1,3,4-Oxadiazole (BioDeep_00000736853)
Volatile Flavor Compounds
代谢物信息卡片
1,3,4-Oxadiazole
化学式: C2H2N2O (70.0167122)
中文名称: 1,3,4-噁二唑, 1,3,4-恶二唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NN=CO1
InChI: InChI=1S/C2H2N2O/c1-3-4-2-5-1/h1-2H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tuğçe Gür Maz, Philipp Dahlke, Azize Gizem Ergül, Abdurrahman Olğaç, Paul M Jordan, Burcu Çalışkan, Oliver Werz, Erden Banoglu. Novel 1,3,4-oxadiazole derivatives as highly potent microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors.
Bioorganic chemistry.
2024 Jun; 147(?):107383. doi:
10.1016/j.bioorg.2024.107383. [PMID: 38653151] - Awei Zhang, Hongfu He, Ronghua Wang, Zhongjie Shen, Zengxue Wu, Runjiang Song, Baoan Song. Synthesis, Bioactivities, and Antibacterial Mechanism of 5-(Thioether)-N-phenyl/benzyl-1,3,4-oxadiazole-2-carboxamide/amine Derivatives.
Journal of agricultural and food chemistry.
2024 Jan; 72(3):1444-1453. doi:
10.1021/acs.jafc.3c05816. [PMID: 38206812] - Anastasia A Zhukovets, Vladimir V Chernyshov, Aidar Z Al'mukhametov, Tatiana A Seregina, Svetlana V Revtovich, Mariia A Kasatkina, Yulia E Isakova, Vitalia V Kulikova, Elena A Morozova, Anastasia I Cherkasova, Timur A Mannanov, Anastasia A Anashkina, Pavel N Solyev, Vladimir A Mitkevich, Roman A Ivanov. Novel Hydroxamic Acids Containing Aryl-Substituted 1,2,4- or 1,3,4-Oxadiazole Backbones and an Investigation of Their Antibiotic Potentiation Activity.
International journal of molecular sciences.
2023 Dec; 25(1):. doi:
10.3390/ijms25010096. [PMID: 38203266] - Fu-Mao Zhang, Ting Huang, Feng Wang, Gui-Shan Zhang, Donglan Liu, Jun Dai, Jian-Wei Zhang, Qing-Hua Li, Guo-Qiang Lin, Dingding Gao, Jincun Zhao, Ping Tian. Discovery of highly potent covalent SARS-CoV-2 3CLpro inhibitors bearing 2-sulfoxyl-1,3,4-oxadiazole scaffold for combating COVID-19.
European journal of medicinal chemistry.
2023 Aug; 260(?):115721. doi:
10.1016/j.ejmech.2023.115721. [PMID: 37598484] - Rongzhu Wen, Wengui Duan, Guishan Lin, Baoyu Li, Zhaolei Zhang, Chuwen Liu. Synthesis, Antifungal Activity, and Molecular Simulation Study of L-Carvone-Derived 1,3,4-Oxadiazole-Thioether Compounds.
Chemistry & biodiversity.
2023 Jul; 20(7):e202300794. doi:
10.1002/cbdv.202300794. [PMID: 37382275] - Xin Luo, Yong Zhang, Xing Liu, Yue Zou, Hongyi Song, Sheng Wang, Jixiang Chen. Screening Method and Antibacterial Activity of 1,3,4-Oxadiazole Sulfone Compounds against Citrus Huanglongbing.
International journal of molecular sciences.
2023 Jun; 24(13):. doi:
10.3390/ijms241310515. [PMID: 37445692] - Ju Peng, Yong Zhang, Xing Liu, Yue Zou, Hongyi Song, Sheng Wang, Qingfeng Cai, Jixiang Chen, Deyu Hu. Design, synthesis, antibacterial activity, and mechanism of novel resveratrol derivatives containing an 1,3,4-oxadiazole moiety.
Pesticide biochemistry and physiology.
