Peplomycin (BioDeep_00000745082)

   


代谢物信息卡片


N1-[3-[(1-Phenylethyl)amino]propyl]bleomycinamide

化学式: C61H88N18O21S2 (1472.5813)
中文名称: 派来霉素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCCNC(C)C7=CC=CC=C7)O
InChI: InChI=1S/C61H88N18O21S2/c1-24-39(76-52(79-50(24)64)31(16-37(63)83)71-17-30(62)51(65)89)56(93)78-41(47(32-18-67-23-72-32)98-60-49(45(87)43(85)35(19-80)97-60)99-59-46(88)48(100-61(66)95)44(86)36(20-81)96-59)57(94)73-27(4)42(84)25(2)53(90)77-40(28(5)82)55(92)70-15-12-38-74-34(22-101-38)58-75-33(21-102-58)54(91)69-14-9-13-68-26(3)29-10-7-6-8-11-29/h6-8,10-11,18,21-23,25-28,30-31,35-36,40-49,59-60,68,71,80-82,84-88H,9,12-17,19-20,62H2,1-5H3,(H2,63,83)(H2,65,89)(H2,66,95)(H,67,72)(H,69,91)(H,70,92)(H,73,94)(H,77,90)(H,78,93)(H2,64,76,79)/t25-,26-,27+,28+,30-,31-,35-,36+,40-,41-,42-,43+,44+,45-,46-,47-,48-,49-,59+,60-/m0/s1

