Cefminox sodium (BioDeep_00000742272)
代谢物信息卡片
Cefminox sodium
化学式: C16H20N7NaO7S3 (541.048401)
中文名称: 头孢米诺七水合钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)(NC(=O)CSCC(C(=O)O)N)OC)SC2)C(=O)[O-].[Na+]
InChI: /q
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002513 - Cephamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity[1]. Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ, upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension[2].
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Xiu-ping Yin, Yan-ming Xie, Ying-jie Zhi, Wei Yang, Zhi-fei Wang, Jian Huo. [Correlation analysis on combined medication with of Xiyanping injection in treatment of lung infection in real world].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2015 Jun; 40(12):2440-4. doi:
". [PMID: 26591539] - Sangeetha Rajenderan, Veeraraghavan Balaji, Shalini Anandan, Rani Diana Sahni, Giannoula S Tansarli, Matthew E Falagas. Determination of MIC distribution of arbekacin, cefminox, fosfomycin, biapenem and other antibiotics against gram-negative clinical isolates in South India: a prospective study.
PloS one.
2014; 9(7):e103253. doi:
10.1371/journal.pone.0103253. [PMID: 25068396] - Hanwen Sun, Lijing Wei, Yuanyuan Wu, Na Liu. Simultaneous determination of aminomethylbenzoic acid, cefminox sodium and etamsylate in human urine by capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Jul; 878(21):1899-903. doi:
10.1016/j.jchromb.2010.05.017. [PMID: 20570576] - A J Torres, L D Valladares, J M Jover, A Sánchez-Pernaute, J Frías, A J Carcas, P Coronel, E Ródenas, I Pérez-Balcabao, R Fernández-Roblas, M Moreno, J L Balibrea. Cefminox versus metronidazole plus gentamicin intra-abdominal infections: a prospective randomized controlled clinical trial.
Infection.
2000 Sep; 28(5):318-22. doi:
10.1007/s150100070027. [PMID: 11073141] - N Funakoshi, A Fujiwara, H Nagaoka, F Murayama. [Clinical study on transfer into lung tissue of cefminox].
The Japanese journal of antibiotics.
1994 Feb; 47(2):210-4. doi:
NULL. [PMID: 8151913] - L Aguilar, C Esteban, J Frias, I Pérez-Balcabao, A J Carcas, R Dal-Ré. Cefminox: correlation between in-vitro susceptibility and pharmacokinetics and serum bactericidal activity in healthy volunteers.
The Journal of antimicrobial chemotherapy.
1994 Jan; 33(1):91-101. doi:
10.1093/jac/33.1.91. [PMID: 8157579] - S Arai, R Kawamura, H Kamiya, T Ishii, M Sakurai. The in vivo and in vitro postantibiotic effect of aminoglycosides using a clinically isolated micro-organism.
Acta paediatrica Japonica : Overseas edition.
1993 Feb; 35(1):17-21. doi:
10.1111/j.1442-200x.1993.tb02998.x. [PMID: 8460539] - M Imaizumi, T Ojika, H Watanabe, M Sakakibara, M Nishimura, T Abe. [A clinical study of transfer of cefminox and piperacillin into pulmonary tissue].
The Japanese journal of antibiotics.
1992 Aug; 45(8):1039-49. doi:
NULL. [PMID: 1433893] - Y DeGuchi, T Terasaki, H Yamada, A Tsuji. An application of microdialysis to drug tissue distribution study: in vivo evidence for free-ligand hypothesis and tissue binding of beta-lactam antibiotics in interstitial fluids.
Journal of pharmacobio-dynamics.
1992 Feb; 15(2):79-89. doi:
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International urology and nephrology.
1991; 23(6):569-72. doi:
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Hinyokika kiyo. Acta urologica Japonica.
1990 Jun; 36(6):737-9. doi:
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Nihon geka hokan. Archiv fur japanische Chirurgie.
1989 Sep; 58(5):445-51. doi:
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The Japanese journal of antibiotics.
1988 Jan; 41(1):25-36. doi:
NULL. [PMID: 3367512] - T Motohiro, M Aramaki, K Tanaka, T Koga, Y Shimada, S Tomita, Y Sakata, T Fujimoto, T Nishiyama, N Kuda. [Effect of cefminox on bacterial flora in human adult feces].
The Japanese journal of antibiotics.
1986 Apr; 39(4):909-57. doi:
NULL. [PMID: 3761549] - S Takamura. [Fundamental and clinical study on cefminox in the obstetrical and gynecological field].
The Japanese journal of antibiotics.
1985 Aug; 38(8):2124-8. doi:
NULL. [PMID: 3935823] - F Chiba, T Sakurai, T Nakayoshi, S Shinkai, M Fujita, I Komiya. [Tissue distribution of cefminox in beagle dogs].
The Japanese journal of antibiotics.
