fenfluramine hydrochloride (BioDeep_00000741801)

   


代谢物信息卡片


fenfluramine hydrochloride

化学式: C12H17ClF3N (267.1002)
中文名称: 芬氯拉明
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNC(C)CC1=CC(=CC=C1)C(F)(F)F.Cl
InChI: 1H

描述信息

D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant
D049990 - Membrane Transport Modulators

同义名列表

1 个代谢物同义名

fenfluramine hydrochloride



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Joon Ho Moon, Chang-Myung Oh, Hail Kim. Serotonin in the regulation of systemic energy metabolism. Journal of diabetes investigation. 2022 Oct; 13(10):1639-1645. doi: 10.1111/jdi.13879. [PMID: 35762288]
  • Parthena Martin, Maciej Czerwiński, Pallavi B Limaye, Brian W Ogilvie, Steven Smith, Brooks Boyd. In vitro evaluation suggests fenfluramine and norfenfluramine are unlikely to act as perpetrators of drug interactions. Pharmacology research & perspectives. 2022 06; 10(3):e00959. doi: 10.1002/prp2.959. [PMID: 35599347]
  • Adam Strzelczyk, Susanne Schubert-Bast. A Practical Guide to the Treatment of Dravet Syndrome with Anti-Seizure Medication. CNS drugs. 2022 03; 36(3):217-237. doi: 10.1007/s40263-022-00898-1. [PMID: 35156171]
  • An-Sofie Schoonjans, Laurence Roosens, Wendy Dewals, Bernard P Paelinck, Berten Ceulemans. Therapeutic drug monitoring of fenfluramine in clinical practice: Pharmacokinetic variability and impact of concomitant antiseizure medications. Epilepsia. 2022 03; 63(3):686-696. doi: 10.1111/epi.17162. [PMID: 35032026]
  • Meagan A Quinlan, Danielle Krout, Rania M Katamish, Matthew J Robson, Catherine Nettesheim, Paul J Gresch, Deborah C Mash, L Keith Henry, Randy D Blakely. Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences. ACS chemical neuroscience. 2019 07; 10(7):3249-3260. doi: 10.1021/acschemneuro.8b00689. [PMID: 30668912]
  • Arnold Gammaitoni, Steven Smith, Brooks Boyd. The Lack of Effect of Food on the Pharmacokinetics of ZX008 (Fenfluramine Oral Solution): Results of a Single-dose, Two-period Crossover Study. Clinical therapeutics. 2018 08; 40(8):1338-1346. doi: 10.1016/j.clinthera.2018.05.013. [PMID: 29941151]
  • S Stevens Negus, Matthew L Banks. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences. 2017; 32(?):119-131. doi: 10.1007/7854_2016_18. [PMID: 27696217]
  • Julie A Suyama, Farhana Sakloth, Renata Kolanos, Richard A Glennon, Matthew F Lazenka, S Stevens Negus, Matthew L Banks. Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin. The Journal of pharmacology and experimental therapeutics. 2016 Jan; 356(1):182-90. doi: 10.1124/jpet.115.229559. [PMID: 26645638]
  • C L Bethea, K Coleman, K Phu, A P Reddy, A Phu. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. 2014 Aug; 274(?):341-56. doi: 10.1016/j.neuroscience.2014.05.056. [PMID: 24909896]
  • Marjolein S Kops, Joergen B Kjaer, Onur Güntürkün, Koen G C Westphal, Gerdien A H Korte-Bouws, Berend Olivier, J Elizabeth Bolhuis, S Mechiel Korte. Serotonin release in the caudal nidopallium of adult laying hens genetically selected for high and low feather pecking behavior: an in vivo microdialysis study. Behavioural brain research. 2014 Jul; 268(?):81-7. doi: 10.1016/j.bbr.2014.03.050. [PMID: 24720936]
  • Michael H Baumann, Simon Bulling, Tova S Benaderet, Kusumika Saha, Mario A Ayestas, John S Partilla, Syed F Ali, Thomas Stockner, Richard B Rothman, Walter Sandtner, Harald H Sitte. Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2014 May; 39(6):1355-65. doi: 10.1038/npp.2013.331. [PMID: 24287719]
