Procaine penicillin (BioDeep_00000744081)

   


代谢物信息卡片


Penicillin G Procaine

化学式: C29H40N4O7S (588.261757)
中文名称: 青霉素G普鲁卡因水合物
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCOC(=O)C1=CC=C(C=C1)N.CC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)O)C.O
InChI: /m1../s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

2 个代谢物同义名

Penicillin G Procaine; Procaine penicillin



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shelia B Dunaway, Clare L Maxwell, Lauren C Tantalo, Sharon K Sahi, Christina M Marra. Neurosyphilis Treatment Outcomes After Intravenous Penicillin G Versus Intramuscular Procaine Penicillin Plus Oral Probenecid. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 07; 71(2):267-273. doi: 10.1093/cid/ciz795. [PMID: 31504293]
  • Jarrod T Younkin, Elizabeth M Santschi, Butch Kukanich, Brian V Lubbers, Matthew Warner. Evaluation of plasma concentration after intravenous and intramuscular penicillin administration over 24 hr in healthy adult horses. Journal of veterinary pharmacology and therapeutics. 2019 Mar; 42(2):239-242. doi: 10.1111/jvp.12730. [PMID: 30387161]
  • Mohamed Zeineldin, Brian Aldridge, Benjamin Blair, Katherine Kancer, James Lowe. Impact of parenteral antimicrobial administration on the structure and diversity of the fecal microbiota of growing pigs. Microbial pathogenesis. 2018 May; 118(?):220-229. doi: 10.1016/j.micpath.2018.03.035. [PMID: 29578067]
  • Aimal Khan, Tanveer Ahmed, Muhammad Rizwan, Najma Khan. Comparative therapeutic efficacy of Phyllanthus emblica (Amla) fruit extract and procaine penicillin in the treatment of subclinical mastitis in dairy buffaloes. Microbial pathogenesis. 2018 Feb; 115(?):8-11. doi: 10.1016/j.micpath.2017.12.038. [PMID: 29253597]
  • Fatima Mir, Imran Nisar, Shiyam S Tikmani, Benazir Baloch, Sadia Shakoor, Fyezah Jehan, Imran Ahmed, Simon Cousens, Anita K M Zaidi. Simplified antibiotic regimens for treatment of clinical severe infection in the outpatient setting when referral is not possible for young infants in Pakistan (Simplified Antibiotic Therapy Trial [SATT]): a randomised, open-label, equivalence trial. The Lancet. Global health. 2017 02; 5(2):e177-e185. doi: 10.1016/s2214-109x(16)30335-7. [PMID: 27988146]
  • Antoinette Tshefu, Adrien Lokangaka, Serge Ngaima, Cyril Engmann, Fabian Esamai, Peter Gisore, Adejumoke Idowu Ayede, Adegoke Gbadegesin Falade, Ebunoluwa A Adejuyigbe, Chineme Henry Anyabolu, Robinson D Wammanda, Clara L Ejembi, William N Ogala, Lu Gram, Simon Cousens. Simplified antibiotic regimens compared with injectable procaine benzylpenicillin plus gentamicin for treatment of neonates and young infants with clinical signs of possible serious bacterial infection when referral is not possible: a randomised, open-label, equivalence trial. Lancet (London, England). 2015 May; 385(9979):1767-1776. doi: 10.1016/s0140-6736(14)62284-4. [PMID: 25842221]
  • Abdullah H Baqui, Samir K Saha, A S M Nawshad Uddin Ahmed, Mohammad Shahidullah, Iftekhar Quasem, Daniel E Roth, A K M Samsuzzaman, Wazir Ahmed, S M Shahnawaz Bin Tabib, Dipak K Mitra, Nazma Begum, Maksuda Islam, Arif Mahmud, Mohammad Hefzur Rahman, Mamun Ibne Moin, Luke C Mullany, Simon Cousens, Shams El Arifeen, Stephen Wall, Neal Brandes, Mathuram Santosham, Robert E Black. Safety and efficacy of alternative antibiotic regimens compared with 7 day injectable procaine benzylpenicillin and gentamicin for outpatient treatment of neonates and young infants with clinical signs of severe infection when referral is not possible: a randomised, open-label, equivalence trial. The Lancet. Global health. 2015 May; 3(5):e279-87. doi: 10.1016/s2214-109x(14)70347-x. [PMID: 25841891]
