Bendamustine (BioDeep_00000745402)
代谢物信息卡片
化学式: C16H22Cl3N3O2 (393.0777522)
中文名称: 盐酸苯达莫司汀, 苯达莫司汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl
InChI: 1H
描述信息
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D07085
- PubChem: 77082
- ChEMBL: CHEMBL1201734
- MeSH: Bendamustine Hydrochloride
- CAS: 97832-05-8
- CAS: 3543-75-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Akie Hirata, Kaname Miyashita, Takafumi Tanaka, Kiyoko Hirata, Taisuke Narazaki, Hayato Utsunomiya, Hirofumi Ohno, Eriko Nakashima, Yoshimichi Tachikawa, Ilseung Choi, Kenichi Taguchi, Youko Suehiro. Serum immunoglobulin G as a discriminator of infection in follicular lymphoma patients undergoing chemotherapy with bendamustine in combination with rituximab.
Hematology (Amsterdam, Netherlands).
2022 Dec; 27(1):384-395. doi:
10.1080/16078454.2022.2051863
. [PMID: 35344477] - Harsha K Tripathy, S V Nair Manju, Rama Murthy Bestha, Vinay Kiran, Sreekanth Dittakavi, Ramesh Mullangi. Validated liquid chromatography-tandem mass spectrometry method for simultaneous quantitation of bendamustine and copanlisib in mouse plasma: Application to a pharmacokinetic study in mice.
Biomedical chromatography : BMC.
2022 Aug; 36(8):e5387. doi:
10.1002/bmc.5387
. [PMID: 35470912] - Kohei Kamegai, Noriko Iwamoto, Tomiteru Togano, Kenji Maeda, Yuki Takamatsu, Yusuke Miyazato, Masahiro Ishikane, Masashi Mizokami, Masaya Sugiyama, Shun Iida, Sho Miyamoto, Tadaki Suzuki, Norio Ohmagari. A Fatal Breakthrough COVID-19 Case Following Bendamustine-Rituximab Therapy.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Aug; 121(?):85-88. doi:
10.1016/j.ijid.2022.04.058
. [PMID: 35500795] - Manabu Suzuki, Daisuke Koyama, Shohei Ikeda, Masumi Sukegawa, Mayumi Teshirogi, Kyohei Misawa, Saburo Tsunoda. Serum IgG and lymphocyte counts are useful for the early detection of infection in patients receiving bendamustine-rituximab therapy.
Journal of clinical and experimental hematopathology : JCEH.
2022 Jun; 62(2):91-98. doi:
10.3960/jslrt.21031
. [PMID: 35153257] - Tatsuya Arai, Satoru Mukai, Ryo Kazama, Yoshihiko Ogawa, Koji Nishida, Kazuo Hatanaka, Iwao Gohma. Persistent viral shedding of severe acute respiratory syndrome coronavirus 2 after treatment with bendamustine and rituximab: A case report.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Jun; 28(6):810-813. doi:
10.1016/j.jiac.2022.01.014
. [PMID: 35115239] - Guy Pratt, Dima El-Sharkawi, Jaimal Kothari, Shirley D'Sa, Rebecca Auer, Helen McCarthy, Rajesh Krishna, Oliver Miles, Charalampia Kyriakou, Roger Owen. Diagnosis and management of Waldenström macroglobulinaemia-A British Society for Haematology guideline.
British journal of haematology.
2022 04; 197(2):171-187. doi:
10.1111/bjh.18036
. [PMID: 35020191] - Qinhong Xu, Jieni Yu, Xiaoyan Lin, Youli Li, Kejie Zhang. CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disorders.
Medicine.
2021 Nov; 100(47):e27874. doi:
10.1097/md.0000000000027874
. [PMID: 34964755] - Yunjiang Zhou, Yaxin Chen, Xing Huang, Yingying Tan, Rong Hu, Chong Li, Miao-Miao Niu. A Supramolecular Nanomedicine Based on Bendamustine and MDM2-Targeted D-peptide Inhibitor for Breast Cancer Therapy.
Advanced healthcare materials.
2021 11; 10(21):e2100980. doi:
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International journal of hematology.
2021 Aug; 114(2):205-216. doi:
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Blood.
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BMJ case reports.