  • Cody A Siciliano, Erin S Calipari, Mark J Ferris, Sara R Jones. Biphasic mechanisms of amphetamine action at the dopamine terminal. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Apr; 34(16):5575-82. doi: 10.1523/jneurosci.4050-13.2014. [PMID: 24741047]
  • M Elizabeth Sublette, Hanga C Galfalvy, Joseph R Hibbeln, John G Keilp, Kevin M Malone, Maria A Oquendo, J John Mann. Polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder. The international journal of neuropsychopharmacology. 2014 Mar; 17(3):383-91. doi: 10.1017/s1461145713001399. [PMID: 24300434]
  • H Yamanaka, C Yokoyama, H Mizuma, S Kurai, S J Finnema, C Halldin, H Doi, H Onoe. A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques. Translational psychiatry. 2014 Jan; 4(?):e342. doi: 10.1038/tp.2013.112. [PMID: 24399045]
  • Adarsh M Kumar, Mahendra Kumar, Benjamin B Lahey, Debra A Katz, Benny Fernandez, Jon A Shaw, Ana Campo, Charles B Nemeroff. Marked reduction in serotonergic activity in a sexually aggressive adolescent male. The Journal of neuropsychiatry and clinical neurosciences. 2014; 26(3):262-70. doi: 10.1176/appi.neuropsych.13060138. [PMID: 25093765]
  • Gisela Skopp, Ricarda Jantos. [Phentermine--a "weighty" or a dangerous substance?]. Archiv fur Kriminologie. 2013 Mar; 231(3-4):116-29. doi: . [PMID: 23678625]
  • H Wang, Y Wu, Y Zhao, W Sun, L Ding, B Guo, B Chen. Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2012 Aug; 29(8):1194-201. doi: 10.1080/19440049.2012.692395. [PMID: 22784191]
  • Eileen K Sawyer, Jiyoung Mun, Jonathon A Nye, Heather L Kimmel, Ronald J Voll, Jeffrey S Stehouwer, Kenner C Rice, Mark M Goodman, Leonard L Howell. Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012 Jul; 37(8):1816-24. doi: 10.1038/npp.2012.29. [PMID: 22434223]
  • J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caron. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. 2012 Jul; 17(7):694-704. doi: 10.1038/mp.2011.50. [PMID: 21537332]
  • Hyeyoung Choi, Seungkyung Baeck, Moonhee Jang, Sooyeun Lee, Hwakyung Choi, Heesun Chung. Simultaneous analysis of psychotropic phenylalkylamines in oral fluid by GC-MS with automated SPE and its application to legal cases. Forensic science international. 2012 Feb; 215(1-3):81-7. doi: 10.1016/j.forsciint.2011.02.011. [PMID: 21377815]
  • Laure Buydens-Branchey, Marc Branchey, Joseph R Hibbeln. Higher n-3 fatty acids are associated with more intense fenfluramine-induced ACTH and cortisol responses among cocaine-abusing men. Psychiatry research. 2011 Aug; 188(3):422-7. doi: 10.1016/j.psychres.2011.05.027. [PMID: 21658782]
  • Mario Thevis, Gerd Sigmund, Vassilios Gougoulidis, Simon Beuck, Nils Schlörer, Andreas Thomas, Dorota Kwiatkowska, Andrzej Pokrywka, Wilhelm Schänzer. Screening for benfluorex and its major urinary metabolites in routine doping controls. Analytical and bioanalytical chemistry. 2011 Aug; 401(2):543-51. doi: 10.1007/s00216-010-4455-4. [PMID: 21116611]
  • Amal Kaddoumi, Mitsuhiro Wada, Kenichiro Nakashima. Pharmacokinetic properties of N-nitrosofenfluramine after its administration to rats. Biomedical chromatography : BMC. 2011 May; 25(5):579-87. doi: 10.1002/bmc.1485. [PMID: 20857399]
  • Kejia Cai, Shelton D Caruthers, Wenjing Huang, Todd A Williams, Huiying Zhang, Samuel A Wickline, Gregory M Lanza, Patrick M Winter. MR molecular imaging of aortic angiogenesis. JACC. Cardiovascular imaging. 2010 Aug; 3(8):824-32. doi: 10.1016/j.jcmg.2010.03.012. [PMID: 20705262]
