Setoperone (BioDeep_00000745895)

   


代谢物信息卡片


5H-THIAZOLO[3,2A]PYRIMIDIN-5-ONE, 6-[2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL]-2,3-DIHYDRO-7-METHYL-

化学式: C21H24FN3O2S (401.1573176)
中文名称: 噻托哌隆
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(C(=O)N2CCSC2=N1)CCN3CCC(CC3)C(=O)C4=CC=C(C=C4)F
InChI: InChI=1S/C21H24FN3O2S/c1-14-18(20(27)25-12-13-28-21(25)23-14)8-11-24-9-6-16(7-10-24)19(26)15-2-4-17(22)5-3-15/h2-5,16H,6-13H2,1H3

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent

同义名列表

2 个代谢物同义名

5H-THIAZOLO[3,2A]PYRIMIDIN-5-ONE, 6-[2-[4-(4-FLUOROBENZOYL)-1-PIPERIDINYL]ETHYL]-2,3-DIHYDRO-7-METHYL-; Setoperone



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • David Mamo, Ariel Graff, Romina Mizrahi, C M Shammi, Françoise Romeyer, Shitij Kapur. Differential effects of aripiprazole on D(2), 5-HT(2), and 5-HT(1A) receptor occupancy in patients with schizophrenia: a triple tracer PET study. The American journal of psychiatry. 2007 Sep; 164(9):1411-7. doi: 10.1176/appi.ajp.2007.06091479. [PMID: 17728427]
  • David Mamo, Shitij Kapur, C M Shammi, George Papatheodorou, Steve Mann, François Therrien, Gary Remington. A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone. The American journal of psychiatry. 2004 May; 161(5):818-25. doi: 10.1176/appi.ajp.161.5.818. [PMID: 15121646]
  • L N Yatham, P F Liddle, I S Shiah, R W Lam, M J Adam, A P Zis, T J Ruth. Effects of rapid tryptophan depletion on brain 5-HT(2) receptors: a PET study. The British journal of psychiatry : the journal of mental science. 2001 May; 178(?):448-53. doi: 10.1192/bjp.178.5.448. [PMID: 11331561]
  • S Kapur, R B Zipursky, G Remington, C Jones, J DaSilva, A A Wilson, S Houle. 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. The American journal of psychiatry. 1998 Jul; 155(7):921-8. doi: 10.1176/ajp.155.7.921. [PMID: 9659858]
  • A J Fischman, A A Bonab, J W Babich, N M Alpert, S L Rauch, D R Elmaleh, T M Shoup, S A Williams, R H Rubin. Positron emission tomographic analysis of central 5-hydroxytryptamine2 receptor occupancy in healthy volunteers treated with the novel antipsychotic agent, ziprasidone. The Journal of pharmacology and experimental therapeutics. 1996 Nov; 279(2):939-47. doi: NULL. [PMID: 8930203]
  • M C Petit-Taboué, B Landeau, A Osmont, I Tillet, L Barré, J C Baron. Estimation of neocortical serotonin-2 receptor binding potential by single-dose fluorine-18-setoperone kinetic PET data analysis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1996 Jan; 37(1):95-104. doi: NULL. [PMID: 8544011]
  • J Blin, J C Baron, B Dubois, C Crouzel, M Fiorelli, D Attar-Lévy, B Pillon, D Fournier, M Vidailhet, Y Agid. Loss of brain 5-HT2 receptors in Alzheimer's disease. In vivo assessment with positron emission tomography and [18F]setoperone. Brain : a journal of neurology. 1993 Jun; 116 ( Pt 3)(?):497-510. doi: 10.1093/brain/116.3.497. [PMID: 8513389]
  • J Blin, G Sette, M Fiorelli, O Bletry, J L Elghozi, C Crouzel, J C Baron. A method for the in vivo investigation of the serotonergic 5-HT2 receptors in the human cerebral cortex using positron emission tomography and 18F-labeled setoperone. Journal of neurochemistry. 1990 May; 54(5):1744-54. doi: 10.1111/j.1471-4159.1990.tb01229.x. [PMID: 2182776]
  • G Meco, L Lestingi, M G Buzzi, P Petrini, V Pasqualoni, P Falaschi, S Marini. Neuroendocrine effects of setoperone: a new neuroleptic drug. International journal of clinical pharmacology research. 1986; 6(6):465-8. doi: NULL. [PMID: 2879803]