Nimustine HCL (BioDeep_00000744674)
Secondary id: BioDeep_00001899778
代谢物信息卡片
nimustine hydrochloride
化学式: C9H14Cl2N6O2 (308.05552439999997)
中文名称: 盐酸尼莫司汀, 尼莫司汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC=C(C(=N1)N)CNC(=O)N(CCCl)N=O.Cl
InChI: 1H
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:7576
- KEGGdrug: D01059
- PubChem: 91657
- ChEMBL: CHEMBL1256616
- MeSH: Nimustine
- CAS: 52208-23-8
- CAS: 55661-38-6
- KEGG: C11276
- PubChem: 13453
- NIKKAJI: J239.129E
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dong-Yi Yang, Xue Cheng, Xing-Yao Bu, Zhao-Yue Yan, Ming-Qi Qu, Yue-Wu Zhao, Ling-Fei Kong, Yao-Wei Wang, Jian-Chao Luo. Granulocyte-macrophage colony stimulating factor enhances efficacy of nimustine rendezvousing with temozolomide plus irradiation in patients with glioblastoma.
Technology and health care : official journal of the European Society for Engineering and Medicine.
2022 Oct; ?(?):. doi:
10.3233/thc-220194. [PMID: 36314174] - Makoto Akiyoshi, Masami Akiyoshi. A case of feline large granular lymphocyte lymphoma with complete remission and long survival by surgical resection and adjuvant nimustine administration.
Veterinary medicine and science.
2021 11; 7(6):2103-2107. doi:
10.1002/vms3.612. [PMID: 34405564] - Qinghao Zhang, Mei Gao, Guifen Luo, Xiaofeng Han, Wenjing Bao, Yanyan Cheng, Wang Tian, Maocai Yan, Guanlin Yang, Jing An. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction.
PloS one.
2016; 11(3):e0152407. doi:
10.1371/journal.pone.0152407. [PMID: 27014877] - N Morikawa, T Mori, T Abe, H Kawashima, M Takeyama, S Hori. Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy.
Biological & pharmaceutical bulletin.
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FEBS letters.
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European journal of clinical pharmacology.
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International journal of radiation oncology, biology, physics.
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Clinical cancer research : an official journal of the American Association for Cancer Research.
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1994 Mar; 21(4):539-42. doi:
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Stereotactic and functional neurosurgery.
1994; 63(1-4):154-9. doi:
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Japanese journal of cancer research : Gann.
1992 Jan; 83(1):121-6. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1990 Nov; 17(11):2247-52. doi:
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Cancer chemotherapy and pharmacology.
1990; 27(1):20-6. doi:
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No shinkei geka. Neurological surgery.
1989 Aug; 17(8):741-6. doi:
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Journal of chemotherapy (Florence, Italy).
1989 Jul; 1(4 Suppl):1183-4. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1988 Aug; 15(8 Pt 2):2405-9. doi:
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Japanese journal of cancer research : Gann.
1988 Apr; 79(4):509-16. doi:
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Journal of neurosurgery.
1987 Mar; 66(3):372-8. doi:
10.3171/jns.1987.66.3.0372. [PMID: 3469331] - F Fujita, M Fujita, T Hirai, T Taguchi. [Evaluation by multiple regression analysis of factors influencing the chemosensitivity of human tumors xenografted into nude mice].
Gan to kagaku ryoho. Cancer & chemotherapy.
1987 Mar; 14(3 Pt 1):618-25. doi:
NULL. [PMID: 2950823] - H Kaneko, T Yamakawa, Y Yamanaka, Y Sekizawa, S Togo, K Nishiyama, S Tsuchiya. [Clinical or experimental use of an anticancer drug-oil suspension and its characteristics].
Gan to kagaku ryoho. Cancer & chemotherapy.
1986 Jul; 13(7):2363-9. doi:
NULL. [PMID: 3015042] - M Kobayashi, K Imai, K Nakai, F Kumasaka, T Suzuki, Y Ito, H Yamanaka, S Sugihara. [Chemotherapy of renal cell carcinoma. 2. Combined chemotherapy using ACNU and VBL].
Hinyokika kiyo. Acta urologica Japonica.
