NPS-2143 (BioDeep_00000736825)
代谢物信息卡片
NPS-2143
化学式: C24H25ClN2O2 (408.160446)
中文名称: NPS-2143
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(CC1=CC2=CC=CC=C2C=C1)NCC(COC3=C(C(=CC=C3)Cl)C#N)O
InChI: InChI=1S/C24H25ClN2O2/c1-24(2,13-17-10-11-18-6-3-4-7-19(18)12-17)27-15-20(28)16-29-23-9-5-8-22(25)21(23)14-26/h3-12,20,27-28H,13,15-16H2,1-2H3/t20-/m1/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lvyang Wang, Liren Ding, Weiyun Zhu, Suqin Hang. Soybean protein hydrolysate stimulated cholecystokinin secretion and inhibited feed intake through calcium-sensing receptors and intracellular calcium signalling in pigs.
Food & function.
2021 Oct; 12(19):9286-9299. doi:
10.1039/d1fo01596f. [PMID: 34606544] - Ipek Acar, Alper Cetinkaya, Incilay Lay, Esin Ileri-Gurel. The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats.
Nutritional neuroscience.
2020 Jun; 23(6):481-489. doi:
10.1080/1028415x.2018.1521906. [PMID: 30222528] - Taha Elajnaf, Luca Iamartino, Ildiko Mesteri, Christian Müller, Marcella Bassetto, Teresa Manhardt, Sabina Baumgartner-Parzer, Enikö Kallay, Martin Schepelmann. Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice.
Nutrients.
2019 Dec; 11(12):. doi:
10.3390/nu11123072. [PMID: 31888253] - Anna Szczoczarz, Aleksandra Marchwińska, Aleksandra Dyś, Konrad Boblewski, Artur Lehmann, Barbara Lewko, Apolonia Rybczyńska. Verapamil prevents the effect of calcium-sensing receptor activation on the blood glucose and insulin levels in rats.
Pharmacological reports : PR.
2019 Jun; 71(3):478-484. doi:
10.1016/j.pharep.2019.01.004. [PMID: 31003161] - Maria Lo Giudice, Balázs Mihalik, Zsófia Turi, András Dinnyés, Julianna Kobolák. Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAβPPα Release from PSEN1 Mutant iPSC-Derived Neurons.
Journal of Alzheimer's disease : JAD.
2019; 72(3):885-899. doi:
10.3233/jad-190602. [PMID: 31640098] - Shane D Hellyer, Sabine Albold, Taide Wang, Amy N Y Chen, Lauren T May, Katie Leach, Karen J Gregory. "Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu5 Allosteric Ligands.
Molecular pharmacology.
2018 05; 93(5):504-514. doi:
10.1124/mol.117.111518. [PMID: 29514854] - Apolonia Rybczyńska, Aleksandra Marchwińska, Aleksandra Dyś, Konrad Boblewski, Artur Lehmann, Barbara Lewko. Activity of the calcium-sensing receptor influences blood glucose and insulin levels in rats.
Pharmacological reports : PR.
2017 Aug; 69(4):709-713. doi:
10.1016/j.pharep.2017.01.034. [PMID: 28551530] - Anna Chiarini, Ubaldo Armato, Daisong Liu, Ilaria Dal Prà. Calcium-Sensing Receptor Antagonist NPS 2143 Restores Amyloid Precursor Protein Physiological Non-Amyloidogenic Processing in Aβ-Exposed Adult Human Astrocytes.
Scientific reports.
2017 04; 7(1):1277. doi:
10.1038/s41598-017-01215-3. [PMID: 28455519] - Caroline M Gorvin, Fadil M Hannan, Sarah A Howles, Valerie N Babinsky, Sian E Piret, Angela Rogers, Andrew J Freidin, Michelle Stewart, Anju Paudyal, Tertius A Hough, M Andrew Nesbit, Sara Wells, Tonia L Vincent, Stephen Dm Brown, Roger D Cox, Rajesh V Thakker. Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.
JCI insight.
2017 02; 2(3):e91103. doi:
10.1172/jci.insight.91103. [PMID: 28194447] - Wenda Wu, Hui-Ren Zhou, Steven J Bursian, Jane E Link, James J Pestka. Calcium-Sensing Receptor and Transient Receptor Ankyrin-1 Mediate Emesis Induction by Deoxynivalenol (Vomitoxin).
Toxicological sciences : an official journal of the Society of Toxicology.
2017 01; 155(1):32-42. doi:
10.1093/toxsci/kfw191. [PMID: 27667315] - Wenda Wu, Hui-Ren Zhou, James J Pestka. Potential roles for calcium-sensing receptor (CaSR) and transient receptor potential ankyrin-1 (TRPA1) in murine anorectic response to deoxynivalenol (vomitoxin).
Archives of toxicology.
2017 Jan; 91(1):495-507. doi:
10.1007/s00204-016-1687-x. [PMID: 26979077] - Fadil M Hannan, Gerard V Walls, Valerie N Babinsky, M Andrew Nesbit, Enikö Kallay, Tertius A Hough, William D Fraser, Roger D Cox, Jianxin Hu, Allen M Spiegel, Rajesh V Thakker. The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).