2021 Jan; 14(1):. doi:
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Frontiers in immunology.
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Blood.
2020 07; 136(4):480-488. doi:
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Haematologica.
2020 06; 105(6):1621-1629. doi:
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Bone marrow transplantation.
2019 12; 54(12):1923-1925. doi:
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The British journal of dermatology.
2019 12; 181(6):1315-1317. doi:
10.1111/bjd.18215
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Haematologica.
2019 10; 104(10):2053-2060. doi:
10.3324/haematol.2018.205930
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Drug and chemical toxicology.
2019 Jul; 42(4):394-402. doi:
10.1080/01480545.2018.1458236
. [PMID: 29681187] - Silvia Maria Lavezzi, Jan de Jong, Martine Neyens, Paula Cramer, Fatih Demirkan, Graeme Fraser, Nancy Bartlett, Marie-Sarah Dilhuydy, Javier Loscertales, Abraham Avigdor, Simon Rule, Olga Samoilova, Andre Goy, Siddhartha Ganguly, Mariya Salman, Angela Howes, Michelle Mahler, Giuseppe De Nicolao, Italo Poggesi. Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial.
Pharmaceutical research.
2019 May; 36(7):93. doi:
10.1007/s11095-019-2605-8
. [PMID: 31044267] - Matthew Ettleson, Kale S Bongers, Kaitlyn Vitale, Anthony J Perissinotti, Tycel Phillips, Bernard L Marini. Successful use of cytarabine and bendamustine in a patient with mantle cell lymphoma and acute renal failure using intermittent hemodialysis: A case report.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2019 Apr; 25(3):731-734. doi:
10.1177/1078155217754244
. [PMID: 29385883] - Alessandro Isidori, Federica Loscocco, Barbara Guiducci, Giuseppe Visani. Benda-EAM prior to ASCT and renal toxicity: Much ado about nothing.
American journal of hematology.
2019 04; 94(4):E104-E105. doi:
10.1002/ajh.25413
. [PMID: 30663798] - Andrew Rogers, Pulkit Gandhi, Joseph Bautista, Jie Tang. Acquired Gitelman Syndrome Secondary to Bendamustine Use.
Rhode Island medical journal (2013).
2018 Nov; 101(9):36-38. doi:
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. [PMID: 30384518] - Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo, Deok-Hwan Yang. Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL).
BMC cancer.
2018 Jul; 18(1):729. doi:
10.1186/s12885-018-4632-y
. [PMID: 29986691] - Sylvain P Chantepie, Sylvain Garciaz, Emmanuelle Tchernonog, Frederic Peyrade, Marie-Virginie Larcher, Momar Diouf, Luc-Mathieu Fornecker, Roch Houot, Thomas Gastinne, Carole Soussain, Sandra Malak, Richard Lemal, Caroline Delette, Ahmad Ibrahim, Anne-Claire Gac, Emilie Reboursière, Jean-Pierre Vilque, Mohamed-Amine Bekadja, Rene-Olivier Casasnovas, Remy Gressin, Stéphanie Guidez, Diane Coso, Charles Herbaux, Ibrahim Yakoub-Agha, Krimo Bouabdallah, Eric Durot, Gandhi Damaj. Bendamustine-based conditioning prior to autologous stem cell transplantation (ASCT): Results of a French multicenter study of 474 patients from LYmphoma Study Association (LYSA) centers.
American journal of hematology.
2018 Jun; 93(6):729-735. doi:
10.1002/ajh.25077
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American journal of hematology.
2018 03; 93(3):356-362. doi:
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Actas dermo-sifiliograficas.
2018 Jan; 109(1):75-78. doi:
10.1016/j.ad.2017.04.021
. [PMID: 28784233] - Anat Gafter-Gvili, Ronit Gurion, Pia Raanani, Ofer Shpilberg, Liat Vidal. Bendamustine-associated infections-systematic review and meta-analysis of randomized controlled trials.
Hematological oncology.
2017 Dec; 35(4):424-431. doi:
10.1002/hon.2350
. [PMID: 27734524] - Eric M Cheung, William J Edenfield, Bassam Mattar, Stephen P Anthony, Peter J Mutch, Brian Chanas, Mark Smith, Adrian Hepner. Safety and Pharmacokinetics of Bendamustine Rapid-Infusion Formulation.
