Bretylium tosylate (BioDeep_00000745418)

   


代谢物信息卡片


Bretylium (tosylate)

化学式: C18H24BrNO3S (413.0660174000001)
中文名称: 托西溴苄铵
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC[N+](C)(C)CC1=CC=CC=C1Br.CC1=CC=C(C=C1)S(=O)(=O)[O-]
InChI: /p-1

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BD - Antiarrhythmics, class iii
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Bretylium (tosylate) is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters. It is the sympathetic nerve and adrenergic ganglion blocking agent . (1) Bretylium tosylate inhibits adrenergic function presynaptically only after an initial release in neurotransmitter substance. (2) The reference for administration dose is 15 mg/kg (I.P).

同义名列表

2 个代谢物同义名

Bretylium (tosylate); Bretylium tosylate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
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  • R Gáspár, G Panyi, D L Ypey, Z Krasznai, G Vereb, C Pieri, S Damjanovich. Effects of bretylium tosylate on voltage-gated potassium channels in human T lymphocytes. Molecular pharmacology. 1994 Oct; 46(4):762-6. doi: NULL. [PMID: 7969057]
  • H Bjørnstad, E Mortensen, G Sager, H Refsum. Effect of bretylium tosylate on ventricular fibrillation threshold during hypothermia in dogs. The American journal of emergency medicine. 1994 Jul; 12(4):407-12. doi: 10.1016/0735-6757(94)90049-3. [PMID: 8031422]
  • W E Crowe, J P Leader. Resistive properties of the epithelial membranes of the urinary bladder of the toad, Bufo marinus, determined using the fluorescent dye, RH160. Pflugers Archiv : European journal of physiology. 1994 Jun; 427(3-4):210-8. doi: 10.1007/bf00374526. [PMID: 8072838]
  • A Orts, C Alcaraz, K A Delaney, L R Goldfrank, H Turndorf, M M Puig. Bretylium tosylate and electrically induced cardiac arrhythmias during hypothermia in dogs. The American journal of emergency medicine. 1992 Jul; 10(4):311-6. doi: 10.1016/0735-6757(92)90008-l. [PMID: 1616517]
  • N Hatori, R L Roberts, H Tadokoro, L Ryden, K Satomura, M C Fishbein, E R Stiehm, E Corday, J K Drury. Differences in infarct size with lidocaine as compared with bretylium tosylate in acute myocardial ischemia and reperfusion in pigs. Journal of cardiovascular pharmacology. 1991 Oct; 18(4):581-8. doi: 10.1097/00005344-199110000-00015. [PMID: 1724536]
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  • H J Duff, D M Roden, A Yacobi, D Robertson, T Wang, R J Maffucci, J A Oates, R L Woosley. Bretylium: relations between plasma concentrations and pharmacologic actions in high-frequency ventricular arrhythmias. The American journal of cardiology. 1985 Feb; 55(4):395-401. doi: 10.1016/0002-9149(85)90383-2. [PMID: 3969876]
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  • J Adir, P K Narang, J Josselson. Nomogram for bretylium dosing in renal impairment. Therapeutic drug monitoring. 1985; 7(3):265-8. doi: 10.1097/00007691-198507030-00004. [PMID: 4049461]
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  • J E Doherty. Clinical use of digitalis glycosides. An update. Cardiology. 1985; 72(5-6):225-54. doi: 10.1159/000173883. [PMID: 2866838]
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  • K M Murphy, S M Caplen, R M Nowak, W N Lin, A R Kelly, R Slocombe, M C Tomlanovich. Endotracheal bretylium tosylate in a canine model. Annals of emergency medicine. 1984 Feb; 13(2):87-91. doi: 10.1016/s0196-0644(84)80567-3. [PMID: 6419651]
  • A Pfeiffer, G Feuerstein, R L Zerbe, A I Faden, I J Kopin. Mu-receptors mediate opioid cardiovascular effects at anterior hypothalamic sites through sympatho-adrenomedullary and parasympathetic pathways. Endocrinology. 1983 Sep; 113(3):929-38. doi: 10.1210/endo-113-3-929. [PMID: 6307671]
  • A Yacobi, B L Kamath, C M Lai, H F Stampfli. Tissue distribution of [14C]bretylium tosylate in rats. Journal of pharmaceutical sciences. 1983 May; 72(5):556-9. doi: 10.1002/jps.2600720520. [PMID: 6864505]
  • J Josselson, P K Narang, J Adir, A Yacobi, J H Sadler. Bretylium kinetics in renal insufficiency. Clinical pharmacology and therapeutics. 1983 Feb; 33(2):144-50. doi: 10.1038/clpt.1983.22. [PMID: 6822027]
  • B Elger, H Hentschel. Effect of adrenergic blockade with bretylium and phentolamine on glomerular filtration rate in the rainbow trout, Salmo gairdneri Rich., adapting to saline water. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 1983; 75(2):253-8. doi: 10.1016/0742-8413(83)90189-5. [PMID: 6138194]
  • B L Kamath, T P Gibson, Z M Look, C M McEntegart, E B Comrie, A Yacobi. Pharmacokinetics of bretylium in dogs and the effect of hemoperfusion on elimination. Journal of pharmaceutical sciences. 1982 Nov; 71(11):1294-6. doi: 10.1002/jps.2600711129. [PMID: 7175729]
  • E R Garrett, J R Green, M Bialer. Bretylium pharmacokinetics and bioavailabilities in man with various doses and modes of administration. Biopharmaceutics & drug disposition. 1982 Apr; 3(2):129-64. doi: 10.1002/bdd.2510030206. [PMID: 7104462]
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  • B L Kamath, H F Stampfli, C M Lai, A Yacobi. Pharmacokinetics of [14C]bretylium tosylate in rats. Journal of pharmaceutical sciences. 1981 Jun; 70(6):667-9. doi: 10.1002/jps.2600700623. [PMID: 7252812]
  • J L Anderson, E Patterson, J G Wagner, T A Johnson, B R Lucchesi, B Pitt. Clinical pharmacokinetics of intravenous and oral bretylium tosylate in survivors of ventricular tachycardia or fibrillation: clinical application of a new assay for bretylium. Journal of cardiovascular pharmacology. 1981 May; 3(3):485-99. doi: 10.1097/00005344-198105000-00008. [PMID: 6168830]
  • J L Anderson, E Patterson, J G Wagner, J R Stewart, H L Behm, B R Lucchesi. Oral and intravenous bretylium disposition. Clinical pharmacology and therapeutics. 1980 Oct; 28(4):468-78. doi: 10.1038/clpt.1980.190. [PMID: 7408407]
  • P K Narang, J Adir, J Josselson, A Yacobi, J Sadler. Pharmacokinetics of bretylium in man after intravenous administration. Journal of pharmacokinetics and biopharmaceutics. 1980 Aug; 8(4):363-72. doi: 10.1007/bf01059384. [PMID: 7431227]
  • R McCarty, I J Kopin. Stress-induced alterations in plasma catecholamines and behavior of rats: effects of chlorisondamine and bretylium. Behavioral and neural biology. 1979 Nov; 27(3):249-65. doi: 10.1016/s0163-1047(79)92314-8. [PMID: 518456]
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