Undecafluoro-2-methyl-3-oxahexanoic acid (BioDeep_00000743601)
代谢物信息卡片
2,3,3,3-Tetrafluoro-2-(heptafluoropropoxy)propanoic acid
化学式: C6HF11O3 (329.97500479999997)
中文名称: 全氟(2-甲基-3-氧杂己酸)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=O)(C(C(F)(F)F)(OC(C(C(F)(F)F)(F)F)(F)F)F)O
InChI: InChI=1S/C6HF11O3/c7-2(1(18)19,4(10,11)12)20-6(16,17)3(8,9)5(13,14)15/h(H,18,19)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kaylie I Kirkwood-Donelson, Jessie Chappel, Emma Tobin, James N Dodds, David M Reif, Jamie C DeWitt, Erin S Baker. Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS).
Chemosphere.
2024 Apr; 354(?):141654. doi:
10.1016/j.chemosphere.2024.141654. [PMID: 38462188] - Wanlan Ren, Zhiru Wang, Hua Guo, Yong Gou, Jiayin Dai, Xuming Zhou, Nan Sheng. GenX analogs exposure induced greater hepatotoxicity than GenX mainly via activation of PPARα pathway while caused hepatomegaly in the absence of PPARα in female mice.
Environmental pollution (Barking, Essex : 1987).
2024 Mar; 344(?):123314. doi:
10.1016/j.envpol.2024.123314. [PMID: 38218542] - Wenshan Shi, Zengli Zhang, Xinyu Li, Jingsi Chen, Xiaojun Liang, Jiafu Li. GenX Disturbs the Indicators of Hepatic Lipid Metabolism Even at Environmental Concentration in Drinking Water via PPARα Signaling Pathways.
Chemical research in toxicology.
2024 Jan; 37(1):98-108. doi:
10.1021/acs.chemrestox.3c00342. [PMID: 38150050] - Justin M Conley, Christy S Lambright, Nicola Evans, Aimen K Farraj, Jacob Smoot, Rachel D Grindstaff, Donna Hill, James McCord, Elizabeth Medlock-Kakaley, Aaron Dixon, Erin Hines, L Earl Gray. Dose additive maternal and offspring effects of oral maternal exposure to a mixture of three PFAS (HFPO-DA, NBP2, PFOS) during pregnancy in the Sprague-Dawley rat.
The Science of the total environment.
2023 Sep; 892(?):164609. doi:
10.1016/j.scitotenv.2023.164609. [PMID: 37271399] - Yonghua Wang, Xi Chen, Beibei Wang, Guanghua Lu, Jianchao Liu, Donghai Wu, Zhenhua Yan. Toxicity comparison of perfluorooctanoic acid (PFOA), hexafluoropropylene oxide dimer acid (HFPO-DA), and hexafluoropropylene oxide trimer acid (HFPO-TA) in zebrafish gut.
Aquatic toxicology (Amsterdam, Netherlands).
2023 Sep; 262(?):106655. doi:
10.1016/j.aquatox.2023.106655. [PMID: 37598522] - Lei Chen, Daijie Chen, Shunyi Zhou, Jieying Lin, Yun Liu, Xiongfei Huang, Qingqi Lin, Jean Louis Morel, Zhuobiao Ni, Shizhong Wang, Rongliang Qiu. New Insights into the Accumulation, Transport, and Distribution Mechanisms of Hexafluoropropylene Oxide Homologues, Important Alternatives to Perfluorooctanoic Acid, in Lettuce (Lactuca sativa L.).
Environmental science & technology.
2023 Jul; 57(26):9702-9712. doi:
10.1021/acs.est.2c09226. [PMID: 37314230] - Weiqiang Sun, Xuemin Zhang, Ying Qiao, Nathan Griffin, Hongxia Zhang, Li Wang, Hui Liu. Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish.
Ecotoxicology and environmental safety.
2023 Jul; 259(?):115020. doi:
10.1016/j.ecoenv.2023.115020. [PMID: 37201426] - Melissa M Heintz, Laurie C Haws, James E Klaunig, John M Cullen, Chad M Thompson. Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans.
Toxicological sciences : an official journal of the Society of Toxicology.
2023 03; 192(1):15-29. doi:
10.1093/toxsci/kfad004. [PMID: 36629480] - Sujie Sun, Xue Li, Li Zhang, Zilin Zhong, Chao Chen, Yuhua Zuo, Yu Chen, Hongmei Hu, Fasheng Liu, Guanghua Xiong, Huiqiang Lu, Jianjun Chen, Jiayin Dai. Hexafluoropropylene oxide trimer acid (HFPO-TA) disturbs embryonic liver and biliary system development in zebrafish.
The Science of the total environment.