2023 Jun; 193(?):105457. doi:
10.1016/j.pestbp.2023.105457. [PMID: 37248023] - Jinchao Shi, Yao Tian, Shunshun Chen, Changzhou Liao, Guoqing Mao, Xiaoqian Deng, Linhua Yu, Xiang Zhu, Junkai Li. Design, synthesis and antifungal evaluation of phenylthiazole-1,3,4-oxadiazole thione (ketone) derivatives inspired by natural thiasporine A.
Pest management science.
2023 Mar; ?(?):. doi:
10.1002/ps.7481. [PMID: 36966468] - Dan Zeng, Shuai-Shuai Liu, Wu-Bin Shao, Tai-Hong Zhang, Pu-Ying Qi, Hong-Wu Liu, Xiang Zhou, Li-Wei Liu, Heng Zhang, Song Yang. New Inspiration of 1,3,4-Oxadiazole Agrochemical Candidates: Manipulation of a Type III Secretion System-Induced Bacterial Starvation Mechanism to Prevent Plant Bacterial Diseases.
Journal of agricultural and food chemistry.
2023 Feb; 71(6):2804-2816. doi:
10.1021/acs.jafc.2c07486. [PMID: 36744848] - Feng Peng, Tingting Liu, Yunying Zhu, Fang Liu, Xiao Cao, Qifan Wang, Liwei Liu, Wei Xue. Novel 1,3,4-oxadiazole sulfonate/carboxylate flavonoid derivatives: synthesis and biological activity.
Pest management science.
2023 Jan; 79(1):274-283. doi:
10.1002/ps.7197. [PMID: 36148624] - Deeksha Tiwari, Rakesh Narang, Kalvatala Sudhakar, Vikramjeet Singh, Sukhbir Lal, Manish Devgun. 1,3,4-oxadiazole derivatives as potential antimicrobial agents.
Chemical biology & drug design.
2022 12; 100(6):1086-1121. doi:
10.1111/cbdd.14100. [PMID: 35676800] - Ting Xu, Jie-Ru Meng, Wanqing Cheng, Jia-Zheng Liu, Junyan Chu, Qian Zhang, Nannan Ma, Li-Ping Bai, Yong Guo. Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors.
Bioorganic & medicinal chemistry.
2022 08; 67(?):116838. doi:
10.1016/j.bmc.2022.116838. [PMID: 35617790] - Jin Ji, Wu-Bin Shao, Pan-Long Chu, Hong-Mei Xiang, Pu-Ying Qi, Xiang Zhou, Pei-Yi Wang, Song Yang. 1,3,4-Oxadiazole Derivatives as Plant Activators for Controlling Plant Viral Diseases: Preparation and Assessment of the Effect of Auxiliaries.
Journal of agricultural and food chemistry.
2022 Jul; 70(26):7929-7940. doi:
10.1021/acs.jafc.2c01988. [PMID: 35731909] - Arbaz Sujat Shaikh, Gaddam Kiranmai, G Parimala Devi, Priyanka N Makhal, Dilep Kumar Sigalapalli, Ramya Tokala, Venkata Rao Kaki, Nagula Shankaraiah, Narayana Nagesh, Bathini Nagendra Babu, Neelima D Tangellamudi. Exploration of mercaptoacetamide-linked pyrimidine-1,3,4-oxadiazole derivatives as DNA intercalative topo II inhibitors: Cytotoxicity and apoptosis induction.
Bioorganic & medicinal chemistry letters.
2022 06; 65(?):128697. doi:
10.1016/j.bmcl.2022.128697. [PMID: 35339645] - Caizhi Tian, Shuoqi Huang, Zihua Xu, Wenwu Liu, Deping Li, Mingyue Liu, Chengze Zhu, Limeng Wu, Xiaowen Jiang, Huaiwei Ding, Qingchun Zhao. Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects.
Bioorganic & medicinal chemistry letters.
