Lorcaserin (BioDeep_00000743468)
代谢物信息卡片
Lorcaserin
化学式: C11H14ClN (195.0814714)
中文名称: 氯卡色林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CNCCC2=C1C=C(C=C2)Cl
InChI: InChI=1S/C11H14ClN/c1-8-7-13-5-4-9-2-3-10(12)6-11(8)9/h2-3,6,8,13H,4-5,7H2,1H3/t8-/m0/s1
描述信息
A - Alimentary tract and metabolism > A08 - Antiobesity preparations, excl. diet products > A08A - Antiobesity preparations, excl. diet products > A08AA - Centrally acting antiobesity products
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:65353
- PubChem: 11658860
- DrugBank: DB04871
- ChEMBL: CHEMBL360328
- CAS: 616202-92-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Glenn-Milo Santos, Janet Ikeda, Phillip Coffin, John E Walker, Tim Matheson, Matthew McLaughlin, Jennifer Jain, Eric Vittinghoff, Steven L Batki. Pilot study of extended-release lorcaserin for cocaine use disorder among men who have sex with men: A double-blind, placebo-controlled randomized trial.
PloS one.
2021; 16(7):e0254724. doi:
10.1371/journal.pone.0254724. [PMID: 34265007] - Vishal Patel, Amit Joharapurkar, Samadhan Kshirsagar, Maulik Patel, Hardikkumar Savsani, Rajesh Bahekar, Mukul Jain. Combination of Lorcaserin and GLP-1/glucagon Coagonist Improves Metabolic Dysfunction in Diet Induced-obese Mice.
Drug research.
2020 Aug; 70(8):376-384. doi:
10.1055/a-1201-2700. [PMID: 32645724] - Hsiao-Huai Kuo, Kuang-Te Wang, Ying-Hsiang Lee, Po-Lin Lin, Ming-En Liu, Chien-Yu Lin, Lawrence Yu-Min Liu. Effects of lorcaserin on cardiometabolic risk factors in overweight and obese patients: A systematic review and meta-analysis.
Journal of clinical pharmacy and therapeutics.
2020 Feb; 45(1):35-44. doi:
10.1111/jcpt.13047. [PMID: 31544267] - Sanjay Sharma, Komal S Aware, Ketan Hatware, Kiran Patil. Chemistry, Analysis, Pharmacokinetics and Pharmacodynamics Aspects of Lorcaserin, a Selective Serotonin 5-HT2C Receptor Agonist: An Update.
Mini reviews in medicinal chemistry.
2020; 20(9):768-778. doi:
10.2174/1389557519666190408154443. [PMID: 30961494] - Beverly G Tchang, Brittany Abel, Christina Zecca, Katherine H Saunders, Alpana P Shukla. An up-to-date evaluation of lorcaserin hydrochloride for the treatment of obesity.
Expert opinion on pharmacotherapy.
2020 Jan; 21(1):21-28. doi:
10.1080/14656566.2019.1685496. [PMID: 31693425] - Hai Zeng, Meng Luo, Zunjiang Li, Junru Wen, Guoxin He, Yuelin Jin, Wenbin Fu, Peng Zhou. Lorcaserin for prevention and remission of type 2 diabetes mellitus in people with overweight or obesity: protocol for a systematic review and meta-analysis.
BMJ open.
2019 07; 9(7):e029426. doi:
10.1136/bmjopen-2019-029426. [PMID: 31352420] - Peter Rossing, Frederik Persson, Marie Frimodt-Møller. Improvements in albuminuria and chronic kidney disease progression with the appetite suppressant lorcaserin.
Kidney international.
2019 06; 95(6):1287-1288. doi:
10.1016/j.kint.2019.03.002. [PMID: 31029502] - Dario Tuccinardi, Olivia M Farr, Jagriti Upadhyay, Sabrina M Oussaada, Hannah Mathew, Stavroula A Paschou, Nikolaos Perakakis, Anastasia Koniaris, Theodoros Kelesidis, Christos S Mantzoros. Lorcaserin treatment decreases body weight and reduces cardiometabolic risk factors in obese adults: A six-month, randomized, placebo-controlled, double-blind clinical trial.
