Ornipressin (BioDeep_00000741026)

   


代谢物信息卡片


Ornipressin

化学式: C45H63N13O12S2 (1041.4160358)
中文名称: 鸟氨酸加压素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)NC(CCCN)C(=O)NCC(=O)N
InChI: InChI=1S/C45H63N13O12S2/c46-16-4-8-28(39(64)51-21-37(50)62)53-44(69)34-9-5-17-58(34)45(70)33-23-72-71-22-27(47)38(63)54-30(19-25-10-12-26(59)13-11-25)42(67)55-31(18-24-6-2-1-3-7-24)41(66)52-29(14-15-35(48)60)40(65)56-32(20-36(49)61)43(68)57-33/h1-3,6-7,10-13,27-34,59H,4-5,8-9,14-23,46-47H2,(H2,48,60)(H2,49,61)(H2,50,62)(H,51,64)(H,52,66)(H,53,69)(H,54,63)(H,55,67)(H,56,65)(H,57,68)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1

描述信息

H - Systemic hormonal preparations, excl. sex hormones and insulins > H01 - Pituitary and hypothalamic hormones and analogues > H01B - Posterior pituitary lobe hormones > H01BA - Vasopressin and analogues
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C80212 - Antidiuretic Hormone Analogue
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents > D014667 - Vasopressins
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
Ornipressin is a potent vasoconstrictor, hemostatic and renal agent.

