Sodium phenylbutyrate (BioDeep_00000742951)
代谢物信息卡片
Sodium phenylbutyrate
化学式: C10H11NaO2 (186.0656706)
中文名称: 4-苯基丁酸钠盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CCCC(=O)[O-].[Na+]
InChI: /q
描述信息
A - Alimentary tract and metabolism > A16 - Other alimentary tract and metabolism products > A16A - Other alimentary tract and metabolism products > A16AX - Various alimentary tract and metabolism products
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lu Liu, Jie Wu, Changlin Zhang, Tong Cao, Yongli Lu, Zhi He, Zicheng Li. Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice.
Brain research.
2024 Jul; 1835(?):148930. doi:
10.1016/j.brainres.2024.148930. [PMID: 38604556] - Yuanqun Zhou, Yu Zhu, Yue Wu, Xinming Xiang, Xingnan Ouyang, Liangming Liu, Tao Li. 4-phenylbutyric acid improves sepsis-induced cardiac dysfunction by modulating amino acid metabolism and lipid metabolism via Comt/Ptgs2/Ppara.
Metabolomics : Official journal of the Metabolomic Society.
2024 Apr; 20(3):46. doi:
10.1007/s11306-024-02112-3. [PMID: 38641695] - Caroline N Rivera, Carly E Smith, Lillian V Draper, Rachel M Watne, Andrew J Wommack, Roger A Vaughan. Physiological 4-phenylbutyrate promotes mitochondrial biogenesis and metabolism in C2C12 myotubes.
Biochimie.
2024 Apr; 219(?):155-164. doi:
10.1016/j.biochi.2023.11.009. [PMID: 38008282] - Lei Wang, Daoliang Zhang, Benzheng Jiang, Hongyan Ding, Shibin Feng, Chang Zhao, Xichun Wang, Jinjie Wu. 4-Phenylbutyric Acid Attenuates Soybean Glycinin/β-Conglycinin-Induced IPEC-J2 Cells Apoptosis by Regulating the Mitochondria-Associated Endoplasmic Reticulum Membrane and NLRP-3.
Journal of agricultural and food chemistry.
2024 Mar; 72(11):5926-5934. doi:
10.1021/acs.jafc.3c09630. [PMID: 38457471] - Rui Li, Fan Li, Xuning Wang, Mingxin Bai, Hu Fu, Zhengli Yan, Xiaoping Yang, Yongfei Zhu. 4-Phenylbutyric acid may prevent mouse ovarian and uterine damage due to procymidone-induced alteration of circRNA Scar and circZc3h4 levels by controlling excessive unfolded protein response.
Pesticide biochemistry and physiology.
2023 Nov; 196(?):105631. doi:
10.1016/j.pestbp.2023.105631. [PMID: 37945263] - Cong-Shu Huang, Hui-Fang Deng, Lei Zhou, Pan Shen, Yu-Hao Ni, Ning-Ning Wang, Gao-Fu Li, Lan-Xin Yue, Yong-Qiang Zhou, Wei Zhou, Yue Gao. Undesirable ER stress induced by bavachin contributed to follicular atresia in zebrafish ovary.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 166(?):115322. doi:
10.1016/j.biopha.2023.115322. [PMID: 37586115] - Can Can Guo, Zhao Meng Xu, Yi Lyu, Xiao Hui Li, Zhao Fei Li, Hui He, Feng Jie Tian, Jin Ping Zheng. PM2.5 induces autophagy-dependent ferroptosis by endoplasmic reticulum stress in SH-SY5Y cells.
Journal of applied toxicology : JAT.
2023 07; 43(7):1013-1025. doi:
10.1002/jat.4439. [PMID: 36700298] - Lixia Hong, Yide Xu, Dongdong Wang, Qi Zhang, Xiaoting Li, Chunfeng Xie, Jieshu Wu, Caiyun Zhong, Jinyan Fu, Shanshan Geng. Sulforaphane ameliorates bisphenol A-induced hepatic lipid accumulation by inhibiting endoplasmic reticulum stress.
Scientific reports.
2023 01; 13(1):1147. doi:
10.1038/s41598-023-28395-5. [PMID: 36670177] - Bo He, Zhigang Wang, Régis Moreau. Chylomicron production is repressed by RPTOR knockdown, R-α-lipoic acid and 4-phenylbutyric acid in human enterocyte-like Caco-2 cells.
The Journal of nutritional biochemistry.
2022 10; 108(?):109087. doi:
10.1016/j.jnutbio.2022.109087. [PMID: 35691593] - Hai Jia, Tongkun Zhang, Ning Liu, Xuemeng Si, Jun Bai, Ying Yang, Zhaohui Chen, Zhenlong Wu. 4-Phenylbutyric acid alleviates 3-acetyldeoxynivalenol-induced immune cells response by inhibiting endoplasmic reticulum stress in mouse spleen.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Jun; 164(?):113002. doi:
10.1016/j.fct.2022.113002. [PMID: 35413383] - Tianmu He, Qiyi Wang, Jingwen Ao, Kuan Chen, Xiaofei Li, Jianyong Zhang, Cancan Duan. Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 May; 163(?):112986. doi:
10.1016/j.fct.2022.112986. [PMID: 35398186] - Mark Sicking, Martina Živná, Pratiti Bhadra, Veronika Barešová, Andrea Tirincsi, Drazena Hadzibeganovic, Kateřina Hodaňová, Petr Vyleťal, Jana Sovová, Ivana Jedličková, Martin Jung, Thomas Bell, Volkhard Helms, Anthony J Bleyer, Stanislav Kmoch, Adolfo Cavalié, Sven Lang. Phenylbutyrate rescues the transport defect of the Sec61α mutations V67G and T185A for renin.