Endocrinology.
2015 Sep; 156(9):3114-21. doi:
10.1210/en.2015-1269. [PMID: 26052899] - Hui Li, Christine Feinle-Bisset, Claudine Frisby, Stephen Kentish, Gary A Wittert, Amanda J Page. Gastric neuropeptide W is regulated by meal-related nutrients.
Peptides.
2014 Dec; 62(?):6-14. doi:
10.1016/j.peptides.2014.09.003. [PMID: 25270269] - Yongfeng Gong, Jianghui Hou. Claudin-14 underlies Ca⁺⁺-sensing receptor-mediated Ca⁺⁺ metabolism via NFAT-microRNA-based mechanisms.
Journal of the American Society of Nephrology : JASN.
2014 Apr; 25(4):745-60. doi:
10.1681/asn.2013050553. [PMID: 24335970] - Kristian Daly, Miran Al-Rammahi, Andrew Moran, Marco Marcello, Yuzo Ninomiya, Soraya P Shirazi-Beechey. Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion.
American journal of physiology. Gastrointestinal and liver physiology.
2013 Feb; 304(3):G271-82. doi:
10.1152/ajpgi.00074.2012. [PMID: 23203156] - Alexandre Loupy, Suresh Krishna Ramakrishnan, Bharath Wootla, Régine Chambrey, Renaud de la Faille, Soline Bourgeois, Patrick Bruneval, Chantal Mandet, Erik Ilso Christensen, Hélène Faure, Lydie Cheval, Kamel Laghmani, Corinne Collet, Dominique Eladari, Robert H Dodd, Martial Ruat, Pascal Houillier. PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor.
The Journal of clinical investigation.
2012 Sep; 122(9):3355-67. doi:
10.1172/jci57407. [PMID: 22886306] - Anna E Davey, Katie Leach, Celine Valant, Arthur D Conigrave, Patrick M Sexton, Arthur Christopoulos. Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.
Endocrinology.
2012 Mar; 153(3):1232-41. doi:
10.1210/en.2011-1426. [PMID: 22210744] - Jianying Feng, Clark D Petersen, David H Coy, Jian-Kang Jiang, Craig J Thomas, Martin R Pollak, Stephen A Wank. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Oct; 107(41):17791-6. doi:
10.1073/pnas.1009078107. [PMID: 20876097] - Saskia Letz, Ramona Rus, Christine Haag, Helmuth-Günther Dörr, Dirk Schnabel, Matthias Möhlig, Egbert Schulze, Karin Frank-Raue, Friedhelm Raue, Bernhard Mayr, Christof Schöfl. Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors.
The Journal of clinical endocrinology and metabolism.
2010 Oct; 95(10):E229-33. doi:
10.1210/jc.2010-0651. [PMID: 20668040] - A Rybczynska, A Jurska-Jasko, K Boblewski, A Lehmann, C Orlewska. Blockade of calcium channels and AT1 receptor prevents the hypertensive effect of calcilytic NPS 2143 in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2010 Apr; 61(2):163-70. doi:
. [PMID: 20436216] - Robert W Marquis, Amparo M Lago, James F Callahan, Attiq Rahman, Xiaoyang Dong, George B Stroup, Sandra Hoffman, Maxine Gowen, Eric G DelMar, Bradford C Van Wagenen, Sarah Logan, Scott Shimizu, John Fox, Edward F Nemeth, Theresa Roethke, Brian R Smith, Keith W Ward, Pradip Bhatnagar. Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.
Journal of medicinal chemistry.
2009 Nov; 52(21):6599-605. doi:
10.1021/jm900563e. [PMID: 19821575] - Apolonia Rybczynska, Artur Lehmann, Anna Jurska-Jasko, Konrad Boblewski, Czeslawa Orlewska, Henryk Foks, Krystyna Drewnowska. Hypertensive effect of calcilytic NPS 2143 administration in rats.
The Journal of endocrinology.
2006 Oct; 191(1):189-95. doi:
10.1677/joe.1.06924. [PMID: 17065402] - Brian J Arey, Ramakrishna Seethala, Zhengping Ma, Aberra Fura, Jennifer Morin, Joann Swartz, Viral Vyas, Wu Yang, John K Dickson, Jean H M Feyen. A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo.
Endocrinology.
2005 Apr; 146(4):2015-22. doi:
10.1210/en.2004-1318. [PMID: 15637285] - Apolonia Rybczyńska, Anzelm Hoppe. [Calcimimmetic and calcilytics: new perspectives of correction of abnormal parathormone (PTH) secretion].
Przeglad lekarski.
2003; 60(6):418-24. doi:
NULL. [PMID: 14974181] - E F Nemeth. The search for calcium receptor antagonists (calcilytics).
Journal of molecular endocrinology.
2002 Aug; 29(1):15-21. doi:
10.1677/jme.0.0290015. [PMID: 12200226] - E F Nemeth, E G Delmar, W L Heaton, M A Miller, L D Lambert, R L Conklin, M Gowen, J G Gleason, P K Bhatnagar, J Fox. Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.
The Journal of pharmacology and experimental therapeutics.
2001 Oct; 299(1):323-31. doi:
NULL. [PMID: 11561095]