KU-0063794 (BioDeep_00000743413)

   


代谢物信息卡片


(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol

化学式: C25H31N5O4 (465.2375926)
中文名称: KU-0063794
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CN(CC(O1)C)C2=NC3=C(C=CC(=N3)C4=CC(=C(C=C4)OC)CO)C(=N2)N5CCOCC5
InChI: InChI=1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+

描述信息

D004791 - Enzyme Inhibitors
KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC50s of 10 nM.
KU-0063794 is a potent and specific mTOR inhibitor, inhibiting both the mTORC1 and mTORC2 complexes with IC50s of 10 nM.

同义名列表

2 个代谢物同义名

(5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; KU-0063794



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tomoyasu Fujii, Mizuho Ogasawara, Jun Kamishikiryo, Tetsuo Morita. β-Estradiol Enhanced Secretion of Lipoprotein Lipase from Mouse Mammary Tumor FM3A Cells. Biological & pharmaceutical bulletin. 2020; 43(9):1407-1412. doi: 10.1248/bpb.b20-00408. [PMID: 32879215]
  • Jessica M Olsen, Masaaki Sato, Olof S Dallner, Anna L Sandström, Didier F Pisani, Jean-Claude Chambard, Ez-Zoubir Amri, Dana S Hutchinson, Tore Bengtsson. Glucose uptake in brown fat cells is dependent on mTOR complex 2-promoted GLUT1 translocation. The Journal of cell biology. 2014 Nov; 207(3):365-74. doi: 10.1083/jcb.201403080. [PMID: 25385184]
  • K Harada, H Miyake, M Kumano, M Fujisawa. Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2. British journal of cancer. 2013 Oct; 109(9):2389-95. doi: 10.1038/bjc.2013.602. [PMID: 24091619]
  • Qingsong Liu, Jinhua Wang, Seong A Kang, Carson C Thoreen, Wooyoung Hur, Tausif Ahmed, David M Sabatini, Nathanael S Gray. Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer. Journal of medicinal chemistry. 2011 Mar; 54(5):1473-80. doi: 10.1021/jm101520v. [PMID: 21322566]
  • Juan M García-Martínez, Jennifer Moran, Rosemary G Clarke, Alex Gray, Sabina C Cosulich, Christine M Chresta, Dario R Alessi. Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). The Biochemical journal. 2009 Jun; 421(1):29-42. doi: 10.1042/bj20090489. [PMID: 19402821]