Life science alliance.
2022 04; 5(4):. doi:
10.26508/lsa.202101150. [PMID: 35064074] - Qianqian Xiao, Xiaohong Hou, Chenping Kang, Linglu Xu, Lilan Yuan, Zhe Zhao, Qinghe Meng, Jianjun Jiang, Weidong Hao. Chlorocholine chloride induced testosterone secretion inhibition mediated by endoplasmic reticulum stress in primary rat Leydig cells.
Toxicology letters.
2022 Mar; 356(?):161-171. doi:
10.1016/j.toxlet.2021.12.018. [PMID: 34958886] - Duygu Elif Yilmaz, Karin Kirschner, Hasan Demirci, Nina Himmerkus, Sebastian Bachmann, Kerim Mutig. Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells.
The Journal of biological chemistry.
2022 03; 298(3):101589. doi:
10.1016/j.jbc.2022.101589. [PMID: 35033536] - Jing Chen, Hongbo Wu, Xudong Tang, Lei Chen. 4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress.
Bioengineered.
2022 02; 13(2):2866-2877. doi:
10.1080/21655979.2021.2024970. [PMID: 35045794] - Xiangyan Liu, Ze Wang, Xianglin Wang, Xiaona Yan, Qing He, Sha Liu, Mengke Ye, Xiaowen Li, Zhihang Yuan, Jing Wu, Jine Yi, Lixin Wen, Rongfang Li. Involvement of endoplasmic reticulum stress-activated PERK-eIF2α-ATF4 signaling pathway in T-2 toxin-induced apoptosis of porcine renal epithelial cells.
Toxicology and applied pharmacology.
2021 12; 432(?):115753. doi:
10.1016/j.taap.2021.115753. [PMID: 34637808] - Yujie Zhong, Chengni Jin, Jiahui Han, Jiachang Zhu, Qi Liu, Dianjun Sun, Xiaodong Xia, Xiaoli Peng. Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca2+ homeostasis.
Cell biology and toxicology.
2021 10; 37(5):795-809. doi:
10.1007/s10565-021-09589-x. [PMID: 33651226] - Zhaoling Shi, Yue Yin, Chen Li, Hui Ding, Nan Mu, Yishi Wang, Shanshan Jin, Heng Ma, Manling Liu, Jie Zhou. Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities.
Science China. Life sciences.
2021 Jun; 64(6):1000-1012. doi:
10.1007/s11427-019-1772-8. [PMID: 32915407] - Shaimaa H Gadallah, Hala M Ghanem, Amany Abdel-Ghaffar, Fatma G Metwaly, Laila K Hanafy, Emad K Ahmed. 4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy.
Archives of physiology and biochemistry.
2021 Jun; 127(3):235-244. doi:
10.1080/13813455.2019.1628069. [PMID: 31215250] - Rulin Ma, Bei Li, Cheng Zhang, Rongrong Lei, Xiao Zhang, Chao Wang, Shun Zhang, Aiguo Wang. Roles of endoplasmic reticulum stress in 2,2',4,4'-tetrabromodiphenylether-induced thyroid cell apoptosis and autophagy.
Ecotoxicology and environmental safety.
2021 May; 214(?):112077. doi:
10.1016/j.ecoenv.2021.112077. [PMID: 33647853] - Wenlai He, Dezhe Qin, Balun Li, Huimin Zhang, Xuedi Cheng, Jing Sun, Jinlian Hua, Sha Peng. Immortalized canine adipose-derived mesenchymal stem cells alleviate gentamicin-induced acute kidney injury by inhibiting endoplasmic reticulum stress in mice and dogs.
Research in veterinary science.
2021 May; 136(?):39-50. doi:
10.1016/j.rvsc.2021.02.001. [PMID: 33582313] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Shuhei Osaka, Satoshi Nakano, Tadahaya Mizuno, Yuka Hiraoka, Kei Minowa, Saeko Hirai, Ayumu Mizutani, Yusuke Sabu, Yoshiki Miura, Toshiaki Shimizu, Hiroyuki Kusuhara, Mitsuyoshi Suzuki, Hisamitsu Hayashi. A randomized trial to examine the impact of food on pharmacokinetics of 4-phenylbutyrate and change in amino acid availability after a single oral administration of sodium 4-phenylbutyrarte in healthy volunteers.
Molecular genetics and metabolism.
2021 04; 132(4):220-226. doi:
10.1016/j.ymgme.2021.02.002. [PMID: 33648834] - Rachida Amzal, Alice Thébaut, Martine Lapalus, Marion Almes, Brigitte Grosse, Elodie Mareux, Mauricette Collado-Hilly, Anne Davit-Spraul, Laure Bidou, Olivier Namy, Emmanuel Jacquemin, Emmanuel Gonzales. Pharmacological Premature Termination Codon Readthrough of ABCB11 in Bile Salt Export Pump Deficiency: An In Vitro Study.