同义名列表

2 个代谢物同义名

Ornipressin; POR-8



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mladena Glavaš, Agata Gitlin-Domagalska, Dawid Dębowski, Natalia Ptaszyńska, Anna Łęgowska, Krzysztof Rolka. Vasopressin and Its Analogues: From Natural Hormones to Multitasking Peptides. International journal of molecular sciences. 2022 Mar; 23(6):. doi: 10.3390/ijms23063068. [PMID: 35328489]
  • Michael B Hennessy, Fadao Tai, Kendra A Carter, W Tang Watanasriyakul, Darci M Gallimore, Andrea L Molina, Patricia A Schiml. Central oxytocin alters cortisol and behavioral responses of guinea pig pups during isolation in a novel environment. Physiology & behavior. 2019 12; 212(?):112710. doi: 10.1016/j.physbeh.2019.112710. [PMID: 31629763]
  • D V Golosova, V V Natochin. New Approach to Calculation of Renal Cation Clearance in Rats after V1a Receptor Stimulation. Bulletin of experimental biology and medicine. 2017 Oct; 163(6):701-704. doi: 10.1007/s10517-017-3884-x. [PMID: 29063315]
  • Andrea E Kudwa, Robert F McGivern, Robert J Handa. Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. Physiology & behavior. 2014 Apr; 129(?):287-96. doi: 10.1016/j.physbeh.2014.03.004. [PMID: 24631553]
  • June Sung Lee. Albumin for end-stage liver disease. The Korean journal of internal medicine. 2012 Mar; 27(1):13-9. doi: 10.3904/kjim.2012.27.1.13. [PMID: 22403494]
  • Juan Carlos Q Velez, Paul J Nietert. Therapeutic response to vasoconstrictors in hepatorenal syndrome parallels increase in mean arterial pressure: a pooled analysis of clinical trials. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2011 Dec; 58(6):928-38. doi: 10.1053/j.ajkd.2011.07.017. [PMID: 21962618]
  • Jayanta K Mitra, Jayeeta Roy, Saikat Sengupta. Vasopressin: Its current role in anesthetic practice. Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine. 2011 Apr; 15(2):71-7. doi: 10.4103/0972-5229.83006. [PMID: 21814369]
  • Mohammad Minakari, Leila Faiiaz, Mehdi Rowshandel, Ahmad Shavakhi. Comparison of the effect of midodrine versus octreotide on hemodynamic status in cirrhotic patients with ascites. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2011 Jan; 16(1):87-93. doi: . [PMID: 21448389]
  • D G Shirley, M F Walter, B D Keeler, N J Waters, S J Walter. Selective blockade of oxytocin and vasopressin V(1a) receptors in anaesthetised rats: evidence that activation of oxytocin receptors rather than V(1a) receptors increases sodium excretion. Nephron. Physiology. 2011; 117(3):p21-6. doi: 10.1159/000320290. [PMID: 21071981]
  • Vladimir Krejci, Luzius B Hiltebrand, Stephan M Jakob, Jukka Takala, Gisli H Sigurdsson. Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow. Critical care (London, England). 2007; 11(6):R129. doi: 10.1186/cc6197. [PMID: 18078508]
  • Tyree H Kiser, Douglas N Fish, Marilee D Obritsch, Rose Jung, Robert MacLaren, Chirag R Parikh. Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2005 Sep; 20(9):1813-20. doi: 10.1093/ndt/gfh930. [PMID: 15956066]
  • A B Roald, O Tenstad, K Aukland. The effect of AVP-V receptor stimulation on local GFR in the rat kidney. Acta physiologica Scandinavica. 2004 Oct; 182(2):197-204. doi: 10.1111/j.1365-201x.2004.01352.x. [PMID: 15450116]
  • Niwanthi W Rajapakse, Richard J Roman, John R Falck, Jeremy J Oliver, Roger G Evans. Modulation of V1-receptor-mediated renal vasoconstriction by epoxyeicosatrienoic acids. American journal of physiology. Regulatory, integrative and comparative physiology. 2004 Jul; 287(1):R181-7. doi: 10.1152/ajpregu.00555.2002. [PMID: 14988086]
  • Tea Restuccia, Rolando Ortega, Monica Guevara, Pere Ginès, Carlo Alessandria, Osman Ozdogan, Miquel Navasa, Antoni Rimola, Juan Carlos Garcia-Valdecasas, Vicente Arroyo, Juan Rodés. Effects of treatment of hepatorenal syndrome before transplantation on posttransplantation outcome. A case-control study. Journal of hepatology. 2004 Jan; 40(1):140-6. doi: 10.1016/j.jhep.2003.09.019. [PMID: 14672625]
