Perfluorooctyl iodide (BioDeep_00000744120)
代谢物信息卡片
Perfluorooctyl iodide
化学式: C8F17I (545.8773)
中文名称: 全氟辛基碘烷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(C(C(F)(F)I)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F
InChI: InChI=1S/C8F17I/c9-1(10,3(13,14)5(17,18)7(21,22)23)2(11,12)4(15,16)6(19,20)8(24,25)26
描述信息
D011838 - Radiation-Sensitizing Agents
D019440 - Anti-Obesity Agents
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Andrea Berni, Danilo Malandrino, Giovanni Corona, Mario Maggi, Gabriele Parenti, Benedetta Fibbi, Loredana Poggesi, Alessandro Bartoloni, Federico Lavorini, Andrea Fanelli, Giulia Scocchera, Carlo Nozzoli, Adriano Peris, Filippo Pieralli, Riccardo Pini, Andrea Ungar, Alessandro Peri. Serum sodium alterations in SARS CoV-2 (COVID-19) infection: impact on patient outcome.
European journal of endocrinology.
2021 May; 185(1):137-144. doi:
10.1530/eje-20-1447. [PMID: 33950864] - Veronica Swystun, Francis H Y Green, John H Dennis, Emmanouil Rampakakis, Gurkeet Lalli, Morenike Fadayomi, Andrea Chiu, Grishma Shrestha, Sharif Galal El Shahat, David Evan Nelson, Tamer Y El Mays, Cora A Pieron, Richard Leigh. A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma.
Trials.
2018 Jun; 19(1):321. doi:
10.1186/s13063-018-2720-6. [PMID: 29914544] - Xiao Li, Zhongguo Sui, Xin Li, Wen Xu, Qie Guo, Jialin Sun, Fanbo Jing. Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery.
International journal of nanomedicine.
2018; 13(?):3053-3067. doi:
10.2147/ijn.s164905. [PMID: 29872293] - Francis H Y Green, Richard Leigh, Morenike Fadayomi, Gurkeet Lalli, Andrea Chiu, Grishma Shrestha, Sharif G ElShahat, David Evan Nelson, Tamer Y El Mays, Cora A Pieron, John H Dennis. A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers.
Trials.
2016 07; 17(?):361. doi:
10.1186/s13063-016-1489-8. [PMID: 27464582] - Tamer Y El Mays, Parichita Choudhury, Richard Leigh, Emmanuel Koumoundouros, Joanne Van der Velden, Grishma Shrestha, Cora A Pieron, John H Dennis, Francis Hy Green, Ken J Snibson. Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma.
Respiratory research.
2014 Sep; 15(?):98. doi:
10.1186/s12931-014-0098-x. [PMID: 25355286] - Xiao Li, Fei Qin, Li Yang, Liqian Mo, Lei Li, Lianbing Hou. Sulfatide-containing lipid perfluorooctylbromide nanoparticles as paclitaxel vehicles targeting breast carcinoma.
International journal of nanomedicine.
2014; 9(?):3971-85. doi:
10.2147/ijn.s67343. [PMID: 25170267] - Melissa L Hill, Ivan Gorelikov, Farnaz Niroui, Ronald B Levitin, James G Mainprize, Martin J Yaffe, J A Rowlands, Naomi Matsuura. Towards a nanoscale mammographic contrast agent: development of a modular pre-clinical dual optical/x-ray agent.
Physics in medicine and biology.
2013 Aug; 58(15):5215-35. doi:
10.1088/0031-9155/58/15/5215. [PMID: 23851978] - Allison E McDonald, Alex G Ivanov, Rainer Bode, Denis P Maxwell, Steven R Rodermel, Norman P A Hüner. Flexibility in photosynthetic electron transport: the physiological role of plastoquinol terminal oxidase (PTOX).
Biochimica et biophysica acta.
2011 Aug; 1807(8):954-67. doi:
10.1016/j.bbabio.2010.10.024. [PMID: 21056542] - Sun-Joo Lee, Brett Olsen, Paul H Schlesinger, Nathan A Baker. Characterization of perfluorooctylbromide-based nanoemulsion particles using atomistic molecular dynamics simulations.
The journal of physical chemistry. B.
2010 Aug; 114(31):10086-96. doi:
10.1021/jp103228c. [PMID: 20684632] - R Díaz-López, D Libong, N Tsapis, E Fattal, P Chaminade. Quantification of pegylated phospholipids decorating polymeric microcapsules of perfluorooctyl bromide by reverse phase HPLC with a charged aerosol detector.
Journal of pharmaceutical and biomedical analysis.