1985 Jul; 38(7):1769-75. doi:
NULL. [PMID: 3934421] - K Hirabayashi, E Okada. [Basic and clinical studies on cefminox in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1985 May; 38(5):1304-10. doi:
NULL. [PMID: 3930801] - H Kosakai, K Hiraoka, I Shimamoto, M Ichijo. [Clinical trial and basic study on the tissue transfer of cefminox].
The Japanese journal of antibiotics.
1985 May; 38(5):1272-8. doi:
NULL. [PMID: 3930797] - T Yamamoto, J Yasuda, M Tomioka, M Kanao, H Okada. [Basic and clinical studies on cefminox in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1985 May; 38(5):1260-7. doi:
NULL. [PMID: 3930795] - Y Kisaka, H Hiraoka, T Matsuoka, S Tanaka, H Kishida, M Aihara, T Urabe, A Fujiwara. [Basic and clinical studies on cefminox in obstetrics and gynecology].
The Japanese journal of antibiotics.
1985 May; 38(5):1287-300. doi:
NULL. [PMID: 3930799] - M Hongo, R Shimizu, K Sakae, S Hayashi, Y Mitsui, M Ando. [Study on the transfer of cefminox into female genital organs].
The Japanese journal of antibiotics.
1985 May; 38(5):1311-7. doi:
NULL. [PMID: 3930802] - F Doko. [Basic study on cefminox in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1985 May; 38(5):1301-3. doi:
NULL. [PMID: 3930800] - K Itoh, H Kondo, M Hayasaki, K Noda. [Basic and clinical studies on cefminox in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1985 May; 38(5):1244-53. doi:
NULL. [PMID: 3930793] - T Shimizu, K Sengoku. [Transfer of cefminox to tissues in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1985 May; 38(5):1198-202. doi:
NULL. [PMID: 3930786] - N Cho, M Mitsukawa, K Aoki, M Togo, T Tamura, K Kunii, K Fukunaga. [Pharmacokinetics and clinical studies on cefminox in the field of obstetrics and gynecology].
The Japanese journal of antibiotics.
1985 May; 38(5):1213-24. doi:
NULL. [PMID: 3930789] - H Majima, F Ichikawa, M Kondo, Y S Tada, M Fukushima. [A study on transference of cefminox into intrapelvic tissues].
The Japanese journal of antibiotics.
1985 May; 38(5):1241-3. doi:
NULL. [PMID: 3930792] - T Motohiro, K Tanaka, T Koga, Y Shimada, N Tomita, Y Sakata, T Fujimoto, T Nishiyama, K Ishimoto, K Tominaga. [Fundamental and clinical studies of cefminox in children].
The Japanese journal of antibiotics.
1985 Mar; 38(3):791-804. doi:
NULL. [PMID: 3839864] - T Sato, H Tasaki, K Ueda, T Kuroiwa. [Clinical studies on cefminox in pediatric field].
The Japanese journal of antibiotics.
1985 Mar; 38(3):784-90. doi:
NULL. [PMID: 3897609] - T Okada, S Furukawa. [Fundamental and clinical studies on cefminox].
The Japanese journal of antibiotics.
1985 Mar; 38(3):743-50. doi:
NULL. [PMID: 3875739] - T Hosoda, T Ichioka, M Ito, T Sekiguchi, M Miyao. [Laboratory and clinical studies on cefminox in the pediatric field].
The Japanese journal of antibiotics.
1985 Mar; 38(3):766-72. doi:
NULL. [PMID: 3897607] - H Sato, Y Hirama, A Narita, S Nakazawa, H Suzuki, K Matsumoto, K Tazoe, H Chikaoka, S Nakazawa. [Study on a new cephamycin preparation cefminox in the field of pediatrics].
The Japanese journal of antibiotics.
1985 Mar; 38(3):679-92. doi:
NULL. [PMID: 3839861] - S Arai, K Kawai, S Shimizu, Y Kawamura, H Kamiya, M Sakurai. [Fundamental and clinical studies on cefminox in the field of pediatrics].
The Japanese journal of antibiotics.
1985 Mar; 38(3):720-9. doi:
NULL. [PMID: 3897605] - N Iwai, Y Taneda, M Shibata, F Mizoguchi, M Katayama. [Fundamental and clinical studies on cefminox in the field of pediatrics].
The Japanese journal of antibiotics.
1985 Mar; 38(3):705-19. doi:
. [PMID: 3897604] - K Ichihara, S Ueda, T Nakashima, Y Miyachi, M Yafuso, K Kuno. [Clinical evaluation of cefminox in pediatric field].
The Japanese journal of antibiotics.
1985 Mar; 38(3):693-704. doi:
NULL. [PMID: 3897603] - T Nishimura, T Takashima, K Tabuki, M Takagi. [Laboratory and clinical studies of cefminox in the pediatric field].
The Japanese journal of antibiotics.