2022 05; 64(?):128663. doi:
10.1016/j.bmcl.2022.128663. [PMID: 35272009] - Jian-Jun Zhu, Pei-Yi Wang, Zhou-Qing Long, Shu-Zhen Xiang, Jun-Rong Zhang, Zhen-Xing Li, Yuan-Yuan Wu, Wu-Bin Shao, Xiang Zhou, Li-Wei Liu, Song Yang. Design, Synthesis, and Biological Profiles of Novel 1,3,4-Oxadiazole-2-carbohydrazides with Molecular Diversity.
Journal of agricultural and food chemistry.
2022 Mar; 70(9):2825-2838. doi:
10.1021/acs.jafc.1c07190. [PMID: 35201749] - Qing-Tian Ji, Xian-Fu Mu, De-Kun Hu, Li-Jun Fan, Shu-Zhen Xiang, Hao-Jie Ye, Xiu-Hui Gao, Pei-Yi Wang. Fabrication of Host-Guest Complexes between Adamantane-Functionalized 1,3,4-Oxadiazoles and β-Cyclodextrin with Improved Control Efficiency against Intractable Plant Bacterial Diseases.
ACS applied materials & interfaces.
2022 Jan; 14(2):2564-2577. doi:
10.1021/acsami.1c19758. [PMID: 34981928] - Shaobo Wang, Jixiang Chen, Jing Shi, Zhijia Wang, Deyu Hu, Baoan Song. Novel Cinnamic Acid Derivatives Containing the 1,3,4-Oxadiazole Moiety: Design, Synthesis, Antibacterial Activities, and Mechanisms.
Journal of agricultural and food chemistry.
2021 Oct; 69(40):11804-11815. doi:
10.1021/acs.jafc.1c03087. [PMID: 34597041] - Xiang Yu, You-Fang Zhao, Guo-Juan Huang, Ya-Fang Chen. Design and synthesis of 7-diethylaminocoumarin-based 1,3,4-oxadiazole derivatives with anti-acetylcholinesterase activities.
Journal of Asian natural products research.
2021 Sep; 23(9):866-876. doi:
10.1080/10286020.2020.1803293. [PMID: 32815409] - Zhou-Qing Long, Lin-Li Yang, Jun-Rong Zhang, Shi-Tao Liu, Jiao Xie, Pei-Yi Wang, Jian-Jun Zhu, Wu-Bin Shao, Li-Wei Liu, Song Yang. Fabrication of Versatile Pyrazole Hydrazide Derivatives Bearing a 1,3,4-Oxadiazole Core as Multipurpose Agricultural Chemicals against Plant Fungal, Oomycete, and Bacterial Diseases.
Journal of agricultural and food chemistry.
2021 Aug; 69(30):8380-8393. doi:
10.1021/acs.jafc.1c02460. [PMID: 34296859] - Alexandru Sava, Frederic Buron, Sylvain Routier, Alina Panainte, Nela Bibire, Sandra Mădălina Constantin, Florentina Geanina Lupașcu, Alin Viorel Focșa, Lenuţa Profire. Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-oxadiazole-2-thiol Scaffold.
International journal of molecular sciences.
2021 Jun; 22(13):. doi:
10.3390/ijms22137079. [PMID: 34209248] - Ahmed A Elbarbary, El-Refaie Kenawy, Elsayed G I Hamada, Tarek B Edries, Wesam S Meshrif. Insecticidal activity of some synthesized 1,3,4-oxadiazole derivatives grafted on chitosan and polymethylmethacrylate against the cotton leafworm Spodoptera littoralis.
International journal of biological macromolecules.
2021 Jun; 180(?):539-546. doi:
10.1016/j.ijbiomac.2021.03.050. [PMID: 33722622] - Z H Hu, T S Zhao, H Y Liu, Q X Lin, G G Tu, B W Yang. Synthesis and receptor dependent 4D-QSAR studies of 4,5-dihydro-1,3,4-oxadiazole derivatives targeting cannabinoid receptor.