Hepatology (Baltimore, Md.).
2021 04; 73(4):1449-1463. doi:
10.1002/hep.31476. [PMID: 32702170] - Amany Abdel-Ghaffar, Ghada G Elhossary, Atef M Mahmoud, Amany H M Elshazly, Olfat A Hassanin, Anisa Saleh, Sahar M Mansour, Fatma G Metwally, Laila K Hanafy, Sawsan H Karam, Neveen Darweesh, Ahmed Mostafa Ata. Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation.
Archives of physiology and biochemistry.
2021 Mar; ?(?):1-11. doi:
10.1080/13813455.2021.1888302. [PMID: 33653182] - Tanyel Zubarioglu, Elif Dede, Humeyra Cigdem, Ertugrul Kiykim, Mehmet S Cansever, Cigdem Aktuglu-Zeybek. Impact of sodium phenylbutyrate treatment in acute management of maple syrup urine disease attacks: a single-center experience.
Journal of pediatric endocrinology & metabolism : JPEM.
2021 Jan; 34(1):121-126. doi:
10.1515/jpem-2020-0356. [PMID: 33180043] - Beatriz Delgado-Valero, Lucía de la Fuente-Chávez, Ana Romero-Miranda, María Visitación Bartolomé, Bunty Ramchandani, Fabián Islas, María Luaces, Victoria Cachofeiro, Ernesto Martínez-Martínez. Role of endoplasmic reticulum stress in renal damage after myocardial infarction.
Clinical science (London, England : 1979).
2021 01; 135(1):143-159. doi:
10.1042/cs20201137. [PMID: 33355632] - Jiyoung Lee, Shuo Geng, Song Li, Liwu Li. Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits.
Frontiers in immunology.
2021; 12(?):627036. doi:
10.3389/fimmu.2021.627036. [PMID: 33708217] - Jian-Ri Li, Yen-Chuan Ou, Chih-Cheng Wu, Jiaan-Der Wang, Shih-Yi Lin, Ya-Yu Wang, Wen-Ying Chen, Su-Lan Liao, Chun-Jung Chen. Endoplasmic reticulum stress and autophagy contributed to cadmium nephrotoxicity in HK-2 cells and Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2020 Dec; 146(?):111828. doi:
10.1016/j.fct.2020.111828. [PMID: 33127495] - Ke Gao, Chengfei Zhang, Yihong Tian, Sajid Naeem, Yingmei Zhang, Yongmei Qi. The role of endoplasmic reticulum stress in lead (Pb)-induced mitophagy of HEK293 cells.
Toxicology and industrial health.
2020 Dec; 36(12):1002-1009. doi:
10.1177/0748233720971882. [PMID: 33169630] - Hannah Crossland, Kenneth Smith, Iskandar Idris, Bethan E Phillips, Philip J Atherton, Daniel J Wilkinson. Exploring mechanistic links between extracellular branched-chain amino acids and muscle insulin resistance: an in vitro approach.
American journal of physiology. Cell physiology.
2020 12; 319(6):C1151-C1157. doi:
10.1152/ajpcell.00377.2020. [PMID: 33026831] - Sabrina Paganoni, Eric A Macklin, Suzanne Hendrix, James D Berry, Michael A Elliott, Samuel Maiser, Chafic Karam, James B Caress, Margaret A Owegi, Adam Quick, James Wymer, Stephen A Goutman, Daragh Heitzman, Terry Heiman-Patterson, Carlayne E Jackson, Colin Quinn, Jeffrey D Rothstein, Edward J Kasarskis, Jonathan Katz, Liberty Jenkins, Shafeeq Ladha, Timothy M Miller, Stephen N Scelsa, Tuan H Vu, Christina N Fournier, Jonathan D Glass, Kristin M Johnson, Andrea Swenson, Namita A Goyal, Gary L Pattee, Patricia L Andres, Suma Babu, Marianne Chase, Derek Dagostino, Samuel P Dickson, Noel Ellison, Meghan Hall, Kent Hendrix, Gale Kittle, Michelle McGovern, Joseph Ostrow, Lindsay Pothier, Rebecca Randall, Jeremy M Shefner, Alexander V Sherman, Eric Tustison, Prasha Vigneswaran, Jason Walker, Hong Yu, James Chan, Janet Wittes, Joshua Cohen, Justin Klee, Kent Leslie, Rudolph E Tanzi, Walter Gilbert, Patrick D Yeramian, David Schoenfeld, Merit E Cudkowicz. Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.
The New England journal of medicine.
2020 09; 383(10):919-930. doi:
10.1056/nejmoa1916945. [PMID: 32877582] - Ross Mangum, Claudia Soler-Alfonso, Sherri Birchansky, Alexandra Stevens. Survival and Neurologic Recovery After Prompt Diagnosis and Aggressive Management of Severe Idiopathic Hyperammonemic Encephalopathy in a Patient with Acute Myeloid Leukemia.
Journal of pediatric hematology/oncology.
