Vinburnine (BioDeep_00000000747)

 

Secondary id: BioDeep_00000408950

PANOMIX_OTCML-2023 Chemicals and Drugs natural product


代谢物信息卡片


(41S,13aS)-13a-Ethyl-2,3,5,6,13,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(41H)-one

化学式: C19H22N2O (294.1732042)
中文名称: (-)-象牙(洪达木)酮宁, 长春布宁
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 92.42%

分子结构信息

SMILES: CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=O)C2
InChI: InChI=1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3

描述信息

Eburnamonine is an alkaloid.
Vinburnine is a natural product found in Kopsia pauciflora, Aspidosperma quebracho-blanco, and other organisms with data available.
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product > C932 - Vinca Alkaloid Compound
C - Cardiovascular system > C04 - Peripheral vasodilators > C04A - Peripheral vasodilators
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000970 - Antineoplastic Agents > D014748 - Vinca Alkaloids
C1907 - Drug, Natural Product
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.645
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.638
Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.
Vincamone is a vinca alkaloid and a metabolite of vincamine, is a vasodilator.

同义名列表

76 个代谢物同义名

(41S,13aS)-13a-Ethyl-2,3,5,6,13,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(41H)-one; (31S,6aS)-6a-ethyl-31,4,5,6,6a,7-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-8(2H)-one; (15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one; eburnamonine monohydrochloride, (3alpha,16alpha)-isomer; (3alpha,16alpha)-Eburnamenin-14(15H)-one, Vincamone]; eburnamonine phosphate, (3alpha,16alpha)-isomer; Eburnamin-14(15H)-one, (3-alpha,16-alpha)-; (3-alpha,16-alpha)-Eburnamin-14(15H)-one; (3alpha,16alpha)-Eburnamenin-14(15H)-one; eburnamonine, (3alpha,16alpha)-isomer; Eburnamenin-14(15H)-one, (3a,16a)-; 3.alpha.,16.alpha.-eburnamonine; Eburnamenin-14(15H)-one, (+/-)-; 3-alpha,16-alpha-Eburnamonine; Eburnamonine (+/-)-form [MI]; 3alpha,16alpha-Eburnamonine; EBURNAMONINE (-)-FORM [MI]; (-)-Eburnamonina [Spanish]; Vinburnina [INN-Spanish]; Vinburninum [INN-Latin]; Eburnamonine (-)-form; Vincamona [Spanish]; VINBURNINE [WHO-DD]; VINBURNINE [MART.]; Vinburnine, (+/-)-; (+/-)-Eburnamonine; Prestwick0_000607; Prestwick3_000607; Prestwick1_000607; Prestwick2_000607; Spectrum5_000938; NCIStruc2_000870; Spectrum2_001504; Eburnamonine (-); Vinburnine [INN]; NCIStruc1_000941; Spectrum3_001199; (-)-Eburnamonina; Spectrum4_000751; (-)-eburnamonine; Vinburnine (INN); (+/-)-Vincamone; UNII-G54D0HMY25; Eburnal ritardo; DL-Eburnamonine; UNII-64UB2942IE; Tox21_110060_1; l-Eburnamonine; Eburnalritardo; MEGxp0_001871; BPBio1_000566; Cervoxan (TN); DivK1c_000411; cis-Vincamone; (-)-Vincamone; Tox21_110060; eburnamonine; KBio2_005995; NCI60_002800; ACon1_000004; KBio2_000859; KBio1_000411; KBio2_003427; KBio3_002377; Vinburninum; Vincanorine; IDI1_000411; G54D0HMY25; Vinburnina; 64UB2942IE; Vinburnine; Vincamona; Vincamone; Cervoxan; Eburnal; Eburnamonine



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

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28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kam-Weng Chong, Joanne Soon-Yee Yeap, Siew-Huah Lim, Jean-Frédéric F Weber, Yun-Yee Low, Toh-Seok Kam. Biosynthetic Enantiodivergence in the Eburnane Alkaloids from Kopsia. Journal of natural products. 2017 11; 80(11):3014-3024. doi: 10.1021/acs.jnatprod.7b00621. [PMID: 29087707]
  • Franziska Kellner, Fernando Geu-Flores, Nathaniel H Sherden, Stephanie Brown, Emilien Foureau, Vincent Courdavault, Sarah E O'Connor. Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids. Chemical communications (Cambridge, England). 2015 May; 51(36):7626-8. doi: 10.1039/c5cc01309g. [PMID: 25850027]
  • Marta Martinez-Vicente, Zsolt Talloczy, Esther Wong, Guomei Tang, Hiroshi Koga, Susmita Kaushik, Rosa de Vries, Esperanza Arias, Spike Harris, David Sulzer, Ana Maria Cuervo. Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nature neuroscience. 2010 May; 13(5):567-76. doi: 10.1038/nn.2528. [PMID: 20383138]
  • Adám Vas, Balázs Gulyás. Eburnamine derivatives and the brain. Medicinal research reviews. 2005 Nov; 25(6):737-57. doi: 10.1002/med.20043. [PMID: 16158388]
  • C Le Devehat, M Vimeux. Pharmacoclinical study of the action of vinburnin versus placebo: study of the hemodynamic, microcirculatory and rheological effects in angiopathy of the lower limbs in diabetes mellitus. International angiology : a journal of the International Union of Angiology. 1989 Jan; 8(1):57-61. doi: . [PMID: 2671200]
  • P A Sado, D Gibassier, R Leverge. [Simultaneous determination of vinburnine and 6-hydroxyvinburnine in human plasma by high-performance liquid chromatography]. Journal of chromatography. 1988 Dec; 434(1):157-67. doi: NULL. [PMID: 3243809]