  • Marcio C Costa, Henry R Stämpfli, Luis G Arroyo, Emma Allen-Vercoe, Roberta G Gomes, J Scott Weese. Changes in the equine fecal microbiota associated with the use of systemic antimicrobial drugs. BMC veterinary research. 2015 Feb; 11(?):19. doi: 10.1186/s12917-015-0335-7. [PMID: 25644524]
  • S J Lupton, W L Shelver, D J Newman, S Larsen, D J Smith. Depletion of penicillin G residues in heavy sows after intramuscular injection. Part I: tissue residue depletion. Journal of agricultural and food chemistry. 2014 Jul; 62(30):7577-85. doi: 10.1021/jf501492v. [PMID: 25025185]
  • Weilin L Shelver, Sara J Lupton, David J Newman, Steven Larsen, David J Smith. Depletion of penicillin G residues in heavy sows after intramuscular injection. Part II: application of kidney inhibition swab tests. Journal of agricultural and food chemistry. 2014 Jul; 62(30):7586-92. doi: 10.1021/jf501494w. [PMID: 25029357]
  • Lena Olsén, Hanna Bremer, Karin Olofsson, Johan Bröjer, Ulf Bondesson, Anna Bergh, Katarina Nostell, Hans Broström, Björn Bengtsson, Carina Ingvast-Larsson. Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin. Research in veterinary science. 2013 Aug; 95(1):212-8. doi: 10.1016/j.rvsc.2013.01.019. [PMID: 23419937]
  • Jeffrey J Post, Candice Khor, Virginia Furner, Don E Smith, L Ross Whybin, Peter W Robertson. Case report and evaluation of the frequency of the prozone phenomenon in syphilis serology - an infrequent but important laboratory phenomenon. Sexual health. 2012 Nov; 9(5):488-90. doi: 10.1071/sh11156. [PMID: 22958508]
  • Sabine Mann, Julie D Siler, David Jordan, Lorin D Warnick. Antimicrobial susceptibility of fecal Escherichia coli isolates in dairy cows following systemic treatment with ceftiofur or penicillin. Foodborne pathogens and disease. 2011 Aug; 8(8):861-7. doi: 10.1089/fpd.2010.0751. [PMID: 21381922]
  • Peter Busk, Stine Jacobsen, T Martinussen. Administration of perioperative penicillin reduces postoperative serum amyloid A response in horses being castrated standing. Veterinary surgery : VS. 2010 Jul; 39(5):638-43. doi: 10.1111/j.1532-950x.2010.00704.x. [PMID: 20459482]
  • A L Chicoine, J O Boison, S Parker, C Clark, P M Dowling. Kinetics and residues after intraperitoneal procaine penicillin G administration in lactating dairy cows. Journal of veterinary pharmacology and therapeutics. 2009 Jun; 32(3):289-95. doi: 10.1111/j.1365-2885.2008.01040.x. [PMID: 19646094]
  • Rong-lian Zhang, Qi-yan Chen, Lie-ping Chen, Xiu-yun Wang, Li-ping Zhang, Xiao-yan Xiu, Na Yang, Xiao-zhen Bao. [Study on interventional methods and the pattern of maternal-fetal transmission of syphilis during pregnancy]. Zhonghua fu chan ke za zhi. 2007 Jul; 42(7):438-42. doi: NULL. [PMID: 17961330]
  • Elizabeth Doré, Gilles Fecteau, Pierre Hélie, David Francoz. Liver abscesses in Holstein dairy cattle: 18 cases (1992-2003). Journal of veterinary internal medicine. 2007 Jul; 21(4):853-6. doi: NULL. [PMID: 17708409]
