Ipamorelin (BioDeep_00000738077)
代谢物信息卡片
化学式: C38H49N9O5 (711.3856463999999)
中文名称: 伊帕瑞林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCCN)C(=O)N)N
InChI: InChI=1S/C38H49N9O5/c1-38(2,41)37(52)47-32(21-28-22-42-23-43-28)36(51)46-31(20-25-15-16-26-12-6-7-13-27(26)18-25)35(50)45-30(19-24-10-4-3-5-11-24)34(49)44-29(33(40)48)14-8-9-17-39/h3-7,10-13,15-16,18,22-23,29-32H,8-9,14,17,19-21,39,41H2,1-2H3,(H2,40,48)(H,42,43)(H,44,49)(H,45,50)(H,46,51)(H,47,52)
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C76358 - Growth Hormone-Releasing Hormone Analogue
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 22573923
- PubChem: 9831659
- DrugBank: DB12370
- ChEMBL: CHEMBL58547
- CAS: 170851-70-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- P Ferro, G Krotov, I Zvereva, G Rodchenkov, J Segura. Structure-activity relationship for peptídic growth hormone secretagogues.
Drug testing and analysis.
2017 Jan; 9(1):87-95. doi:
10.1002/dta.1947. [PMID: 26811125] - Ekaterina Semenistaya, Irina Zvereva, Andreas Thomas, Mario Thevis, Grigory Krotov, Grigory Rodchenkov. Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin.
Drug testing and analysis.
2015 Oct; 7(10):919-25. doi:
10.1002/dta.1787. [PMID: 25869809] - Holly D Cox, Cole M Hughes, Daniel Eichner. Detection of GHRP-2 and GHRP-6 in urine samples from athletes.
Drug testing and analysis.
2015 May; 7(5):439-44. doi:
10.1002/dta.1791. [PMID: 25809000] - Chung-Man Yeung, Chi-Bun Chan, Norman Y S Woo, Christopher H K Cheng. Seabream ghrelin: cDNA cloning, genomic organization and promoter studies.
The Journal of endocrinology.
2006 May; 189(2):365-79. doi:
10.1677/joe.1.06593. [PMID: 16648303] - Peter B Johansen, Yael Segev, Daniel Landau, Moshe Phillip, Allan Flyvbjerg. Growth hormone (GH) hypersecretion and GH receptor resistance in streptozotocin diabetic mice in response to a GH secretagogue.
Experimental diabesity research.
2003 Apr; 4(2):73-81. doi:
10.1155/edr.2003.73. [PMID: 14630569] - S Lall, L Y Tung, C Ohlsson, J O Jansson, S L Dickson. Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues.
Biochemical and biophysical research communications.
2001 Jan; 280(1):132-8. doi:
10.1006/bbrc.2000.4065. [PMID: 11162489] - J Svensson, S Lall, S L Dickson, B A Bengtsson, J Rømer, I Ahnfelt-Rønne, C Ohlsson, J O Jansson. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats.
The Journal of endocrinology.
2000 Jun; 165(3):569-77. doi:
10.1677/joe.0.1650569. [PMID: 10828840] - K Malmlöf, P B Johansen, P M Haahr, M Wilken, H Oxlund. Methylprednisolone does not inhibit the release of growth hormone after intravenous injection of a novel growth hormone secretagogue in rats.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
1999 Dec; 9(6):445-50. doi:
10.1054/ghir.1999.0128. [PMID: 10629165] - P B Johansen, J Nowak, C Skjaerbaek, A Flyvbjerg, T T Andreassen, M Wilken, H Orskov. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
1999 Apr; 9(2):106-13. doi:
10.1054/ghir.1999.9998. [PMID: 10373343] - K Raun, B S Hansen, N L Johansen, H Thøgersen, K Madsen, M Ankersen, P H Andersen. Ipamorelin, the first selective growth hormone secretagogue.
European journal of endocrinology.
1998 Nov; 139(5):552-61. doi:
10.1530/eje.0.1390552. [PMID: 9849822] - P B Johansen, K T Hansen, J V Andersen, N L Johansen. Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorption.
Xenobiotica; the fate of foreign compounds in biological systems.
1998 Nov; 28(11):1083-92. doi:
10.1080/004982598238976. [PMID: 9879640]