SAR and QSAR in environmental research.
2021 Mar; 32(3):175-190. doi:
10.1080/1062936x.2021.1879256. [PMID: 33618568] - Zi-Long Song, Yun Zhu, Jing-Rui Liu, Shu-Ke Guo, Yu-Cheng Gu, Xinya Han, Hong-Qiang Dong, Qi Sun, Wei-Hua Zhang, Ming-Zhi Zhang. Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety.
Molecular diversity.
2021 Feb; 25(1):205-221. doi:
10.1007/s11030-020-10048-8. [PMID: 32056130] - Guangqian Yang, Huanlin Zheng, Wubin Shao, Liwei Liu, Zhibing Wu. Study of the in vivo antiviral activity against TMV treated with novel 1-(t-butyl)-5-amino-4-pyrazole derivatives containing a 1,3,4-oxadiazole sulfide moiety.
Pesticide biochemistry and physiology.
2021 Jan; 171(?):104740. doi:
10.1016/j.pestbp.2020.104740. [PMID: 33357562] - Łukasz Szczukowski, Edward Krzyżak, Adrianna Zborowska, Patrycja Zając, Katarzyna Potyrak, Krzysztof Peregrym, Benita Wiatrak, Aleksandra Marciniak, Piotr Świątek. Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors.
International journal of molecular sciences.
2020 Dec; 21(24):. doi:
10.3390/ijms21249623. [PMID: 33348757] - Jie Xiang, Dengyue Liu, Jixiang Chen, Deyu Hu, Baoan Song. Design and synthesis of novel 1,3,4-oxadiazole sulfone compounds containing 3,4-dichloroisothiazolylamide moiety and evaluation of rice bacterial activity.
Pesticide biochemistry and physiology.
2020 Nov; 170(?):104695. doi:
10.1016/j.pestbp.2020.104695. [PMID: 32980058] - Jixiang Chen, Yuqin Luo, Chengqian Wei, Sikai Wu, Rong Wu, Shaobo Wang, Deyu Hu, Baoan Song. Novel sulfone derivatives containing a 1,3,4-oxadiazole moiety: design and synthesis based on the 3D-QSAR model as potential antibacterial agent.
Pest management science.
2020 Sep; 76(9):3188-3198. doi:
10.1002/ps.5873. [PMID: 32343024] - Arooj Mohsin Alvi, Lina Tariq Al Kury, Muhammad Umar Ijaz, Fawad Ali Shah, Muhammad Tariq Khan, Ahmed Sadiq Sheikh, Humaira Nadeem, Arif-Ullah Khan, Alam Zeb, Shupeng Li. Post-Treatment of Synthetic Polyphenolic 1,3,4 Oxadiazole Compound A3, Attenuated Ischemic Stroke-Induced Neuroinflammation and Neurodegeneration.
Biomolecules.
2020 05; 10(6):. doi:
10.3390/biom10060816. [PMID: 32466476] - Yuan-Yuan Wu, Wu-Bin Shao, Jian-Jun Zhu, Zhou-Qing Long, Li-Wei Liu, Pei-Yi Wang, Zhong Li, Song Yang. Novel 1,3,4-Oxadiazole-2-carbohydrazides as Prospective Agricultural Antifungal Agents Potentially Targeting Succinate Dehydrogenase.
Journal of agricultural and food chemistry.
2019 Dec; 67(50):13892-13903. doi:
10.1021/acs.jafc.9b05942. [PMID: 31774673] - Ming-Wei Wang, Huai-He Zhu, Pei-Yi Wang, Dan Zeng, Yuan-Yuan Wu, Li-Wei Liu, Zhi-Bing Wu, Zhong Li, Song Yang. Synthesis of Thiazolium-Labeled 1,3,4-Oxadiazole Thioethers as Prospective Antimicrobials: In Vitro and in Vivo Bioactivity and Mechanism of Action.
Journal of agricultural and food chemistry.
