Prazosin hydrochloride (BioDeep_00000745003)
代谢物信息卡片
Prazosin hydrochloride
化学式: C19H22ClN5O4 (419.13602420000007)
中文名称: 盐酸哌唑嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Prazosin hydrochloride is a well-tolerated, CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders[1]. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM[2].Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13 μM, respectively[3].
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:8365
- KEGGdrug: D00609
- PubChem: 68546
- ChEMBL: CHEMBL1558
- MeSH: Prazosin
- CAS: 19237-84-4
- medchemexpress: HY-B0193A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ben A Chindo, Melanie-Jayne R Howes, Sawsan Abuhamdah, Danjuma Mallam, Timothy Micah, Rosemary I Awotula, Robin Battison, Paul L Chazot. Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.
Journal of ethnopharmacology.
2024 Mar; 321(?):117500. doi:
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Drug research.
2023 Mar; ?(?):. doi:
10.1055/a-2015-7976. [PMID: 36940722] - Zahra Malekinejad, Shadi Aghajani, Mostafa Jeddi, Reihane Qahremani, Sina Shahbazi, Yasin Bagheri, Elham Ahmadian. Prazosin Treatment Protects Brain and Heart by Diminishing Oxidative Stress and Apoptotic Pathways After Renal Ischemia Reperfusion.
Drug research.
2022 Jul; 72(6):336-342. doi:
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Current drug delivery.
2022; 19(4):508-517. doi:
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International journal of clinical pharmacology and therapeutics.
2022 Jan; 60(1):57-66. doi:
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Human & experimental toxicology.
2021 Aug; 40(8):1263-1273. doi:
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Urology journal.
2021 Apr; 18(3):337-342. doi:
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2020 Jan; 58(2):178-186. doi:
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Luminescence : the journal of biological and chemical luminescence.
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Materials science & engineering. C, Materials for biological applications.
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2016 Sep; 16(3):212-217. doi:
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2015; 10(3):254-6. doi:
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Journal of ethnopharmacology.
2014 Dec; 158 Pt A(?):123-31. doi:
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Indian journal of pharmacology.
2014 Nov; 46(6):644-8. doi:
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The international journal of neuropsychopharmacology.
2014 Oct; 18(1):. doi:
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Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2014 Oct; 78(4):304-15. doi:
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Endocrinology.
2014 Aug; 155(8):2845-57. doi:
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Molecular and cellular biochemistry.
2014 Jul; 392(1-2):205-11. doi:
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JPMA. The Journal of the Pakistan Medical Association.
2014 Jun; 64(6):683-5. doi:
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Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2014 Mar; 30(2):184-8. doi:
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The Journal of veterinary medical science.
2014 Mar; 76(2):173-82. doi:
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Molecular and cellular biochemistry.
2014 Mar; 388(1-2):135-47. doi:
10.1007/s11010-013-1905-2. [PMID: 24287564] - Sae Uchida, Fusako Kagitani. Effects of electrical stimulation of autonomic nerves to the ovary on the ovarian testosterone secretion rate in rats.
Autonomic neuroscience : basic & clinical.
2014 Feb; 180(?):48-52. doi:
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Journal of cellular and molecular medicine.
2014 Feb; 18(2):263-73. doi:
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Journal of cardiovascular pharmacology.
2014 Jan; 63(1):9-15. doi:
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Colloids and surfaces. B, Biointerfaces.
2013 Dec; 112(?):171-6. doi:
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Journal of pharmaceutical and biomedical analysis.
2013 Jul; 81-82(?):50-5. doi:
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British journal of pharmacology.
2013 May; 169(1):230-8. doi:
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Andrologia.
2013 Apr; 45(2):128-34. doi:
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Life sciences.
2013 Feb; 92(2):125-30. doi:
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Experimental physiology.
2013 Feb; 98(2):451-61. doi:
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Chirality.
2012 Dec; 24(12):1047-50. doi:
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American journal of physiology. Heart and circulatory physiology.
2012 Oct; 303(8):H1022-34. doi:
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Bioelectrochemistry (Amsterdam, Netherlands).
2012 Oct; 87(?):96-103. doi:
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Canadian journal of physiology and pharmacology.
2012 Aug; 90(8):1087-93. doi:
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The Journal of biological chemistry.
2012 Apr; 287(16):12952-65. doi:
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Behavioural brain research.
2012 Mar; 228(1):66-73. doi:
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Alcoholism, clinical and experimental research.
2012 Feb; 36(2):351-60. doi:
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Pharmacology.
2012; 90(5-6):242-6. doi:
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The Journal of nutritional biochemistry.
2012 Jan; 23(1):76-84. doi:
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Pharmacological reports : PR.
2012; 64(4):796-807. doi:
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Planta medica.
2011 Dec; 77(18):1990-5. doi:
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Bulletin of experimental biology and medicine.
2011 Dec; 152(2):249-52. doi:
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Journal of receptor and signal transduction research.
2011 Oct; 31(5):374-80. doi:
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Bioorganic & medicinal chemistry letters.
2011 Oct; 21(19):5905-9. doi:
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Circulation. Cardiovascular interventions.
2011 Oct; 4(5):481-7. doi:
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The Cochrane database of systematic reviews.
2011 Sep; ?(9):CD003851. doi:
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Journal of pharmaceutical sciences.
2011 Aug; 100(8):3055-3061. doi:
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The journal of physiological sciences : JPS.
2011 May; 61(3):247-51. doi:
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