pyridine oxide (BioDeep_00000743930)
代谢物信息卡片
Pyridine-N-oxide
化学式: C5H5NO (95.03711200000001)
中文名称: 吡啶-N-氧化物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=[N+](C=C1)[O-]
InChI: InChI=1S/C5H5NO/c7-6-4-2-1-3-5-6/h1-5H
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yogesh Dubey, Paramasivam Mahalingavelar, Deeksha Rajput, Dipeshwari J Shewale, Virupakshi Soppina, Sriram Kanvah. Fluorescent styryl pyridine-N-oxide probes for imaging lipid droplets.
Organic & biomolecular chemistry.
2023 10; 21(41):8393-8402. doi:
10.1039/d3ob01365k. [PMID: 37819137] - Adib Ghaleb, Adnane Aouidate, Hicham Ben El Ayouchia, Mohammed Aarjane, Hafid Anane, Salah-Eddine Stiriba. In silico molecular investigations of pyridine N-Oxide compounds as potential inhibitors of SARS-CoV-2: 3D QSAR, molecular docking modeling, and ADMET screening.
Journal of biomolecular structure & dynamics.
2022 Jan; 40(1):143-153. doi:
10.1080/07391102.2020.1808530. [PMID: 32799761] - Petra Krejčová, Petra Kučerová, Gary I Stafford, Anna K Jäger, Roman Kubec. Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum).
Journal of ethnopharmacology.
2014 May; 154(1):176-82. doi:
10.1016/j.jep.2014.03.066. [PMID: 24721027] - Veronika Biricová, Alice Lázničková, Milan Lázníček, Miloslav Polášek, Petr Hermann. Radiolabeling of PAMAM dendrimers conjugated to a pyridine-N-oxide DOTA analog with ¹¹¹In: Optimization of reaction conditions and biodistribution.
Journal of pharmaceutical and biomedical analysis.
2011 Nov; 56(3):505-12. doi:
10.1016/j.jpba.2011.06.009. [PMID: 21757312] - Daniel T Schühle, Miloslav Polásek, Ivan Lukes, Thomas Chauvin, Eva Tóth, Jürgen Schatz, Ulf Hanefeld, Marc C A Stuart, Joop A Peters. Densely packed Gd(III)-chelates with fast water exchange on a calix[4]arene scaffold: a potential MRI contrast agent.
Dalton transactions (Cambridge, England : 2003).
2010 Jan; ?(1):185-91. doi:
10.1039/b917673j. [PMID: 20023949] - R A Hilger, H Richly, M Grubert, S Kredtke, D Thyssen, W Eberhardt, J Hense, M Schuler, M E Scheulen. Pharmacokinetics of sorafenib in patients with renal impairment undergoing hemodialysis.
International journal of clinical pharmacology and therapeutics.
2009 Jan; 47(1):61-4. doi:
10.5414/cpp47061. [PMID: 19203541] - Jan Balzarini, Els Keyaerts, Leen Vijgen, Frank Vandermeer, Miguel Stevens, Erik De Clercq, Herman Egberink, Marc Van Ranst. Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture.
The Journal of antimicrobial chemotherapy.
2006 Mar; 57(3):472-81. doi:
10.1093/jac/dki481. [PMID: 16387746] - Erik De Clercq. HIV-chemotherapy and -prophylaxis: new drugs, leads and approaches.
The international journal of biochemistry & cell biology.
2004 Sep; 36(9):1800-22. doi:
10.1016/j.biocel.2004.02.015. [PMID: 15183346] - Erzsébet Kiss, Kenji Kawabe, Asuka Tamura, Tamás Jakusch, Hiromu Sakurai, Tamás Kiss. Chemical speciation of insulinomimetic VO(IV) complexes of pyridine-N-oxide derivatives: binary and ternary systems.
Journal of inorganic biochemistry.
2003 Jun; 95(2-3):69-76. doi:
10.1016/s0162-0134(03)00103-x. [PMID: 12763650] - M M Iba, J Fung, J V Giannone, A B Okey. Comparative induction of CYP1A1 expression by pyridine and its metabolites.
Archives of biochemistry and biophysics.
2000 Jun; 378(2):299-310. doi:
10.1006/abbi.2000.1826. [PMID: 10860547] - S G Carmella, A Borukhova, S A Akerkar, S S Hecht. Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
1997 Feb; 6(2):113-20. doi:
. [PMID: 9037562] - G P Carlson. Comparison of the effects of pyridine and its metabolites on rat liver and kidney.
Toxicology letters.
1996 Jun; 85(3):173-8. doi:
10.1016/0378-4274(96)03660-0. [PMID: 8644130] - H Kim, S G Kim, M Y Lee, R F Novak. Evidence for elevation of cytochrome P4502E1 (alcohol-inducible form) mRNA levels in rat kidney following pyridine administration.
Biochemical and biophysical research communications.
1992 Jul; 186(2):846-53. doi:
10.1016/0006-291x(92)90823-4. [PMID: 1379807] - A Silvestro, J Pommier, M C Pascal, G Giordano. The inducible trimethylamine N-oxide reductase of Escherichia coli K12: its localization and inducers.
Biochimica et biophysica acta.
1989 Nov; 999(2):208-16. doi:
10.1016/0167-4838(89)90220-3. [PMID: 2512991]