2020 08; 42(6):e452-e455. doi:
10.1097/mph.0000000000001579. [PMID: 31415019] - Kyung Hwan Jegal, Eun Ok Kim, Jae Kwang Kim, Sang Mi Park, Dae Hwa Jung, Gum Hwa Lee, Sung Hwan Ki, Sung Hui Byun, Sae Kwang Ku, Il Je Cho, Sang Chan Kim. Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.
Toxicology and applied pharmacology.
2020 07; 399(?):115036. doi:
10.1016/j.taap.2020.115036. [PMID: 32407927] - Chongshan Dai, Qiangqiang Liu, Daowen Li, Gaurav Sharma, Jianli Xiong, Xilong Xiao. Molecular Insights of Copper Sulfate Exposure-Induced Nephrotoxicity: Involvement of Oxidative and Endoplasmic Reticulum Stress Pathways.
Biomolecules.
2020 07; 10(7):. doi:
10.3390/biom10071010. [PMID: 32650488] - Bingwei Yang, Qi Qin, Lei Xu, Xuying Lv, Zixuan Liu, Erqun Song, Yang Song. Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36.
Chemical research in toxicology.
2020 06; 33(6):1497-1507. doi:
10.1021/acs.chemrestox.0c00123. [PMID: 32434321] - Jingshu Liu, Rachel L Taylor, Richard A Baines, Lisa Swanton, Sally Freeman, Barbara Corneo, Achchhe Patel, Alan Marmorstein, Travis Knudsen, Graeme C Black, Forbes Manson. Small Molecules Restore Bestrophin 1 Expression and Function of Both Dominant and Recessive Bestrophinopathies in Patient-Derived Retinal Pigment Epithelium.
Investigative ophthalmology & visual science.
2020 05; 61(5):28. doi:
10.1167/iovs.61.5.28. [PMID: 32421148] - Martin D Salazar, Nathan B Zelt, Robert Saldivar, Charles P Kuntz, Sheng Chen, Wesley D Penn, Richard Bonneau, Julia Koehler Leman, Jonathan P Schlebach. Classification of the Molecular Defects Associated with Pathogenic Variants of the SLC6A8 Creatine Transporter.
Biochemistry.
2020 04; 59(13):1367-1377. doi:
10.1021/acs.biochem.9b00956. [PMID: 32207963] - Ke Chen, Hu Hua, Ziyang Zhu, Tong Wu, Zhanjun Jia, Qianqi Liu. Artemisinin and dihydroartemisinin promote β-cell apoptosis induced by palmitate via enhancing ER stress.
Apoptosis : an international journal on programmed cell death.
2020 04; 25(3-4):192-204. doi:
10.1007/s10495-019-01587-z. [PMID: 31894447] - Mayumi Matsufuji, Eiko Takeshita, Masayuki Nakashima, Yoriko Watanabe, Kaori Fukui, Toshio Hanai, Hiromi Ishibashi, Sachio Takashima. Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency.
Brain & development.
2020 Feb; 42(2):231-235. doi:
10.1016/j.braindev.2019.09.002. [PMID: 31604595] - Yuxin Zhong, Baoqiang Wang, Shan Hu, Tingting Wang, Yumiao Zhang, Jinling Wang, Yuqing Liu, Hongxia Zhang. The role of endoplasmic reticulum stress in renal damage caused by acute mercury chloride poisoning.
The Journal of toxicological sciences.
2020; 45(9):589-598. doi:
10.2131/jts.45.589. [PMID: 32879258] - Yifan Wu, Yiyang Zhao, Xuanhong He, Zhiqiang He, Tian Wang, Linxi Wan, Lai Chen, Nianlong Yan. Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Molecular medicine reports.
2020 01; 21(1):249-257. doi:
10.3892/mmr.2019.10802. [PMID: 31746388] - Yingli Yu, Ruili Yu, Weijie Men, Panyang Zhang, Yue Zhang, Lei Song, Kun Zhou. Psoralen induces hepatic toxicity through PERK and ATF6 related ER stress pathways in HepG2 cells.
Toxicology mechanisms and methods.
2020 Jan; 30(1):39-47. doi:
10.1080/15376516.2019.1650150. [PMID: 31364909] - Ali El-Kasaby, Ameya Kasture, Florian Koban, Matej Hotka, Hafiz M M Asjad, Helmut Kubista, Michael Freissmuth, Sonja Sucic. Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.
Neuropharmacology.
2019 12; 161(?):107572. doi:
10.1016/j.neuropharm.2019.03.015. [PMID: 30885608] - Fernando Andrade, Isidro Vitoria, Elena Martín Hernández, Guillem Pintos-Morell, Patricia Correcher, Rocío Puig-Piña, Pilar Quijada-Fraile, Luis Peña-Quintana, Ana Mª Marquez, Olatz Villate, Mª Teresa García Silva, Javier de Las Heras, Leticia Ceberio, Esmeralda Rodrigues, Teresa Almeida Campos, Raquel Yahyaoui, Javier Blasco, Inmaculada Vives-Piñera, David Gil, Mireia Del Toro, Mónica Ruiz-Pons, Elvira Cañedo, Miguel Angel Barba Romero, Mª Concepción García-Jiménez, Luis Aldámiz-Echevarría. Quantification of urinary derivatives of Phenylbutyric and Benzoic acids by LC-MS/MS as treatment compliance biomarkers in Urea Cycle disorders.