  • John G Keilp, Maria A Oquendo, Barbara H Stanley, Ainsley K Burke, Thomas B Cooper, Kevin M Malone, J John Mann. Future suicide attempt and responses to serotonergic challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010 Apr; 35(5):1063-72. doi: 10.1038/npp.2008.28. [PMID: 18354392]
  • Y Hayashi, S Jacob-Vadakot, E A Dugan, S McBride, R Olexa, K Simansky, M Murray, J S Shumsky. 5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats. Experimental neurology. 2010 Jan; 221(1):68-78. doi: 10.1016/j.expneurol.2009.10.003. [PMID: 19840787]
  • Sanjeev Bhattacharyya, Anthony H Schapira, Dimitri P Mikhailidis, Joseph Davar. Drug-induced fibrotic valvular heart disease. Lancet (London, England). 2009 Aug; 374(9689):577-85. doi: 10.1016/s0140-6736(09)60252-x. [PMID: 19683643]
  • Cecilie L Licht, Anders B Marcussen, Gregers Wegener, David H Overstreet, Susana Aznar, Gitte M Knudsen. The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. Journal of neurochemistry. 2009 Jun; 109(5):1363-74. doi: 10.1111/j.1471-4159.2009.06050.x. [PMID: 19476548]
  • Naoki Fujitsuka, Akihiro Asakawa, Mizuki Hayashi, Marie Sameshima, Haruka Amitani, Shinya Kojima, Mineko Fujimiya, Akio Inui. Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin. Biological psychiatry. 2009 May; 65(9):748-59. doi: 10.1016/j.biopsych.2008.10.031. [PMID: 19058784]
  • Richard B Rothman, Michael H Baumann. Serotonergic drugs and valvular heart disease. Expert opinion on drug safety. 2009 May; 8(3):317-29. doi: 10.1517/14740330902931524. [PMID: 19505264]
  • P Moulin, M André, H Alawi, L C Dos Santos, A K Khalid, D Koev, R Moore, V Serban, B Picandet, M Francillard. Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18 to 34-week, open-label, extension period. Diabetes & metabolism. 2009 Feb; 35(1):64-70. doi: 10.1016/j.diabet.2008.10.002. [PMID: 19150252]
  • Ling Wang, Fang Feng, Xue Quan Wang, Lan Zhu. Influences of urinary pH on the pharmacokinetics of three amphetamine-type stimulants using a new high-performance liquid chromatographic method. Journal of pharmaceutical sciences. 2009 Feb; 98(2):728-38. doi: 10.1002/jps.21438. [PMID: 18481797]
  • I Poizot-Martin, M P Drogoul-Vey, D Di Stefano, E Jouve, G Fabre, A Saout, J A Gastaut. A randomized, double-blind, placebo-controlled study of benfluorex in HIV-infected patients with insulin resistance or impaired glucose tolerance. HIV clinical trials. 2009 Jan; 10(1):33-40. doi: 10.1310/hct1001-033. [PMID: 19362994]
  • Richard B Rothman, Dorota Zolkowska, Michael H Baumann. Serotonin (5-HT) transporter ligands affect plasma 5-HT in rats. Annals of the New York Academy of Sciences. 2008 Oct; 1139(?):268-84. doi: 10.1196/annals.1432.042. [PMID: 18991872]
  • A Pringle, K A Jennings, S Line, D M Bannerman, S Higgs, T Sharp. Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine. Psychopharmacology. 2008 Oct; 200(2):291-300. doi: 10.1007/s00213-008-1206-8. [PMID: 18560807]
  • J-P Voigt, W Raasch, H Hörtnagl, M Bader, H Fink, O Jöhren. Changes in the brain serotonin satiety system in transgenic rats lacking brain angiotensinogen. Journal of neuroendocrinology. 2008 Feb; 20(2):182-7. doi: 10.1111/j.1365-2826.2007.01631.x. [PMID: 18047554]
  • Dorota Zolkowska, Michael H Baumann, Richard B Rothman. Chronic fenfluramine administration increases plasma serotonin (5-hydroxytryptamine) to nontoxic levels. The Journal of pharmacology and experimental therapeutics. 2008 Feb; 324(2):791-7. doi: 10.1124/jpet.107.132654. [PMID: 18032571]
