tosufloxacin tosilate (BioDeep_00000738302)

   

Chemicals and Drugs


代谢物信息卡片


Tosufloxacin monohydrate

化学式: C26H25F3N4O7S (594.1395976)
中文名称: 甲苯磺酸妥舒沙星
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.C1CN(CC1N)C2=C(C=C3C(=O)C(=CN(C3=N2)C4=C(C=C(C=C4)F)F)C(=O)O)F.O
InChI: 1H2

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
Tosufloxacin tosylate hydrate (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

同义名列表

5 个代谢物同义名

Tosufloxacin monohydrate; tosufloxacin tosilate; A-61827 (tosylate hydrate); T-3262; Tosufloxacin (tosylate hydrate)



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
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  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Risa Matsubara, Tetsuya Kibe, Takemasa Nomura. Crystalline nephropathy caused by tosufloxacin. Pediatrics international : official journal of the Japan Pediatric Society. 2016 Nov; 58(11):1219-1221. doi: 10.1111/ped.13116. [PMID: 27882736]
  • Dorota Kowalczuk, Agata Przekora, Grazyna Ginalska. Biological safety evaluation of the modified urinary catheter. Materials science & engineering. C, Materials for biological applications. 2015 Apr; 49(?):274-280. doi: 10.1016/j.msec.2015.01.001. [PMID: 25686950]
  • Feng-Yu Deng, Chun-Xiu Huang, Ying Liu. [Mn2+-cTMAB-sensitized fluorescent microscopic determination of tosufloxacin tosylate based on a self-ordered ring]. Guang pu xue yu guang pu fen xi = Guang pu. 2014 Feb; 34(2):445-9. doi: NULL. [PMID: 24822418]
  • Jahye Kim, Hisakazu Ohtani, Masayuki Tsujimoto, Yasufumi Sawada. Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. Drug metabolism and pharmacokinetics. 2009; 24(2):167-74. doi: 10.2133/dmpk.24.167. [PMID: 19430173]
  • Yoshiko Fukuda, Masahiro Takahata, Junichi Mitsuyama. Pharmacodynamic evaluation of tosufloxacin against Streptococcus pneumoniae in an in vitro model simulating serum concentration. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2006 Feb; 12(1):1-8. doi: 10.1007/s10156-005-0420-0. [PMID: 16506083]
  • Yu Liu, Shilv Chen, Huichun Zhao, Linpei Jin. Terbium sensitized determination of tosufloxacin using electrochemiluminescence method. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2005 Apr; 21(4):373-5. doi: 10.2116/analsci.21.373. [PMID: 15844328]
  • Hirokazu Okada, Yusuke Watanabe, Shuhei Kotaki, Naofumi Ikeda, Hiroshi Takane, Yoshihiko Kanno, Souichi Sugahara, Shinichi Ban, Makoto Nagata, Hiromichi Suzuki. An unusual form of crystal-forming chronic interstitial nephritis following long-term exposure to tosufloxacin tosilate. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2004 Nov; 44(5):902-7. doi: 10.1016/s0272-6386(04)01089-3. [PMID: 15492957]
  • T Yamamoto, T Tanida, E Ueta, T Kimura, S Doi, T Osaki. Pulmonary infiltration with eosinophilia (PIE) syndrome induced by antibiotics, PIPC and TFLX during cancer treatment. Oral oncology. 2001 Jul; 37(5):471-5. doi: 10.1016/s1368-8375(00)00108-1. [PMID: 11377237]
  • K Ohnishi, K Kimura. Salmonella excretion after cessation of tosufloxacin therapy in acute nontyphoid salmonella enterocolitis. Antimicrobial agents and chemotherapy. 2001 Jun; 45(6):1892-3. doi: 10.1128/aac.45.6.1892-1893.2001. [PMID: 11353646]
  • K Ohnishi, K Kimura, G Masuda, T Tsunoda, M Obana, H Yoshida, T Goto, Y Sakaue, Y K Kim, M Sakamoto, H Sagara. Oral administration of fluoroquinolones in the treatment of typhoid fever and paratyphoid fever in Japan. Internal medicine (Tokyo, Japan). 2000 Dec; 39(12):1044-8. doi: 10.2169/internalmedicine.39.1044. [PMID: 11197787]
