottini, Marco Segatto. Inhibition of Bromodomain and Extraterminal Domain (BET) Proteins by JQ1 Unravels a Novel Epigenetic Modulation to Control Lipid Homeostasis.
International journal of molecular sciences.
2020 Feb; 21(4):. doi:
10.3390/ijms21041297
. [PMID: 32075110] - Fei Jiang, Qingyun Wei, Huili Li, Hongmei Li, Yong Cui, Yu Ma, Haifang Chen, Peng Cao, Tao Lu, Yadong Chen. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.
Bioorganic & medicinal chemistry.
2020 01; 28(1):115181. doi:
10.1016/j.bmc.2019.115181
. [PMID: 31767403] - Xuan Wang, Yueyuan Zhou, Yi Peng, Ting Huang, Fan Xia, Tianlun Yang, Qiong Duan, Weiru Zhang. Bromodomain-containing protein 4 contributes to renal fibrosis through the induction of epithelial-mesenchymal transition.
Experimental cell research.
2019 10; 383(2):111507. doi:
10.1016/j.yexcr.2019.111507
. [PMID: 31356816] - Yanle Zhi, Shu Wang, Wenhai Huang, Shenxin Zeng, Meihao Liang, Chixiao Zhang, Zhen Ma, Zunyuan Wang, Zhimin Zhang, Zhengrong Shen. Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.
European journal of medicinal chemistry.
2019 Oct; 179(?):502-514. doi:
10.1016/j.ejmech.2019.06.067
. [PMID: 31276895] - Kaisheng Liu, Zhifan Zhou, Hengyuan Gao, Fang Yang, Yajun Qian, Hongtao Jin, Yaomin Guo, Ying Liu, Haili Li, Cheng Zhang, Jinan Guo, Yong Wan, Rui Chen. JQ1, a BET-bromodomain inhibitor, inhibits human cancer growth and suppresses PD-L1 expression.
Cell biology international.
2019 Jun; 43(6):642-650. doi:
10.1002/cbin.11139
. [PMID: 30958600] - Liping Sun, Jing Liu, Yanggang Yuan, Xinzhou Zhang, Zheng Dong. Protective effect of the BET protein inhibitor JQ1 in cisplatin-induced nephrotoxicity.
American journal of physiology. Renal physiology.
2018 09; 315(3):F469-F478. doi:
10.1152/ajprenal.00527.2017
. [PMID: 29767555] - Dario R Lemos, Michael McMurdo, Gamze Karaca, Julia Wilflingseder, Irina A Leaf, Navin Gupta, Tomoya Miyoshi, Koichiro Susa, Bryce G Johnson, Kirolous Soliman, Guanghai Wang, Ryuji Morizane, Joseph V Bonventre, Jeremy S Duffield. Interleukin-1β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis.
Journal of the American Society of Nephrology : JASN.
2018 06; 29(6):1690-1705. doi:
10.1681/asn.2017121283
. [PMID: 29739813] - Erik Abner, Mateusz Stoszko, Lei Zeng, Heng-Chang Chen, Andrea Izquierdo-Bouldstridge, Tsuyoshi Konuma, Eduard Zorita, Elisa Fanunza, Qiang Zhang, Tokameh Mahmoudi, Ming-Ming Zhou, Guillaume J Filion, Albert Jordan. A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other "Shock" Drugs.
Journal of virology.
2018 05; 92(10):. doi:
10.1128/jvi.02056-17
. [PMID: 29343578] - Mélanie Mahe, Florent Dufour, Hélène Neyret-Kahn, Aura Moreno-Vega, Claire Beraud, Mingjun Shi, Imene Hamaidi, Virginia Sanchez-Quiles, Clementine Krucker, Marion Dorland-Galliot, Elodie Chapeaublanc, Remy Nicolle, Hervé Lang, Celio Pouponnot, Thierry Massfelder, François Radvanyi, Isabelle Bernard-Pierrot. An FGFR3/MYC positive feedback loop provides new opportunities for targeted therapies in bladder cancers.
EMBO molecular medicine.
2018 04; 10(4):. doi:
10.15252/emmm.201708163
. [PMID: 29463565] - Daniele C Cary, B Matija Peterlin. Procyanidin trimer C1 reactivates latent HIV as a triple combination therapy with kansui and JQ1.
PloS one.
2018; 13(11):e0208055. doi:
10.1371/journal.pone.0208055
. [PMID: 30475902] - Ershun Liang, Min Ma, Lei Wang, Xue Liu, Jinfeng Xu, Mingxiang Zhang, Ruixue Yang, Yuxia Zhao. The BET/BRD inhibitor JQ1 attenuates diabetes-induced cognitive impairment in rats by targeting Nox4-Nrf2 redox imbalance.
Biochemical and biophysical research communications.
2018 01; 495(1):204-211. doi:
10.1016/j.bbrc.2017.11.020
. [PMID: 29113796] - Baoshang Zhou, Jiao Mu, Yi Gong, Caibao Lu, Youguang Zhao, Ting He, Zhexue Qin. Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression.
Redox biology.