  • Katsunori Nonogaki, Kana Nozue, Tomifusa Kuboki, Yoshitomo Oka. Milnacipran, a serotonin and norepinephrine reuptake inhibitor, induces appetite-suppressing effects without inducing hypothalamic stress responses in mice. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 May; 292(5):R1775-81. doi: 10.1152/ajpregu.00527.2006. [PMID: 17218444]
  • Una D McCann, Zsolt Szabo, Melin Vranesic, Esen Seckin, Gary Wand, Anna Duval, Robert F Dannals, George A Ricaurte. Quantitative positron emission tomography studies of the serotonin transporter in humans previously treated with the appetite suppressants fenfluramine or dexfenfluramine. Molecular imaging and biology. 2007 May; 9(3):151-7. doi: 10.1007/s11307-007-0082-7. [PMID: 17473958]
  • R I Caamaño-Tubío, J Pérez, S Ferreiro, M Aldegunde. Peripheral serotonin dynamics in the rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2007 Mar; 145(2):245-55. doi: 10.1016/j.cbpc.2006.12.017. [PMID: 17303475]
  • Udi E Ghitza, Richard B Rothman, David A Gorelick, Jack E Henningfield, Michael H Baumann. Serotonergic responsiveness in human cocaine users. Drug and alcohol dependence. 2007 Jan; 86(2-3):207-13. doi: 10.1016/j.drugalcdep.2006.06.007. [PMID: 16930852]
  • Katsunori Nonogaki, Kana Nozue, Yoshitomo Oka. Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice. Endocrinology. 2006 Dec; 147(12):5893-900. doi: 10.1210/en.2006-0418. [PMID: 16973729]
  • Yoshio Nakagawa, Sumiko Tayama, Akio Ogata, Toshinari Suzuki, Hidemi Ishii. ATP-generating glycolytic substrates prevent N-nitrosofenfluramine-induced cytotoxicity in isolated rat hepatocytes. Chemico-biological interactions. 2006 Dec; 164(1-2):93-101. doi: 10.1016/j.cbi.2006.08.024. [PMID: 17056023]
  • Tao Xie, Liqiong Tong, Michael W McLane, George Hatzidimitriou, Jie Yuan, Una McCann, George Ricaurte. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006 Dec; 31(12):2639-51. doi: 10.1038/sj.npp.1301031. [PMID: 16452989]
  • Tori L Schaefer, Lisa A Ehrman, Gary A Gudelsky, Charles V Vorhees, Michael T Williams. Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. Journal of neurochemistry. 2006 Sep; 98(5):1369-78. doi: 10.1111/j.1471-4159.2006.04034.x. [PMID: 16923155]
  • Kanako Satoh, Ryouichi Nonaka, Yukie Tada, Nobutaka Fukumori, Akio Ogata, Arisa Yamada, Tsuyoshi Satoh, Fumiko Nagai. Effects of N-nitrosofenfluramine, a component of Chinese dietary supplement for weight loss, on CD-1 mice. Archives of toxicology. 2006 Sep; 80(9):605-13. doi: 10.1007/s00204-006-0082-4. [PMID: 16518644]
  • Katsunori Nonogaki, Kana Ohashi-Nozue, Yoshitomo Oka. A negative feedback system between brain serotonin systems and plasma active ghrelin levels in mice. Biochemical and biophysical research communications. 2006 Mar; 341(3):703-7. doi: 10.1016/j.bbrc.2006.01.021. [PMID: 16430857]
  • Philippe Moulin, Marie Andre, Hasan Alawi, Lelita C dos Santos, Abdul K Khalid, Dragomir Koev, Ray Moore, Viorel Serban, Brigitte Picandet, Marie Francillard. Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study. Diabetes care. 2006 Mar; 29(3):515-20. doi: 10.2337/diacare.29.03.06.dc05-1439. [PMID: 16505498]
  • J J G Hillebrand, A C M Heinsbroek, M J H Kas, R A H Adan. The appetite suppressant d-fenfluramine reduces water intake, but not food intake, in activity-based anorexia. Journal of molecular endocrinology. 2006 Feb; 36(1):153-62. doi: 10.1677/jme.1.01887. [PMID: 16461935]