Journal of clinical pharmacology.
2017 Nov; 57(11):1400-1408. doi:
10.1002/jcph.942
. [PMID: 28561902] - Devaraj V Chandrashekar, Ponnayyan S Suresh, Rajnish Kumar, Ravi Kanth Bhamidipati, Ramesh Mullangi, Wolfgang Richter, Nuggehally R Srinivas. Sensitive LC-MS/MS Method for the Simultaneous Determination of Bendamustine and its Active Metabolite, γ-Hydroxybendamustine in Small Volume Mice and Dog Plasma and its Application to a Pharmacokinetic Study in Mice and Dogs.
Drug research.
2017 Sep; 67(9):497-508. doi:
10.1055/s-0043-108124
. [PMID: 28561238] - Prashant Kapoor, Stephen M Ansell, Rafael Fonseca, Asher Chanan-Khan, Robert A Kyle, Shaji K Kumar, Joseph R Mikhael, Thomas E Witzig, Michelle Mauermann, Angela Dispenzieri, Sikander Ailawadhi, A Keith Stewart, Martha Q Lacy, Carrie A Thompson, Francis K Buadi, David Dingli, William G Morice, Ronald S Go, Dragan Jevremovic, Taimur Sher, Rebecca L King, Esteban Braggio, Ann Novak, Vivek Roy, Rhett P Ketterling, Patricia T Greipp, Martha Grogan, Ivana N Micallef, P Leif Bergsagel, Joseph P Colgan, Nelson Leung, Wilson I Gonsalves, Yi Lin, David J Inwards, Suzanne R Hayman, Grzegorz S Nowakowski, Patrick B Johnston, Steven J Russell, Svetomir N Markovic, Steven R Zeldenrust, Yi L Hwa, John A Lust, Luis F Porrata, Thomas M Habermann, S Vincent Rajkumar, Morie A Gertz, Craig B Reeder. Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines 2016.
JAMA oncology.
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. [PMID: 28056114] - Nsabimana A Uwumugambi, Vaishali Sanchorawala, Anthony C Shelton, Lauren Stern, Craig E Gordon. Bendamustine-Induced Nephrogenic Diabetes Insipidus in a Patient With AL Amyloidosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 Feb; 69(2):317-319. doi:
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The American journal of tropical medicine and hygiene.
2017 Jan; 96(1):221-228. doi:
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Journal of chromatographic science.
2017 01; 55(1):30-39. doi:
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. [PMID: 27993861] - Dipti Talaulikar, Constantine S Tam, Douglas Joshua, Joy Phoebe Ho, Jeff Szer, Hang Quach, Andrew Spencer, Simon Harrison, Peter Mollee, Andrew W Roberts, Noemi Horvath, Cindy Lee, Andrew Zannettino, Ross Brown, Bradley Augustson, Wilfrid Jaksic, John Gibson, Anna Kalff, Anna Johnston, Judith Trotman, Akash Kalro, George Grigoriadis, Chris Ward, H Miles Prince. Treatment of patients with Waldenström macroglobulinaemia: clinical practice guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group.
Internal medicine journal.
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Clinical nephrology.
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British journal of haematology.
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Drug research.
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Clinical chemistry and laboratory medicine.
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Obesity surgery.
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Bone marrow transplantation.
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The pharmacogenomics journal.
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Cancer chemotherapy and pharmacology.
2015 Jul; 76(1):211-6. doi:
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. [PMID: 26006703] - Morie A Gertz. The role of bendamustine in the management of plasma cell myeloma.
Leukemia & lymphoma.
2015 May; 56(5):1195-6. doi:
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Leukemia & lymphoma.
2015 Mar; 56(3):559-67. doi:
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American journal of physiology. Renal physiology.
2015 Feb; 308(4):F330-8. doi:
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British journal of haematology.
2015 Feb; 168(4):470. doi:
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. [PMID: 25384540] - Philipp Zimmer, Andreas Mierau, Wilhelm Bloch, Heiko K Strüder, Thorben Hülsdünker, Alexander Schenk, Leonie Fiebig, Freek T Baumann, Moritz Hahn, Nina Reinart, Michael Hallek, Thomas Elter. Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine.
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