Tilisolol hydrochloride (BioDeep_00000739695)
代谢物信息卡片
化学式: C17H25ClN2O3 (340.15536099999997)
中文名称: 盐酸替利洛尔
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)NCC(COC1=CN(C(=O)C2=CC=CC=C21)C)O.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hitoshi Sasaki, Toshiaki Nagano, Koji Sakanaka, Shigeru Kawakami, Koyo Nishida, Junzo Nakamura, Nobuhiro Ichikawa, Junji Iwashita, Tadahiro Nakamura, Mikiro Nakashima. One-side-coated insert as a unique ophthalmic drug delivery system.
Journal of controlled release : official journal of the Controlled Release Society.
2003 Oct; 92(3):241-7. doi:
10.1016/s0168-3659(03)00362-6. [PMID: 14568405] - Shigeru Kawakami, Nao Ohshima, Ryu Hirayama, Masami Hi Al, Takashi Kitahara, Toshiyuki Sakaeda, Takahiro Mukai, Koyo Nishida, Junzo Nakamura, Mikiro Nakashima, Hitoshi Sasaki. Biodistribution and pharmacokinetics of O-palmitoyl tilisolol, a lipophilic prodrug of tilisolol, after intravenous administration in rats.
Biological & pharmaceutical bulletin.
2002 Aug; 25(8):1072-6. doi:
10.1248/bpb.25.1072. [PMID: 12186412] - S Kawakami, K Nishida, T Mukai, K Yamamura, J Nakamura, T Sakaeda, M Nakashima, H Sasaki. Controlled release and ocular absorption of tilisolol utilizing ophthalmic insert-incorporated lipophilic prodrugs.
Journal of controlled release : official journal of the Controlled Release Society.
2001 Oct; 76(3):255-63. doi:
10.1016/s0168-3659(01)00441-2. [PMID: 11578740] - H Sasaki, K Yamamura, T Mukai, K Nishida, J Nakamura, M Nakashima, M Ichikawa. Pharmacokinetic prediction of the ocular absorption of an instilled drug with ophthalmic viscous vehicle.
Biological & pharmaceutical bulletin.
2000 Nov; 23(11):1352-6. doi:
10.1248/bpb.23.1352. [PMID: 11085365] - T Mano, R Shinohara, A Nagasaka, H Nakagawa, K Uchimura, R Hayashi, I Nakano, T Tsugawa, F Watanabe, T Kobayashi, K Fujiwara, A Nakai, M Itoh. Scavenging effect of nicorandil on free radicals and lipid peroxide in streptozotocin-induced diabetic rats.
Metabolism: clinical and experimental.
2000 Apr; 49(4):427-31. doi:
10.1016/s0026-0495(00)80003-7. [PMID: 10778863] - H Sasaki, S Kashiwagi, T Mukai, K Nishida, J Nakamura, M Nakashima, M Ichikawa. Drug absorption behavior after periocular injections.
Biological & pharmaceutical bulletin.
1999 Sep; 22(9):956-60. doi:
10.1248/bpb.22.956. [PMID: 10513620] - H Sasaki, M Ichikawa, S Kawakami, K Yamamura, K Nishida, J Nakamura. In situ ocular absorption of tilisolol through ocular membranes in albino rabbits.
Journal of pharmaceutical sciences.
1996 Sep; 85(9):940-3. doi:
10.1021/js960045r. [PMID: 8877883] - K Yonezawa, K Sato, A Kobayashi. High-performance liquid chromatography of a new beta-blocker, 4-[3-(tert.-butylamino)-2-hydroxypropoxy]-N-methylisocarbostyril hydrochloride, in plasma using fluorometric detection.
Journal of chromatography.
1985 Apr; 339(1):219-22. doi:
10.1016/s0378-4347(00)84648-4. [PMID: 2862154] - N Kubota, K Kishi, H Sokabe, K Kawashima, Y Ishii, S Kawase. Chronic effects of a beta-adrenoceptor blocking drug, 4-[3-(tert-butylamino)-2-hydroxypropoxy]-N-methylisocarbostyril hydrochloride (N-696), in hypertensive rats.
Journal of pharmacobio-dynamics.
1985 Feb; 8(2):134-41. doi:
10.1248/bpb1978.8.134. [PMID: 2861268] - M Ishii, S Komori, H Satoh, T Ohta, S Motomura, K Hashimoto. [Effects of N-696, a new beta-blocking agent, on canine experimental arrhythmias].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1984 Sep; 84(3):259-66. doi:
10.1254/fpj.84.259. [PMID: 6149986] - Y Nakagawa, T Sugai, W P Chin, T Shibuya, K Hashimoto, S Imai. Pharmacological profile of a new beta-adrenoceptor blocker, 4-[3-(tert-butylamino)-2-hydroxypropoxy]-N-methylisocarbostyril hydrochloride (N-696).
Arzneimittel-Forschung.
1984; 34(2):194-9. doi:
NULL. [PMID: 6144313] - K Hashimoto, H Satoh, T Shibuya, S Imai. Canine-effective plasma concentrations of antiarrhythmic drugs on the two-stage coronary ligation arrhythmia.
The Journal of pharmacology and experimental therapeutics.
1982 Dec; 223(3):801-10. doi:
NULL. [PMID: 7143241]