  • M Eriksson, U Berggren, C Fahlke, J Engel, J Balldin. Platelet monoamine oxidase B (MAO-B) activity and its relationship to DL-fenfluramine-induced prolactin response in healthy men. Journal of neural transmission (Vienna, Austria : 1996). 2006 Jan; 113(1):33-41. doi: 10.1007/s00702-005-0306-4. [PMID: 15959855]
  • Paul P Bertrand, Udeni T Paranavitane, Carolina Chavez, Andrea Gogos, Margaret Jones, Maarten van den Buuse. The effect of low estrogen state on serotonin transporter function in mouse hippocampus: a behavioral and electrochemical study. Brain research. 2005 Dec; 1064(1-2):10-20. doi: 10.1016/j.brainres.2005.10.018. [PMID: 16298349]
  • Elizabeth J Meredith, Michelle J Holder, Anita Chamba, Anita Challa, Adrian Drake-Lee, Christopher M Bunce, Mark T Drayson, Geoffrey Pilkington, Randy D Blakely, Martin J S Dyer, Nicholas M Barnes, John Gordon. The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005 Jul; 19(9):1187-9. doi: 10.1096/fj.04-3477fje. [PMID: 15870169]
  • Yoshio Nakagawa, Toshinari Suzuki, Hisashi Kamimura, Fumiko Nagai. N-Nitrosofenfluramine induces cytotoxicity via mitochondrial dysfunction and oxidative stress in isolated rat hepatocytes. Archives of toxicology. 2005 Jun; 79(6):312-20. doi: 10.1007/s00204-004-0635-3. [PMID: 15696257]
  • Stephen B Manuck, Maria E Bleil, Karen L Petersen, Janine D Flory, J John Mann, Robert E Ferrell, Matthew F Muldoon. The socio-economic status of communities predicts variation in brain serotonergic responsivity. Psychological medicine. 2005 Apr; 35(4):519-28. doi: 10.1017/s0033291704003757. [PMID: 15856722]
  • Margaret J Bradbury, Una Campbell, Darlene Giracello, Deborah Chapman, Chris King, Lida Tehrani, Nicholas D P Cosford, Jeff Anderson, Mark A Varney, Alison M Strack. Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice. The Journal of pharmacology and experimental therapeutics. 2005 Apr; 313(1):395-402. doi: 10.1124/jpet.104.076406. [PMID: 15590770]
  • Cynthia L Bethea, Francis K-Y Pau, Sam Fox, David L Hess, Sarah L Berga, Judy L Cameron. Sensitivity to stress-induced reproductive dysfunction linked to activity of the serotonin system. Fertility and sterility. 2005 Jan; 83(1):148-55. doi: 10.1016/j.fertnstert.2004.06.051. [PMID: 15652901]
  • Leo Sher, Maria A Oquendo, Hanga C Galfalvy, Thomas B Cooper, J John Mann. The number of previous depressive episodes is positively associated with cortisol response to fenfluramine administration. Annals of the New York Academy of Sciences. 2004 Dec; 1032(?):283-6. doi: 10.1196/annals.1314.039. [PMID: 15677429]
  • C Reist, C Mazzanti, R Vu, K Fujimoto, D Goldman. Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr. Molecular psychiatry. 2004 Sep; 9(9):871-8. doi: 10.1038/sj.mp.4001495. [PMID: 15037867]
  • Janine D Flory, Stephen B Manuck, James M Perel, Matthew F Muldoon. A comparison of d, l-fenfluramine and citalopram challenges in healthy adults. Psychopharmacology. 2004 Jul; 174(3):376-80. doi: 10.1007/s00213-003-1763-9. [PMID: 14997271]
  • Stephen B Manuck, Janine D Flory, Robert E Ferrell, Matthew F Muldoon. Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. Psychoneuroendocrinology. 2004 Jun; 29(5):651-68. doi: 10.1016/s0306-4530(03)00094-5. [PMID: 15041087]
  • Cynthia L Bethea, John M Streicher, Kristine Coleman, Francis K-Y Pau, Rainald Moessner, Judy L Cameron. Anxious behavior and fenfluramine-induced prolactin secretion in young rhesus macaques with different alleles of the serotonin reuptake transporter polymorphism (5HTTLPR). Behavior genetics. 2004 May; 34(3):295-307. doi: 10.1023/b:bege.0000017873.61607.be. [PMID: 14990868]