Diabetes, obesity & metabolism.
2019 06; 21(6):1487-1492. doi:
10.1111/dom.13655. [PMID: 30724455] - Paul J Fletcher, Zhaoxia Li, Leo B Silenieks, Cam MacMillan, Ines DeLannoy, Guy A Higgins. Preclinical evidence for combining the 5-HT2C receptor agonist lorcaserin and varenicline as a treatment for nicotine dependence.
Addiction biology.
2019 05; 24(3):376-387. doi:
10.1111/adb.12602. [PMID: 29498158] - Muzaffar Iqbal, Nasr Y Khalil, Essam Ezzeldin, Khalid A Al-Rashood. Simultaneous Detection and Quantification of Three Novel Prescription Drugs of Abuse (Suvorexant, Lorcaserin and Brivaracetam) in Human Plasma by UPLC-MS-MS.
Journal of analytical toxicology.
2019 Apr; 43(3):203-211. doi:
10.1093/jat/bky078. [PMID: 30295849] - Benjamin M Scirica, Erin A Bohula, Jamie P Dwyer, Arman Qamar, Silvio E Inzucchi, Darren K McGuire, Anthony C Keech, Steven R Smith, Sabina A Murphy, Kyungah Im, Lawrence A Leiter, Milan Gupta, Tushar Patel, Wenfeng Miao, Carlos Perdomo, Marc P Bonaca, Christian T Ruff, Marc S Sabatine, Stephen D Wiviott. Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial.
Circulation.
2019 01; 139(3):366-375. doi:
10.1161/circulationaha.118.038341. [PMID: 30586726] - Sankar D Navaneethan. Trials and Tribulations in Studying Kidney Outcomes With Intentional Weight Loss.
Circulation.
2019 01; 139(3):376-379. doi:
10.1161/circulationaha.118.038677. [PMID: 30640548] - L Ravithej Singh, Ajeet Kumar, Akanksha Upadhyay, Sampa Gupta, Gopala Reddy Palanati, Kamakshi Sikka, Mohammad Imran Siddiqi, Prem N Yadav, Koneni V Sashidhara. Discovery of coumarin-dihydroquinazolinone analogs as niacin receptor 1 agonist with in-vivo anti-obesity efficacy.
European journal of medicinal chemistry.
2018 May; 152(?):208-222. doi:
10.1016/j.ejmech.2018.04.037. [PMID: 29709786] - Guy A Higgins, Leonardo B Silenieks, Amy Patrick, Ines A M De Lannoy, Paul J Fletcher, Linda A Parker, Neil J MacLusky, Laura C Sullivan, Teresa A Chavera, Kelly A Berg. Studies To Examine Potential Tolerability Differences between the 5-HT2C Receptor Selective Agonists Lorcaserin and CP-809101.
ACS chemical neuroscience.
2017 05; 8(5):1074-1084. doi:
10.1021/acschemneuro.6b00444. [PMID: 28338324] - Faidon Magkos, Elena Nikonova, Randi Fain, Sharon Zhou, Tony Ma, William Shanahan. Effect of lorcaserin on glycemic parameters in patients with type 2 diabetes mellitus.
Obesity (Silver Spring, Md.).
2017 05; 25(5):842-849. doi:
10.1002/oby.21798. [PMID: 28345809] - Richard Nesto, Randi Fain, Yuhan Li, William Shanahan. Evaluation of lorcaserin on progression of prediabetes to type 2 diabetes and reversion to euglycemia.
Postgraduate medicine.