2019 Nov; 67(46):12696-12708. doi:
10.1021/acs.jafc.9b03952. [PMID: 31657554] - Tianlei Li, Gang Wen, Jishun Li, Wenxuan Zhang, Song Wu. A Useful Synthesis of 2-Acylamino-1,3,4-oxadiazoles from Acylthiosemicarbazides Using Potassium Iodate and the Discovery of New Antibacterial Compounds.
Molecules (Basel, Switzerland).
2019 Apr; 24(8):. doi:
10.3390/molecules24081490. [PMID: 30988267] - Lan Wen, Weilin Jian, Junbing Shang, Daohang He. Synthesis and antifungal activities of novel thiophene-based stilbene derivatives bearing an 1,3,4-oxadiazole unit.
Pest management science.
2019 Apr; 75(4):1123-1130. doi:
10.1002/ps.5229. [PMID: 30284404] - Shaobo Wang, Xiuhai Gan, Yanju Wang, Shaoyuan Li, Chongfen Yi, Jixiang Chen, Fangcheng He, Yuyuan Yang, Deyu Hu, Baoan Song. Novel 1,3,4-Oxadiazole Derivatives Containing a Cinnamic Acid Moiety as Potential Bactericide for Rice Bacterial Diseases.
International journal of molecular sciences.
2019 Feb; 20(5):. doi:
10.3390/ijms20051020. [PMID: 30813628] - Jixiang Chen, Yongzhong Chen, Xiuhai Gan, Baojing Song, Deyu Hu, Baoan Song. Synthesis, Nematicidal Evaluation, and 3D-QSAR Analysis of Novel 1,3,4-Oxadiazole-Cinnamic Acid Hybrids.
Journal of agricultural and food chemistry.
2018 Sep; 66(37):9616-9623. doi:
10.1021/acs.jafc.8b03020. [PMID: 30145894] - Pei Li, Deyu Hu, Dandan Xie, Jixiang Chen, Linhong Jin, Baoan Song. Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents.
Journal of agricultural and food chemistry.
2018 Mar; 66(12):3093-3100. doi:
10.1021/acs.jafc.7b06061. [PMID: 29502398] - Zi-Zhen Wang, Wen-Xue Sun, Xue Wang, Ya-Han Zhang, Han-Yue Qiu, Jin-Liang Qi, Yan-Jun Pang, Gui-Hua Lu, Xiao-Ming Wang, Fu-Gen Yu, Yong-Hua Yang. Design, synthesis, biological evaluation, and 3D-QSAR analysis of podophyllotoxin-dioxazole combination as tubulin targeting anticancer agents.
Chemical biology & drug design.
2017 08; 90(2):236-243. doi:
10.1111/cbdd.12942. [PMID: 28079286] - Shihu Su, Xia Zhou, Guoping Liao, Puying Qi, Linhong Jin. Synthesis and Antibacterial Evaluation of New Sulfone Derivatives Containing 2-Aroxymethyl-1,3,4-Oxadiazole/Thiadiazole Moiety.
Molecules (Basel, Switzerland).
2016 Dec; 22(1):. doi:
10.3390/molecules22010064. [PMID: 28042864] - Khairujjaman Laskar, Parvez Alam, Rizwan Hasan Khan, Abdul Rauf. Synthesis, characterization and interaction studies of 1,3,4-oxadiazole derivatives of fatty acid with human serum albumin (HSA): A combined multi-spectroscopic and molecular docking study.
European journal of medicinal chemistry.
2016 Oct; 122(?):72-78. doi:
10.1016/j.ejmech.2016.06.012. [PMID: 27343854] - Yan Zhang, Xing-Hai Liu, Yi-Zhou Zhan, Li-Yuan Zhang, Zheng-Ming Li, Yong-Hong Li, Xiao Zhang, Bao-Lei Wang. Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors.
Bioorganic & medicinal chemistry letters.