  • Fuat H Saner, Nils R Frühauf, Rafael F Schäfers, Hauke Lang, Massimo Malagó, Christoph E Broelsch. Terlipressin plus hydroxyethyl starch infusion: an effective treatment for hepatorenal syndrome. European journal of gastroenterology & hepatology. 2003 Aug; 15(8):925-7. doi: 10.1097/00042737-200308000-00015. [PMID: 12867805]
  • M Guevara. [Treatment of hepatorenal syndrome]. Gastroenterologia y hepatologia. 2003 Apr; 26(4):270-4. doi: 10.1016/s0210-5705(03)70353-7. [PMID: 12681123]
  • V Arroyo. [Physiopathology of refractory ascites and the hepatorenal syndrome]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia. 2002; 22 Suppl 5(?):41-6. doi: NULL. [PMID: 12107916]
  • A G Correia, K M Denton, R G Evans. Effects of activation of vasopressin-V1-receptors on regional kidney blood flow and glomerular arteriole diameters. Journal of hypertension. 2001 Mar; 19(3 Pt 2):649-57. doi: 10.1097/00004872-200103001-00019. [PMID: 11327642]
  • J P Mulkay, H Louis, V Donckier, N Bourgeois, M Adler, J Deviere, O Le Moine. Long-term terlipressin administration improves renal function in cirrhotic patients with type 1 hepatorenal syndrome: a pilot study. Acta gastro-enterologica Belgica. 2001 Jan; 64(1):15-9. doi: NULL. [PMID: 11322061]
  • R G Evans, A G Correia, S R Weekes, A C Madden. Responses of regional kidney perfusion to vasoconstrictors in anaesthetized rabbits: dependence on agent and renal artery pressure. Clinical and experimental pharmacology & physiology. 2000 Dec; 27(12):1007-12. doi: 10.1046/j.1440-1681.2000.03377.x. [PMID: 11117220]
  • P Ginès, V Arroyo. Is there still a need for albumin infusions to treat patients with liver disease?. Gut. 2000 May; 46(5):588-90. doi: 10.1136/gut.46.5.588. [PMID: 10764695]
  • V Gülberg, M Bilzer, A L Gerbes. Long-term therapy and retreatment of hepatorenal syndrome type 1 with ornipressin and dopamine. Hepatology (Baltimore, Md.). 1999 Oct; 30(4):870-5. doi: 10.1002/hep.510300430. [PMID: 10498636]
  • N J Curtis, A Lauto, R Trickett, E Owen, D M Walker. Preliminary study of microsurgical repairs of the inferior alveolar nerve in rats using primary suturing and laser weld techniques. International journal of oral and maxillofacial surgery. 1998 Dec; 27(6):476-81. doi: 10.1016/s0901-5027(98)80042-8. [PMID: 9869292]
  • V Gülberg, P Luppa, J Pauletzki, G Paumgartner, A L Gerbes. [Successful conservative therapy of hepatorenal syndrome with vasopressin-1-receptor antagonist ornipressin]. Zeitschrift fur Gastroenterologie. 1998 Dec; 36(12):1053-8. doi: NULL. [PMID: 10025057]
  • A W Cowley, M M Skelton, T M Kurth. Effects of long-term vasopressin receptor stimulation on medullary blood flow and arterial pressure. The American journal of physiology. 1998 11; 275(5):R1420-4. doi: 10.1152/ajpregu.1998.275.5.r1420. [PMID: 9791056]
  • R G Evans, G Bergström, A J Lawrence. Effects of the vasopressin V1 agonist [Phe2,Ile3,Orn8]] vasopressin on regional kidney perfusion and renal excretory function in anesthetized rabbits. Journal of cardiovascular pharmacology. 1998 Oct; 32(4):571-81. doi: 10.1097/00005344-199810000-00009. [PMID: 9781925]
  • G Bergström, R G Evans. Effects of renal medullary infusion of a vasopressin V1 agonist on renal antihypertensive mechanisms in rabbits. The American journal of physiology. 1998 07; 275(1):R76-85. doi: 10.1152/ajpregu.1998.275.1.r76. [PMID: 9688963]
  • M Guevara, P Ginès, G Fernández-Esparrach, P Sort, J M Salmerón, W Jiménez, V Arroyo, J Rodés. Reversibility of hepatorenal syndrome by prolonged administration of ornipressin and plasma volume expansion. Hepatology (Baltimore, Md.). 1998 Jan; 27(1):35-41. doi: 10.1002/hep.510270107. [PMID: 9425914]
  • J Saló, A Ginès, J C Quer, G Fernández-Esparrach, M Guevara, P Ginès, R Bataller, R Planas, W Jiménez, V Arroyo, J Rodés. Renal and neurohormonal changes following simultaneous administration of systemic vasoconstrictors and dopamine or prostacyclin in cirrhotic patients with hepatorenal syndrome. Journal of hepatology. 1996 Dec; 25(6):916-23. doi: 10.1016/s0168-8278(96)80297-2. [PMID: 9007721]
