Etidronate disodium (BioDeep_00000742961)
代谢物信息卡片
Etidronate disodium
化学式: C2H6Na2O7P2 (249.9384186)
中文名称: 依替膦酸二钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
InChI: /q
描述信息
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:4906
- KEGGdrug: D00314
- PubChem: 23894
- ChEMBL: CHEMBL1201042
- MeSH: Etidronic Acid
- CAS: 7414-83-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sawita Suwannarat, Naowarat Tephiruk, Suwanna Sunan, Khomsan Ruangwong, Siwapon Srisonphan. Disinfection Efficacy of Electrohydraulic Discharge Plasma against Xanthomonas campestris pv campestris: A Sustainable Seed Treatment Approach.
ACS applied bio materials.
2024 Mar; 7(3):1469-1477. doi:
10.1021/acsabm.3c00862. [PMID: 38231151] - Fatemeh Gholamian, Naser Karimi, Forouzan Gholamian, Parviz Bayat. Phycoremediation potential and agar yield of red macroalgae (Gracilaria corticata) against HEDP (hydroxyethylidene diphosphonic acid) and CAPB (cocoamidopropyl betaine) detergents and the heavy metal pollutants.
Environmental science and pollution research international.
2023 Aug; ?(?):. doi:
10.1007/s11356-023-29427-3. [PMID: 37648916] - Nancy Waltman, Kevin A Kupzyk, Laura E Flores, Lynn R Mack, Joan M Lappe, Laura D Bilek. Bone-loading exercises versus risedronate for the prevention of osteoporosis in postmenopausal women with low bone mass: a randomized controlled trial.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2022 Feb; 33(2):475-486. doi:
10.1007/s00198-021-06083-2. [PMID: 34519832] - Koichi Ishida, Naoki Ashizawa, Shota Morikane, Naoki Kurita, Seiichi Kobashi, Takashi Iwanaga. Assessment of calciprotein particle formation by AUC of the absorbance change: effect of FYB-931, a novel bisphosphonate compound.
The Journal of pharmacy and pharmacology.
2021 Jun; 73(7):947-955. doi:
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Cell reports.
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Immunopharmacology and immunotoxicology.
2021 Feb; 43(1):51-57. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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Scientific reports.
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Pharmacological reports : PR.
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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
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Drug research.
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Postgraduate medicine.
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Fundamental & clinical pharmacology.
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The British journal of ophthalmology.
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Clinical rheumatology.
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Clinical interventions in aging.
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Mayo Clinic proceedings.
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Journal of pediatric rehabilitation medicine.
2013; 6(2):85-93. doi:
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Scandinavian journal of rheumatology.
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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
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Transplant international : official journal of the European Society for Organ Transplantation.
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Clinical endocrinology.
2011 Jun; 74(6):699-704. doi:
10.1111/j.1365-2265.2011.04041.x. [PMID: 21521310] - F Furukawa, C Kaminaka, T Ikeda, N Kanazawa, Y Yamamoto, C Ohta, T Nishide, K Tsujioka, M Hattori, K Uede, M Hata. Preliminary study of etidronate for prevention of corticosteroid-induced osteoporosis caused by oral glucocorticoid therapy.
Clinical and experimental dermatology.
2011 Mar; 36(2):165-8. doi:
10.1111/j.1365-2230.2010.03856.x. [PMID: 20497186] - Keiji Okamoto, Masaaki Inaba, Yutaka Furumitsu, Akihiko Ban, Naoto Mori, Kazuhiko Yukioka, Yasuo Imanishi, Yoshiki Nishizawa. Beneficial effect of risedronate on arterial thickening and stiffening with a reciprocal relationship to its effect on bone mass in female osteoporosis patients: a longitudinal study.
Life sciences.
2010 Dec; 87(23-26):686-91. doi:
10.1016/j.lfs.2010.10.006. [PMID: 20951147] - I Kh Valeeva, A F Titarenko, L E Ziganshina. [Comparative analysis of dimephosphon, ionol, and xydiphone effects on indomethacin-induced gastric lesions in rats].
Eksperimental'naia i klinicheskaia farmakologiia.
2010 Dec; 73(12):21-4. doi:
NULL. [PMID: 21395012] - Masataka Shiraki, Yasushi Yamazaki, Yumiko Shiraki, Takayuki Hosoi, Naoko Tsugawa, Toshio Okano. High level of serum undercarboxylated osteocalcin in patients with incident fractures during bisphosphonate treatment.
Journal of bone and mineral metabolism.