2016 10; 26(19):4661-4665. doi:
10.1016/j.bmcl.2016.08.059. [PMID: 27575481] - Pei-Yi Wang, Lei Zhou, Jian Zhou, Zhi-Bing Wu, Wei Xue, Bao-An Song, Song Yang. Synthesis and antibacterial activity of pyridinium-tailored 2,5-substituted-1,3,4-oxadiazole thioether/sulfoxide/sulfone derivatives.
Bioorganic & medicinal chemistry letters.
2016 Feb; 26(4):1214-7. doi:
10.1016/j.bmcl.2016.01.029. [PMID: 26810264] - Pei Li, Yuhua Ma, Junliang Zhou, Hui Luo, Jiawen Yan, Yongya Mao, Zhuang Wang. The Efficacy and Underlying Mechanism of Sulfone Derivatives Containing 1,3,4-oxadiazole on Citrus Canker.
Molecules (Basel, Switzerland).
2015 Aug; 20(8):14103-17. doi:
10.3390/molecules200814103. [PMID: 26247929] - Pu Li, Xin Wang, Jian Li, Zhi-Yun Meng, Shu-Chun Li, Zhong-Jun Li, Ying-Yuan Lu, Hong Ren, Ya-Qing Lou, Chuang Lu, Gui-Fang Dou, Guo-Liang Zhang. Quantitative and qualitative analysis of the novel antitumor 1,3,4-oxadiazole derivative (GLB) and its metabolites using HPLC-UV and UPLC-QTOF-MS.
Scientific reports.
2015 Jul; 5(?):11906. doi:
10.1038/srep11906. [PMID: 26148672] - Li Shi, Pei Li, Wenli Wang, Manni Gao, Zengxue Wu, Xianpeng Song, Deyu Hu. Antibacterial Activity and Mechanism of Action of Sulfone Derivatives Containing 1,3,4-Oxadiazole Moieties on Rice Bacterial Leaf Blight.
Molecules (Basel, Switzerland).
2015 Jun; 20(7):11660-75. doi:
10.3390/molecules200711660. [PMID: 26114927] - Pei Li, Li Shi, Man-Ni Gao, Xia Yang, Wei Xue, Lin-Hong Jin, De-Yu Hu, Bao-An Song. Antibacterial activities against rice bacterial leaf blight and tomato bacterial wilt of 2-mercapto-5-substituted-1,3,4-oxadiazole/thiadiazole derivatives.
Bioorganic & medicinal chemistry letters.
2015 Feb; 25(3):481-4. doi:
10.1016/j.bmcl.2014.12.038. [PMID: 25563889] - Pei Li, Li Shi, Xia Yang, Lei Yang, Xue-Wen Chen, Fang Wu, Qing-Cai Shi, Wei-Ming Xu, Ming He, De-Yu Hu, Bao-An Song. Design, synthesis, and antibacterial activity against rice bacterial leaf blight and leaf streak of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivative.
Bioorganic & medicinal chemistry letters.
2014 Apr; 24(7):1677-80. doi:
10.1016/j.bmcl.2014.02.060. [PMID: 24631191] - Yoshihiro Shibata, Katsuji Kagechika, Mitsuhiro Yamaguchi, Kenji Yoshikawa, Kiyoshi Chiba, Hiromichi Takano, Chiyuki Akiyama, Mayumi Ono, Mina Nishi, Hideo Kubo, Yoshimasa Kobayashi, Hiroyuki Usui. Synthesis and structure-activity relationships of novel zwitterionic compounds as peroxisome proliferator activated receptor α/γ dual agonists with improved physicochemical properties.
Chemical & pharmaceutical bulletin.
2013; 61(12):1248-63. doi:
10.1248/cpb.c13-00513. [PMID: 24292787] - Gita Chawla, Umesh Kumar, Sandhya Bawa, Jagdish Kumar. Syntheses and evaluation of anti-inflammatory, analgesic and ulcerogenic activities of 1,3,4-oxadiazole and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives.