  • I Neumann, A J Douglas, Q J Pittman, J A Russell, R Landgraf. Oxytocin released within the supraoptic nucleus of the rat brain by positive feedback action is involved in parturition-related events. Journal of neuroendocrinology. 1996 Mar; 8(3):227-33. doi: 10.1046/j.1365-2826.1996.04557.x. [PMID: 8730656]
  • C Ledderhos, D L Mattson, M M Skelton, A W Cowley. In vivo diuretic actions of renal vasopressin V1 receptor stimulation in rats. The American journal of physiology. 1995 Mar; 268(3 Pt 2):R796-807. doi: 10.1152/ajpregu.1995.268.3.r796. [PMID: 7900923]
  • E Szczepanska-Sadowska, K Stepniakowski, M M Skelton, A W Cowley. Prolonged stimulation of intrarenal V1 vasopressin receptors results in sustained hypertension. The American journal of physiology. 1994 Nov; 267(5 Pt 2):R1217-25. doi: 10.1152/ajpregu.1994.267.5.r1217. [PMID: 7977848]
  • A W Cowley, E Szczepanska-Sadowska, K Stepniakowski, D Mattson. Chronic intravenous administration of V1 arginine vasopressin agonist results in sustained hypertension. The American journal of physiology. 1994 Aug; 267(2 Pt 2):H751-6. doi: 10.1152/ajpheart.1994.267.2.h751. [PMID: 8067431]
  • L W Popp, A Colditz, R Gaetje. Management of early ectopic pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 1994 Mar; 44(3):239-44. doi: 10.1016/0020-7292(94)90173-2. [PMID: 7513658]
  • P Evrard, P Ruedin, E Installé, P M Suter. Low-dose ornipressin improves renal function in the hepatorenal syndrome. Critical care medicine. 1994 Feb; 22(2):363-6. doi: 10.1097/00003246-199402000-00032. [PMID: 8306699]
  • J S Han, Y Maeda, M A Knepper. Dual actions of vasopressin and oxytocin in regulation of water permeability in terminal collecting duct. The American journal of physiology. 1993 Jul; 265(1 Pt 2):F26-34. doi: 10.1152/ajprenal.1993.265.1.f26. [PMID: 8393623]
  • L W Popp, R Gaetje, S Status, W Lierse. A rabbit model for the evaluation of minimal access treatment of ectopic pregnancy in humans, using intrachorionic injection and local hyperthermia. Clinical and experimental obstetrics & gynecology. 1993; 20(4):226-35. doi: NULL. [PMID: 8281704]
  • H Kaiser, H C Niesel, J Biscoping, S al-Rafai, L Klimpel. Plasma prilocaine and mepivacaine concentrations after combined lumbosacral plexus block. Acta anaesthesiologica Scandinavica. 1992 Oct; 36(7):689-91. doi: 10.1111/j.1399-6576.1992.tb03545.x. [PMID: 1441871]
  • T A Voorhuis, E R De Kloet, D De Wied. Effect of a vasotocin analog on singing behavior in the canary. Hormones and behavior. 1991 Dec; 25(4):549-59. doi: 10.1016/0018-506x(91)90020-i. [PMID: 1813380]
  • K Lenz, H Hörtnagl, W Druml, H Reither, R Schmid, B Schneeweiss, A Laggner, G Grimm, A L Gerbes. Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis. Effects on renal hemodynamics and atrial natriuretic factor. Gastroenterology. 1991 Oct; 101(4):1060-7. doi: 10.1016/0016-5085(91)90734-3. [PMID: 1832407]
  • P G Atanassoff, E Alon, T Pasch, W H Ziegler, K Gautschi. Intercostal nerve block for minor breast surgery. Regional anesthesia. 1991 Jan; 16(1):23-7. doi: NULL. [PMID: 2007101]
  • J N Cohn. Hepatocirculatory failure: diverse pathogeneses deserve diverse therapies. Hepatology (Baltimore, Md.). 1990 Mar; 11(3):510-1. doi: 10.1002/hep.1840110328. [PMID: 2312065]
  • K Lenz, H Hörtnagl, W Druml, G Grimm, A Laggner, B Schneeweisz, G Kleinberger. Beneficial effect of 8-ornithin vasopressin on renal dysfunction in decompensated cirrhosis. Gut. 1989 Jan; 30(1):90-6. doi: 10.1136/gut.30.1.90. [PMID: 2646181]
  • E G Schneider. Effect of vasopressin on adrenal steroidogenesis. The American journal of physiology. 1988 Nov; 255(5 Pt 2):R806-11. doi: 10.1152/ajpregu.1988.255.5.r806. [PMID: 2847563]
  • D R Ganger, J Gottstein, A T Blei. Hemodynamic and renal effects of atrial natriuretic factor in portal hypertensive rats. Potentiation by Phe-Ile-Orn-vasopressin. The Journal of pharmacology and experimental therapeutics. 1988 Sep; 246(3):941-5. doi: NULL. [PMID: 2971104]
  • K Lenz, W Druml, G Kleinberger, H Hörtnagl, A Laggner, B Schneeweiss, E Deutsch. Enhancement of renal function with ornipressin in a patient with decompensated cirrhosis. Gut. 1985 Dec; 26(12):1385-6. doi: 10.1136/gut.26.12.1385. [PMID: 4085913]