2010 Sep; 28(5):578-84. doi:
10.1007/s00774-010-0167-2. [PMID: 20221651] - N L Waltman, J J Twiss, C D Ott, G J Gross, A M Lindsey, T E Moore, K Berg, K Kupzyk. The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trial.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2010 Aug; 21(8):1361-9. doi:
10.1007/s00198-009-1083-y. [PMID: 19802506] - Kousei Yoh, Shinjiro Takata, Noriko Yoshimura, Jun Hashimoto. Efficacy, tolerability, and safety of risedronate in Japanese patients with Paget's disease of bone.
Journal of bone and mineral metabolism.
2010 Jul; 28(4):468-76. doi:
10.1007/s00774-009-0152-9. [PMID: 20179977] - José-Vicente Torregrosa, David Fuster, Miguel-Angel Gentil, Roberto Marcen, Luís Guirado, Sofía Zarraga, Juan Bravo, Dolores Burgos, Ana Monegal, Africa Muxí, Sagrario García. Open-label trial: effect of weekly risedronate immediately after transplantation in kidney recipients.
Transplantation.
2010 Jun; 89(12):1476-81. doi:
10.1097/tp.0b013e3181dc13d0. [PMID: 20393402] - Damir Obad, Niels A Larsen, Erling B Pedersen. [Regression of severe periarticular calcifications during treatment with bisphosphonate in a dialysis patient].
Ugeskrift for laeger.
2010 Mar; 172(9):719-21. doi:
NULL. [PMID: 20199755] - Seiji Ohtori, Tsutomu Akazawa, Yasuaki Murata, Tomoaki Kinoshita, Masaomi Yamashita, Koichi Nakagawa, Gen Inoue, Junichi Nakamura, Sumihisa Orita, Nobuyasu Ochiai, Shunji Kishida, Masashi Takaso, Yawara Eguchi, Kazuyo Yamauchi, Munetaka Suzuki, Yasuchika Aoki, Kazuhisa Takahashi. Risedronate decreases bone resorption and improves low back pain in postmenopausal osteoporosis patients without vertebral fractures.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2010 Feb; 17(2):209-13. doi:
10.1016/j.jocn.2009.06.013. [PMID: 20044258] - Jeffrey S Willey, Eric W Livingston, Michael E Robbins, J Daniel Bourland, Leidamarie Tirado-Lee, Hope Smith-Sielicki, Ted A Bateman. Risedronate prevents early radiation-induced osteoporosis in mice at multiple skeletal locations.
Bone.
2010 Jan; 46(1):101-11. doi:
10.1016/j.bone.2009.09.002. [PMID: 19747571] - Takashi Takei, Mitsuyo Itabashi, Misao Tsukada, Hidekazu Sugiura, Takahito Moriyama, Chiari Kojima, Shunji Shiohira, Ari Shimizu, Kazunori Karasawa, Nobuyuki Amemiya, Kunio Kawanishi, Tetsuya Ogawa, Keiko Uchida, Ken Tsuchiya, Kosaku Nitta. Risedronate therapy for the prevention of steroid-induced osteoporosis in patients with minimal-change nephrotic syndrome.
Internal medicine (Tokyo, Japan).
2010; 49(19):2065-70. doi:
10.2169/internalmedicine.49.3707. [PMID: 20930431] - Takayoshi Hozuki, Tomihiro Imai, Emiko Tsuda, Akihiro Matsumura, Daisuke Yamamoto, Takanobu Toyoshima, Syuuichiro Suzuki, Rika Yamauchi, Takashi Hayashi, Shin Hisahara, Shun Shimohama. Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study.
Internal medicine (Tokyo, Japan).
2010; 49(5):371-6. doi:
10.2169/internalmedicine.49.2551. [PMID: 20190467] - Yong-Dae Kwon, Deog-Yoon Kim, Joo-Young Ohe, Ji-Yeon Yoo, Christian Walter. Correlation between serum C-terminal cross-linking telopeptide of type I collagen and staging of oral bisphosphonate-related osteonecrosis of the jaws.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2009 Dec; 67(12):2644-8. doi:
10.1016/j.joms.2009.04.067. [PMID: 19925985] - M Takakuwa, K Otsuka, M Konishi, K Itabashi. Evaluation of the effect of 4 months of risedronate therapy on femoral strength using femoral strength analysis tools.
The Journal of international medical research.
2009 Nov; 37(6):1972-81. doi:
10.1177/147323000903700635. [PMID: 20146897] - C M Weaver, B R Martin, G S Jackson, G P McCabe, J R Nolan, L D McCabe, S Barnes, S Reinwald, M E Boris, M Peacock. Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology.
The Journal of clinical endocrinology and metabolism.