2016 May; 128(4):364-70. doi:
10.1080/00325481.2016.1178590. [PMID: 27116910] - Abu J M Sadeque, Safet Palamar, Khawja A Usmani, Chuan Chen, Matthew A Cerny, Weichao G Chen. Identification of Human Sulfotransferases Involved in Lorcaserin N-Sulfamate Formation.
Drug metabolism and disposition: the biological fate of chemicals.
2016 Apr; 44(4):570-5. doi:
10.1124/dmd.115.067397. [PMID: 26758853] - Amal A Bajrai, Essam Ezzeldin, Khalid A Al-Rashood, Mohammad Raish, Muzaffar Iqbal. A Validated UPLC-MS-MS Assay for the Rapid Determination of Lorcaserin in Plasma and Brain Tissue Samples.
Journal of analytical toxicology.
2016 Mar; 40(2):133-9. doi:
10.1093/jat/bkv126. [PMID: 26567546] - Parim Brahma Naidu, V V Sathibabu Uddandrao, Ramavat Ravindar Naik, Pothani Suresh, Balaji Meriga, Mustapha Shabana Begum, Rajesh Pandiyan, Ganapathy Saravanan. Ameliorative potential of gingerol: Promising modulation of inflammatory factors and lipid marker enzymes expressions in HFD induced obesity in rats.
Molecular and cellular endocrinology.
2016 Jan; 419(?):139-47. doi:
10.1016/j.mce.2015.10.007. [PMID: 26493465] - Gregory T Collins, Lisa R Gerak, Martin A Javors, Charles P France. Lorcaserin Reduces the Discriminative Stimulus and Reinforcing Effects of Cocaine in Rhesus Monkeys.
The Journal of pharmacology and experimental therapeutics.
2016 Jan; 356(1):85-95. doi:
10.1124/jpet.115.228833. [PMID: 26534942] - Jonathan W Cunningham, Stephen D Wiviott. Modern obesity pharmacotherapy: weighing cardiovascular risk and benefit.
Clinical cardiology.
2014 Nov; 37(11):693-9. doi:
10.1002/clc.22304. [PMID: 25223901] - Louis Aronne, William Shanahan, Randi Fain, Alan Glicklich, William Soliman, Yuhan Li, Steven Smith. Safety and efficacy of lorcaserin: a combined analysis of the BLOOM and BLOSSOM trials.
Postgraduate medicine.
2014 Oct; 126(6):7-18. doi:
10.3810/pgm.2014.10.2817. [PMID: 25414931] - G A Higgins, L B Silenieks, W Lau, I A M de Lannoy, D K H Lee, J Izhakova, K Coen, A D Le, P J Fletcher. Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles.
Psychopharmacology.
2013 Apr; 226(3):475-90. doi:
10.1007/s00213-012-2919-2. [PMID: 23184281] - Kelly Anne Holes-Lewis, Robert Malcolm, Patrick M O'Neil, Kathie Hermayer. Pharmacotherapy of obesity: clinical treatments and considerations.
The American journal of the medical sciences.
2013 Apr; 345(4):284-288. doi:
10.1097/maj.0b013e31828abcfd. [PMID: 23531960] - Abu J M Sadeque, Khawja A Usmani, Safet Palamar, Matthew A Cerny, Weichao G Chen. Identification of human UDP-glucuronosyltransferases involved in N-carbamoyl glucuronidation of lorcaserin.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Apr; 40(4):772-8. doi:
10.1124/dmd.111.043448. [PMID: 22259019] - David B Allison, Kishore M Gadde, William Timothy Garvey, Craig A Peterson, Michael L Schwiers, Thomas Najarian, Peter Y Tam, Barbara Troupin, Wesley W Day. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP).
Obesity (Silver Spring, Md.).
2012 Feb; 20(2):330-42. doi:
10.1038/oby.2011.330. [PMID: 22051941] - Remigiusz Zieba. [Obesity: a review of currently used antiobesity drugs and new compounds in clinical development].
Postepy higieny i medycyny doswiadczalnej (Online).
2007 Oct; 61(?):612-26. doi:
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