  • ". Hidden amphetamines: from smoking cessation to diabetes. Prescrire international. 2004 Feb; 13(69):18-20. doi: ". [PMID: 15055218]
  • Richard B Rothman, Subramaniam Jayanthi, Xiaoying Wang, Christina M Dersch, Jean L Cadet, Thomas Prisinzano, Kenner C Rice, Michael H Baumann. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). 2003 Dec; 50(3):233-9. doi: 10.1002/syn.10266. [PMID: 14515341]
  • Stephen B Manuck, Jay R Kaplan, Beth A Rymeski, Lynn A Fairbanks, Mark E Wilson. Approach to a social stranger is associated with low central nervous system serotonergic responsivity in female cynomolgus monkeys (Macaca fascicularis). American journal of primatology. 2003 Dec; 61(4):187-94. doi: 10.1002/ajp.10118. [PMID: 14669270]
  • Stefan Tiefenbacher, Matthew D Davenport, Melinda A Novak, Amber L Pouliot, Jerrold S Meyer. Fenfluramine challenge, self-injurious behavior, and aggression in rhesus monkeys. Physiology & behavior. 2003 Nov; 80(2-3):327-31. doi: 10.1016/j.physbeh.2003.08.001. [PMID: 14637232]
  • Yossef Itzhak, Syed F Ali, Karen L Anderson. Fenfluramine-induced serotonergic neurotoxicity in mice: lack of neuroprotection by inhibition/ablation of nNOS. Journal of neurochemistry. 2003 Oct; 87(1):268-71. doi: 10.1046/j.1471-4159.2003.02023.x. [PMID: 12969273]
  • Sean D Stocker, Matthew F Muldoon, Alan F Sved. Blunted fenfluramine-evoked prolactin secretion in hypertensive rats. Hypertension (Dallas, Tex. : 1979). 2003 Oct; 42(4):719-24. doi: 10.1161/01.hyp.0000082807.71659.4c. [PMID: 12885788]
  • ". Summaries for patients. Liver injury in 12 patients taking the herbal weight loss aids Chaso or Onshido. Annals of internal medicine. 2003 Sep; 139(6):I47. doi: 10.7326/0003-4819-139-6-200309160-00005. [PMID: 13679348]
  • Masayuki Adachi, Hidetsugu Saito, Hisashi Kobayashi, Yoshinori Horie, Shinzo Kato, Masahiro Yoshioka, Hiromasa Ishii. Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido. Annals of internal medicine. 2003 Sep; 139(6):488-92. doi: 10.7326/0003-4819-139-6-200309160-00012. [PMID: 13679326]
  • Moshe Birger, Marnina Swartz, David Cohen, Ya'akov Alesh, Chaim Grishpan, Moshe Kotelr. Aggression: the testosterone-serotonin link. The Israel Medical Association journal : IMAJ. 2003 Sep; 5(9):653-8. doi: NULL. [PMID: 14509157]
  • Philip Morris, Malcolm Hopwood, Kay Maguire, Trevor Norman, Isaac Schweitzer. Blunted prolactin response to D-fenfluramine in post-stroke major depression. Journal of affective disorders. 2003 Sep; 76(1-3):273-8. doi: 10.1016/s0165-0327(02)00078-2. [PMID: 12943959]
  • Amal Kaddoumi, Mihoko N Nakashima, Toshihide Maki, Yoshihiro Matsumura, Junzo Nakamura, Kenichiro Nakashima. Liquid chromatography studies on the pharmacokinetics of phentermine and fenfluramine in brain and blood microdialysates after intraperitoneal administration to rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jul; 791(1-2):291-303. doi: 10.1016/s1570-0232(03)00231-9. [PMID: 12798189]
  • Silvana Gaetani, Fariba Oveisi, Daniele Piomelli. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 Jul; 28(7):1311-6. doi: 10.1038/sj.npp.1300166. [PMID: 12700681]
  • John F Bowyer, John F Young, William Slikker, Yossef Itzak, A J Mayorga, Glenn D Newport, Syed F Ali, David L Frederick, Merle G Paule. Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations. Neurotoxicology. 2003 Jun; 24(3):379-90. doi: 10.1016/s0161-813x(03)00030-5. [PMID: 12782103]