  • Y Nakaya, S Shiota, K Sakamoto, A Iwase, S Aoki, R Matsuoka, Y Tei, Y Okada, Y Miyake. Double infection with Giardia lamblia and Salmonella paratyphi A associated with acute renal failure. Internal medicine (Tokyo, Japan). 1998 May; 37(5):489-92. doi: 10.2169/internalmedicine.37.489. [PMID: 9652908]
  • T Deguchi, M Yasuda, M Nakano, S Ozeki, E Kanematsu, H Fukuda, S Maeda, I Saito, Y Kawada. Comparison of in vitro antimicrobial activity of AM-1155 with those of tosufloxacin and fleroxacin against clinical isolates of Neisseria gonorrhoeae harboring quinolone resistance alterations in GyrA and ParC. Chemotherapy. 1997 Jul; 43(4):239-44. doi: 10.1159/000239573. [PMID: 9209780]
  • N Masuda, Y Takahashi, M Otsuki, E Ibuki, H Miyoshi, T Nishino. In vitro and in vivo antibacterial activities of CS-940, a new 6-fluoro-8-difluoromethoxy quinolone. Antimicrobial agents and chemotherapy. 1996 May; 40(5):1201-7. doi: 10.1128/aac.40.5.1201. [PMID: 8723467]
  • Y Tsuji, K Okamura, K Miyake, H Ito, T Kinukawa, T Otani, M Narushima, S Kanai, Y Takagi, T Murase. [Antibiotic prophylaxis for transurethral resection of the prostate--comparison of oral administration therapy with intravenous administration therapy]. Hinyokika kiyo. Acta urologica Japonica. 1993 Dec; 39(12):1145-52. doi: NULL. [PMID: 7506866]
  • Y Yamashiro, M Nunome, M Takahata, T Yasuda. [Penetration into bone and joint tissues of rabbits and in vitro antibacterial activity of tosufloxacin]. The Japanese journal of antibiotics. 1993 Jan; 46(1):31-5. doi: NULL. [PMID: 8384277]
  • J W Gu, W Fang, N X Chin, H C Neu. In vitro activity of CP-74,667. A new fluoroquinolone compared with other quinolones. Diagnostic microbiology and infectious disease. 1992 Sep; 15(7):613-20. doi: 10.1016/0732-8893(90)90039-x. [PMID: 1330421]
  • M A Cooper, J M Andrews, R Wise. In-vitro activity of tosufloxacin, a new quinolone antibacterial agent. The Journal of antimicrobial chemotherapy. 1992 Jun; 29(6):639-47. doi: 10.1093/jac/29.6.639. [PMID: 1506348]
  • H Kiyota, T Machida, F Masuda, Y Ohishi, S Onodera, H Suzuki, H Goto, M Kawahara, H Igarashi, K Endou. [Single-dose treatment of tosufloxacin (TFLX) for acute uncomplicated cystitis]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 1992 Apr; 66(4):529-35. doi: 10.11150/kansenshogakuzasshi1970.66.529. [PMID: 1624848]
  • T Uchibayashi, H Hisazumi, J Kanayama, K Kumano. Diffusion of tosufloxacin into prostatic tissue. Chemotherapy. 1992; 38(3):150-4. doi: 10.1159/000238955. [PMID: 1380905]
  • A G Arguedas, J C Akaniro, H R Stutman, M I Marks. In vitro activity of tosufloxacin, a new quinolone, against respiratory pathogens derived from cystic fibrosis sputum. Antimicrobial agents and chemotherapy. 1990 Nov; 34(11):2223-7. doi: 10.1128/aac.34.11.2223. [PMID: 2073112]
  • M Tanaka, T Satoh. [Studies on suppurative lesion and bone distribution of peroral antimicrobial agents (LAPC and TFLX) to experimental infected rabbits]. Shigaku = Odontology; journal of Nihon Dental College. 1990 Oct; 78(3):527-52. doi: NULL. [PMID: 2134803]
  • F Matsumoto, T Takahashi, M Morita. [Therapeutic drug monitoring of fluoroquinolone]. Nihon rinsho. Japanese journal of clinical medicine. 1990 Feb; 48 Suppl(?):1217-22. doi: NULL. [PMID: 2355524]
  • D T Chu, I M Lico, R N Swanson, K C Marsh, J J Plattner, A G Pernet. Synthesis and biological properties of A-71497: a prodrug of tosufloxacin. Drugs under experimental and clinical research. 1990; 16(9):435-43. doi: NULL. [PMID: 2100244]
  • F Sugata, S Ohguri, Y Takamura, S Tominaga, K Iwamura, T Yamada, H Shibata, N Yamada, K Okabe, Y Kato. [Biliary excretion and clinical efficacy of T-3262 (tosufloxacin tosilate) administered in the treatment of cholecystitis]. The Japanese journal of antibiotics. 1989 Sep; 42(9):1873-81. doi: NULL. [PMID: 2810750]