  • L Olsén, C Ingvast-Larsson, H Broström, P Larsson, H Tjälve. Clinical signs and etiology of adverse reactions to procaine benzylpenicillin and sodium/potassium benzylpenicillin in horses. Journal of veterinary pharmacology and therapeutics. 2007 Jun; 30(3):201-7. doi: 10.1111/j.1365-2885.2007.00851.x. [PMID: 17472651]
  • P Gaig, M J Paniagua. [Hoigne's syndrome]. Allergologia et immunopathologia. 2005 Jan; 33(1):57-8. doi: 10.1157/13070611. [PMID: 15777526]
  • N H Smith, D M Musher, D B Huang, P S Rodriguez, M E Dowell, W Ace, A C White. Response of HIV-infected patients with asymptomatic syphilis to intensive intramuscular therapy with ceftriaxone or procaine penicillin. International journal of STD & AIDS. 2004 May; 15(5):328-32. doi: 10.1177/095646240401500511. [PMID: 15117503]
  • C A Rogers, A C Fitzgerald, M A Carr, B R Covey, J D Thomas, M L Looper. On-farm management decisions to improve beef quality of market dairy cows. Journal of dairy science. 2004 May; 87(5):1558-64. doi: 10.3168/jds.s0022-0302(04)73308-1. [PMID: 15291006]
  • B Ranheim, H Ween, A K Egeli, V Hormazabal, M Yndestad, N E Søli. Benzathine penicillin G and procaine penicillin G in piglets: comparison of intramuscular and subcutaneous injection. Veterinary research communications. 2002 Aug; 26(6):459-65. doi: 10.1023/a:1020590408947. [PMID: 12241099]
  • P Dubreuil, J Daigneault, Y Couture, P Guay, D Landry. Penicillin concentrations in serum, milk, and urine following intramuscular and subcutaneous administration of increasing doses of procaine penicillin G in lactating dairy cows. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2001 Jul; 65(3):173-80. doi: NULL. [PMID: 11480523]
  • J M Musser, K L Anderson. Bioavailability and disposition of sodium and procaine penicillin G (benzylpenicillin) administered orally with milk to calves. Journal of veterinary pharmacology and therapeutics. 2001 Jun; 24(3):161-9. doi: 10.1046/j.1365-2885.2001.00325.x. [PMID: 11442793]
  • C E Uboh, L R Soma, Y Luo, E McNamara, M A Fennell, L May, D C Teleis, J A Rudy, A O Watson. Pharmacokinetics of penicillin G procaine versus penicillin G potassium and procaine hydrochloride in horses. American journal of veterinary research. 2000 Jul; 61(7):811-5. doi: 10.2460/ajvr.2000.61.811. [PMID: 10895905]
  • C Salgado Legorreta, F Martínez Zurita, G Alarcón Santos, S Martínez Cairo. [Effect of naproxen sodium on serum concentrations of IL-1, IL-6, and TNF in patients with acute, purulent pharyngo-tonsillitis]. Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993). 1999 May; 46(3):78-82. doi: NULL. [PMID: 10425885]
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  • B I Smith, G A Donovan, C Risco, R Littell, C Young, L H Stanker, J Elliott. Comparison of various antibiotic treatments for cows diagnosed with toxic puerperal metritis. Journal of dairy science. 1998 Jun; 81(6):1555-62. doi: 10.3168/jds.s0022-0302(98)75721-2. [PMID: 9684161]
  • C Cabellos, J Ariza, B Barreiro, F Tubau, J Liñares, R Pallarés, F Manresa, F Gudiol. Current usefulness of procaine penicillin in the treatment of pneumococcal pneumonia. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 1998 Apr; 17(4):265-8. doi: 10.1007/bf01699983. [PMID: 9707309]
  • G Hirsbrunner, J Lang, J Nicolet, A Steiner. [Nephrectomy for chronic, unilateral suppurative pyleonephritis in cattle]. Tierarztliche Praxis. 1996 Feb; 24(1):17-21. doi: NULL. [PMID: 8720950]
