azetidinone (BioDeep_00000745024)

   


代谢物信息卡片


2-Azetidinone

化学式: C3H5NO (71.03711200000001)
中文名称: 2-氮杂环丁酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CNC1=O
InChI: InChI=1S/C3H5NO/c5-3-1-2-4-3/h1-2H2,(H,4,5)

描述信息

同义名列表

2 个代谢物同义名

2-Azetidinone; azetidinone



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yineng Xia, Lijuan Zhu, Xinrui Yuan, Yubin Wang. Synthesis and Evaluation of 2-Azetidinone and 1H-Pyrrole-2,5-dione Derivatives as Cholesterol Absorption Inhibitors for Reducing Inflammation Response and Oxidative Stress. Chemistry & biodiversity. 2019 Feb; 16(2):e1800189. doi: 10.1002/cbdv.201800189. [PMID: 30230227]
  • Daria Giacomini, Rosario Musumeci, Paola Galletti, Giulia Martelli, Lorenzo Assennato, Gianni Sacchetti, Alessandra Guerrini, Enrico Calaresu, Marianna Martinelli, Clementina Cocuzza. 4-Alkyliden-azetidinones modified with plant derived polyphenols: Antibacterial and antioxidant properties. European journal of medicinal chemistry. 2017 Nov; 140(?):604-614. doi: 10.1016/j.ejmech.2017.09.048. [PMID: 28992569]
  • Xinrui Yuan, Peng Lu, Xiaojian Xue, Hui Qin, Chen Fan, Yubin Wang, Qi Zhang. Discovery of 2-azetidinone and 1H-pyrrole-2,5-dione derivatives containing sulfonamide group at the side chain as potential cholesterol absorption inhibitors. Bioorganic & medicinal chemistry letters. 2016 Feb; 26(3):849-853. doi: 10.1016/j.bmcl.2015.12.077. [PMID: 26783178]
  • Annalisa Fiasella, Andrea Nuzzi, Maria Summa, Andrea Armirotti, Glauco Tarozzo, Giorgio Tarzia, Marco Mor, Fabio Bertozzi, Tiziano Bandiera, Daniele Piomelli. 3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration. ChemMedChem. 2014 Jul; 9(7):1602-14. doi: 10.1002/cmdc.201300546. [PMID: 24828120]
  • Nikhilesh Arya, Jaya Dwivedi, Vijay M Khedkar, Evans C Coutinho, Kishor S Jain. Design, synthesis and biological evaluation of some 2-azetidinone derivatives as potential antihyperlipidemic agents. Archiv der Pharmazie. 2013 Dec; 346(12):872-81. doi: 10.1002/ardp.201300262. [PMID: 24142910]
  • Nikhilesh Arya, Manoj K Munde, Jaya Dwivedi, Archana Y Jagdale, Kishor S Jain. Design, synthesis, and antihyperlipidemic evaluation of novel 2-[1-(substitutedphenyl)-4-oxo-azetidin-2-yl]-5,6-disubstitutedthieno[2,3-d]pyrimidin-4(3H)-ones. Archiv der Pharmazie. 2013 Aug; 346(8):588-95. doi: 10.1002/ardp.201300001. [PMID: 23881664]
  • Mahreen Arooj, Sundarapandian Thangapandian, Shalini John, Swan Hwang, Jong Keun Park, Keun Woo Lee. 3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors. International journal of molecular sciences. 2011; 12(12):9236-64. doi: 10.3390/ijms12129236. [PMID: 22272131]
  • Yogita Dalla, Nirmal Singh, Amteshwar Singh Jaggi, Dhandeep Singh, Pooja Ghulati. Potential of ezetimibe in memory deficits associated with dementia of Alzheimer's type in mice. Indian journal of pharmacology. 2009 Dec; 41(6):262-7. doi: 10.4103/0253-7613.59925. [PMID: 20407557]
  • Shaukath A Khanum, Sheena Shashikanth, Syagadadu Giriyanna Sathyanarayana, Siddalingaiah Lokesh, Saligrama A Deepak. Synthesis and antifungal activity of 2-azetidinonyl-5-(2-benzoylphenoxy)methyl-1,3,4-oxadiazoles against seed-borne pathogens of Eleusine coracana (L.) Gaertn. Pest management science. 2009 Jul; 65(7):776-80. doi: 10.1002/ps.1752. [PMID: 19319825]
  • Dong Xiao, Anandan Palani, Robert Aslanian, Brian A McKittrick, Andrew T McPhail, Craig C Correll, P Tara Phelps, John C Anthes, Diane Rindgen. Spiro-piperidine azetidinones as potent TRPV1 antagonists. Bioorganic & medicinal chemistry letters. 2009 Feb; 19(3):783-7. doi: 10.1016/j.bmcl.2008.12.024. [PMID: 19114307]
  • Hanna Slim, Paul D Thompson. Ezetimibe-related myopathy: A systematic review. Journal of clinical lipidology. 2008 Oct; 2(5):328-34. doi: 10.1016/j.jacl.2008.08.430. [PMID: 21291757]
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  • Brian E Hawes, Kim A O'neill, Xiaorui Yao, James H Crona, Harry R Davis, Michael P Graziano, Scott W Altmann. In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs. Molecular pharmacology. 2007 Jan; 71(1):19-29. doi: 10.1124/mol.106.027896. [PMID: 17005902]
  • Xianxiu Xu, Renzhong Fu, Jin Chen, Shengwu Chen, Xu Bai. Ezetimibe analogs with a reorganized azetidinone ring: Design, synthesis, and evaluation of cholesterol absorption inhibitions. Bioorganic & medicinal chemistry letters. 2007 Jan; 17(1):101-4. doi: 10.1016/j.bmcl.2006.09.078. [PMID: 17049851]
  • Dana Ferraris, Yao-Sen Ko, David Calvin, Tiffany Chiou, Susan Lautar, Bert Thomas, Krystyna Wozniak, Camilo Rojas, Vincent Kalish, Sergei Belyakov. Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors. Bioorganic & medicinal chemistry letters. 2004 Nov; 14(22):5579-83. doi: 10.1016/j.bmcl.2004.08.057. [PMID: 15482928]
  • Wendelin Frick, Andrea Bauer-Schäfer, Jochen Bauer, Frank Girbig, Daniel Corsiero, Hubert Heuer, Werner Kramer. Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors. Bioorganic & medicinal chemistry. 2003 Apr; 11(8):1639-42. doi: 10.1016/s0968-0896(03)00047-6. [PMID: 12659749]
  • Tsukasa Nakamura, Chifuyu Ushiyama, Yoshimasa Suzuki, Shiwori Osada, Teruo Inoue, Hisataka Shoji, Masanori Hara, Noriaki Shimada, Hikaru Koide. Hemoperfusion with polymyxin B-immobilized fiber in septic patients with methicillin-resistant Staphylococcus aureus-associated glomerulonephritis. Nephron. Clinical practice. 2003; 94(2):c33-9. doi: 10.1159/000071279. [PMID: 12845235]
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  • Thomas Sudhop, Klaus von Bergmann. Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia. Drugs. 2002; 62(16):2333-47. doi: 10.2165/00003495-200262160-00002. [PMID: 12396226]
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