Journal of pharmaceutical and biomedical analysis.
2019 Nov; 176(?):112798. doi:
10.1016/j.jpba.2019.112798. [PMID: 31394303] - Satoshi Nakano, Shuhei Osaka, Yusuke Sabu, Kei Minowa, Saeko Hirai, Hiroki Kondou, Takeshi Kimura, Yoshihiro Azuma, Satoshi Watanabe, Ayano Inui, Kazuhiko Bessho, Hidefumi Nakamura, Hironori Kusano, Atsuko Nakazawa, Ken Tanikawa, Masayoshi Kage, Toshiaki Shimizu, Hiroyuki Kusuhara, Yoh Zen, Mitsuyoshi Suzuki, Hisamitsu Hayashi. Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis.
Scientific reports.
2019 11; 9(1):17075. doi:
10.1038/s41598-019-53628-x. [PMID: 31745229] - Junlin Pan, YuanYuan Yao, Xiuxiu Guo, Fengyun Kong, Jun Zhou, Xiaoqian Meng. Endoplasmic reticulum stress, a novel significant mechanism responsible for DEHP-induced increased distance between seminiferous tubule of mouse testis.
Journal of cellular physiology.
2019 11; 234(11):19807-19823. doi:
10.1002/jcp.28580. [PMID: 30989653] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Hailong Hu, Xingpei Fan, Yao Yin, Qian Guo, Daqian Yang, Xiangjuan Wei, Boya Zhang, Jing Liu, Qiong Wu, Yuri Oh, Kun Chen, Yujie Feng, Liping Hou, Li Li, Ning Gu. Mechanisms of titanium dioxide nanoparticle-induced oxidative stress and modulation of plasma glucose in mice.
Environmental toxicology.
2019 Nov; 34(11):1221-1235. doi:
10.1002/tox.22823. [PMID: 31298478] - Shaolei Ma, Xiangrong Zuo, Yujie Wang, Jing Yao, Yongzhi Zhou, Changsheng Xu. [Protective effect of sodium 4-phenylbutyrate on rats with acute respiratory distress syndrome related right ventricular dysfunction by alleviating endoplasmic reticulum stress].
Zhonghua wei zhong bing ji jiu yi xue.
2019 Oct; 31(10):1269-1274. doi:
10.3760/cma.j.issn.2095-4352.2019.10.017. [PMID: 31771727] - Ester Zito. Targeting ER stress/ER stress response in myopathies.
Redox biology.
2019 09; 26(?):101232. doi:
10.1016/j.redox.2019.101232. [PMID: 31181458] - Logan K Townsend, Kyle D Medak, Willem T Peppler, Grace M Meers, R Scott Rector, Paul J LeBlanc, David C Wright. High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.
Journal of lipid research.
2019 07; 60(7):1236-1249. doi:
10.1194/jlr.m092510. [PMID: 31085628] - Edward G Lynn, Šárka Lhoták, Paul Lebeau, Jae Hyun Byun, Jack Chen, Khrystyna Platko, Chunhua Shi, Edward R O'Brien, Richard C Austin. 4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe-/- mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 07; 33(7):8406-8422. doi:
10.1096/fj.201802293rr. [PMID: 30964709] - Kuo-How Huang, Siao-Syun Guan, Wei-Han Lin, Cheng-Tien Wu, Meei-Ling Sheu, Chih-Kang Chiang, Shing-Hwa Liu. Role of Calbindin-D28k in Diabetes-Associated Advanced Glycation End-Products-Induced Renal Proximal Tubule Cell Injury.
Cells.
2019 06; 8(7):. doi:
10.3390/cells8070660. [PMID: 31262060] - Qi Zhou, Wenjia Guo, Yanan Jia, Jiancheng Xu. Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice.
Biological trace element research.
2019 Jun; 189(2):501-510. doi:
10.1007/s12011-018-1494-8. [PMID: 30171596] - Bo He, Régis Moreau. Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.
Pharmacological research.
2019 06; 144(?):116-131. doi:
10.1016/j.phrs.2019.04.002. [PMID: 30954630] - Yun-Dong You, Wen-Hong Deng, Wen-Yi Guo, Liang Zhao, Fang-Chao Mei, Yu-Pu Hong, Yu Zhou, Jia Yu, Sheng Xu, Wei-Xing Wang. 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.
Digestive diseases and sciences.
2019 06; 64(6):1535-1547. doi:
10.1007/s10620-018-5437-1. [PMID: 30607691] - Safaa Naiel, Rachel E Carlisle, Chao Lu, Victor Tat, Jeffrey G Dickhout. Endoplasmic reticulum stress inhibition blunts the development of essential hypertension in the spontaneously hypertensive rat.
American journal of physiology. Heart and circulatory physiology.
2019 05; 316(5):H1214-H1223. doi:
10.1152/ajpheart.00523.2018. [PMID: 30848678] - Richa Randhawa, Rishi Bhardwaj, Tanzeer Kaur. Amelioration of hyperoxaluria-induced kidney dysfunction by chemical chaperone 4-phenylbutyric acid.