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

N1-[3-[(1-Phenylethyl)amino]propyl]bleomycinamide; Peplomycin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Kunio Fujiwara, Masashi Shin, David M Hougaard, Tetsuya Saita. Distribution study of peplomycin in rat kidney revealed by immunocytochemistry using monoclonal antibodies. Histochemistry and cell biology. 2011 Jan; 135(1):93-101. doi: 10.1007/s00418-010-0768-9. [PMID: 21153656]
  • Yoichi Aoki, Masahiko Higashino, Shiro Ishii, Kenichi Tanaka. Yolk sac tumor of the ovary during pregnancy: a case report. Gynecologic oncology. 2005 Nov; 99(2):497-9. doi: 10.1016/j.ygyno.2005.06.022. [PMID: 16051324]
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  • E Okada, H Kamizaki. Primary squamous cell carcinoma of the prostate. International journal of urology : official journal of the Japanese Urological Association. 2000 Sep; 7(9):347-50. doi: 10.1046/j.1442-2042.2000.00204.x. [PMID: 11020062]
  • T Sugiyama, T Nishida, Y Hasuo, K Fujiyoshi, M Yakushiji. Neoadjuvant intraarterial chemotherapy followed by radical hysterectomy and/or radiotherapy for locally advanced cervical cancer. Gynecologic oncology. 1998 May; 69(2):130-6. doi: 10.1006/gyno.1998.4976. [PMID: 9600820]
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  • M Tamaki, S Maeda, H Iwata, N Yamamoto, M Kuriyama, Y Ban, Y Kawada. [A case of lung metastasis from renal cell carcinoma showing complete response by a combination chemotherapy with methotrexate, vinblastine and pepleomycin (MVP)]. Hinyokika kiyo. Acta urologica Japonica. 1995 Mar; 41(3):205-7. doi: . [PMID: 7741073]
  • T Konishi, S Fujino, Y Chino, Y Asada, S Asakura, H Kato, A Mori, H Okabe. Posterior mediastinal endodermal sinus (yolk sac) tumor in a female patient. The Annals of thoracic surgery. 1994 Jul; 58(1):244-5. doi: 10.1016/0003-4975(94)91116-9. [PMID: 7518667]
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  • S T Lin. [Study on chemosensitivity test (in vitro) of cultured human urogenital carcinoma cell lines by MTT assay]. Nihon Ika Daigaku zasshi. 1990 Apr; 57(2):127-36. doi: 10.1272/jnms1923.57.127. [PMID: 1694861]
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  • O Iwanari, Y Date, N Yoshino, J Miyako, K Ryuhkoh, M Moriyama, S Nakayama, M Kitao. [Studies on renal dysfunction after intra-arterial hypertensive chemotherapy (CDDP, PEP) for advanced cancer of the uterine cervix--serum.urinary alpha 1-microglobulin, beta 2-microglobulin and urinary lysozyme, albumin]. Nihon Sanka Fujinka Gakkai zasshi. 1990 Feb; 42(2):115-20. doi: NULL. [PMID: 1690251]
  • R Yasumoto, M Asakawa, T Iseki, T Nakatani, T Kishimoto, M Maekawa, M Umeda, M Senju, A Horii, M Kawamura. [Treatment with a new preparation using peplomycin emulsion in hydroxypropylcellulosum. Analysis of immediate response in sixty-two patients with bladder cancer]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology. 1989 Dec; 80(12):1728-32. doi: 10.5980/jpnjurol1989.80.1728. [PMID: 2483184]
  • H Matsumoto, Y Furukawa, A Fujii, H Yamamoto, K Suzuki, K Mashima, H Ohmine. A study on the toxicity of antineoplastic drugs (bleomycin, peplomycin and cis-diamminedichloroplatinum) by simultaneous administration (Part 1). The Journal of Nihon University School of Dentistry. 1989 Dec; 31(4):597-611. doi: 10.2334/josnusd1959.31.597. [PMID: 2482879]
  • O Iwanari, Y Date, N Yoshino, J Miyako, K Ryukou, M Moriyama, S Nakayama, M Kitao, Y Fujita, K Yasui. [Effects and side effects of hypertensive intra-arterial chemotherapy (CDDP, PEP) in advanced cancer of the uterine cervix]. Gan to kagaku ryoho. Cancer & chemotherapy. 1989 Aug; 16(8 Pt 2):2792-6. doi: NULL. [PMID: 2476964]
  • H Kuramochi, K Takahashi, T Takeuchi. Tumor cell permeability to peplomycin. The Journal of antibiotics. 1989 Jul; 42(7):1163-70. doi: 10.7164/antibiotics.42.1163. [PMID: 2473972]
  • C Nishimura, H Suzuki, N Tanaka, H Yamaguchi. Intracellular degradation of bleomycin hydrolase in two Chinese hamster cell lines in relation to their peplomycin susceptibility. Biochimica et biophysica acta. 1989 Jun; 1012(1):29-35. doi: 10.1016/0167-4889(89)90007-4. [PMID: 2471552]
  • W Thamavit, S Fukushima, Y Kurata, M Asamoto, N Ito. Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model. Cancer letters. 1989 May; 45(2):93-101. doi: 10.1016/0304-3835(89)90142-0. [PMID: 2471582]
  • O Kamiya, A Hoshino, K Ohara, K Nagata, Y Ono, M Saito, T Itou, K Yamamoto. [Combination chemotherapy of MCNU, melphalan, procarbazine, and prednisolone (MMPP) in multiple myeloma; disappearance of M-peak on serum electrophoretic pattern]. Gan to kagaku ryoho. Cancer & chemotherapy. 1989 Apr; 16(4 Pt 1):863-5. doi: NULL. [PMID: 2469398]
  • H Sakura, T Fujii, T Ohashi, S Tsuruta. Occurrence of an anti-peplomycin IgE antibody cross-reacting with bleomycin in a patient with cervical uterine cancer. Cancer chemotherapy and pharmacology. 1989; 23(5):333-6. doi: 10.1007/bf00292416. [PMID: 2468427]