  • Richard B Rothman, Robert D Clark, John S Partilla, Michael H Baumann. (+)-Fenfluramine and its major metabolite, (+)-norfenfluramine, are potent substrates for norepinephrine transporters. The Journal of pharmacology and experimental therapeutics. 2003 Jun; 305(3):1191-9. doi: 10.1124/jpet.103.049684. [PMID: 12649307]
  • George I Papakostas, Timothy Petersen, David Mischoulon, Megan E Hughes, Jonathan E Alpert, Andrew A Nierenberg, Jerrold F Rosenbaum, Maurizio Fava. Serum cholesterol and serotonergic function in major depressive disorder. Psychiatry research. 2003 May; 118(2):137-45. doi: 10.1016/s0165-1781(03)00066-0. [PMID: 12798978]
  • Royce Lee, Francisca Garcia, Louis D van de Kar, Richard D Hauger, Emil F Coccaro. Plasma oxytocin in response to pharmaco-challenge to D-fenfluramine and placebo in healthy men. Psychiatry research. 2003 May; 118(2):129-36. doi: 10.1016/s0165-1781(03)00070-2. [PMID: 12798977]
  • Hang Zeng, Yuzhong Deng, Jing-Tao Wu. Fast analysis using monolithic columns coupled with high-flow on-line extraction and electrospray mass spectrometric detection for the direct and simultaneous quantitation of multiple components in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 May; 788(2):331-7. doi: 10.1016/s1570-0232(03)00040-0. [PMID: 12705973]
  • Philippe Unger, Joëlle Nortier, Marie-Carmen Muniz Martinez, Danièle Plein, Jean-Luc Vandenbossche, Pierre Vereerstraeten, Jean-Louis Vanherweghem. High prevalence of fenfluramine-related aortic regurgitation in women with end-stage renal disease secondary to Chinese herb nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2003 May; 18(5):906-10. doi: 10.1093/ndt/gfg083. [PMID: 12686663]
  • M A Oquendo, G Echavarria, H C Galfalvy, M F Grunebaum, A Burke, A Barrera, T B Cooper, K M Malone, J John Mann. Lower cortisol levels in depressed patients with comorbid post-traumatic stress disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 Mar; 28(3):591-8. doi: 10.1038/sj.npp.1300050. [PMID: 12629542]
  • S Del Prato, D W Erkelens, M Leutenegger. Six-month efficacy of benfluorex vs. placebo or metformin in diet-failed type 2 diabetic patients. Acta diabetologica. 2003 Mar; 40(1):20-7. doi: 10.1007/s005920300004. [PMID: 12682825]
  • Didier Jourdan, Isabelle Piec, Jean-Michel Gaulier, Eric Lacassie, Josette Alliot. Effect of fenfluramine on caloric intake and macronutrient selection in Lou/c rats during aging. Neurobiology of aging. 2003 Jan; 24(1):67-76. doi: 10.1016/s0197-4580(02)00049-0. [PMID: 12493552]
  • Hugh Jones, Vivienne A Curtis, Padraig Wright, Lyn S Pilowsky, James V Lucey. D-fenfluramine-evoked serotonergic responses in olanzapine-treated schizophrenic patients. Psychiatry research. 2002 Dec; 113(1-2):41-7. doi: 10.1016/s0165-1781(02)00224-x. [PMID: 12467944]
  • C Corns, K Metcalfe. Risks associated with herbal slimming remedies. The journal of the Royal Society for the Promotion of Health. 2002 Dec; 122(4):213-9. doi: 10.1177/146642400212200407. [PMID: 12557729]
  • Stephen B Manuck, Janine D Flory, Matthew F Muldoon, Robert E Ferrell. Central nervous system serotonergic responsivity and aggressive disposition in men. Physiology & behavior. 2002 Dec; 77(4-5):705-9. doi: 10.1016/s0031-9384(02)00922-8. [PMID: 12527023]