2008 Nov; 48(3):702-7. doi:
10.1016/j.jpba.2008.06.027. [PMID: 18818041] - J N Marsh, A Senpan, G Hu, M J Scott, P J Gaffney, S A Wickline, G M Lanza. Fibrin-targeted perfluorocarbon nanoparticles for targeted thrombolysis.
Nanomedicine (London, England).
2007 Aug; 2(4):533-43. doi:
10.2217/17435889.2.4.533. [PMID: 17716136] - Neelesh R Soman, Jon N Marsh, Michael S Hughes, Gregory M Lanza, Samuel A Wickline. Acoustic activation of targeted liquid perfluorocarbon nanoparticles does not compromise endothelial integrity.
IEEE transactions on nanobioscience.
2006 Jun; 5(2):69-75. doi:
10.1109/tnb.2006.875052. [PMID: 16805101] - Gregor I Kemming, Franz G Meisner, Christoph J Wojtczyk, Kristian B Packert, Thomas Minor, Manfred Thiel, Jochen Tillmanns, Jens Meier, Daniel Bottino, Peter E Keipert, Simon Faithfull, Oliver P Habler. Oxygent as a top load to colloid and hyperoxia is more effective in resuscitation from hemorrhagic shock than colloid and hyperoxia alone.
Shock (Augusta, Ga.).
2005 Sep; 24(3):245-54. doi:
10.1097/01.shk.0000176184.51676.89. [PMID: 16135964] - Yutaka Makino. [Effects of perfluorochemicals on severe hemo-diluted cardiopulmonary bypass in dogs].
[Hokkaido igaku zasshi] The Hokkaido journal of medical science.
2004 Jan; 79(1):41-6. doi:
NULL. [PMID: 14978973] - Markus Paxian, Steve A Keller, Toan T Huynh, Mark G Clemens. Perflubron emulsion improves hepatic microvascular integrity and mitochondrial redox state after hemorrhagic shock.
Shock (Augusta, Ga.).
2003 Nov; 20(5):449-57. doi:
10.1097/01.shk.0000090601.26659.87. [PMID: 14560110] - Markus Paxian, Hauke Rensing, Katrin Geckeis, Inge Bauer, Darius Kubulus, Donat R Spahn, Michael Bauer. Perflubron emulsion in prolonged hemorrhagic shock: influence on hepatocellular energy metabolism and oxygen-dependent gene expression.
Anesthesiology.
2003 Jun; 98(6):1391-9. doi:
10.1097/00000542-200306000-00014. [PMID: 12766648] - Alexandre T Rotta, Björn Gunnarsson, Bradley P Fuhrman, Budi Wiryawan, Lynn J Hernan, David M Steinhorn. Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2003 Apr; 4(2):233-8. doi:
10.1097/01.pcc.0000059729.21375.d0. [PMID: 12749658] - Cynthia Cox, Robert L Stavis, Marla R Wolfson, Thomas H Shaffer. Long-term tidal liquid ventilation in premature lambs: physiologic, biochemical and histological correlates.
Biology of the neonate.
2003; 84(3):232-42. doi:
10.1159/000072307. [PMID: 14504447] - Jeffrey F Ellena, Viktor V Obraztsov, Valerie L Cumbea, Catherine M Woods, David S Cafiso. Perfluorooctyl bromide has limited membrane solubility and is located at the bilayer center. Locating small molecules in lipid bilayers through paramagnetic enhancements of NMR relaxation.
Journal of medicinal chemistry.
2002 Dec; 45(25):5534-42. doi:
10.1021/jm020278x. [PMID: 12459021] - Daniel J Weiss, Gary B Baskin, Mary K Shean, James L Blanchard, Jay K Kolls. Use of perflubron to enhance lung gene expression: safety and initial efficacy studies in non-human primates.
Molecular therapy : the journal of the American Society of Gene Therapy.
2002 Jan; 5(1):8-15. doi:
10.1006/mthe.2001.0507. [PMID: 11786040] - D K Kaul, X Liu, R L Nagel. Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature.
Blood.
2001 Nov; 98(10):3128-31. doi:
10.1182/blood.v98.10.3128. [PMID: 11698300] - D J Smith, L M Gambone, T Tarara, D R Meays, L A Dellamary, C M Woods, J Weers. Liquid dose pulmonary instillation of gentamicin PulmoSpheres formulations: tissue distribution and pharmacokinetics in rabbits.
Pharmaceutical research.
2001 Nov; 18(11):1556-61. doi:
10.1023/a:1013078330485. [PMID: 11758763] - C Reickert, T Pranikoff, M Overbeck, E Kazerooni, K Massey, R Bartlett, R Hirschl. The pulmonary and systemic distribution and elimination of perflubron from adult patients treated with partial liquid ventilation.