2009 Oct; 94(10):3798-805. doi:
10.1210/jc.2009-0332. [PMID: 19584189] - Yang Ye, Shen-Jiang Hu. Re 'Effect of long-term treatment with risedronate on arterial compliance in osteoporotic patients with cardiovascular risk factors' by A. Luckish et al.
Bone.
2009 Sep; 45(3):609-10; author reply 611. doi:
10.1016/j.bone.2009.05.011. [PMID: 19465167] - Marnix G E H Lam, Tjitske B Bosma, Peter P van Rijk, Bernard A Zonnenberg. (188)Re-HEDP combined with capecitabine in hormone-refractory prostate cancer patients with bone metastases: a phase I safety and toxicity study.
European journal of nuclear medicine and molecular imaging.
2009 Sep; 36(9):1425-33. doi:
10.1007/s00259-009-1119-8. [PMID: 19319526] - Afef Bahlous, Kahena Bouzid, Héla Sahli, Slaheddine Sallami, Jaouidia Abdelmoula. Effects of risedronate on bone turnover markers in osteoporotic postmenopausal women: comparison of two protocols of treatment.
La Tunisie medicale.
2009 Aug; 87(8):525-6. doi:
NULL. [PMID: 20180356] - Ayako Shiraishi, Sayaka Miyabe, Takayoshi Nakano, Yukichi Umakoshi, Masako Ito, Masahiko Mihara. The combination therapy with alfacalcidol and risedronate improves the mechanical property in lumbar spine by affecting the material properties in an ovariectomized rat model of osteoporosis.
BMC musculoskeletal disorders.
2009 Jun; 10(?):66. doi:
10.1186/1471-2474-10-66. [PMID: 19527501] - Kouji Izumi, Atsushi Mizokami, Kazuhiro Sugimoto, Kazutaka Narimoto, Sotaro Miwa, Yuji Maeda, Yoshifumi Kadono, Mitsuhiro Takashima, Eitetsu Koh, Mikio Namiki. Risedronate recovers bone loss in patients with prostate cancer undergoing androgen-deprivation therapy.
Urology.
2009 Jun; 73(6):1342-6. doi:
10.1016/j.urology.2009.01.046. [PMID: 19371939] - Afef Bahlous, Kahena Bouzid, Héla Sahli, Slaheddine Sallami, Jaouda Abdelmoula. Effects of risedronate on bone turnover markers in osteoporotic postmenopausal women: comparison of two protocols of treatment.
La Tunisie medicale.
2009 Jun; 87(6):380-1. doi:
NULL. [PMID: 19927782] - Vit Zikan, Jan J Stepan. Marked reduction of bone turnover by alendronate attenuates the acute response of bone resorption marker to endogenous parathyroid hormone.
Bone.
2009 Apr; 44(4):634-8. doi:
10.1016/j.bone.2008.12.013. [PMID: 19150421] - Koba A Lomashvili, Marie-Claude Monier-Faugere, Xiaonan Wang, Hartmut H Malluche, W Charles O'Neill. Effect of bisphosphonates on vascular calcification and bone metabolism in experimental renal failure.
Kidney international.
2009 Mar; 75(6):617-25. doi:
10.1038/ki.2008.646. [PMID: 19129793] - Ellen G Neven, Marc E De Broe, Patrick C D'Haese. Prevention of vascular calcification with bisphosphonates without affecting bone mineralization: a new challenge?.
Kidney international.
2009 Mar; 75(6):580-2. doi:
10.1038/ki.2008.663. [PMID: 19247382] - Cesar E Fernandes, Cristiano Zerbini, Luís A Russo, Marco A Albernaz, Sergi R Eis, Vera L Szejnfeld, Luciano M Pompei. Effects of short-term risedronate on bone resorption and patient satisfaction in postmenopausal osteoporosis patients.
Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.
2009 Jan; 12(1):77-83. doi:
10.1016/j.jocd.2008.09.001. [PMID: 19004654] - Umit Dundar, Vural Kavuncu, Ihsan H Ciftci, Deniz Evcik, Ozlem Solak, Tuncay Cakir. The effect of risedronate treatment on serum cytokines in postmenopausal osteoporosis: a 6-month randomized and controlled study.
Journal of bone and mineral metabolism.
2009; 27(4):464-70. doi:
10.1007/s00774-009-0055-9. [PMID: 19301089] - Takafumi Majima, Akira Shimatsu, Yasato Komatsu, Noriko Satoh, Atsushi Fukao, Kiyoshi Ninomiya, Tadashi Matsumura, Kazuwa Nakao. Effects of risedronate or alfacalcidol on bone mineral density, bone turnover, back pain, and fractures in Japanese men with primary osteoporosis: results of a two-year strict observational study.
Journal of bone and mineral metabolism.