Journal of enzyme inhibition and medicinal chemistry.
2012 Oct; 27(5):658-65. doi:
10.3109/14756366.2011.606543. [PMID: 21899490] - Wei-Ming Xu, Fei-Fei Han, Ming He, De-Yu Hu, Jiang He, Song Yang, Bao-An Song. Inhibition of tobacco bacterial wilt with sulfone derivatives containing an 1,3,4-oxadiazole moiety.
Journal of agricultural and food chemistry.
2012 Feb; 60(4):1036-41. doi:
10.1021/jf203772d. [PMID: 22208183] - Cr Biju, K Ilango, Manju Prathap, K Rekha. Design and Microwave-assisted Synthesis of 1,3,4-Oxadiazole Derivatives for Analgesic and Anti-inflammatory Activity.
Journal of young pharmacists : JYP.
2012 Jan; 4(1):33-7. doi:
10.4103/0975-1483.93576. [PMID: 22523458] - Mymoona Akhter, Nayeema Akhter, M M Alam, M S Zaman, Rikta Saha, A Kumar. Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity.
Journal of enzyme inhibition and medicinal chemistry.
2011 Dec; 26(6):767-76. doi:
10.3109/14756366.2010.550890. [PMID: 21314246] - Weiming Xu, Jiang He, Ming He, Feifei Han, Xuehai Chen, Zhaoxi Pan, Jian Wang, Maoguo Tong. Synthesis and antifungal activity of novel sulfone derivatives containing 1,3,4-oxadiazole moieties.
Molecules (Basel, Switzerland).
2011 Nov; 16(11):9129-41. doi:
10.3390/molecules16119129. [PMID: 22045041] - Sadaf J Gilani, Suroor A Khan, Nadeem Siddiqui. Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid.
Bioorganic & medicinal chemistry letters.
2010 Aug; 20(16):4762-5. doi:
10.1016/j.bmcl.2010.06.125. [PMID: 20643545] - Gamal A Idrees, Omar M Aly, Gamal El-Din A A Abuo-Rahma, M F Radwan. Design, synthesis and hypolipidemic activity of novel 2-(naphthalen-2-yloxy)propionic acid derivatives as desmethyl fibrate analogs.
European journal of medicinal chemistry.
2009 Oct; 44(10):3973-80. doi:
10.1016/j.ejmech.2009.04.026. [PMID: 19450906] - A Husain, Priyanka Ahuja, Sarafroz. Synthesis and Biological Evaluation of beta-Aroylpropionic acid based 1,3,4-Oxadiazoles.
Indian journal of pharmaceutical sciences.
2009 Jan; 71(1):62-6. doi:
10.4103/0250-474x.51963. [PMID: 20177461] - Mohammad Amir, Harish Kumar, Sadique A Javed. Non-carboxylic analogues of naproxen: design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives.
Archiv der Pharmazie.
2007 Nov; 340(11):577-85. doi:
10.1002/ardp.200700065. [PMID: 17924361] - Shaukath A Khanum, Sheena Shashikanth, Belgur S Sudha, Saligrama A Deepak, Huntrike S Shetty. Synthesis and anti-mildew activity of 5-(2-aroyl)aryloxymethyl-2-phenyl-1 ,3,4-oxadiazoles against downy mildew of pearl millet.
Pest management science.
2004 Nov; 60(11):1119-24. doi:
10.1002/ps.917. [PMID: 15532687] - Erhan Palaska, Gülay Sahin, Pelin Kelicen, N Tuğba Durlu, Gülçin Altinok. Synthesis and anti-inflammatory activity of 1-acylthiosemicarbazides, 1,3,4-oxadiazoles, 1,3,4-thiadiazoles and 1,2,4-triazole-3-thiones.
Farmaco (Societa chimica italiana : 1989).
2002 Feb; 57(2):101-7. doi:
10.1016/s0014-827x(01)01176-4. [PMID: 11902651]