Chest.
2001 Feb; 119(2):515-22. doi:
10.1378/chest.119.2.515. [PMID: 11171732] - B Nakstad, M R Wolfson, T Aspelin, R Lindemann, T H Shaffer, D Fugelseth, T Lyberg. Perfluorochemical liquids do not stimulate endothelin-1 or nitric oxide production in human blood leukocytes.
Biology of the neonate.
2001; 80(4):267-72. doi:
10.1159/000047155. [PMID: 11641549] - D Nolte, S Pickelmann, M Lang, P Keipert, K Messmer. Compatibility of different colloid plasma expanders with perflubron emulsion: an intravital microscopic study in the hamster.
Anesthesiology.
2000 Nov; 93(5):1261-70. doi:
10.1097/00000542-200011000-00020. [PMID: 11046215] - R J Noveck, E J Shannon, P T Leese, J S Shorr, K E Flaim, P E Keipert, C M Woods. Randomized safety studies of intravenous perflubron emulsion. II. Effects on immune function in healthy volunteers.
Anesthesia and analgesia.
2000 Oct; 91(4):812-22. doi:
10.1097/00000539-200010000-00009. [PMID: 11004031] - V V Obraztsov, G G Neslund, E S Kornbrust, S F Flaim, C M Woods. In vitro cellular effects of perfluorochemicals correlate with their lipid solubility.
American journal of physiology. Lung cellular and molecular physiology.
2000 May; 278(5):L1018-24. doi:
10.1152/ajplung.2000.278.5.l1018. [PMID: 10781433] - K Kawamae, G Pristine, D Chiumello, L N Tremblay, A S Slutsky. Partial liquid ventilation decreases serum tumor necrosis factor-alpha concentrations in a rat acid aspiration lung injury model.
Critical care medicine.
2000 Feb; 28(2):479-83. doi:
10.1097/00003246-200002000-00032. [PMID: 10708187] - A T Rotta, B Gunnarsson, L J Hernan, B P Fuhrman, D M Steinhorn. Partial liquid ventilation with perflubron attenuates in vivo oxidative damage to proteins and lipids.
Critical care medicine.
2000 Jan; 28(1):202-8. doi:
10.1097/00003246-200001000-00033. [PMID: 10667523] - A B Cullen, C A Cox, S J Hipp, M R Wolfson, T H Shaffer. Intra-tracheal delivery strategy of gentamicin with partial liquid ventilation.
Respiratory medicine.
1999 Nov; 93(11):770-8. doi:
10.1016/s0954-6111(99)90261-5. [PMID: 10603625] - A P Shepherd, J M Steinke. CO-oximetry interference by perflubron emulsion: comparison of hemolyzing and nonhemolyzing instruments.
Clinical chemistry.
1998 Oct; 44(10):2183-90. doi:
10.1093/clinchem/44.10.2183. [PMID: 9761254] - D M Colton, G O Till, K J Johnson, J J Gater, R B Hirschl. Partial liquid ventilation decreases albumin leak in the setting of acute lung injury.
Journal of critical care.
1998 Sep; 13(3):136-9. doi:
10.1016/s0883-9441(98)90017-x. [PMID: 9758028] - C J Henry, J W Tyler, T Fields, W G Brewer, N Royer. Accuracy of fluorocrit in determination of blood perflubron concentration.
Artificial cells, blood substitutes, and immobilization biotechnology.
1998 May; 26(3):285-92. doi:
10.3109/10731199809117459. [PMID: 9635121] - O P Habler, M S Kleen, J W Hutter, A H Podtschaske, M Tiede, G I Kemming, M V Welte, C O Corso, S Batra, P E Keipert, N S Faithfull, K F Messmer. Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs.
Transfusion.
1998 Feb; 38(2):145-55. doi:
10.1046/j.1537-2995.1998.38298193096.x. [PMID: 9531945] - Z Ma, T G Monk, L T Goodnough, A McClellan, M Gawryl, T Clark, P Moreira, P E Keipert, M G Scott. Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests.
Clinical chemistry.
1997 Sep; 43(9):1732-7. doi:
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Transplantation proceedings.
1997 Feb; 29(1-2):1322-3. doi:
10.1016/s0041-1345(96)00576-3. [PMID: 9123324] - P E Keipert. Use of Oxygent, a perfluorochemical-based oxygen carrier, as an alternative to intraoperative blood transfusion.
Artificial cells, blood substitutes, and immobilization biotechnology.
