Sardomozide (BioDeep_00000747077)

   


代谢物信息卡片


(1E)-1-{[(Diaminomethylidene)amino]imino}-2,3-dihydro-1H-indene-4-carboximidamide

化学式: C11H14N6 (230.1279884)
中文名称: Sardomozide
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(=NN=C(N)N)C2=C1C(=CC=C2)C(=N)N
InChI: InChI=1S/C11H14N6/c12-10(13)8-3-1-2-7-6(8)4-5-9(7)16-17-11(14)15/h1-3H,4-5H2,(H3,12,13)(H4,14,15,17)/b16-9-

描述信息

D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors

同义名列表

2 个代谢物同义名

(1E)-1-{[(Diaminomethylidene)amino]imino}-2,3-dihydro-1H-indene-4-carboximidamide; Sardomozide



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Lia van Zuylen, John Bridgewater, Alex Sparreboom, Ferry A L M Eskens, Peter de Bruijn, Ivo Sklenar, Andre S T Planting, Les Choi, Douglas Bootle, Christian Mueller, Jonathan A Ledermann, Jaap Verweij. Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 Mar; 10(6):1949-55. doi: 10.1158/1078-0432.ccr-02-0995. [PMID: 15041711]
  • Lillian L Siu, Eric K Rowinsky, Lisa A Hammond, Geoffrey R Weiss, Manuel Hidalgo, Gary M Clark, Judy Moczygemba, Les Choi, Ron Linnartz, Nicholas C Barbet, Ivo T Sklenar, Renaud Capdeville, Gregory Gan, Carl W Porter, Daniel D Von Hoff, S Gail Eckhardt. A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies. Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 Jul; 8(7):2157-66. doi: NULL. [PMID: 12114416]
  • W Kern, E Schleyer, M Bergmann, H Gschaidmeier, G Ehninger, W Hiddemann, J Braess. Detection and separation of the S-adenosylmethionine-decarboxylase inhibitor SAM486A in human plasma and urine by reversed-phase ion-pairing high-performance liquid chromatography. Journal of pharmacological and toxicological methods. 2001 May; 45(3):175-80. doi: 10.1016/s1056-8719(01)00134-4. [PMID: 11755379]
  • H Zhou, L Choi, H Lau, U Bruntsch, E E Vries, G Eckhardt, A T Oosterom, J Verweij, H Schran, N Barbet, R Linnartz, R Capdeville. Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers. Journal of clinical pharmacology. 2000 Mar; 40(3):275-83. doi: 10.1177/00912700022008946. [PMID: 10709156]
  • F Svensson, H Mett, L Persson. CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme. The Biochemical journal. 1997 Feb; 322 ( Pt 1)(?):297-302. doi: 10.1042/bj3220297. [PMID: 9078276]
  • P H Degen, P Zbinden. Automated quantitative determination of a new polyamine biosynthesis inhibitor (CGP 48 664) and a potential metabolite in human and animal plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1996 Jun; 681(2):339-45. doi: 10.1016/0378-4347(96)00026-6. [PMID: 8811445]