3-Deazaadenosine (BioDeep_00000748348)
Volatile Flavor Compounds
代谢物信息卡片
3-Deazaadenosine
化学式: C11H14N4O4 (266.1015004)
中文名称: 3-Deaza-腺苷, 3-脱氮腺苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN=C(C2=C1N(C=N2)C3C(C(C(O3)CO)O)O)N
InChI: InChI=1S/C11H14N4O4/c12-10-7-5(1-2-13-10)15(4-14-7)11-9(18)8(17)6(3-16)19-11/h1-2,4,6,8-9,11,16-18H,3H2,(H2,12,13)/t6-,8-,9-,11-/m1/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lucyna Dymińska. Imidazopyridines as a source of biological activity and their pharmacological potentials-Infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials.
Bioorganic & medicinal chemistry.
2015 Sep; 23(18):6087-99. doi:
10.1016/j.bmc.2015.07.045. [PMID: 26314922] - Michael R Preusch, Florian Bea, Sara H Yang, Joerg Kreuzer, Berend Isermann, Ingo Pedal, Michael E Rosenfeld, Hugo A Katus, Erwin Blessing. Long-term administration of 3-deazaadenosine does not alter progression of advanced atherosclerotic lesions in apolipoprotein E-deficient mice.
Journal of cardiovascular pharmacology.
2007 Aug; 50(2):206-12. doi:
10.1097/fjc.0b013e318070c66a. [PMID: 17703138] - Monica Hansrani, Gerard Stansby. Extended storage of whole blood with 3-deazaadenosine for homocysteine assay.
Annals of clinical biochemistry.
2007 Jul; 44(Pt 4):388-90. doi:
10.1258/000456307780945732. [PMID: 17594787] - Alexander V Ovechkin, Neetu Tyagi, Utpal Sen, David Lominadze, Mesia M Steed, Karni S Moshal, Suresh C Tyagi. 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice.
American journal of physiology. Lung cellular and molecular physiology.
2006 Nov; 291(5):L905-11. doi:
10.1152/ajplung.00543.2005. [PMID: 16815886] - Ya-Fei Chen, Andrew Y Zhang, Ai-Ping Zou, William B Campbell, Pin-Lan Li. Protein methylation activates reconstituted ryanodine receptor-ca release channels from coronary artery myocytes.
Journal of vascular research.
2004 May; 41(3):229-40. doi:
10.1159/000078178. [PMID: 15118362] - Mauro Panteghini, Franca Pagani. On the comparison of serum and plasma samples in troponin assays.
Clinical chemistry.
2003 May; 49(5):835-6. doi:
10.1373/49.5.835/-a. [PMID: 12709385] - Ruediger C Braun-Dullaeus, Simon Dietrich, Michael J Schoaff, Daniel G Sedding, Boris Leithaeuser, Gerhard Walker, Ulrike Seay, Reinhard F Matthias, Wolfgang Kummer, Harald Tillmanns, Werner Haberbosch. Protective effect of 3-deazaadenosine in a rat model of lipopolysaccharide-induced myocardial dysfunction.
Shock (Augusta, Ga.).
2003 Mar; 19(3):245-51. doi:
10.1097/00024382-200303000-00008. [PMID: 12630524] - Diane M Hill, Lisa J Johnson, Paul J Burns, Angela M Neale, Denise M Harmening, Andrew C Kenney. Effects of temperature on stability of blood homocysteine in collection tubes containing 3-deazaadenosine.
Clinical chemistry.
2002 Nov; 48(11):2017-22. doi:
10.1093/clinchem/48.11.2017. [PMID: 12406988] - Ya-Fei Chen, Pin-Lan Li, Ai-Ping Zou. Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function.
Circulation.
2002 Sep; 106(10):1275-81. doi:
10.1161/01.cir.0000027586.64231.1b. [PMID: 12208805] - J D Stockand, S Zeltwanger, H F Bao, A Becchetti, R T Worrell, D C Eaton. S-adenosyl-L-homocysteine hydrolase is necessary for aldosterone-induced activity of epithelial Na(+) channels.