1995; 23(3):381-94. doi:
10.3109/10731199509117954. [PMID: 7493059] - C J Henry, W G Brewer, R A Henderson, W R Brawner. Pharmacokinetics and tolerance of weekly OXYGENT CA infusions in the dog.
Artificial cells, blood substitutes, and immobilization biotechnology.
1994; 22(4):1155-60. doi:
10.3109/10731199409138810. [PMID: 7849917] - L Brasile, P DelVecchio, K Amyot, C Haisch, J Clarke. Organ preservation without extreme hypothermia using an Oxygen supplemented perfusate.
Artificial cells, blood substitutes, and immobilization biotechnology.
1994; 22(4):1463-8. doi:
10.3109/10731199409138851. [PMID: 7849958] - L Brasile, P DelVecchio, U Rudofsky, C Haisch, J Clarke. Postmortem organ salvage using an Oxygen supplemented perfusate.
Artificial cells, blood substitutes, and immobilization biotechnology.
1994; 22(4):1469-75. doi:
10.3109/10731199409138852. [PMID: 7849959] - P E Keipert, N S Faithfull, J D Bradley, D Y Hazard, J Hogan, M S Levisetti, R M Peters. Enhanced oxygen delivery by perflubron emulsion during acute hemodilution.
Artificial cells, blood substitutes, and immobilization biotechnology.
1994; 22(4):1161-7. doi:
10.3109/10731199409138811. [PMID: 7849918] - D J Smith, E S Kornbrust, T A Lane. Phagocytosis of a fluorescently labeled perflubron emulsion by a human monocyte cell line.
Artificial cells, blood substitutes, and immobilization biotechnology.
1994; 22(4):1215-21. doi:
10.3109/10731199409138818. [PMID: 7849925] - S F Flaim, D R Hazard, J Hogan, R M Peters. Characterization and mechanism of side-effects of Oxygent HT (highly concentrated fluorocarbon emulsion) in swine.
Artificial cells, blood substitutes, and immobilization biotechnology.
1994; 22(4):1511-5. doi:
10.3109/10731199409138857. [PMID: 7849964] - R Satterfield, V M Tarter, D J Schumacher, P Tran, R F Mattrey. Comparison of different perfluorocarbons as ultrasound contrast agents.
Investigative radiology.
1993 Apr; 28(4):325-31. doi:
10.1097/00004424-199304000-00013. [PMID: 8478173] - M Behan, D O'Connell, R F Mattrey, D N Carney. Perfluorooctylbromide as a contrast agent for CT and sonography: preliminary clinical results.
AJR. American journal of roentgenology.
1993 Feb; 160(2):399-405. doi:
10.2214/ajr.160.2.8424361. [PMID: 8424361] - D J Smith, T A Lane. Effect of high concentration perflubron emulsion on platelet function.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology.
1993; 21(2):173-81. doi:
10.3109/10731199309117355. [PMID: 8318610] - M C Hogan, D C Willford, P E Keipert, N S Faithfull, P D Wagner. Increased plasma O2 solubility improves O2 uptake of in situ dog muscle working maximally.
Journal of applied physiology (Bethesda, Md. : 1985).
1992 Dec; 73(6):2470-5. doi:
10.1152/jappl.1992.73.6.2470. [PMID: 1490960] - D J Smith, T A Lane. Effect of a high concentration perfluorocarbon emulsion on platelet function.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology.
1992; 20(2-4):1045-9. doi:
10.3109/10731199209119761. [PMID: 1391425] - G P Biro, N Jing, P J Anderson. Studies on blood substitutes based on hemoglobin and perfluorocarbon.
Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology.
1992; 20(2-4):1013-20. doi:
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Kidney international.
1991 Apr; 39(4):733-9. doi:
10.1038/ki.1991.89. [PMID: 2051731] - B D Coley, R F Mattrey, A Roberts, S Keane. Potential role of PFOB enhanced sonography of the kidney. II. Detection of partial infarction.
Kidney international.
1991 Apr; 39(4):740-5. doi:
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Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
1991; 20 Suppl 1(?):59-64. doi:
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Investigative radiology.
1990 Dec; 25(12):1287-93. doi:
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Investigative radiology.
1990 Sep; 25 Suppl 1(?):S158-9. doi:
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Vestnik Akademii meditsinskikh nauk SSSR.
1990; ?(8):37-41. doi:
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Journal of computer assisted tomography.
1984 Aug; 8(4):739-44. doi:
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Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.
1983 Apr; 2(4):173-6. doi:
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Radiology.
1982 Dec; 145(3):759-62. doi:
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Investigative radiology.
1982 Jan; 17(1):41-5. doi:
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