  • S G Paryani, A J Vaughn, M Crosby, S Lawrence. Treatment of asymptomatic congenital syphilis: benzathine versus procaine penicillin G therapy. The Journal of pediatrics. 1994 Sep; 125(3):471-5. doi: 10.1016/s0022-3476(05)83300-1. [PMID: 8071762]
  • M G Papich, G O Korsrud, J O Boison, W D Yates, J D MacNeil, E D Janzen, J J McKinnon, D A Landry. Disposition of penicillin G after administration of benzathine penicillin G, or a combination of benzathine penicillin G and procaine penicillin G in cattle. American journal of veterinary research. 1994 Jun; 55(6):825-30. doi: NULL. [PMID: 7944023]
  • G O Korsrud, J O Boison, M G Papich, W D Yates, J D MacNeil, E D Janzen, J J McKinnon, D A Landry, G Lambert, M S Yong. Depletion of penicillin G residues in tissues and injection sites of yearling beef steers dosed with benzathine penicillin G alone or in combination with procaine penicillin G. Food additives and contaminants. 1994 Jan; 11(1):1-6. doi: 10.1080/02652039409374196. [PMID: 8181627]
  • G O Korsrud, J O Boison, M G Papich, W D Yates, J D MacNeil, E D Janzen, R D Cohen, D A Landry, G Lambert, M S Yong. Depletion of intramuscularly and subcutaneously injected procaine penicillin G from tissues and plasma of yearling beef steers. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 1993 Oct; 57(4):223-30. doi: NULL. [PMID: 8269359]
  • M G Papich, G O Korsrud, J O Boison, W D Yates, J D MacNeil, E D Janzen, R D Cohen, D A Landry. A study of the disposition of procaine penicillin G in feedlot steers following intramuscular and subcutaneous injection. Journal of veterinary pharmacology and therapeutics. 1993 Sep; 16(3):317-27. doi: 10.1111/j.1365-2885.1993.tb00178.x. [PMID: 8230402]
  • A Saleh-Mghir, A C Cremieux, J M Vallois, M Muffat-Joly, C Devine, C Carbon. Optimal aminoglycoside dosing regimen for penicillin-tobramycin synergism in experimental Streptococcus adjacens endocarditis. Antimicrobial agents and chemotherapy. 1992 Nov; 36(11):2403-7. doi: 10.1128/aac.36.11.2403. [PMID: 1489184]
  • D J Kelly, J D Chulay, P Mikesell, A M Friedlander. Serum concentrations of penicillin, doxycycline, and ciprofloxacin during prolonged therapy in rhesus monkeys. The Journal of infectious diseases. 1992 Nov; 166(5):1184-7. doi: 10.1093/infdis/166.5.1184. [PMID: 1402033]
  • P A Gentry, P D Mansell, D J Mason, P D Conlon. Bovine platelets retain functional activity in the presence of penicillin G. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 1992 Oct; 56(4):365-9. doi: NULL. [PMID: 1477805]
  • B Bengtsson, U Bredberg, J Luthman. Mathematical description of the concentration of oxytetracycline and penicillin-G in tissue cages in calves as related to the serum concentration. Journal of veterinary pharmacology and therapeutics. 1992 Jun; 15(2):202-16. doi: 10.1111/j.1365-2885.1992.tb01008.x. [PMID: 1433482]
  • V N Bednova, K K Borisenko, T I Navolodskaia, T I Milonova, E A Orlina, K S Karimov. [Experimental and clinical data on the combined use of novocaine salt of benzylpenicillin and proteolytic enzymes]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 1991 Aug; 36(8):45-6. doi: NULL. [PMID: 1755711]
  • D L Step, J T Blue, S G Dill. Penicillin-induced hemolytic anemia and acute hepatic failure following treatment of tetanus in a horse. The Cornell veterinarian. 1991 Jan; 81(1):13-8. doi: NULL. [PMID: 1993388]