2009; 27(2):168-74. doi:
10.1007/s00774-008-0024-8. [PMID: 19183836] - Olivier Bruyère, Nansa Burlet, Pierre D Delmas, René Rizzoli, Cyrus Cooper, Jean-Yves Reginster. Evaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
BMC musculoskeletal disorders.
2008 Dec; 9(?):165. doi:
10.1186/1471-2474-9-165. [PMID: 19087296] - Wei Yao, Zhiqiang Cheng, Aaron Pham, Cheryl Busse, Elizabeth A Zimmermann, Robert O Ritchie, Nancy E Lane. Glucocorticoid-induced bone loss in mice can be reversed by the actions of parathyroid hormone and risedronate on different pathways for bone formation and mineralization.
Arthritis and rheumatism.
2008 Nov; 58(11):3485-97. doi:
10.1002/art.23954. [PMID: 18975341] - Kousuke Iba, Junichi Takada, Naoko Hatakeyama, Yasuhiro Ozasa, Takuro Wada, Toshihiko Yamashita. Changes in urinary NTX levels in patients with primary osteoporosis undergoing long-term bisphosphonate treatment.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.
2008 Sep; 13(5):438-41. doi:
10.1007/s00776-008-1265-z. [PMID: 18843458] - T Fujita, M Ohue, Y Fujii, A Miyauchi, Y Takagi. Analgesic and chondroprotective effects of risedronate in osteoarthritis assessed by electroalgometry and measurement of collagen type II fragments in urine.
The Journal of international medical research.
2008 Sep; 36(5):932-41. doi:
10.1177/147323000803600509. [PMID: 18831886] - Takahiro Iizuka, Mitsuhiro Matsukawa. Potential excessive suppression of bone turnover with long-term oral bisphosphonate therapy in postmenopausal osteoporotic patients.
Climacteric : the journal of the International Menopause Society.
2008 Aug; 11(4):287-95. doi:
10.1080/13697130801959590. [PMID: 18645694] - A Luckish, R Cernes, M Boaz, D Gavish, Z Matas, A Fux, M Shargorodsky. Effect of long-term treatment with risedronate on arterial compliance in osteoporotic patients with cardiovascular risk factors.
Bone.
2008 Aug; 43(2):279-283. doi:
10.1016/j.bone.2008.03.030. [PMID: 18515205] - Yasuji Arase, Fumitaka Suzuki, Yoshiyuki Suzuki, Norio Akuta, Masahiro Kobayashi, Yusuke Kawamura, Hiromi Yatsuji, Hitomi Sezaki, Tetsuya Hosaka, Kenji Ikeda, Hiromitsu Kumada. Prolonged-efficacy of bisphosphonate in postmenopausal women with osteoporosis and chronic liver disease.
Journal of medical virology.
2008 Jul; 80(7):1302-7. doi:
10.1002/jmv.21195. [PMID: 18461628] - P Garnero, W S Aronstein, S B Cohen, P G Conaghan, G A Cline, C Christiansen, J F Beary, J M Meyer, C O Bingham. Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trial.
Osteoarthritis and cartilage.
2008 Jun; 16(6):660-6. doi:
10.1016/j.joca.2007.10.002. [PMID: 17993283] - A D Anastasilakis, D G Goulis, S A Polyzos, S Gerou, G N Koukoulis, Z Efstathiadou, M Kita, A Avramidis. Head-to-head comparison of risedronate vs. teriparatide on bone turnover markers in women with postmenopausal osteoporosis: a randomised trial.
International journal of clinical practice.
2008 Jun; 62(6):919-24. doi:
10.1111/j.1742-1241.2008.01768.x. [PMID: 18422590] - Jordan L Geller, Bei Hu, Susan Reed, James Mirocha, John S Adams. Increase in bone mass after correction of vitamin D insufficiency in bisphosphonate-treated patients.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2008 Apr; 14(3):293-7. doi:
10.4158/ep.14.3.293. [PMID: 18463035] - A D Anastasilakis, D G Goulis, S A Polyzos, S Gerou, G Koukoulis, M Kita, A Avramidis. Serum osteoprotegerin and RANKL are not specifically altered in women with postmenopausal osteoporosis treated with teriparatide or risedronate: a randomized, controlled trial.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2008 Apr; 40(4):281-5. doi:
10.1055/s-2008-1046787. [PMID: 18275008] - N B Watts, A Chines, W P Olszynski, C D McKeever, M R McClung, X Zhou, A Grauer. Fracture risk remains reduced one year after discontinuation of risedronate.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2008 Mar; 19(3):365-72. doi:
10.1007/s00198-007-0460-7. [PMID: 17938986]