American journal of physiology. Cell physiology.
2001 Sep; 281(3):C773-85. doi:
10.1152/ajpcell.2001.281.3.c773. [PMID: 11502554] - M Nauck, E Bisse, M Nauck, H Wieland. Pre-analytical conditions affecting the determination of the plasma homocysteine concentration.
Clinical chemistry and laboratory medicine.
2001 Aug; 39(8):675-80. doi:
10.1515/cclm.2001.111. [PMID: 11592432] - K Ashizawa, M Miyamoto, Y Tsuzuki. The possible role of protein-carboxyl methylation in the regulation of flagellar movement of fowl spermatozoa.
Animal reproduction science.
2000 Feb; 58(1-2):137-46. doi:
10.1016/s0378-4320(99)00085-8. [PMID: 10700651] - S Dawling. Stabilizing blood with 3-deazaadenosine interferes in the Abbott FPIA assay for plasma homocyst(e)ine.
Annals of clinical biochemistry.
1999 Sep; 36 ( Pt 5)(?):669-70. doi:
10.1177/000456329903600518. [PMID: 10505221] - S M Siddiqi, K A Jacobson, J L Esker, M E Olah, X D Ji, N Melman, K N Tiwari, J A Secrist, S W Schneller, G Cristalli. Search for new purine- and ribose-modified adenosine analogues as selective agonists and antagonists at adenosine receptors.
Journal of medicinal chemistry.
1995 Mar; 38(7):1174-88. doi:
10.1021/jm00007a014. [PMID: 7707320] - Z Cui, M Houweling, D E Vance. Suppression of rat hepatoma cell growth by expression of phosphatidylethanolamine N-methyltransferase-2.
The Journal of biological chemistry.
1994 Oct; 269(40):24531-3. doi:
10.1016/s0021-9258(17)31421-7. [PMID: 7929120] - R W Kuncl, D B Drachman, R Adams, M Lehar. 3-Deazaadenosine: a therapeutic strategy for myasthenia gravis by decreasing the endocytosis of acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics.
1993 Nov; 267(2):582-9. doi:
NULL. [PMID: 8246131] - R W Samborski, N D Ridgway, D E Vance. Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase.
Journal of lipid research.
1993 Jan; 34(1):125-37. doi:
. [PMID: 8445336] - D M Smith, J A Johnson, R A Turner. Biochemical perturbations of BW 91Y (3-deazaadenosine) on human neutrophil chemotactic potential and lipid metabolism.
International journal of tissue reactions.
1991; 13(1):1-18. doi:
". [PMID: 1653773] - M K Hise, D A Steplock, E J Weinman. Lipid methylation, sodium transport and the response to PTH in renal tubules.
Life sciences.
1986 Sep; 39(9):831-5. doi:
10.1016/0024-3205(86)90462-5. [PMID: 3747733] - R C Benyon, M K Church, S T Holgate. IgE-dependent activation of mast cells is not associated with enhanced phospholipid methylation.
Biochemical pharmacology.
1986 Aug; 35(15):2535-44. doi:
10.1016/0006-2952(86)90051-1. [PMID: 2427083] - J E Vance, T M Nguyen, D E Vance. The biosynthesis of phosphatidylcholine by methylation of phosphatidylethanolamine derived from ethanolamine is not required for lipoprotein secretion by cultured rat hepatocytes.
Biochimica et biophysica acta.
1986 Feb; 875(3):501-9. doi:
10.1016/0005-2760(86)90070-6. [PMID: 3947655] - O Cantoni, P Sestili, W Balduini, G Cristalli, M Grifantini, F Cattabeni. Inhibition of nucleic acids and protein synthesis by deazaadenosine derivatives: a study on structure-activity relationships.
Pharmacological research communications.