1986 Mar; 32(3):375-83. doi:
NULL. [PMID: 3460318] - R A Joss, P Siegenthaler, C Ludwig, P Alberto, M M Castiglione, F Cavalli. Phase II trial of nimustine (ACNU; 3-[4-amino-2-methyl-5-pyrimidinyl) methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride) in patients with small cell carcinoma of the lung after failure on combination chemotherapy.
Investigational new drugs.
1986; 4(2):175-9. doi:
10.1007/bf00194599. [PMID: 3015827] - T Nishigaki, K Nakamura, T Kinoshita, H Kuwano, M Tanaka. Identification of major urinary metabolites of ACNU, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitroso urea hydrochloride in rats.
Journal of pharmacobio-dynamics.
1985 Jun; 8(6):401-8. doi:
10.1248/bpb1978.8.401. [PMID: 3863921] - F Nakanishi, M Sugiishi, T Ogasawara, I Sugiura, T Kinoshita, Y Ito, A Hoshino. [Combination chemotherapy with cyclophosphamide, adriamycin, cisplatin, nimustine(ACNU), and methotrexate (EACAM) in advanced adenocarcinoma of the lung].
Gan to kagaku ryoho. Cancer & chemotherapy.
1985 Jun; 12(6):1339-44. doi:
NULL. [PMID: 3859252] - Y Saito. [Long-term survival of patients with brain tumors treated with ACNU and PSK after surgery--with special reference to there immunological follow-up].
Gan to kagaku ryoho. Cancer & chemotherapy.
1984 Oct; 11(10):2185-92. doi:
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No shinkei geka. Neurological surgery.
1984 Jun; 12(7):795-805. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1984 May; 11(5):1056-63. doi:
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Journal of surgical oncology.
1984 Mar; 25(3):218-26. doi:
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No to shinkei = Brain and nerve.
1984 Mar; 36(3):221-6. doi:
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Cancer chemotherapy and pharmacology.
1984; 13(1):22-6. doi:
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Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology.
1984 Jan; 94(1):39-43. doi:
NULL. [PMID: 6433083] - K Muraoka. [ACNU delivery to malignant tumor tissue and serum--route of administration and combined use of phenobarbital].
No to shinkei = Brain and nerve.
1983 Dec; 35(12):1199-206. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1983 Sep; 10(9):1963-71. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1983 May; 10(5):1354-62. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1982 Sep; 9(9):1543-8. doi:
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Gan to kagaku ryoho. Cancer & chemotherapy.
1982 Aug; 9(8):1327-38. doi:
". [PMID: 6223595] - Y Saito, K Muraoka, M Takami, Y Hokama, T Hori. [Postoperative treatment of malignant brain tumors with ACNU and PSK-particularly immunological follow-up research].
Gan to kagaku ryoho. Cancer & chemotherapy.
1982 Jul; 9(6):1081-90. doi:
NULL. [PMID: 6964044] - M Fujii, T Ohnoshi, T Namba, I Kimura. [Inhibitory effect of antineoplastic agents on human cholinesterases].
Gan to kagaku ryoho. Cancer & chemotherapy.
1982 May; 9(5):831-5. doi:
. [PMID: 6964039] - M Domyo, M Ogawa, J Inagaki, N Horikoshi, K Ezaki, K Inoue, K Aiba, T Nagata, H Miyamoto. [A combination chemotherapy of ACNU and DTIC for advanced malignant melanoma].
Gan to kagaku ryoho. Cancer & chemotherapy.
1982 May; 9(5):874-9. doi:
. [PMID: 6964041] - H Kaneko, Y Sekizawa, A Ohashi, T Inuo, S Tsuchiya. [Physiological effects and antitumor efficiency of ACNU in postoperative patients with stomach cancer--an evaluation of the treatment combined with FT-207 or 5-FU dry syrup].
Gan to kagaku ryoho. Cancer & chemotherapy.
1982 Mar; 9(3):496-502. doi:
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Surgical neurology.
1981 Jun; 15(6):410-4. doi:
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Cancer treatment reports.
1980 Apr; 64(4-5):575-80. doi:
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