TFIIH Modulator19 (BioDeep_00000744510)
代谢物信息卡片
化学式: C12H8O2 (184.0524)
中文名称: 2-苯基-14-苯醌
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C2=CC(=O)C=CC2=O
InChI: InChI=1S/C12H8O2/c13-10-6-7-12(14)11(8-10)9-4-2-1-3-5-9/h1-8H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yu Miao, Yanling Wu, Yingjin Jin, Mengze Lei, Jixing Nan, Xue Wu. Benzoquinone derivatives with antioxidant activity inhibit activated hepatic stellate cells and attenuate liver fibrosis in TAA-induced mice.
Chemico-biological interactions.
2020 Feb; 317(?):108945. doi:
10.1016/j.cbi.2020.108945
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Journal of natural products.
2015 Aug; 78(8):1799-808. doi:
10.1021/acs.jnatprod.5b00246
. [PMID: 26192250] - Isabel Gómez-Betancur, Natalie Cortés, Dora Benjumea, Edison Osorio, Francisco León, Stephen J Cutler. Antinociceptive activity of extracts and secondary metabolites from wild growing and micropropagated plants of Renealmia alpinia.
Journal of ethnopharmacology.
2015 May; 165(?):191-7. doi:
10.1016/j.jep.2015.02.012
. [PMID: 25686780] - Sergio M Borghi, Thacyana T Carvalho, Larissa Staurengo-Ferrari, Miriam S N Hohmann, Phileno Pinge-Filho, Rubia Casagrande, Waldiceu A Verri. Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines.
Journal of natural products.
2013 Jun; 76(6):1141-9. doi:
10.1021/np400222v
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Biochemistry.
2012 Jan; 51(1):138-48. doi:
10.1021/bi200627j
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The Journal of pharmacology and experimental therapeutics.
2011 Feb; 336(2):468-78. doi:
10.1124/jpet.110.172817
. [PMID: 21036913] - H Păunescu, O A Coman, L Coman, I Ghiţă, S R Georgescu, F Drăghia, I Fulga. Cannabinoid system and cyclooxygenases inhibitors.
Journal of medicine and life.
2011 Jan; 4(1):11-20. doi:
"
. [PMID: 21505570] - Jason M Dwyer, Brian J Platt, Stacey J Sukoff Rizzo, Claudine M Pulicicchio, Caitlin Wantuch, Mei-Yi Zhang, Terri Cummons, Liza Leventhal, Corey N Bender, Jean Zhang, Dianne Kowal, Shendi Lu, S Johannes R Rajarao, Deborah L Smith, Adam D Shilling, Jianyao Wang, John Butera, Lynn Resnick, Sharon Rosenzweig-Lipson, Lee E Schechter, Chad E Beyer. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism.
The international journal of neuropsychopharmacology.
2010 Oct; 13(9):1193-205. doi:
10.1017/s1461145709991088
. [PMID: 20047711] - Qiang Wang, Camille L Hall, Mustafa Z Al-Adami, Qingfang He. IsiA is required for the formation of photosystem I supercomplexes and for efficient state transition in synechocystis PCC 6803.
PloS one.
2010 May; 5(5):e10432. doi:
10.1371/journal.pone.0010432
. [PMID: 20454661] - Tae Doo Kim, Ji Yun Lee, Bong Jae Cho, Tae Wook Park, Chang Jong Kim. The analgesic and anti-inflammatory effects of 7-oxosandaracopimaric acid isolated from the roots of Aralia cordata.
Archives of pharmacal research.
2010 Apr; 33(4):509-14. doi:
10.1007/s12272-010-0403-2
. [PMID: 20422358] - An T Vu, Stephen T Cohn, Puwen Zhang, Callain Y Kim, Paige E Mahaney, Jenifer A Bray, Grace H Johnston, Elizabeth J Koury, Scott A Cosmi, Darlene C Deecher, Valerie A Smith, James E Harrison, Liza Leventhal, Garth T Whiteside, Jeffrey D Kennedy, Eugene J Trybulski. 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors.
Journal of medicinal chemistry.
2010 Mar; 53(5):2051-62. doi:
10.1021/jm901559e
. [PMID: 20131864] - Alírica I Suárez, Reinaldo S Compagnone, Maria M Salazar-Bookaman, Stephen Tillett, Franco Delle Monache, Camilo Di Giulio, Gustavo Bruges. Antinociceptive and anti-inflammatory effects of Croton malambo bark aqueous extract.
Journal of ethnopharmacology.
2003 Sep; 88(1):11-4. doi:
10.1016/s0378-8741(03)00179-x
. [PMID: 12902046] - P Henschke, E Almstadt, S Lüttgert, K E Appel. Metabolites of the biocide o-phenylphenol generate oxidative DNA lesions in V 79 cells.
Archives of toxicology.
2000 Jan; 73(10-11):607-10. doi:
10.1007/s002040050014
. [PMID: 10663393] - A Freyberger, G H Degen. Inhibition of prostaglandin-H-synthase by o-phenylphenol and its metabolites.
Archives of toxicology.
1998 Oct; 72(10):637-44. doi:
10.1007/s002040050554
. [PMID: 9851679] - K Goto, H Ochi, Y Yasunaga, H Matsuyuki, T Imayoshi, H Kusuhara, T Okumoto. Analgesic effect of mofezolac, a non-steroidal anti-inflammatory drug, against phenylquinone-induced acute pain in mice.
Prostaglandins & other lipid mediators.
1998 Jul; 56(4):245-54. doi:
10.1016/s0090-6980(98)00054-9
. [PMID: 9777656] - H Kusuhara, H Matsuyuki, T Okumoto. Involvement of prostaglandins produced by cyclooxygenase-1 in murine visceronociception induced by phenylquinone.