  • C Koechlin, F Jehl, L Linger, H Monteil. High-performance liquid chromatography for the determination of three new fluoroquinolones, fleroxacin, temafloxacin and A-64730, in biological fluids. Journal of chromatography. 1989 Jul; 491(2):379-87. doi: 10.1016/s0378-4347(00)82855-8. [PMID: 2509509]
  • T Aoki, Y Matsubara, H Sagara, N Shimizu, I Tomizawa, Y Takizawa, Y Nitia, T Seo, M Kamimura, N Kanehisa. [Clinical trial of T-3262 (Tosufloxacin tosilate) on Salmonella enteritis, and fecal drug concentration and change in the fecal microflora in the acute diarrheal patients. Japan Research Committee of T-3262, Research Group for Acute Infectious Enteritis]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 1989 Jul; 63(7):659-75. doi: 10.11150/kansenshogakuzasshi1970.63.659. [PMID: 2693543]
  • T Aoki, Y Matsubara, H Sagara, I Tomizawa, Y Takizawa, Y Nitta, T Seo, M Kamimura, G Masuda, M Negishi. [Clinical trial of T-3262 on acute enteritis. Japan Research Committee of T-3262, Research Group for Acute Infectious Enteritis]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 1989 Jun; 63(6):593-605. doi: 10.11150/kansenshogakuzasshi1970.63.593. [PMID: 2693541]
  • M Tai, H Sakai, J Nitta, H Hayakawa, Y Sugimoto, K Hayashi, T Maeda. [Study on metabolism of pyridonecarboxylic acid II. Determination of metabolites of (+-)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate (T-3262) in blood, urine, bile, and feces]. The Japanese journal of antibiotics. 1989 Apr; 42(4):876-86. doi: NULL. [PMID: 2769940]
  • T Maeda, H Sakai, H Hayakawa, K Hayashi, K Yoneda. [Studies on absorption, distribution and excretion of 14C labeled (+-)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1-(2,4-difluorophenyl)-1,4- dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluene-sulfonate hydrate (14C-T-3262) in rats and mice]. The Japanese journal of antibiotics. 1989 Apr; 42(4):854-67. doi: NULL. [PMID: 2769938]
  • A Nagai, M Nagasawa, S Ooyama, H Kaga, N Kitou, T Yoneda. [Nephrotoxicity test on T-3262 in rats with experimental nephropathy]. The Japanese journal of antibiotics. 1989 Apr; 42(4):817-30. doi: NULL. [PMID: 2769936]
  • T Yoneda, S Nakamura, Y Nojima, A Nagai, M Nagasawa, Y Nishio. [Toxicity studies on T-3262 in rat upon intravenous injection for 14 days]. The Japanese journal of antibiotics. 1989 Apr; 42(4):800-16. doi: NULL. [PMID: 2504970]
  • S Hirai, T Hiraiwa, H Arai, S Ono, K Tanaka, K Hashiba, Y Nakada, K Goden, K Tanada, M Maekawa. [General pharmacology of T-3262, a new pyridonecarboxylic acid]. The Japanese journal of antibiotics. 1989 Apr; 42(4):831-53. doi: NULL. [PMID: 2769937]
  • M Tai, Y Konishi, Y Sugimoto, K Demachi, T Maeda. [Study on metabolism of pyridonecarboxylic acid. I. Isolation and identification of metabolites of (+-)-7-(3-amino-1-pyrrolidinyl)-6-fluoro-1- (2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate (T-3262) in urine]. The Japanese journal of antibiotics. 1989 Apr; 42(4):868-75. doi: NULL. [PMID: 2769939]
  • K Takagi, T Hasegawa, Y Ogura, R Suzuki, K Yamaki, T Watanabe, S Kitazawa, T Satake. Comparative studies on interaction between theophylline and quinolones. The Journal of asthma : official journal of the Association for the Care of Asthma. 1988; 25(2):63-71. doi: 10.3109/02770908809071356. [PMID: 3182580]
  • P B Fernandes, D T Chu, R N Swanson, N R Ramer, C W Hanson, R R Bower, J M Stamm, D J Hardy. A-61827 (A-60969), a new fluoronaphthyridine with activity against both aerobic and anaerobic bacteria. Antimicrobial agents and chemotherapy. 1988 Jan; 32(1):27-32. doi: 10.1128/aac.32.1.27. [PMID: 3348609]