1985 Mar; 38(3):730-6. doi:
NULL. [PMID: 3839862] - S Ohnari, H Meguro, C Nonaka, T Tajima, S Takahashi, R Fujii. [Clinical evaluation of cefminox, a new cephamycin antibiotic, in the pediatric infections].
The Japanese journal of antibiotics.
1985 Mar; 38(3):671-8. doi:
NULL. [PMID: 3928938] - S Miyamoto, T Tamiya, K Takatsuka, Y Kumamoto. Comparison of rapid bacteriological response to MT-141 and latamoxef in complicated urinary tract infections.
Drugs under experimental and clinical research.
1985; 11(6):383-5. doi:
NULL. [PMID: 3939124] - K Kawaharajo, K Shitoh, M Niizeki, S Murata, Y Sekizawa. Therapeutic efficacy of a new cephamycin, MT-141, in compromised mice.
The Journal of antibiotics.
1984 Dec; 37(12):1703-11. doi:
10.7164/antibiotics.37.1703. [PMID: 6441793] - S Inouye, H Goi, T Watanabe, T Hara, K Miyauchi, T Yoshida, Y Kazuno, H Kadosawa, F Hirano, K Kawaharajo. In vitro and in vivo antibacterial activities of MT-141, a new semisynthetic cephamycin, compared with those of five cephalosporins.
Antimicrobial agents and chemotherapy.
1984 Nov; 26(5):722-9. doi:
10.1128/aac.26.5.722. [PMID: 6440478] - Y Yamaki, Y Shibazaki, H Kadosawa, S Murata, T Nishimori, F Kobayashi. [Pharmacological studies on a new cephamycin, MT-141. (2) Its effect on preparations of neuromuscular junction, smooth muscle organs and gastro-intestinal system].
The Japanese journal of antibiotics.
1984 Aug; 37(8):1470-87. doi:
NULL. [PMID: 6438365] - M Kurebe, H Asaoka, M Izawa, S Nagai, C Hirota. [Toxicological studies on a new cephamycin, MT-141. XI. Immunological properties].
The Japanese journal of antibiotics.
1984 Jul; 37(7):1417-27. doi:
NULL. [PMID: 6436554] - M Kurebe, M Yokota, H Kawaoto, T Niizato, H Hayasaka, M Seki. [Toxicological studies on a new cephamycin, MT-141, IV. Its acute toxicity in beagle dogs].
The Japanese journal of antibiotics.
1984 Jun; 37(6):1070-99. doi:
NULL. [PMID: 6436546] - T Watanabe, T Hara, T Kasai, T Ishii, K Miyauchi, H Date, M Jinzaki, H Shindo, A Matsugami, H Goi. [Antibacterial activity of MT-141 against anaerobic bacteria].
The Japanese journal of antibiotics.
1984 Jun; 37(6):1058-69. doi:
. [PMID: 6092738] - M Kurebe, H Sasaki, M Yokota, H Watanabe, H Suzuki, K Sakamoto, H Hayasaka. [Toxicological studies on a new cephamycin, MT-141. V. Its subacute toxicity in beagle dogs].
The Japanese journal of antibiotics.
1984 Jun; 37(6):1100-36. doi:
NULL. [PMID: 6436547] - M Kurebe, M Yokota, H Sasaki, T Niizato, H Kawaoto, H Suzuki, K Kumagai, M Seki. [Toxicological studies on a new cephamycin, MT-141. VI. Its chronic toxicity in beagle dogs].
The Japanese journal of antibiotics.
1984 Jun; 37(6):1137-62. doi:
NULL. [PMID: 6436548] - I Komiya, T Ishizuka, M Nishio, S Murata, Y Esumi, T Washino, K Matsunaga, K Mitsugi, T Yokoshima. [Distribution, metabolism and excretion of 14C-MT-141 in rats. I. Distribution, metabolism and excretion after single intravenous administration in male rats].
The Japanese journal of antibiotics.
1984 May; 37(5):927-37. doi:
NULL. [PMID: 6434764] - M Kurebe, M Yokota, Y Yuda, H Sasaki, T Niizato, H Watanabe, H Hayasaka. [Toxicological studies of a new cephamycin, MT-141. II. Its subacute toxicity in rats].
The Japanese journal of antibiotics.
1984 May; 37(5):855-89. doi:
NULL. [PMID: 6434761] - M Kurebe, M Yokota, H Kawaoto, T Niizato, H Watanabe, H Hayasaka. [Toxicological studies of a new cephamycin, MT-141. III. Its chronic toxicity in rats].
The Japanese journal of antibiotics.
1984 May; 37(5):890-917. doi:
NULL. [PMID: 6434762] - M Kurebe, M Yokota, H Sasaki, H Watanabe, T Ito, N Ishiwatari. [Toxicological studies on a new cephamycin, MT-141. I. Its acute toxicities in mice and rats].
The Japanese journal of antibiotics.
1984 May; 37(5):847-53. doi:
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