  • P T Zoirov, K Kh Khaĭdarov, M S Isaeva, D F Iskhaki. [A lymphotropic method of therapy for patients with fresh forms of syphilis (clinical and experimental research)]. Vestnik dermatologii i venerologii. 1990; ?(12):30-4. doi: NULL. [PMID: 2094098]
  • B Bengtsson, A Franklin, J Luthman, S O Jacobsson. Concentrations of sulphadimidine, oxytetracycline and penicillin G in serum, synovial fluid and tissue cage fluid after parenteral administration to calves. Journal of veterinary pharmacology and therapeutics. 1989 Mar; 12(1):37-45. doi: 10.1111/j.1365-2885.1989.tb00639.x. [PMID: 2704059]
  • A Iu Budiev, T I Navolotskaia, S V Rotanov, A E Podgornyĭ. [The level of penicillin in the blood serum during treatment of gonococcal infection with various doses of bicillin-3 and its combination with etamid]. Vestnik dermatologii i venerologii. 1989; ?(3):74-5. doi: NULL. [PMID: 2741554]
  • K C Mohanty, R Deighton Fimls, R G Strachan. A comparative study of aztreonam and procaine penicillin/probenecid in the treatment of uncomplicated gonorrhoea. Scandinavian journal of infectious diseases. 1988; 20(1):33-6. doi: 10.3109/00365548809117214. [PMID: 3283921]
  • D V Philcox, J J Callanan, A A Forder. Treatment of neurosyphilis. A comparison of penicillin regimens. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1987 Jul; 72(2):110-3. doi: NULL. [PMID: 3616781]
  • M Ingerman, P G Pitsakis, A Rosenberg, M T Hessen, E Abrutyn, B E Murray, M E Levison. beta-Lactamase production in experimental endocarditis due to aminoglycoside-resistant Streptococcus faecalis. The Journal of infectious diseases. 1987 Jun; 155(6):1226-32. doi: 10.1093/infdis/155.6.1226. [PMID: 3106510]
  • O O Oduye, D H Lloyd, H O Aghomo, L R Thomsett. Serum antibiotic concentration and bovine skin susceptibility to infection by Dermatophilus congolensis. Journal of veterinary pharmacology and therapeutics. 1987 Jun; 10(2):160-3. doi: 10.1111/j.1365-2885.1987.tb00093.x. [PMID: 3612944]
  • K K Borisenko, V N Bednova, T I Navolotskaia, K S Karimov, S V Rotanov. [Effect of different doses of the novocaine salt of benzylpenicillin and its combination with chymotrypsin on the penicillin content of the blood serum in syphilis patients]. Vestnik dermatologii i venerologii. 1987; ?(8):15-7. doi: . [PMID: 3687188]
  • N K Henry, W R Wilson, J E Geraci. Treatment of streptomycin-susceptible enterococcal experimental endocarditis with combinations of penicillin and low- or high-dose streptomycin. Antimicrobial agents and chemotherapy. 1986 Nov; 30(5):725-8. doi: 10.1128/aac.30.5.725. [PMID: 3800348]
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  • A Stapiński, W Mazurkiewicz, B Ochelska, H Maciejewska, I Szreder, D Weyman-Rzucidło. [Effect of probenecid on penicillin levels of the cerebrospinal fluid and blood serum in patients treated with procaine G penicillin]. Przeglad dermatologiczny. 1984 Jul; 71(4):375-82. doi: NULL. [PMID: 6515034]
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  • A Stapiński, B Ochelska, H Maciejewska, I Szreder, W Mazurkiewicz, D Weyman-Rzucidło. [Penicillin levels of the cerebrospinal fluid and serum of patients treated with procaine penicillin in daily doses of 2,4 million units]. Przeglad dermatologiczny. 1984 May; 71(3):245-51. doi: NULL. [PMID: 6543019]
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