Urolithiasis.
2019 Apr; 47(2):171-179. doi:
10.1007/s00240-018-1064-8. [PMID: 29947992] - Min-Ge Wang, Rui-Feng Fan, Wen-Hui Li, Dong Zhang, Du-Bao Yang, Zhen-Yong Wang, Lin Wang. Activation of PERK-eIF2α-ATF4-CHOP axis triggered by excessive ER stress contributes to lead-induced nephrotoxicity.
Biochimica et biophysica acta. Molecular cell research.
2019 04; 1866(4):713-726. doi:
10.1016/j.bbamcr.2018.12.002. [PMID: 30528975] - Xin Chou, Fan Ding, Xiaoyan Zhang, Xiaoqiang Ding, Hui Gao, Qing Wu. Sirtuin-1 ameliorates cadmium-induced endoplasmic reticulum stress and pyroptosis through XBP-1s deacetylation in human renal tubular epithelial cells.
Archives of toxicology.
2019 04; 93(4):965-986. doi:
10.1007/s00204-019-02415-8. [PMID: 30796460] - Qian Guo, Hailong Hu, Ying Zhou, Yuheng Yan, Xiangjuan Wei, Xingpei Fan, Daqian Yang, Hongjuan He, Yuri Oh, Kun Chen, Qiong Wu, Chuanpeng Liu, Ning Gu. Glucosamine induces increased musclin gene expression through endoplasmic reticulum stress-induced unfolding protein response signaling pathways in mouse skeletal muscle cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Mar; 125(?):95-105. doi:
10.1016/j.fct.2018.12.051. [PMID: 30602124] - Xiaohan Zhang, Shanshan Shao, Lifang Zhao, Rui Yang, Meng Zhao, Li Fang, Mengzhu Li, Wenbin Chen, Yongfeng Song, Chao Xu, Xiaoming Zhou, Jiajun Zhao, Ling Gao. ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism.
American journal of physiology. Endocrinology and metabolism.
2019 03; 316(3):E510-E518. doi:
10.1152/ajpendo.00194.2018. [PMID: 30620634] - Mathilde L Bonnemaison, Eileen S Marks-Nelson, Erika I Boesen. Sodium 4-phenylbutyrate treatment protects against renal injury in NZBWF1 mice.
Clinical science (London, England : 1979).
2019 01; 133(2):167-180. doi:
10.1042/cs20180562. [PMID: 30617186] - S Giva, J Finnegan, P Ihidero, G Maguire, B Power, I Knerr, A Monavari. Hyperammonaemia in Neonates and Young Children: Potential Metabolic Causes, Diagnostic Approaches and Clinical Consequences.
Irish medical journal.
2019 01; 112(1):858. doi:
NULL. [PMID: 30719899] - Senait Ashenafi, Wondwossen Amogne, Endale Kassa, Nebiat Gebreselassie, Amsalu Bekele, Getachew Aseffa, Meron Getachew, Abraham Aseffa, Alemayehu Worku, Ulf Hammar, Peter Bergman, Getachew Aderaye, Jan Andersson, Susanna Brighenti. Daily Nutritional Supplementation with Vitamin D₃ and Phenylbutyrate to Treatment-Naïve HIV Patients Tested in a Randomized Placebo-Controlled Trial.
Nutrients.
2019 Jan; 11(1):. doi:
10.3390/nu11010133. [PMID: 30634590] - Sheng Wang, Jiajie Luan, Xiongwen Lv. Inhibition of Endoplasmic Reticulum Stress Attenuated Ethanol-Induced Exosomal miR-122 and Acute Liver Injury in Mice.
Alcohol and alcoholism (Oxford, Oxfordshire).
2019 Jan; 54(5):465-471. doi:
10.1093/alcalc/agz058. [PMID: 31361816] - Minu Sharma, Amarjit S Naura, S K Singla. Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation.
Molecular and cellular biochemistry.
2019 Jan; 451(1-2):185-196. doi:
10.1007/s11010-018-3405-x. [PMID: 30066041] - Chang Ho Kang, Joung Hun Park, Eun Seon Lee, Seol Ki Paeng, Ho Byoung Chae, Yong Hun Chi, Sang Yeol Lee. Exploring Novel Functions of the Small GTPase Ypt1p under Heat-Shock by Characterizing a Temperature-Sensitive Mutant Yeast Strain, ypt1-G80D.
International journal of molecular sciences.
2019 Jan; 20(1):. doi:
10.3390/ijms20010132. [PMID: 30609659] - Yuya Urano, Shingo Oda, Koichi Tsuneyama, Tsuyoshi Yokoi. Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice.
Chemico-biological interactions.
2018 Dec; 296(?):185-197. doi:
10.1016/j.cbi.2018.09.011. [PMID: 30243991] - Er Hui Wang, San Qiao Yao, Ling Tao, Jin Yan Xi. Sodium 4-phenylbutyrate Attenuates High-fat Diet-induced Impaired Spermatogenesis.
Biomedical and environmental sciences : BES.
