BMS-690514 (BioDeep_00000737465)

   


代谢物信息卡片


(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol

化学式: C19H24N6O2 (368.1961)
中文名称: (3R,4R)-4-氨基-1-[[4-[(3-甲氧基苯基)氨基]吡咯并[2,1-f][1,2,4]三嗪-5-基]甲基]哌啶-3-醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=CC(=C1)NC2=NC=NN3C2=C(C=C3)CN4CCC(C(C4)O)N
InChI: InChI=1S/C19H24N6O2/c1-27-15-4-2-3-14(9-15)23-19-18-13(5-8-25(18)22-12-21-19)10-24-7-6-16(20)17(26)11-24/h2-5,8-9,12,16-17,26H,6-7,10-11,20H2,1H3,(H,21,22,23)/t16-,17-/m1/s1

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor > C1967 - Tyrosine Kinase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor

同义名列表

2 个代谢物同义名

(3R,4R)-4-Amino-1-[[4-[(3-methoxyphenyl)amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]methyl]piperidin-3-ol; BMS-690514



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hiroshi Nokihara, Noboru Yamamoto, Yasuhide Yamada, Kazuhiko Yamada, Taizo Hirata, Yasushi Goto, Maki Tanioka, Yoko Ikeda, Tomohide Tamura. A phase I study of BMS-690514 in Japanese patients with advanced or metastatic solid tumors. Cancer chemotherapy and pharmacology. 2012 Oct; 70(4):559-65. doi: 10.1007/s00280-012-1932-9. [PMID: 22878519]
  • Blisse Vakkalagadda, Jong-Soon Park, Christoph M Ahlers, Stephanie Dorizio, Teresa Has, Vikram Roongta, Kevin N Heller, George M Derbin, Steven Zhang. Food increased the bioavailability of BMS-690514, an orally active EGFR/HER2/VEGF receptor kinase inhibitor, in healthy subjects. Journal of clinical pharmacology. 2012 Sep; 52(9):1350-6. doi: 10.1177/0091270011417826. [PMID: 22031621]
  • Haizheng Hong, Hong Su, Li Ma, Ming Yao, Ramaswamy A Iyer, W Griffith Humphreys, Lisa J Christopher. In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor. Drug metabolism and disposition: the biological fate of chemicals. 2011 Sep; 39(9):1658-67. doi: 10.1124/dmd.111.039776. [PMID: 21673131]
  • Lisa J Christopher, Haizheng Hong, Blisse J Vakkalagadda, Pamela L Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin Heller, Christopher T Harbison, Ramaswamy A Iyer, William G Humphreys, Tai Wong, Steven Zhang. Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans. Drug metabolism and disposition: the biological fate of chemicals. 2010 Nov; 38(11):2049-59. doi: 10.1124/dmd.110.034850. [PMID: 20668249]
  • Punit Marathe, Yuwei Tang, Bogdan Sleczka, David Rodrigues, Ashvinikumar Gavai, Tai Wong, Lisa Christopher, Hongjian Zhang. Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. Journal of pharmaceutical sciences. 2010 Aug; 99(8):3579-93. doi: 10.1002/jps.22099. [PMID: 20166197]
  • Haizheng Hong, Hong Su, Haojun Sun, Alban Allentoff, Ihoezo V Ekhato, Theodore Chando, Janet Caceres-Cortes, Vikram Roongta, Ramaswamy A Iyer, W Griffith Humphreys, Lisa J Christopher. Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs. Drug metabolism and disposition: the biological fate of chemicals. 2010 Jul; 38(7):1189-201. doi: 10.1124/dmd.110.032755. [PMID: 20363952]