Prostaglandins & other lipid mediators.
1998 Jan; 55(1):43-9. doi:
10.1016/s0090-6980(98)00004-5
. [PMID: 9661217] - E S Kwok, D A Eastmond. Effects of pH on nonenzymatic oxidation of phenylhydroquinone: potential role in urinary bladder carcinogenesis induced by o-phenylphenol in Fischer 344 rats.
Chemical research in toxicology.
1997 Jul; 10(7):742-9. doi:
10.1021/tx9700331
. [PMID: 9250407] - J Bonnet, N Kucharczyk, P Robineau, M Lonchampt, C Dacquet, D Regoli, J L Fauchère, E Canet. A water-soluble, stable dipeptide NK1 receptor-selective neurokinin receptor antagonist with potent in vivo pharmacological effects: S18523.
European journal of pharmacology.
1996 Aug; 310(1):37-46. doi:
10.1016/0014-2999(96)00362-7
. [PMID: 8880065] - D Mauleón, R Artigas, M L García, G Carganico. Preclinical and clinical development of dexketoprofen.
Drugs.
1996; 52 Suppl 5(?):24-45; discussion 45. doi:
10.2165/00003495-199600525-00005
. [PMID: 8922555] - A C Lambert, D A Eastmond. Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells.
Mutation research.
1994 Oct; 322(4):243-56. doi:
10.1016/0165-1218(94)90100-7
. [PMID: 7523918] - T J Carty, A Marfat, P F Moore, F C Falkner, T M Twomey, A Weissman. Ampiroxicam, an anti-inflammatory agent which is a prodrug of piroxicam.
Agents and actions.
1993 Jul; 39(3-4):157-65. doi:
10.1007/bf01998969
. [PMID: 8304243] - S Narayan, D Roy. Changes in protein and nonprotein thiol contents in bladder, kidney and liver of mice by the pesticide sodium-o-phenylphenol and their possible role in cellular toxicity.
Biochemistry international.
1992 Feb; 26(1):191-8. doi:
NULL
. [PMID: 1616494] - C Garret, A Carruette, V Fardin, S Moussaoui, J F Peyronel, J C Blanchard, P M Laduron. Pharmacological properties of a potent and selective nonpeptide substance P antagonist.
Proceedings of the National Academy of Sciences of the United States of America.
1991 Nov; 88(22):10208-12. doi:
10.1073/pnas.88.22.10208
. [PMID: 1719549] - R D Guiles, J L Zimmermann, A E McDermott, V K Yachandra, J L Cole, S L Dexheimer, R D Britt, K Wieghardt, U Bossek, K Sauer. The S3 state of photosystem II: differences between the structure of the manganese complex in the S2 and S3 states determined by X-ray absorption spectroscopy.
Biochemistry.
1990 Jan; 29(2):471-85. doi:
10.1021/bi00454a023
. [PMID: 2154247] - F Nagai, K Ushiyama, K Satoh, I Kano. DNA cleavage by phenylhydroquinone: the major metabolite of a fungicide o-phenylphenol.
Chemico-biological interactions.
1990; 76(2):163-79. doi:
10.1016/0009-2797(90)90086-3
. [PMID: 2171789] - K Morimoto, M Sato, M Fukuoka, R Hasegawa, T Takahashi, T Tsuchiya, A Tanaka, A Takahashi, Y Hayashi. Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet.
Carcinogenesis.
1989 Oct; 10(10):1823-7. doi:
10.1093/carcin/10.10.1823
. [PMID: 2791200] - T Fujiyoshi, I Hayashi, S Ohishi, M Kuwashima, H Iida, M Dozen, N Taniguchi, K Ikeda, H Ohnishi. Kaolin-induced writhing in mice, a new model of possible bradykinin-induced pain for assessment of analgesic agents.
Agents and actions.
1989 Jun; 27(3-4):332-4. doi:
10.1007/bf01972814
. [PMID: 2801319] - S N Okpanyi, R Schirpke-von Paczensky, D Dickson. [Anti-inflammatory, analgesic and antipyretic effect of various plant extracts and their combinations in an animal model].
Arzneimittel-Forschung.
1989 Jun; 39(6):698-703. doi:
"
. [PMID: 2476136] - M Amico-Roxas, A Caruso, M Cioni, R Scifo, M G Leone, U Scapagnini. Characterization of the antinociceptive effects of a ganglioside derivative in rodents.
Archives internationales de pharmacodynamie et de therapie.
1988 Jan; 291(?):238-52. doi:
NULL
. [PMID: 3259131] - M Amico-Roxas, A Caruso, S Trombadore, R Scifo, U Scapagnini. Gangliosides antinociceptive effects in rodents.
Archives internationales de pharmacodynamie et de therapie.
1984 Nov; 272(1):103-17. doi:
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. [PMID: 6097198] - P Schiantarelli, S Cadel, D Acerbi. A gastroprotective anti-inflammatory agent: the beta-morpholinoethyl ester of niflumic acid (morniflumate).
Agents and actions.
1984 Feb; 14(2):247-56. doi:
10.1007/bf01966649
. [PMID: 6608862] - M D Aceto, H Awaya, B R Martin, E L May. Antinociceptive action of nicotine and its methiodide derivatives in mice and rats.
British journal of pharmacology.
1983 Aug; 79(4):869-76. doi:
10.1111/j.1476-5381.1983.tb10531.x
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Pharmacology, biochemistry, and behavior.
1983 Jun; 18(6):885-9. doi:
10.1016/s0091-3057(83)80010-0
. [PMID: 6889417]