  • M Asakawa, T Maekawa, K Mori, Y Ozaki, A Horii, R Yasumoto, S Nishio, M Maekawa. [A new clinical trial in intravesical chemotherapy with instillation of peplomycin preparation as an emulsion in hydroxypropylcellulosum--preliminary study of patients with bladder tumor]. Hinyokika kiyo. Acta urologica Japonica. 1989 Jan; 35(1):39-42. doi: NULL. [PMID: 2471398]
  • Y Yasui, K Suzumori, Y Yagami. [Pharmacokinetic and therapeutic studies of the administration of peplomycin by continuous subcutaneous infusion]. Gan no rinsho. Japan journal of cancer clinics. 1988 Nov; 34(14):1975-8. doi: NULL. [PMID: 2462650]
  • O Iwanari, Y Date, S Nakayama, J Miyako, S Kijima, M Moriyama, K Yamamoto, K Takahashi, K Iida, M Kitao. [Studies of intra-arterial hypertensive chemotherapy with cisplatin and peplomycin in advanced cancer of the uterine cervix--suitable dose of angiotensin II determined by intra-arterial digital subtraction angiography]. Nihon Sanka Fujinka Gakkai zasshi. 1988 Jul; 40(7):835-40. doi: NULL. [PMID: 2458418]
  • M Ohta, N Hara, Y Ichikawa, T Kanda, K Shima, K Tamura, M Hokama. [Benefits of cisplatin-based polychemotherapy in non-small cell bronchogenic carcinoma. Kyushu Lung Cancer Chemotherapy Study Group]. Gan to kagaku ryoho. Cancer & chemotherapy. 1988 Jun; 15(6):1901-8. doi: . [PMID: 2454615]
  • M Nakata, T Honma, Y Fukuda, S Yoneda, Y Noguchi, S Yoshida, K Tari, S Kojima, K Takada. [Study of biological markers of pulmonary fibrosis with clinical peplomycin or radiotherapy]. Gan to kagaku ryoho. Cancer & chemotherapy. 1988 Apr; 15(4 Pt 1):723-5. doi: ". [PMID: 2451475]
  • K Fukuma, S Miyamura, T Thoya, N Tanaka, S Fujisaki, H Okamura, M Maeyama. Uterine papillary serous carcinoma with high levels of serum carcinoembryonic antigen. Response to combination chemotherapy. Cancer. 1987 Feb; 59(3):403-5. doi: 10.1002/1097-0142(19870201)59:3<403::aid-cncr2820590308>3.0.co;2-7. [PMID: 2431759]
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  • T Ohta, K Suzuki, K Taguchi, S Ichikawa, R Hongo, T Kohama. [Trial of peplomycin administered as a suppository]. Gan to kagaku ryoho. Cancer & chemotherapy. 1987 Jan; 14(1):203-4. doi: NULL. [PMID: 2432838]
  • Y Araki, K Tamura, M Seita. [Peplomycin for hypercalcemia in a patient with adult T cell leukemia]. Gan to kagaku ryoho. Cancer & chemotherapy. 1986 Aug; 13(8):2671-4. doi: NULL. [PMID: 2427035]
  • K Babaya, K Tsumatani, O Natsume, T Yoshie, K Kubota, S Ozono, Y Hirao, E Okajima. [Complete remission obtained in advanced testicular cancer treated by etoposide (NK-171)]. Gan to kagaku ryoho. Cancer & chemotherapy. 1986 Mar; 13(3 Pt 1):604-7. doi: NULL. [PMID: 2420282]
  • M Ohta, N Hara, Y Ichikawa, T Kanda, K Shima, M Hokama. [Combination chemotherapy for bronchogenic carcinoma based on cell type]. Gan to kagaku ryoho. Cancer & chemotherapy. 1986 Jan; 13(1):86-94. doi: NULL. [PMID: 2417564]
  • Y Hayakawa, H Ishizaki, S Tanabe, A Kimura, N Yamamichi. Squamous cell carcinoma with hypercalcemia and leukocytosis. Dermatologica. 1986; 172(3):169-72. doi: 10.1159/000249324. [PMID: 2422067]
  • S Ikekawa, K Ishihara, S Tanaka, S Ikeda. Basic studies of cryochemotherapy in a murine tumor system. Cryobiology. 1985 Oct; 22(5):477-83. doi: 10.1016/0011-2240(85)90159-2. [PMID: 2414064]
  • T Seki, Y Muraoka, K Takahashi, H Horinishi, H Umezawa. Radioimmunoassay of bleomycins. The Journal of antibiotics. 1985 Sep; 38(9):1251-6. doi: 10.7164/antibiotics.38.1251. [PMID: 2415502]
  • Y Tsuruta, T Sato, H Miyahara, K Yoshino, K Umatani. [A neo-adjuvant chemotherapy for carcinomas of the hypopharynx and cervical esophagus]. Gan to kagaku ryoho. Cancer & chemotherapy. 1985 Jul; 12(7):1496-501. doi: NULL. [PMID: 2409926]
  • T Yamauchi, S Hida, K Ooishi, K Okada, O Yoshida. [Sequential combination chemotherapy consisting of vincristine, peplomycin, methotrexate, cis-diamminedichloroplatinum (II), cytosine arabinoside and 5-fluorouracil, for advanced urothelial cancer]. Hinyokika kiyo. Acta urologica Japonica. 1985 Jul; 31(7):1093-104. doi: NULL. [PMID: 2414981]
  • K Suzuki, A Tajima, Y Aso, Y Ono, S Ohshima, T Fujita, Y Naide, Y Ariyoshi, M Fukushima, K Ohta. [Clinical studies of cis-diamminedichloroplatinum (CDDP) nephrotoxicity--influence of aging and urinary diversion]. Nihon Gan Chiryo Gakkai shi. 1985 May; 20(4):752-7. doi: NULL. [PMID: 2414382]
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  • K Tamura, Y Araki, M Seita. [Treatment for advanced malignant lymphoma in patients with compromised bone marrow--a combination therapy using pepleomycin, vincristine and high-dose adrenocorticoids (POP regimen)]. Gan to kagaku ryoho. Cancer & chemotherapy. 1984 Dec; 11(12 Pt 1):2568-72. doi: NULL. [PMID: 6210054]
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