2018 Dec; 31(12):876-882. doi:
10.3967/bes2018.118. [PMID: 30636657] - Yu-Pu Hong, Wen-Hong Deng, Wen-Yi Guo, Qiao Shi, Liang Zhao, Yun-Dong You, Fang-Chao Mei, Yu Zhou, Chen-Yang Wang, Chen Chen, Jia Yu, Wei-Xing Wang. Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology.
2018 11; 315(5):G838-G847. doi:
10.1152/ajpgi.00102.2018. [PMID: 30138574] - Anne-Sophie Wilding, Christine Patte-Mensah, Omar Taleb, Susana Brun, Véronique Kemmel, Ayikoe-Guy Mensah-Nyagan. Protective effect of 4-Phenylbutyrate against proteolipid protein mutation-induced endoplasmic reticulum stress and oligodendroglial cell death.
Neurochemistry international.
2018 09; 118(?):185-194. doi:
10.1016/j.neuint.2018.06.008. [PMID: 29936187] - Junjie Guo, Jianbing Zhu, Leilei Ma, Hongtao Shi, Jiachang Hu, Shuning Zhang, Lei Hou, Fengqiang Xu, Yi An, Haichu Yu, Junbo Ge. Chronic Kidney Disease Exacerbates Myocardial Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis.
Shock (Augusta, Ga.).
2018 06; 49(6):712-720. doi:
10.1097/shk.0000000000000970. [PMID: 28846567] - Mai Hazekawa, Kazuhiko Ono, Takuya Nishinakagawa, Tomoyo Kawakubo-Yasukochi, Manabu Nakashima. In Vitro Anti-inflammatory Effects of the Phenylbutyric Acid Metabolite Phenylacetyl Glutamine.
Biological & pharmaceutical bulletin.
2018 Jun; 41(6):961-966. doi:
10.1248/bpb.b17-00799. [PMID: 29526885] - Zehe Ge, Haipeng Diao, Xiaoli Ji, Qingping Liu, Xiaoyan Zhang, Qing Wu. Gap junctional intercellular communication and endoplasmic reticulum stress regulate chronic cadmium exposure induced apoptosis in HK-2 cells.
Toxicology letters.
2018 May; 288(?):35-43. doi:
10.1016/j.toxlet.2018.02.013. [PMID: 29444456] - Qian Deng, Liang Liang, Quanhai Liu, Wanli Duan, Yazhuo Jiang, Liandong Zhang. Autophagy is a major mechanism for the dual effects of curcumin on renal cell carcinoma cells.
European journal of pharmacology.
2018 May; 826(?):24-30. doi:
10.1016/j.ejphar.2018.02.038. [PMID: 29501864] - Yu Gu, Fei Huang, Yanling Wang, Chaojin Chen, Shan Wu, Shaoli Zhou, Ziqing Hei, Dongdong Yuan. Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury.
Journal of translational medicine.
2018 05; 16(1):117. doi:
10.1186/s12967-018-1493-8. [PMID: 29728112] - Hailong Hu, Li Li, Qian Guo, He Zong, Yuheng Yan, Yao Yin, Yu Wang, Yuri Oh, Yujie Feng, Qiong Wu, Ning Gu. RNA sequencing analysis shows that titanium dioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice.
Nanotoxicology.
2018 05; 12(4):341-356. doi:
10.1080/17435390.2018.1446560. [PMID: 29510645] - Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang. Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM-CSF paracrine.
Journal of translational medicine.
2018 04; 16(1):105. doi:
10.1186/s12967-018-1481-z. [PMID: 29669585] - Juan Zhang, Wen-Shu Zhao, Xin Wang, Lin Xu, Xin-Chun Yang. Palmitic Acid Increases Endothelin-1 Expression in Vascular Endothelial Cells through the Induction of Endoplasmic Reticulum Stress and Protein Kinase C Signaling.
Cardiology.
2018; 140(3):133-140. doi:
10.1159/000490093. [PMID: 29996135] - Aric Huang, Tayler L Young, Vi T Dang, Yuanyuan Shi, Cameron S McAlpine, Geoff H Werstuck. 4-phenylbutyrate and valproate treatment attenuates the progression of atherosclerosis and stabilizes existing plaques.
Atherosclerosis.
2017 Nov; 266(?):103-112. doi:
10.1016/j.atherosclerosis.2017.09.034. [PMID: 29024862] - Lu Zou, Xiaoyan Li, Nan Wu, Pengyu Jia, Chunting Liu, Dalin Jia. Palmitate induces myocardial lipotoxic injury via the endoplasmic reticulum stress‑mediated apoptosis pathway.
Molecular medicine reports.
2017 Nov; 16(5):6934-6939. doi:
10.3892/mmr.2017.7404. [PMID: 28901411] - Noam Erez, Einav Hubel, Roy Avraham, Raya Cohen, Sigal Fishman, Heike Bantel, Michael Manns, Boaz Tirosh, Isabel Zvibel, Oren Shibolet. Hepatic Amiodarone Lipotoxicity Is Ameliorated by Genetic and Pharmacological Inhibition of Endoplasmatic Reticulum Stress.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 10; 159(2):402-412. doi:
10.1093/toxsci/kfx143. [PMID: 28962527] - Ashraf U Nissar, Love Sharma, Malik A Mudasir, Lone A Nazir, Sheikh A Umar, Parduman R Sharma, Ram A Vishwakarma, Sheikh A Tasduq. Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy.