2023 Feb; 859(Pt 1):160087. doi:
10.1016/j.scitotenv.2022.160087. [PMID: 36372181] - Brecht Attema, Aafke W F Janssen, Deborah Rijkers, Evert M van Schothorst, Guido J E J Hooiveld, Sander Kersten. Exposure to low-dose perfluorooctanoic acid promotes hepatic steatosis and disrupts the hepatic transcriptome in mice.
Molecular metabolism.
2022 12; 66(?):101602. doi:
10.1016/j.molmet.2022.101602. [PMID: 36115532] - Peng Li, Ran Yu, Feng Hou, Yuan Zhao. Legacy and emerging poly- and perfluoroalkyl substances in wastewater treatment plant and receiving water: abundance, removal, and potential ecological risk.
Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
10.1007/s11356-022-24340-7. [PMID: 36417070] - Emily Marques, Marisa Pfohl, Wei Wei, Giuseppe Tarantola, Lucie Ford, Ogochukwu Amaeze, Jessica Alesio, Sangwoo Ryu, Xuelian Jia, Hao Zhu, Geoffrey D Bothun, Angela Slitt. Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes.
Toxicology and applied pharmacology.
2022 05; 442(?):115991. doi:
10.1016/j.taap.2022.115991. [PMID: 35337807] - Justin M Conley, Christy S Lambright, Nicola Evans, Elizabeth Medlock-Kakaley, Donna Hill, James McCord, Mark J Strynar, Leah C Wehmas, Susan Hester, Denise K MacMillan, L Earl Gray. Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS).
Environment international.
2022 02; 160(?):107056. doi:
10.1016/j.envint.2021.107056. [PMID: 34952357] - Justin M Conley, Christy S Lambright, Nicola Evans, James McCord, Mark J Strynar, Donna Hill, Elizabeth Medlock-Kakaley, Vickie S Wilson, L Earl Gray. Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat.
Environment international.
2021 01; 146(?):106204. doi:
10.1016/j.envint.2020.106204. [PMID: 33126064] - Jacqueline Bangma, John Szilagyi, Bevin E Blake, Cinthya Plazas, Stewart Kepper, Suzanne E Fenton, Rebecca C Fry. An assessment of serum-dependent impacts on intracellular accumulation and genomic response of per- and polyfluoroalkyl substances in a placental trophoblast model.
Environmental toxicology.
2020 Dec; 35(12):1395-1405. doi:
10.1002/tox.23004. [PMID: 32790152] - Jaroslav Semerád, Nicolette Hatasová, Alena Grasserová, Tereza Černá, Alena Filipová, Aleš Hanč, Petra Innemanová, Martin Pivokonský, Tomáš Cajthaml. Screening for 32 per- and polyfluoroalkyl substances (PFAS) including GenX in sludges from 43 WWTPs located in the Czech Republic - Evaluation of potential accumulation in vegetables after application of biosolids.
Chemosphere.
2020 Dec; 261(?):128018. doi:
10.1016/j.chemosphere.2020.128018. [PMID: 33113642] - Yi Wen, Niharika Mirji, Joseph Irudayaraj. Epigenetic toxicity of PFOA and GenX in HepG2 cells and their role in lipid metabolism.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Jun; 65(?):104797. doi:
10.1016/j.tiv.2020.104797. [PMID: 32068100] - Chih-Hung Chen, Shih-Hung Yang, Yina Liu, Pierce Jamieson, Libo Shan, Kung-Hui Chu. Accumulation and phytotoxicity of perfluorooctanoic acid and 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate in Arabidopsis thaliana and Nicotiana benthamiana.
Environmental pollution (Barking, Essex : 1987).
2020 Apr; 259(?):113817. doi:
10.1016/j.envpol.2019.113817. [PMID: 31918129] - Justin M Conley, Christy S Lambright, Nicola Evans, Mark J Strynar, James McCord, Barry S McIntyre, Gregory S Travlos, Mary C Cardon, Elizabeth Medlock-Kakaley, Phillip C Hartig, Vickie S Wilson, L Earl Gray. Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats.
Environmental health perspectives.
2019 03; 127(3):37008. doi:
10.1289/ehp4372. [PMID: 30920876] - Jianshe Wang, Xiaoyang Wang, Nan Sheng, Xiujuan Zhou, Ruina Cui, Hongxia Zhang, Jiayin Dai. RNA-sequencing analysis reveals the hepatotoxic mechanism of perfluoroalkyl alternatives, HFPO2 and HFPO4, following exposure in mice.
Journal of applied toxicology : JAT.
2017 04; 37(4):436-444. doi:
10.1002/jat.3376. [PMID: 27553808] - Shawn A Gannon, William J Fasano, Michael P Mawn, Diane L Nabb, Robert C Buck, L William Buxton, Gary W Jepson, Steven R Frame. Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey.
Toxicology.
2016 Jan; 340(?):1-9. doi:
10.1016/j.tox.2015.12.006. [PMID: 26743852]