  • Jie Yuan, Branden J Cord, Una D McCann, Brian T Callahan, George A Ricaurte. Effect of glucoprivation on serotonin neurotoxicity induced by substituted amphetamines. The Journal of pharmacology and experimental therapeutics. 2002 Nov; 303(2):831-9. doi: 10.1124/jpet.102.041277. [PMID: 12388670]
  • C Ruibal, J L Soengas, M Aldegunde. Brain serotonin and the control of food intake in rainbow trout (Oncorhynchus mykiss): effects of changes in plasma glucose levels. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. 2002 Jul; 188(6):479-84. doi: 10.1007/s00359-002-0320-z. [PMID: 12122466]
  • Yoshito Matsuda, Hitoshi Hirano, Yoshifumi Watanabe. Effects of estrogen on acetylcholine release in frontal cortex of female rats: involvement of serotonergic neuronal systems. Brain research. 2002 May; 937(1-2):58-65. doi: 10.1016/s0006-8993(02)02465-4. [PMID: 12020863]
  • Xiao-ling Lei, Jun-de Wang. [Solid-phase microextraction for the analysis of drugs and biological samples]. Se pu = Chinese journal of chromatography. 2002 May; 20(3):210-5. doi: NULL. [PMID: 12541938]
  • P Imbeault, J Chevrier, E Dewailly, P Ayotte, J-P Després, P Mauriège, A Tremblay. Increase in plasma pollutant levels in response to weight loss is associated with the reduction of fasting insulin levels in men but not in women. Metabolism: clinical and experimental. 2002 Apr; 51(4):482-6. doi: 10.1053/meta.2002.31338. [PMID: 11912558]
  • A Kaddoumi, M N Nakashima, K Nakashima. Fluorometric determination of DL-fenfluramine, DL-norfenfluramine and phentermine in plasma by achiral and chiral high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2001 Nov; 763(1-2):79-90. doi: 10.1016/s0378-4347(01)00368-1. [PMID: 11710586]
  • A Kaddoumi, A Kubota, M N Nakashima, M Takahashi, K Nakashima. High performance liquid chromatography with UV detection for the simultaneous determination of sympathomimetic amines using 4-(4,5-diphenyl-1H-imidazole-2-yl)benzoyl chloride as a label. Biomedical chromatography : BMC. 2001 Oct; 15(6):379-88. doi: 10.1002/bmc.85. [PMID: 11559922]
  • M Haney, A S Ward, G Gerra, R W Foltin. Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans. Drug and alcohol dependence. 2001 Sep; 64(1):63-73. doi: 10.1016/s0376-8716(00)00232-5. [PMID: 11470342]
  • M Humbert, H Nunes, O Sitbon, F Parent, P Hervé, G Simonneau. Risk factors for pulmonary arterial hypertension. Clinics in chest medicine. 2001 Sep; 22(3):459-75. doi: 10.1016/s0272-5231(05)70284-7. [PMID: 11590841]
  • A J Cleare, J Miell, E Heap, S Sookdeo, L Young, G S Malhi, V O'Keane. Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy. The Journal of clinical endocrinology and metabolism. 2001 Aug; 86(8):3545-54. doi: 10.1210/jcem.86.8.7735. [PMID: 11502777]
  • C Reist, C Mazzanti, R Vu, D Tran, D Goldman. Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine. American journal of medical genetics. 2001 May; 105(4):363-8. doi: 10.1002/ajmg.1360. [PMID: 11378851]
  • C M Vassallo, E Feldman, T Peto, L Castell, A L Sharpley, P J Cowen. Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome. Psychological medicine. 2001 May; 31(4):585-91. doi: 10.1017/s0033291701003580. [PMID: 11352361]
  • M H Baumann, M A Ayestas, C M Dersch, R B Rothman. 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2001 May; 24(5):492-501. doi: 10.1016/s0893-133x(00)00221-9. [PMID: 11282249]
  • M E Carr, S L Carr, E J Martin, B A Johnson. Rapid clot formation and abnormal fibrin structure in a symptomatic patient taking fenfluramine--a case report. Angiology. 2001 May; 52(5):361-6. doi: 10.1177/000331970105200511. [PMID: 11386389]