2017 04; 11(?):390-402. doi:
10.1016/j.redox.2016.12.031
. [PMID: 28063381] - Beatriz Suarez-Alvarez, José Luis Morgado-Pascual, Sandra Rayego-Mateos, Ramon M Rodriguez, Raul Rodrigues-Diez, Pablo Cannata-Ortiz, Ana B Sanz, Jesus Egido, Pierre-Louis Tharaux, Alberto Ortiz, Carlos Lopez-Larrea, Marta Ruiz-Ortega. Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage.
Journal of the American Society of Nephrology : JASN.
2017 02; 28(2):504-519. doi:
10.1681/asn.2015080910
. [PMID: 27436852] - Sharon Mumby, Natalia Gambaryan, Chao Meng, Frederic Perros, Marc Humbert, S John Wort, Ian M Adcock. Bromodomain and extra-terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension.
Respirology (Carlton, Vic.).
2017 01; 22(1):157-164. doi:
10.1111/resp.12872
. [PMID: 27539364] - Xinchao Wu, Dong Liu, Xuemei Gao, Fei Xie, Dan Tao, Xingyuan Xiao, Liang Wang, Guosong Jiang, Fuqing Zeng. Inhibition of BRD4 Suppresses Cell Proliferation and Induces Apoptosis in Renal Cell Carcinoma.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(5):1947-1956. doi:
10.1159/000472407
. [PMID: 28391274] - Olivier Goupille, Tipparat Penglong, Zahra Kadri, Marine Granger-Locatelli, Suthat Fucharoen, Leila Maouche-Chrétien, Stéphane Prost, Philippe Leboulch, Stany Chrétien. Inhibition of the acetyl lysine-binding pocket of bromodomain and extraterminal domain proteins interferes with adipogenesis.
Biochemical and biophysical research communications.
2016 Apr; 472(4):624-30. doi:
10.1016/j.bbrc.2016.03.013
. [PMID: 26972250] - Alexander M Taylor, Rishi G Vaswani, Victor S Gehling, Michael C Hewitt, Yves Leblanc, James E Audia, Steve Bellon, Richard T Cummings, Alexandre Côté, Jean-Christophe Harmange, Hari Jayaram, Shivangi Joshi, Jose M Lora, Jennifer A Mertz, Adrianne Neiss, Eneida Pardo, Christopher G Nasveschuk, Florence Poy, Peter Sandy, Jeremy W Setser, Robert J Sims, Yong Tang, Brian K Albrecht. Discovery of Benzotriazolo[4,3-d][1,4]diazepines as Orally Active Inhibitors of BET Bromodomains.
ACS medicinal chemistry letters.
2016 Feb; 7(2):145-50. doi:
10.1021/ml500411h
. [PMID: 26985289] - Youjun Xiao, Liuqin Liang, Mingcheng Huang, Qian Qiu, Shan Zeng, Maohua Shi, Yaoyao Zou, Yujin Ye, Xiuyan Yang, Hanshi Xu. Bromodomain and extra-terminal domain bromodomain inhibition prevents synovial inflammation via blocking IκB kinase-dependent NF-κB activation in rheumatoid fibroblast-like synoviocytes.
Rheumatology (Oxford, England).
2016 Jan; 55(1):173-84. doi:
10.1093/rheumatology/kev312
. [PMID: 26324948] - Shitong Wei, Yonghua Sun, Hongyu Sha. Therapeutic targeting of BET protein BRD4 delays murine lupus.
International immunopharmacology.
2015 Dec; 29(2):314-319. doi:
10.1016/j.intimp.2015.10.036
. [PMID: 26590112] - Xia Zhou, Lucy X Fan, Dorien J M Peters, Marie Trudel, James E Bradner, Xiaogang Li. Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD.
Human molecular genetics.
2015 Jul; 24(14):3982-93. doi:
10.1093/hmg/ddv136
. [PMID: 25877301] - Huabo Wang, Lokendra Sharma, Jie Lu, Paul Finch, Steven Fletcher, Edward V Prochownik. Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion.
Oncotarget.
2015 Jun; 6(18):15857-70. doi:
10.18632/oncotarget.4327
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The Journal of clinical investigation.
2015 May; 125(5):1901-12. doi:
10.1172/jci80142
. [PMID: 25822022] - Vishal Rajagopalan, Muthukumar Vaidyanathan, Vanisree Arambakkam Janardhanam, James E Bradner. Pre-clinical analysis of changes in intra-cellular biochemistry of glioblastoma multiforme (GBM) cells due to c-Myc silencing.
Cellular and molecular neurobiology.
2014 Oct; 34(7):1059-69. doi:
10.1007/s10571-014-0083-4
. [PMID: 25056450] - Herman J Kempen, Daniel Bellus, Oleg Fedorov, Silke Nicklisch, Panagis Filippakopoulos, Sarah Picaud, Stefan Knapp. Stimulation of Hepatic Apolipoprotein A-I Production by Novel Thieno-Triazolodiazepines: Roles of the Classical Benzodiazepine Receptor, PAF Receptor, and Bromodomain Binding.
Lipid insights.
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