1985 Dec; 17(12):1087-94. doi:
10.1016/0031-6989(85)90021-9. [PMID: 2419925] - V S Bansal, J N Kanfer. The phospholipid-N-methyltransferase of rat brain microsomes.
Biochimica et biophysica acta.
1985 Aug; 836(1):73-9. doi:
10.1016/0005-2760(85)90222-x. [PMID: 4027261] - M N Llanos, A M Ronco, A M Pino, L E Valladares. The transmethylations inhibitor 3-deazaadenosine, inhibits in vitro testosterone production by rat testis interstitial cells stimulated with HCG.
Journal of steroid biochemistry.
1985 Jul; 23(1):73-6. doi:
10.1016/0022-4731(85)90262-6. [PMID: 2991663] - D W Riches, J L Watkins, P M Henson, D R Stanworth. Regulation of macrophage lysosomal secretion by adenosine, adenosine phosphate esters, and related structural analogues of adenosine.
Journal of leukocyte biology.
1985 May; 37(5):545-57. doi:
10.1002/jlb.37.5.545. [PMID: 2984303] - S Sariban-Sohraby, M Burg, W P Wiesmann, P K Chiang, J P Johnson. Methylation increases sodium transport into A6 apical membrane vesicles: possible mode of aldosterone action.
Science (New York, N.Y.).
1984 Aug; 225(4663):745-6. doi:
10.1126/science.6463652. [PMID: 6463652] - L Best, P Lebrun, M Saceda, P Garcia-Morales, C Hubinont, M Juvent, A Herchuelz, F Malaisse-Lagae, I Valverde, W J Malaisse. Impairment of insulin release by methylation inhibitors.
Biochemical pharmacology.
1984 Jul; 33(13):2033-9. doi:
10.1016/0006-2952(84)90570-7. [PMID: 6378207] - R A Milvae, H W Alila, W Hansel. Methylation in bovine luteal cells as a regulator of luteinizing hormone action.
Biology of reproduction.
1983 Nov; 29(4):849-55. doi:
10.1095/biolreprod29.4.849. [PMID: 6315096] - M N Llanos, S Meizel. Phospholipid methylation increases during capacitation of golden hamster sperm in vitro.
Biology of reproduction.
1983 Jun; 28(5):1043-51. doi:
10.1095/biolreprod28.5.1043. [PMID: 6871307] - E de Clercq, J A Montgomery. Broad-spectrum antiviral activity of the carbocyclic analog of 3-deazaadenosine.
Antiviral research.
1983 Mar; 3(1):17-24. doi:
10.1016/0166-3542(83)90011-6. [PMID: 6307139] - J L Medzihradsky, T P Zimmerman, G Wolberg, G B Elion. Immunosuppressive effects of the S-adenosylhomocysteine hydrolase inhibitor, 3-deazaadenosine.
Journal of immunopharmacology.
1982; 4(1-2):29-41. doi:
10.3109/08923978209031073. [PMID: 7153525] - Y Morita, R P Siraganian. Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
Journal of immunology (Baltimore, Md. : 1950).
1981 Oct; 127(4):1339-44. doi:
". [PMID: 6168684] - S Meizel. Inhibition of the hamster sperm acrosome reaction by transmethylation inhibitors.
The Journal of experimental zoology.
1981 Sep; 217(3):443-6. doi:
10.1002/jez.1402170316. [PMID: 7200124] - G S Johnson, P K Chiang. 1-methylnicotinamide and NAD metabolism in normal and transformed normal rat kidney cells.
Archives of biochemistry and biophysics.
1981 Aug; 210(1):263-9. doi:
10.1016/0003-9861(81)90188-0. [PMID: 6457564] - A J Bodner, G L Cantoni, P K Chiang. Anti-viral activity of 3-deazaadenosine and 5'-deoxy-5'-isobutylthio-3-deazaadenosine (3-deaza-SIBA).
Biochemical and biophysical research communications.
1981 Jan; 98(2):476-81. doi:
10.1016/0006-291x(81)90864-0. [PMID: 6261741]