BMS 299897 (BioDeep_00000736826)
代谢物信息卡片
化学式: C24H21ClF3NO4S (511.0831852000001)
中文名称: 2-((1R)-1-(((4-氯苯基)磺酰基)(2,5-二氟苯基)氨基)乙基)-5-氟苯丁酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1=C(C=C(C=C1)F)CCCC(=O)O)N(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C24H21ClF3NO4S/c1-15(21-11-7-18(26)13-16(21)3-2-4-24(30)31)29(23-14-19(27)8-12-22(23)28)34(32,33)20-9-5-17(25)6-10-20/h5-15H,2-4H2,1H3,(H,30,31)/t15-/m1/s1
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Johann Meunier, Nozha Borjini, Cyril Gillis, Vanessa Villard, Tangui Maurice. Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative.
Journal of Alzheimer's disease : JAD.
2015; 44(2):507-24. doi:
10.3233/jad-140711. [PMID: 25298201] - Johann Meunier, Vanessa Villard, Laurent Givalois, Tangui Maurice. The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease.
European journal of pharmacology.
2013 Jan; 698(1-3):193-9. doi:
10.1016/j.ejphar.2012.10.033. [PMID: 23123349] - Maria Z Kounnas, Anne M Danks, Soan Cheng, Curtis Tyree, Elizabeth Ackerman, Xulun Zhang, Kwangwook Ahn, Phuong Nguyen, Dan Comer, Long Mao, Chengzhi Yu, David Pleynet, Paul J Digregorio, Gonul Velicelebi, Kenneth A Stauderman, William T Comer, William C Mobley, Yue-Ming Li, Sangram S Sisodia, Rudolph E Tanzi, Steven L Wagner. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Neuron.
2010 Sep; 67(5):769-80. doi:
10.1016/j.neuron.2010.08.018. [PMID: 20826309] - M Zheng, J Wang, J Lubinski, O P Flint, R Krishna, M Yao, J M Pursley, A Thakur, D W Boulton, K S Santone, D M Barten, J J Anderson, K M Felsenstein, S B Hansel. Studies on the pharmacokinetics and metabolism of a gamma-secretase inhibitor BMS-299897, and exploratory investigation of CYP enzyme induction.
Xenobiotica; the fate of foreign compounds in biological systems.
2009 Jul; 39(7):544-55. doi:
10.1080/00498250902928555. [PMID: 19480557] - Y J Xue, Janice Pursley, Mark Arnold. Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2007 Apr; 43(5):1728-36. doi:
10.1016/j.jpba.2006.11.035. [PMID: 17204392] - Jeffery J Anderson, Greg Holtz, Patricia P Baskin, Mary Turner, Blake Rowe, Bowei Wang, Maria Z Kounnas, Bruce T Lamb, Donna Barten, Kevin Felsenstein, Ian McDonald, Kumar Srinivasan, Ben Munoz, Steven L Wagner. Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.
Biochemical pharmacology.
2005 Feb; 69(4):689-98. doi:
10.1016/j.bcp.2004.11.015. [PMID: 15670587]