Journal of lipid research.
2017 09; 58(9):1855-1868. doi:
10.1194/jlr.m077537. [PMID: 28655725] - Keishi Yamasaki, Taisuke Enokida, Kazuaki Taguchi, Shigeyuki Miyamura, Akito Kawai, Shuichi Miyamoto, Toru Maruyama, Hakaru Seo, Masaki Otagiri. Species Differences in the Binding of Sodium 4-Phenylbutyrate to Serum Albumin.
Journal of pharmaceutical sciences.
2017 09; 106(9):2860-2867. doi:
10.1016/j.xphs.2017.04.025. [PMID: 28456727] - Dilip Shah, Freddy Romero, Zhi Guo, Jianxin Sun, Jonathan Li, Caleb B Kallen, Ulhas P Naik, Ross Summer. Obesity-Induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury.
American journal of respiratory cell and molecular biology.
2017 08; 57(2):204-215. doi:
10.1165/rcmb.2016-0310oc. [PMID: 28277743] - Mingxue Di, Lin Wang, Mengmeng Li, Yu Zhang, Xinxin Liu, Renya Zeng, Han Wang, Yifei Chen, Weijia Chen, Yun Zhang, Mei Zhang. Dickkopf1 destabilizes atherosclerotic plaques and promotes plaque formation by inducing apoptosis of endothelial cells through activation of ER stress.
Cell death & disease.
2017 07; 8(7):e2917. doi:
10.1038/cddis.2017.277. [PMID: 28703797] - Long The Nguyen, Sonia Saad, Yi Tan, Carol Pollock, Hui Chen. Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus.
Journal of molecular endocrinology.
2017 07; 59(1):81-92. doi:
10.1530/jme-17-0056. [PMID: 28500249] - Neža Palir, Jos P N Ruiter, Ronald J A Wanders, Riekelt H Houtkooper. Identification of enzymes involved in oxidation of phenylbutyrate.
Journal of lipid research.
2017 05; 58(5):955-961. doi:
10.1194/jlr.m075317. [PMID: 28283530] - Chandak Upagupta, Rachel E Carlisle, Jeffrey G Dickhout. Analysis of the potency of various low molecular weight chemical chaperones to prevent protein aggregation.
Biochemical and biophysical research communications.
2017 04; 486(1):163-170. doi:
10.1016/j.bbrc.2017.03.019. [PMID: 28285140] - Yanbiao Ai, Zhenzhen Sun, Chuan Peng, Lingli Liu, Xiaoqiu Xiao, Jibin Li. Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice.
Nutrients.
2017 Apr; 9(4):. doi:
10.3390/nu9040346. [PMID: 28368295] - Doreen Braun, Ulrich Schweizer. The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome.
Endocrinology.
2017 03; 158(3):678-691. doi:
10.1210/en.2016-1530. [PMID: 27977298] - Viola Pomozi, Christopher Brampton, Flóra Szeri, Dóra Dedinszki, Eszter Kozák, Koen van de Wetering, Hi'ilani Hopkins, Ludovic Martin, András Váradi, Olivier Le Saux. Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice.
The Journal of investigative dermatology.
2017 03; 137(3):595-602. doi:
10.1016/j.jid.2016.10.035. [PMID: 27826008] - Shin Mukai, Yoko Ogawa, Fumihiko Urano, Chie Kudo-Saito, Yutaka Kawakami, Kazuo Tsubota. Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.
Scientific reports.
2017 02; 7(?):41939. doi:
10.1038/srep41939. [PMID: 28165054] - Zahraa Mohammed-Ali, Chao Lu, Mandeep K Marway, Rachel E Carlisle, Kjetil Ask, Dusan Lukic, Joan C Krepinsky, Jeffrey G Dickhout. Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Scientific reports.
2017 02; 7(?):41572. doi:
10.1038/srep41572. [PMID: 28148966] - Victoria Yum, Rachel E Carlisle, Chao Lu, Elise Brimble, Jasmine Chahal, Chandak Upagupta, Kjetil Ask, Jeffrey G Dickhout. Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat.
American journal of physiology. Renal physiology.
2017 01; 312(1):F230-F244. doi:
10.1152/ajprenal.00119.2016. [PMID: 28069662] - Daniel R Beriault, Vi T Dang, Lexy H Zhong, Christina I Petlura, Cameron S McAlpine, Yuanyuan Shi, Geoff H Werstuck. Glucosamine induces ER stress by disrupting lipid-linked oligosaccharide biosynthesis and N-linked protein glycosylation.
American journal of physiology. Endocrinology and metabolism.
2017 01; 312(1):E48-E57. doi:
10.1152/ajpendo.00275.2016. [PMID: 27879249] - Jin-Guo Li, Qi Hao, Ying-Xue Liu, Peng Li, Peng Li, Xia-Yan Shao, Hua Tian, Yong-Qi Fang, Shu-Tong Yao. [Advanced glycated albumin induces macrophage apoptosis via activating caspase-12 pathway].
Sheng li xue bao : [Acta physiologica Sinica].
2016 Dec; 68(6):733-739. doi:
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